Abstract: An organometallic compound represented by Formula 1: wherein M1 and M2 are each independently a first row transition metal, a second row transition metal, or a third row transition metal in the Periodic Table of Elements; and wherein L1, L2, a1, a2, Ar1, Ar2, R1 to R4, and LK in Formula 1 are as described in the present disclosure.

Abstract: Methods are provided of measuring and improving attention of a person with first and second eyes. These methods include: displaying one or more stimuli aimed at attracting attention of the person; obtaining, through an eye tracker, positions of the first and second eyes over time; calculating, from the obtained positions of the first and second eyes, a gaze direction evolution for each of the eyes and corresponding angular velocity evolution for each of the gaze directions; determining a motion synchrony evolution of the first and second eyes by comparing the calculated angular velocity evolution of the first eye with the calculated angular velocity evolution of the second eye; and measuring the attention of the person depending on the determined motion synchrony evolution. Computer programs, systems and computer systems that are suitable to perform such methods of measuring and improving attention are also provided.

Abstract: A programmable multiple-point illuminator for an optical microscope includes a light source and a spatial light modulator (SLM) to modulate a light beam from the light source. The modulated light beam scans across a sample provided with fluorophores placed under the microscope objective. The SLM includes a first and a second acousto-optic deflectors, said two acousto-optic deflectors being arranged in cascade to provide respective deflection in different directions, whereby the SLM is enabled to scan in two dimensions across the sample. The SLM further includes a telescope relay to conjugate the first modulation plane with the second modulation plane. The illuminator also has an arbitrary waveform generator configured to synthesize holograms, and is arranged to simultaneously inject a first such hologram into the first acousto-optic deflector and a second such hologram into the second acousto-optic deflector, in order to modulate the light beam in response to said holograms.

Abstract: A composition comprising nanoparticles, a method for the preparation of a composition comprising nanoparticles and uses of the composition for dental treatment are provided. Each nanoparticle is made of polymeric material and includes an antimicrobial agent encapsulated therein. The polymeric material can include Poly(lactic-co-glycolic acid) (PLGA), or other polymers such as Polylactic (PLA), Polyglycolic (PGA), or Polycaprolactone (PCL). The active molecule is calcium hydroxide in the range of 0.1 to 5 mg/ml. The composition has a pH in the range of 8-13.

Abstract: The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.

Abstract: The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

Abstract: In the present invention it is shown that the inactivation of the Pyk2 gene does not alter hippocampal development but prevents hippocampal-dependent memory tasks and LTP. Inventors clearly provide evidence for multiple roles of Pyk2 in spine morphology and postsynaptic structure. Thus, the inventors used direct overexpression of PYK2 by AAV-mediated gene transfer into the brain of Huntington's and Alzheimer's mouse models and found that overexpression of PYK2 in these 2 models improves synaptic properties and spine density deficits which is also accompanied by a rescue of spatial memory. Accordingly it was demonstrated that PYK2 may restore cognitive functions in neurodegenerative diseases. Thus the present invention relates to methods and pharmaceutical compositions for the treatment of neurodegenerative disease.

Abstract: The present application provides novel compositions and methods for treating acute myeloid leukemia (AML). Compounds of the invention are acid ceramidase inhibitors, reduce AML cell viability, inhibit AML cell proliferation, increase cell death of AML cells, and induce apoptosis in AML cells. A primary compound of the invention is SACLAC: 2-chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide. The bromine analog of SACLAC (SABRAC: 2-bromo-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide) is also useful for treating AML. SACLAC has much better activity than other know drugs used to treat AML.

Abstract: A self-powered system and a method for power extraction and measurement of energy-generator units are disclosed. The system comprises an energy generator unit (10) providing an electrical current IFC and a voltage VFC; an instrumentation block (20) to measure the electrical current IFC; and a power management unit (30) connected to the energy generator unit (10) via a first input that collects the electrical current IFC, extracting an electrical power provided by the energy generator unit (10). The power management unit (30) also has a second input which is connected to a feedback element (40) connected to a voltage reference VREF, to the voltage VFC and to the instrumentation block (20). A variation of an equivalent input impedance of the power management unit (30) sets a given parameter of the energy generator unit (10) to a controlled given value and the instrumentation block (20) assists in the control of the parameter.

