Abstract: The present invention relates to liposomal compositions, comprising liposomes comprising tetraether lipids (TELs) and cell penetrating peptides (CPPs), wherein said CPPs are attached to a compound being part of the liposome's lipid double layer. The present invention further relates to uses thereof for the oral delivery of therapeutic and/or diagnostic agents.

Abstract: An anti-CEACAM1 antibody includes at least one antibody heavy chain (VH) domain having antigen binding sites CDR1H, CDR2H and CDR3H, and at least one antibody light chain (VL) domain having antigen binding sites CDR1L, CDR2L and CDR3L. The antigen binding site CDR2H has a sequence homology of at least 80% to the amino acid sequence WINTYTGEPT (SEQ ID No. 21).

Abstract: The present invention relates to a pharmaceutical composition comprising a (poly)peptide which comprises or consists of QEP or a QEP derivative thereof a nucleic acid molecule encoding said (poly)peptide or a vector comprising said nucleic acid molecule, for use in the prevention or in the treatment of a disease or disorder caused by, physiologically linked to or associated with glucose and/or galactose uptake, wherein said pharmaceutical composition is to be administered under a high-sugar condition. Furthermore, the pharmaceutical composition of the invention is for use in increasing insulin sensitivity. The invention further relates to a food composition comprising said (poly)peptide. The invention further relates to a method of screening for and/or identifying a compound suitable to prevent or treat said disease or disorder under a high-sugar condition.

Abstract: The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).

Abstract: What is presented here is a transparent electrode having: at least one carrier layer for stabilizing the electrode; at least one electrically conductive layer containing metal nanowires, which is produced by spreading a suspension of a liquid and the metal nanowires surrounded by a stabilizing layer, along the carrier layer and drying same by removing the liquid; and at least one functional organic layer formed along the carrier layer, which, while the electrically conductive layer dries, by an electrical interaction with the metal nanowires and/or with the stabilizing layers of the metal nanowires, changes an interaction between the metal nanowires and the stabilizing layers such that the result is a substance-to-substance bond between the metal nanowires.

Abstract: A receiving container for a detector which operates in an ultrahigh vacuum or in a protective gas atmosphere that consists of high-purity gas. The receiving container has a receiving portion which forms at least a portion of the receiving space for the detector, and a cover for hermetically sealing the receiving space. A first sealing surface is arranged at the receiving portion and a second sealing surface matching the first sealing surface is arranged at the cover. Between the sealing surfaces a gasket is arranged. A securing device presses the cover against the receiving portion to provide a defined contact pressure of the gasket.

Abstract: In a method for impregnating semi-finished fibrous products using resin as the impregnating means, winding or laying the semi-finished fibrous products in a plurality of layers on top of one another onto a receiving carrier is initially performed. Here, lower layers lie close to the receiving carrier, and upper layers lie more remote therefrom. The receiving carrier is configured so as to be permeable to the impregnating means. The impregnating means is then introduced through the receiving carrier into the semi-finished fibrous products, wherein the impregnating means initially permeates the lower layers and then permeates the upper layers of the semi-finished fibrous products.

Abstract: The invention relates to an isolated nucleic acid molecule comprising at least one promoter that is active in fungal cells of the trichoderma species, wherein a nucleic acid sequence encoding an N-acetylglucosamine-2-epimerase and/or an N-acetylneuraminic acid synthase is operatively bound to each promoter. The at least one promoter that is active in fungal cells is a constitutive promoter.

Abstract: An apparatus for generating at least one audio output signal based on an audio data stream having audio data relating to one or more sound sources is provided. The apparatus has a receiver for receiving the audio data stream having the audio data. The audio data has one or more pressure values for each one of the sound sources. Furthermore, the audio data has one or more position values indicating a position of one of the sound sources for each one of the sound sources. Moreover, the apparatus has a synthesis module for generating the at least one audio output signal based on at least one of the one or more pressure values of the audio data of the audio data stream and based on at least one of the one or more position values of the audio data of the audio data stream.

Abstract: A catheter assembly includes an elongated catheter shaft, a magnetic sensor, and one or more wires. The elongated catheter shaft has a shaft proximal end and a shaft distal end, and the magnetic sensor includes a coil having a coil proximal end and a coil distal end that is situated toward or at the shaft distal end. The one or more wires extend through the elongated catheter shaft and are situated adjacent the magnetic sensor. Each of the one or more wires is electrically coupled to the coil at the coil distal end.

