Patents Assigned to Universitat de les Illes Balears
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Patent number: 11213535Abstract: The present invention is related to a composition comprising phytic acid or a phytate salt, magnesium in the form of salt, hydroxide or oxide and optionally at least one polyphenol. These components may be in isolated form or be part of an enriched plant extract. The invention is also related to the use of this composition for the treatment of renal lithiasis, preferably calcium or calcium oxalate lithiasis, either in the form of a medicament, a nutraceutical or functional food or food supplement.Type: GrantFiled: April 14, 2015Date of Patent: January 4, 2022Assignee: UNIVERSITAT DE LES ILLES BALEARSInventors: Félix Grases Freixedas, Antonia Costa Bauzá, Rafael María Prieto Almirall, Adrián Rodríguez Rodríguez
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Patent number: 11207365Abstract: The present invention is related to the use of a separate, sequential or simultaneous combination of at least one urinary acidifier with at least one calcium phosphate crystallization inhibitor for urine acidification, and thus preventing the pH at which supersaturation of calcium phosphate is produced and consequently, renal lithiasis.Type: GrantFiled: January 25, 2019Date of Patent: December 28, 2021Assignee: UNIVERSITAT DE LES ILLES BALEARSInventors: Félix Grases Freixedas, Antonia Costa Bauzá, Rafael María Prieto Almirall, Adrián Rodríguez Rodríguez
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Patent number: 10588883Abstract: Alpha-derivatives of cis-monounsaturated fatty acids for use as medicines. The present invention refers to pharmaceutically acceptable compounds of Formula I, their salts and derivatives, where (a) and (b) can take any value between 0 and 14, (X) can be substituted by any atom or group of atoms with an atomic/molecular weight between 4 and 200 Da and (R) can be substituted by any atom or group of atoms with an atomic/molecular weight between 1 and 200 Da, for use as medicines.Type: GrantFiled: July 10, 2017Date of Patent: March 17, 2020Assignee: UNIVERSITAT DE LES ILLES BALEARSInventors: Pablo Vicente Escribá Ruiz, Xavier Busquets Xaubet, Gwendolyn Barceló Coblijn, Victoria Lladó Cañellas, Rafael Álvarez Martínez, Silvia Teres Jiménez, Daniel López, Juana Barceló Estarellas, Julian Taylor Green, Gerardo Ávila Martín
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Patent number: 10149851Abstract: The present invention refers to the use of theobromine or its derivatives as an inhibitor of the crystallization of uric acid to avoid the formation of uric acid crystals in urine and as a consequence renal lithiasis or specifically uric acid renal lithiasis.Type: GrantFiled: April 15, 2015Date of Patent: December 11, 2018Assignee: UNIVERSITAT DE LES ILLES BALEARSInventors: Félix Grases Freixedas, Antonia Costa Bauzá, Rafael María Prieto Almirall, Adrián Rodríguez Rodríguez
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Patent number: 10047036Abstract: The present invention relates to hydroxy-triglycerides, their synthesis, a pharmaceutical and/or nutraceutical composition which comprises at least one of said hydroxy-triglycerides, and a method which comprises the administration to a patient of a therapeutically effective quantity of at least one of said hydroxy-triglycerides or at least one of said pharmaceutical and/or nutraceutical compositions, for the prevention and/or treatment of at least one disease selected from cancer, metabolic/cardiovascular diseases, and/or neurological/inflammatory diseases.Type: GrantFiled: October 21, 2015Date of Patent: August 14, 2018Assignee: UNIVERSITAT DE LES ILLES BALEARSInventors: Pablo Vicente Escribá Ruiz, Xavier Busquets Xaubet
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Publication number: 20170313646Abstract: The present invention relates to hydroxy-triglycerides, their synthesis, a pharmaceutical and/or nutraceutical composition which comprises at least one of said hydroxy-triglycerides, and a method which comprises the administration to a patient of a therapeutically effective quantity of at least one of said hydroxy-triglycerides or at least one of said pharmaceutical and/or nutraceutical compositions, for the prevention and/or treatment of at least one disease selected from cancer, metabolic/cardiovascular diseases, and/or neurological/inflammatory diseases.Type: ApplicationFiled: October 21, 2015Publication date: November 2, 2017Applicant: Universitat de les Illes BalearsInventors: Pablo Vicente ESCRIBÁ RUIZ, Xavier BUSQUETS XAUBET
