Abstract: The present invention relates to a process for removing the fouling deposited in a milk processor unit after a thermal processing of milk or a food product including milk at a T between 80° C. and 150° C. for at least 4 hours, including said fouling proteins, lactose, minerals and products formed therefrom, comprising the step of applying a cleaning solution on said fouling deposited in the milk processor unit. The present invention further relates to a cleaning solution for removing the fouling deposited in a milk processor unit.

Abstract: New gene therapy constructions and compositions are the subject of present invention. The gene therapy compositions consist in adeno-associated vectors which jointly express insulin (Ins) and glucokinase (Gck) genes. The new gene therapy constructions are useful for treatment of diabetes either in dosgs or human beings.

Abstract: The invention relates to a viral expression construct and related viral vector and composition and to their use wherein said construct and vector comprise elements a) and b): a) a nucleotide sequence encoding an insulin operably linked to a first promoter, b) a nucleotide sequence encoding a glucokinase operably linked to a second promoter and said viral expression construct and related viral vector comprise at least one of elements c), d) and e): c) the first and the second promoters are positioned in reverse orientation within the expression construct, d) the first and the second promoters are positioned in reverse orientation within the expression construct and are located adjacent to each other and e) the first promoter is a CMV promoter, preferably a mini CMV promoter.

Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.

Abstract: The present invention provides new Adeno-associated virus-derived vectors and pharmaceutical compositions containing the same for the treatment of lysosomal storage disorders and specially, for the treatment of mucopolysaccharidoses Type II.

Abstract: The invention relates to a viral expression construct and related viral vector and nucleic acid molecule and composition and to their use wherein said construct and vector are suitable for expression in a mammal and comprise a nucleotide sequence encoding a Fibroblast growth factor 21 (FGF21) to be expressed in liver, adipose tissue and/or skeletal muscle.

Abstract: The presently disclosed subject matter provides thermoelectric power generating systems that can include an arrangement of power generator units electrically connected to provide a global output voltage, each power generator unit generating an individual output voltage, and an electronic stabilization system. The electronic stabilization system can include DC/DC converters connected to one or more of the power generator units; electrical variable detectors including at least one of voltage detectors and current detectors for automatically measuring the individual voltage or individual current existing at a point of a DC/DC converter; and a microprocessor-based controller connected to the voltage and/or current detectors to receive the measured voltages and/or currents, and, based on the measurements, to control the operation of the DC/DC converters to obtain desired DC/DC converter output voltages and/or desired DC/DC converter currents.

Abstract: The monitoring probe (1) comprises: a FR-4 substrate (2) with two faces; two copper tracks (3) arranged on one of the faces of the substrate (2), with an electrical contact terminal (7) on the outside of the probe (1); a conductive region (6) with reference electrode functions, with an electrical contact terminal (8) on the outside of the probe (1), occupying the entire other face of the substrate (2); a passivating material layer (5) partially covering the copper tracks (3) and leaving two free zones (12, 13) of said tracks (3) uncovered, one of said free zones (12) corresponding to the electrical contact terminal (7) of the two copper tracks (3); and two ISE sensor elements (4) that are sensitive to at least one of the parameters of interest to be monitored in the ground, and arranged in the other of the free zones (13) of the two copper tracks (3).

Abstract: The present invention relates to a specialized pro-resolving lipid mediator comprising maresins, D-series resolvins, E-series resolvins, protectins or lipoxins, or a combination thereof, for use in the treatment of neurodegenerative diseases and/or autoimmune diseases.

Abstract: The present invention relates to compounds able to inhibit ?-synuclein aggregation, their use in the treatment or prophylaxis of a synucleinopathy and to pharmaceutical compositions comprising said compounds.

Abstract: A novel antimicrobial peptide is provided having an inhibitory effect on biofilms produced by biofilm-forming bacteria. The peptide is effective against wide range bacterial targets; generates no antimicrobial resistance; agglutinates bacteria cells enhancing the pathogen removal at the infectious focus; promotes biofilm eradication and prevents biofilm development. Compositions comprising the peptide are provided to treat and prevent infectious diseases, and for other uses such as the disinfection of medical and surgical materials.

Abstract: Conjugates comprising a targeting moiety specific for the CXCR4 and based on the polyphemusin-derived peptide and a therapeutic or imaging agent are provided. Therapeutic and diagnostic methods with the conjugates which require specific targeting to CXCR4+ cells are provided as well.

Abstract: The invention discloses using secreted splicing variant of mammal Klotho (s-KL) as an agent for the prevention N and/or treatment of cognitive and/or behaviour impairments. It also refers to gene constructs and expression vectors useful in gene therapy for the delivery of said s-KL variant to the central nervous system of a mammal, in particular a rodent or a human. Pharmaceutical compositions comprising either the protein s-KL or any gene construct for expressing the protein in the CNS are also disclosed.

Abstract: The present invention relates to a peptide, a magnetic peptide and a method for detecting coeliac disease. It also relates to a deaminated peptide used to prepare said magnetic peptide and to the use of both to detect coeliac disease. Said deaminated peptide comprises a histidine tag and is bonded to a particulated magnetic complex. It also relates to an immunosensor that comprises said magnetic peptide, to an appropriate method for detecting coeliac disease based on a magnetic immunoassay and to a kit that comprises said magnetic peptide.

Abstract: The invention is directed to combinations of acamprosate and ribavirin, to pharmaceutical compositions, kits and treatment methods for the treatment or prevention of neurological damage.

Abstract: A novel antimicrobial peptide is provided having an inhibitory effect on biofilms produced by biofilm-forming bacteria. The peptide is effective against wide range bacterial targets; generates no antimicrobial resistance; agglutinates bacteria cells enhancing the pathogen removal at the infectious focus; promotes biofilm eradication and prevents biofilm development. Compositions comprising the peptide are provided to treat and prevent infectious diseases, and for other uses such as the disinfection of medical and surgical materials.

Abstract: The invention relates to a new method for Arsenic adsorption-desorption and sorbent regeneration with no reagents added by taking advantage of the synergic thermo tuning of redox potential of the adsorption-desorption system.

Abstract: The presently disclosed subject matter provides thermoelectric power generating systems that can include an arrangement of power generator units electrically connected to provide a global output voltage, each power generator unit generating an individual output voltage, and an electronic stabilization system. The electronic stabilization system can include DC/DC converters connected to one or more of the power generator units; electrical variable detectors including at least one of voltage detectors and current detectors for automatically measuring the individual voltage or individual current existing at a point of a DC/DC converter; and a microprocessor-based controller connected to the voltage and/or current detectors to receive the measured voltages and/or currents, and, based on the measurements, to control the operation of the DC/DC converters to obtain desired DC/DC converter output voltages and/or desired DC/DC converter currents.

Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.

Abstract: Methods, systems, and devices are disclosed for the identification of chemical agents and determination of their level of exposure using electrochemical detection and advanced signal processing. In one aspect, a method includes collecting a sample from a surface containing a chemical agent to an electrode on a sensor such that the chemical agent transfers on the electrode, detecting an electrochemical signal of the chemical agent on the electrode to transduce chemical information associated with the chemical agent to an electrical signal, processing the electrical signal to obtain electrochemical spectral signature data to identify the chemical agent and generating a series of coefficients of the electrochemical spectral signature data to reduce the data, and classifying the chemical information based on the series of coefficients among preselected data sets to determine a level of exposure to the chemical agent.