Abstract: A method of measuring a spectral response of a biological sample (1), comprises the steps generation of probe light having a primary spectrum, irradiation of the sample (1) with the probe light, including an interaction of the probe light and the sample (1), and spectrally resolved detection of the probe light having a modified spectrum, which deviates from the primary spectrum as a result of the interaction of the probe light and the sample (1), said modified spectrum being characteristic of the spectral response of the sample (1), wherein the probe light comprises probe light pulses (2) being generated with a fs laser source device (10). Furthermore, a spectroscopic measuring apparatus is described, which is configured for measuring a spectral response of a biological sample (1).

Abstract: The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive bacteria, particularly to carbohydrate structures exposed on the surface of the bacteria. The invention includes monoclonal and chimeric antibodies, as well as fragments, regions and derivatives thereof. This invention also relates to the epitope to which the antibodies of the invention bind as well as the sequences, fragments, and regions of the epitopes. Both the antibodies and peptides that encompass the epitope, and regions and fragments thereof, may be used for diagnostic, prophylactic and therapeutic applications.

Abstract: An illumination unit for lithographic exposure and a device for lithographic exposure are disclosed. In an embodiment the illumination unit includes a beam source, an electronically drivable beam deflection element for generating a temporally varying two-dimensional beam deflection, a collimation lens, a beam homogenizing element, a Fourier lens and a field lens.

Abstract: Positioning structures in at least one indentation present on a or in a support, wherein said indentation is an indentation having a diameter in the nanometer range, makes it possible to position the structure in the indentation substantially centrally with defined orientation. A support having at least one indentation, wherein the indentation has a size in the nanometer range, includes a predetermined structure which is arranged substantially centrally within said indentation and which optionally has a functional unit diametrically opposite to the side pointing to the bottom surface. The arrangement is especially suitable for single molecule analysis and, here especially, for single molecule sequencing and other high-throughput methods.

Abstract: The invention relates to a method of manufacturing triazine, pyrimidine and pyridine derivatives of formula (I), wherein U, V, W and Z are nitrogen or carbon atoms, whereby at least one of U, V and W is nitrogen, and the other substituents are defined as in the specification, by condensing a corresponding halo-triazine, pyrimidine or pyridine in a type of Suzuki coupling with a pyridyl- or pyrimidinyl-borane, wherein the amino function is protected as a formamidine. The invention further relates to suitable intermediates and methods of manufacturing of such intermediates. Furthermore the invention relates to pure 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine in solid form.

Abstract: A mechanical actuator for Magnetic Resonance Elastography (MRE) and a method for inducing shear waves for MRE as well as respective system and method for MRE using the principle of centrifugal force for wave induction is disclosed. The mechanical actuator comprises a passive driver including a rotational turbine vibrator having an eccentric weight, the turbine vibrator being powered by a fluid (e.g. compresses air or water), and an active driver configured to control the pressure of the fluid powering the turbine vibrator.

Abstract: An electric machine, in particular an electric motor, comprising a stator and a rotor, which are separated from each other by an air gap, wherein a measuring coil unit comprising a number of measuring coils which are adjacent to each other is arranged in the air gap. The electric machine is characterised in that the measuring coils are arranged one behind the other in the axial direction in the air gap. The invention further relates to a measuring coil unit which can be inserted in an air gap of an electric machine of this type, and a method for determining operating parameters of an electric machine which has a measuring coil unit of this type.

Abstract: An electrical signal amplifier, having an amplifier input and an amplifier output is provided, which are set up to receive an electrical input signal and to output an amplified signal as electrical output signal, wherein an amplifier circuit arranged between the amplifier input and the amplifier output and amplifying the electrical input signal has a voltage divider circuit and a series circuit of gate-source paths in a transistor arrangement, which is assigned to an amplifier stage, the voltage divider circuit is connected downstream of the amplifier input, and an output of the voltage divider circuit is connected to gate contacts of the series circuit of gate-source paths, and a gate voltage supply circuit is connected to the gate contacts of the series circuit of gate-source paths. The disclosure furthermore relates to a method for amplifying an electrical signal by means of an electrical signal amplifier.

Abstract: An RFID reader includes a transmitter, a receiver, and an evaluator. The receiver receives signals from RFID tags within a given number of slots of a time frame with a given frame size and provides a number of successful slots and a number of collided slots. The evaluator sets a modified frame size based on an estimated number of RFID tags which is determined based on the frame size, the number of successful slots, and the number of collided slots. The invention also refers to a corresponding method.

Abstract: The invention relates to a method for performing a biochemical or chemical reaction for an isolated, spatially separated amplification of sample fragments during a simultaneous immobilization and spatial arrangement of the sample fragments and reaction products, the amplification products, on one or more suitable solid phases for subsequent derivatizations.