Patents Assigned to Universitat de les Illes Balears
  • Patent number: 11213535
    Abstract: The present invention is related to a composition comprising phytic acid or a phytate salt, magnesium in the form of salt, hydroxide or oxide and optionally at least one polyphenol. These components may be in isolated form or be part of an enriched plant extract. The invention is also related to the use of this composition for the treatment of renal lithiasis, preferably calcium or calcium oxalate lithiasis, either in the form of a medicament, a nutraceutical or functional food or food supplement.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: January 4, 2022
    Assignee: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Félix Grases Freixedas, Antonia Costa Bauzá, Rafael María Prieto Almirall, Adrián Rodríguez Rodríguez
  • Patent number: 11207365
    Abstract: The present invention is related to the use of a separate, sequential or simultaneous combination of at least one urinary acidifier with at least one calcium phosphate crystallization inhibitor for urine acidification, and thus preventing the pH at which supersaturation of calcium phosphate is produced and consequently, renal lithiasis.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: December 28, 2021
    Assignee: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Félix Grases Freixedas, Antonia Costa Bauzá, Rafael María Prieto Almirall, Adrián Rodríguez Rodríguez
  • Patent number: 10588883
    Abstract: Alpha-derivatives of cis-monounsaturated fatty acids for use as medicines. The present invention refers to pharmaceutically acceptable compounds of Formula I, their salts and derivatives, where (a) and (b) can take any value between 0 and 14, (X) can be substituted by any atom or group of atoms with an atomic/molecular weight between 4 and 200 Da and (R) can be substituted by any atom or group of atoms with an atomic/molecular weight between 1 and 200 Da, for use as medicines.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: March 17, 2020
    Assignee: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Pablo Vicente Escribá Ruiz, Xavier Busquets Xaubet, Gwendolyn Barceló Coblijn, Victoria Lladó Cañellas, Rafael Álvarez Martínez, Silvia Teres Jiménez, Daniel López, Juana Barceló Estarellas, Julian Taylor Green, Gerardo Ávila Martín
  • Patent number: 10149851
    Abstract: The present invention refers to the use of theobromine or its derivatives as an inhibitor of the crystallization of uric acid to avoid the formation of uric acid crystals in urine and as a consequence renal lithiasis or specifically uric acid renal lithiasis.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: December 11, 2018
    Assignee: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Félix Grases Freixedas, Antonia Costa Bauzá, Rafael María Prieto Almirall, Adrián Rodríguez Rodríguez
  • Patent number: 10047036
    Abstract: The present invention relates to hydroxy-triglycerides, their synthesis, a pharmaceutical and/or nutraceutical composition which comprises at least one of said hydroxy-triglycerides, and a method which comprises the administration to a patient of a therapeutically effective quantity of at least one of said hydroxy-triglycerides or at least one of said pharmaceutical and/or nutraceutical compositions, for the prevention and/or treatment of at least one disease selected from cancer, metabolic/cardiovascular diseases, and/or neurological/inflammatory diseases.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: August 14, 2018
    Assignee: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Pablo Vicente Escribá Ruiz, Xavier Busquets Xaubet
  • Publication number: 20170313646
    Abstract: The present invention relates to hydroxy-triglycerides, their synthesis, a pharmaceutical and/or nutraceutical composition which comprises at least one of said hydroxy-triglycerides, and a method which comprises the administration to a patient of a therapeutically effective quantity of at least one of said hydroxy-triglycerides or at least one of said pharmaceutical and/or nutraceutical compositions, for the prevention and/or treatment of at least one disease selected from cancer, metabolic/cardiovascular diseases, and/or neurological/inflammatory diseases.