Abstract: Method for generating light spectra and corresponding device.

Abstract: The present invention provides a solid oral pharmaceutical composition comprising a pharmaceutically effective amount of living microorganisms and one or more pharmaceutically acceptable water absorbing excipient(s), wherein the composition has a water content, determined according to European Pharmacopoeia 9.4, section 2.5.12., from 0.5 to 30% with respect the total weight of the composition. The invention also provides processes for its preparation as well as it use in therapy. The live-cell based composition of the invention is stable at mild conditions.

Abstract: Methods are provided for generating a barcode with embedded colour palette for colour correction of a captured image in digital format. These methods comprise: generating an initial barcode according to a barcode standard and formed by light colour and dark colour encoding units jointly encoding a reference to storage location; splitting a predefined set of reference colours into reference dark and reference light colours depending on contrast threshold; modifying the initial barcode by replacing dark colour encoding units by reference dark colours and light colour encoding units by reference light colours; and updating the storage location with data representing the reference colours included in the modified barcode and positions of said reference colours in the modified barcode. Methods are provided for colour correction based on a barcode determined by said methods. Computer programs and systems are provided which are suitable for performing said barcode generation methods and colour correction methods.

Abstract: The present invention relates to an in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject based on the determination of the methylation pattern in certain regions of mitochondrial DNA from said subject or determining the nucleotide at the polymorphic position 16519 in the mitochondrial DNA of said subject. Finally, the present invention relates to nucleic acids suitable for application of the invention.

Abstract: Described herein is the use of organic materials in methods of barocaloric cooling. The barocaloric effects may be exhibited where the organic material is near a non-isochoric phase transition, such as a non-isochoric first-order phase transition. The organic material has one or more carbon atoms and may be an organic compound or a salt thereof. In some cases that organic material is a soft matter material, such as a plastic crystal or a liquid crystal. The methods may be adapted for use of the organic material as a heating agent.

Abstract: Method for generating light spectra and corresponding device.

Abstract: Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R?1 are aryl or heteroaryl as defined herein; and R2 and R?2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.

Abstract: Disclosed is an in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject based on the determination of the methylation pattern in certain regions of mitochondrial DNA from the subject or the determination of the nucleotide at the polymorphic position 16519 in the mitochondrial DNA of the subject. Also, disclosed are nucleic acids suitable for the in vitro method to diagnose or determine the risk of developing a neurodegenerative disease in a subject.

Abstract: The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.

Abstract: A programmable multiple-point illuminator for an optical microscope (M) including a light source and a spatial light modulator (SLM) to modulate a light beam from the light source. The modulated light beam scans across a sample placed under the microscope objective, the sample being provided with fluorophores. The SLM includes a first acousto-optic deflector and a second acousto-optic deflector, the first acousto-optic deflector having a first modulation plane and the second acousto-optic deflector having a second modulation plane, said two acousto-optic deflectors being arranged in cascade to provide respective deflection in different directions, whereby the SLM is enabled to scan in two dimensions across the sample. The SLM further a telescope relay to conjugate the first modulation plane with the second modulation plane.

Abstract: The present invention concerns subject matter connected to or making use of IgLON5, IgLON5 fragments and variants of IgLON5 and IgLON5-fragments. In particular the present invention relates to a use of a polypeptide comprising one or more sequences of IgLON5, an IgLON5-fragment or a variant thereof for the diagnosis of a disease, in vitro methods for diagnosing such a disease, a polypeptide comprising one or more sequences of IgLON5, an IgLON5-fragment or a variant thereof or a nucleic acid encoding said polypeptide for use in the treatment of a disease, a pharmaceutical composition comprising such polypeptide, a method for treating such a disease, an autoantibody binding to IgLON5, an IgLON5-fragment or a variant thereof, a method for isolating such autoantibody, a medical or diagnostic device comprising such autoantibody or such polypeptide and a test kit for the diagnosis of a disease, which test kit comprises such autoantibody and/or such polypeptide.