Abstract: The present invention relates to a nucleic acid molecule containing a sequence of tricyclo nucleosides joined by internucleoside phosphorothioate linkage. The invention also relates to synthetic antisense oligonucleotides and to methods employing the same.
Type:
Grant
Filed:
October 12, 2012
Date of Patent:
August 22, 2017
Assignees:
ASSOCIATION INSTITUT DE MYOLOGIE, UNIVERSITAT BER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
Inventors:
Christian Leumann, Luis Garcia, Thomas Voit