    Type: Application
    Filed: October 21, 2015
    Publication date: November 2, 2017
    Applicant: Universitat de les Illes Balears
    Inventors: Pablo Vicente ESCRIBÁ RUIZ, Xavier BUSQUETS XAUBET
  • Patent number: 9730906
    Abstract: Alpha-derivatives of cis-monounsaturated fatty acids for use as medicines. The present invention refers to pharmaceutically acceptable compounds of Formula I, their salts and derivatives, where (a) and (b) can take any value between 0 and 14, (X) can be substituted by any atom or group of atoms with an atomic/molecular weight between 4 and 200 Da and (R) can be substituted by any atom or group of atoms with an atomic/molecular weight between 1 and 200 Da, for use as medicines.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: August 15, 2017
    Assignee: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Pablo Vicente Escribá Ruiz, Xavier Busquets Xaubet, Gwendolyn Barceló Coblijn, Victoria Lladó Cañellas, Rafael Álvarez Martínez, Silvia Teres Jiménez, Daniel López, Juana Barceló Estarellas, Julian Taylor Green, Gerardo Ávila Martín
  • Publication number: 20170128469
    Abstract: The present invention is related to a composition comprising phytic acid or a phytate salt, magnesium in the form of salt, hydroxide or oxide and optionally at least one polyphenol. These components may be in isolated form or be part of an enriched plant extract. The invention is also related to the use of this composition for the treatment of renal lithiasis, preferably calcium or calcium oxalate lithiasis, either in the form of a medicament, a nutraceutical or functional food or food supplement.
    Type: Application
    Filed: April 14, 2015
    Publication date: May 11, 2017
    Applicant: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Félix GRASES FREIXEDAS, Antonia COSTA BAUZÁ, Rafael María PRIETO ALMIRALL, Adrián RODRÍGUEZ RODRÍGUEZ
  • Patent number: 9359281
    Abstract: This invention refers to the synthesis and purification of 2 hydroxide derivatives of fatty acids, as well as to the separation method of its enantiomers (or optic isomers) [?] y [+], to the enantiomers themselves, to pharmaceutical compositions which include them, and to their use as medicines, as well as to an in vitro method of diagnosis/prognosis and evaluation of the potential use of the molecules of the invention in different pathologies, as well as their use for the regulation of certain enzymes and the study of their activity and effects.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: June 7, 2016
    Assignee: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Pablo Vicente Escribá Ruiz, María Laura Martín, María Antònia Noguera Salvà, Xavier Busquets Xaubet, David López Jiménez, Maitane Ibarguren Aizpitarte, José Javier Soto Salvador, Miguel Yus Astiz
  • Patent number: 9155750
    Abstract: This invention relates to a composition that comprises inositol phosphates and/or bisphosphonates, and to the use thereof to prevent the loss of substances of biological interest in the body of patients subjected to dialysis and to maintain sufficient physiological levels of said substances to regulate physiological and/or pathological processes, these substances being inhibitors of pathological crystallization.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: October 13, 2015
    Assignee: Universitat de les Illes Balears
    Inventors: Félix Grases Freixedas, Joan Perello Bestard, Fernando Tur Espinosa, Antonia Costa Bauza, Rafael M. Prieto Almirall, Isabel Gomila Muñiz
  • Patent number: 9144578
    Abstract: The invention relates to a fixed-dose association of phytate and zinc in synergic proportions for use in the treatment of crystallization of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallization of hydroxyapatite in humans.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: September 29, 2015
    Assignee: Universitat de les Illes Balears
    Inventors: Felix Grases Freixedas, Joan Perello Bestard, Bernat Isern Amengual, Pilar Sanchis Cortes, Rafael M. Prieto Almirall, Antonia Costa Bauza
  • Patent number: 9000042
    Abstract: Alpha-derivatives of cis-monounsaturated fatty acids for use as medicines. The present invention refers to pharmaceutically acceptable compounds of Formula I, their salts and derivatives, where (a) and (b) can take any value between 0 and 14, (X) can be substituted by any atom or group of atoms with an atomic/molecular weight between 4 and 200 Da and (R) can be substituted by any atom or group of atoms with an atomic/molecular weight between 1 and 200 Da, for use as medicines.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: April 7, 2015
    Assignee: Universitat de les Illes Balears
    Inventors: Pablo Vicente Escribá Ruiz, Xavier Busquets Xaubet, Gwendolyn Barceló Coblijn, Victoria Lladó Cañellas, Rafael Álvarez Martínez, Silvia Teres Jiménez, Daniel López, Juana Barceló Estarellas, Julian Taylor Green, Gerardo Ávila Martín
  • Publication number: 20140288176
    Abstract: This invention refers to the synthesis and purification of 2 hydroxide derivatives of fatty acids, as well as to the separation method of its enantiomers (or optic isomers) [?] y [+], to the enantiomers themselves, to pharmaceutical compositions which include them, and to their use as medicines, as well as to an in vitro method of diagnosis/prognosis and evaluation of the potential use of the molecules of the invention in different pathologies, as well as their use for the regulation of certain enzymes and the study of their activity and effects.
    Type: Application
    Filed: October 8, 2012
    Publication date: September 25, 2014
    Applicant: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Pablo Vicente Escribá Ruiz, Gwndolyn Barceló Coblijn, María Laura Martín, Silvia Terés Jiménez, María Antònia Noguera Salvà, Xavier Busquets Xaubet, David López Jiménez, Maitane Ibarguren Aizpitarte, José Javier Soto Salvador, Miguel Yus Astiz
  • Patent number: 8778912
    Abstract: This invention relates to a composition that comprises inositol phosphates and/or bisphosphonates, and to the use thereof to prevent the loss of substances of biological interest in the body of patients subjected to dialysis and to maintain sufficient physiological levels of said substances to regulate physiological and/or pathological processes, these substances being inhibitors of pathological crystallization.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: July 15, 2014
    Assignee: Universitat de les Illes Balears
    Inventors: Félix Grases Freixedas, Joan Perello Bestard, Fernando Tur Espinosa, Antonia Costa Bauza, Rafael M. Prieto Almirall, Isabel Gomila Muñiz
  • Publication number: 20140056994
    Abstract: The invention relates to a fixed-dose association of phytate and zinc in synergic proportions for use in the treatment of crystallization of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallization of hydroxyapatite in humans.
    Type: Application
    Filed: February 19, 2013
    Publication date: February 27, 2014
    Applicant: Universitat De Les Illes Balears
    Inventor: Universitat De Les Illes Balears
  • Patent number: 8427559
    Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?) of the learning zone, evaluating a distance (d,d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: April 23, 2013
    Assignees: France/Ecole Normale Seperieure de Cachan, France and Universitat de les Illes Balears, Centre National de la Recherche Scientifique-CNRS
    Inventors: Jean-Michel Morel, Bartomeu Coll, Antonio Buades
  • Patent number: 8377909
    Abstract: The present invention relates to the use of myo-inositol hexaphosphate or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention or treatment of a disease associated with the dissolution of crystals of calcium salts, in particular osteoporosis. These compounds may be utilized in the manufacture of functional foods, dietetic supplements, vitamin supplements, nutritional supplements, food supplements, or phytotherapeutic products having properties of inhibition of dissolution of crystals of calcium salts.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: February 19, 2013
    Assignee: Universitat de les Illes Balears
    Inventors: Felix Grases Freixedas, Pilar Sanchis Cortes, Antonia Costa-Bauza, Joan Perello Bestard, Rafael Mara Prieto Almirall, Bernat Isern Amengual, Ramon Garcia Gonzalez
  • Publication number: 20120268623
    Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?) of the learning zone, evaluating a distance (d,d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.
    Type: Application
    Filed: June 22, 2012
    Publication date: October 25, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, FRANCE AND UNIVERSITAT DE LES ILLES BALEARS, FRANCE/ECOLE NORMALE SUPERIEURE DE CACHAN
    Inventors: Jean-Michel MOREL, Bartomeu COLL, Antonio BUADES
  • Patent number: 8253825
    Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?,) of the learning zone, evaluating a distance (d, d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f?2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: August 28, 2012
    Assignees: France/Ecole Normale Superieure de Cachan, France and Universitat de les Illes Balears, Centre National de la Recherche Scientifique-CNRS
    Inventors: Jean-Michel Morel, Bartomeu Coll, Antonio Buades
  • Publication number: 20100267630
    Abstract: The present invention is addressed to the use of leptin, a fragment of leptin or a mimetic product of leptin action, in the preparation of a pharmaceutical composition, a food composition and/or a nutritional supplement for the prevention of unhealthy food habits and/or cardiovascular disorders during adulthood.
    Type: Application
    Filed: June 20, 2008
    Publication date: October 21, 2010
    Applicant: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Andreu Palou Oliver, Catalina Picó Segura, Paula Oliver Vara, Teresa Priego Cuadra, Juana Sánchez Roig, Mariona Palou March, Aixa Tobaruela Arbona