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Patent number: 9730906Abstract: Alpha-derivatives of cis-monounsaturated fatty acids for use as medicines. The present invention refers to pharmaceutically acceptable compounds of Formula I, their salts and derivatives, where (a) and (b) can take any value between 0 and 14, (X) can be substituted by any atom or group of atoms with an atomic/molecular weight between 4 and 200 Da and (R) can be substituted by any atom or group of atoms with an atomic/molecular weight between 1 and 200 Da, for use as medicines.Type: GrantFiled: March 20, 2015Date of Patent: August 15, 2017Assignee: UNIVERSITAT DE LES ILLES BALEARSInventors: Pablo Vicente Escribá Ruiz, Xavier Busquets Xaubet, Gwendolyn Barceló Coblijn, Victoria Lladó Cañellas, Rafael Álvarez Martínez, Silvia Teres Jiménez, Daniel López, Juana Barceló Estarellas, Julian Taylor Green, Gerardo Ávila Martín
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Publication number: 20170128469Abstract: The present invention is related to a composition comprising phytic acid or a phytate salt, magnesium in the form of salt, hydroxide or oxide and optionally at least one polyphenol. These components may be in isolated form or be part of an enriched plant extract. The invention is also related to the use of this composition for the treatment of renal lithiasis, preferably calcium or calcium oxalate lithiasis, either in the form of a medicament, a nutraceutical or functional food or food supplement.Type: ApplicationFiled: April 14, 2015Publication date: May 11, 2017Applicant: UNIVERSITAT DE LES ILLES BALEARSInventors: Félix GRASES FREIXEDAS, Antonia COSTA BAUZÁ, Rafael María PRIETO ALMIRALL, Adrián RODRÍGUEZ RODRÍGUEZ
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Patent number: 9359281Abstract: This invention refers to the synthesis and purification of 2 hydroxide derivatives of fatty acids, as well as to the separation method of its enantiomers (or optic isomers) [?] y [+], to the enantiomers themselves, to pharmaceutical compositions which include them, and to their use as medicines, as well as to an in vitro method of diagnosis/prognosis and evaluation of the potential use of the molecules of the invention in different pathologies, as well as their use for the regulation of certain enzymes and the study of their activity and effects.Type: GrantFiled: October 8, 2012Date of Patent: June 7, 2016Assignee: UNIVERSITAT DE LES ILLES BALEARSInventors: Pablo Vicente Escribá Ruiz, María Laura Martín, María Antònia Noguera Salvà, Xavier Busquets Xaubet, David López Jiménez, Maitane Ibarguren Aizpitarte, José Javier Soto Salvador, Miguel Yus Astiz
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Patent number: 9155750Abstract: This invention relates to a composition that comprises inositol phosphates and/or bisphosphonates, and to the use thereof to prevent the loss of substances of biological interest in the body of patients subjected to dialysis and to maintain sufficient physiological levels of said substances to regulate physiological and/or pathological processes, these substances being inhibitors of pathological crystallization.Type: GrantFiled: February 12, 2014Date of Patent: October 13, 2015Assignee: Universitat de les Illes BalearsInventors: Félix Grases Freixedas, Joan Perello Bestard, Fernando Tur Espinosa, Antonia Costa Bauza, Rafael M. Prieto Almirall, Isabel Gomila Muñiz
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Patent number: 9144578Abstract: The invention relates to a fixed-dose association of phytate and zinc in synergic proportions for use in the treatment of crystallization of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallization of hydroxyapatite in humans.Type: GrantFiled: February 19, 2013Date of Patent: September 29, 2015Assignee: Universitat de les Illes BalearsInventors: Felix Grases Freixedas, Joan Perello Bestard, Bernat Isern Amengual, Pilar Sanchis Cortes, Rafael M. Prieto Almirall, Antonia Costa Bauza
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Patent number: 9000042Abstract: Alpha-derivatives of cis-monounsaturated fatty acids for use as medicines. The present invention refers to pharmaceutically acceptable compounds of Formula I, their salts and derivatives, where (a) and (b) can take any value between 0 and 14, (X) can be substituted by any atom or group of atoms with an atomic/molecular weight between 4 and 200 Da and (R) can be substituted by any atom or group of atoms with an atomic/molecular weight between 1 and 200 Da, for use as medicines.Type: GrantFiled: December 4, 2009Date of Patent: April 7, 2015Assignee: Universitat de les Illes BalearsInventors: Pablo Vicente Escribá Ruiz, Xavier Busquets Xaubet, Gwendolyn Barceló Coblijn, Victoria Lladó Cañellas, Rafael Álvarez Martínez, Silvia Teres Jiménez, Daniel López, Juana Barceló Estarellas, Julian Taylor Green, Gerardo Ávila Martín
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Publication number: 20140288176Abstract: This invention refers to the synthesis and purification of 2 hydroxide derivatives of fatty acids, as well as to the separation method of its enantiomers (or optic isomers) [?] y [+], to the enantiomers themselves, to pharmaceutical compositions which include them, and to their use as medicines, as well as to an in vitro method of diagnosis/prognosis and evaluation of the potential use of the molecules of the invention in different pathologies, as well as their use for the regulation of certain enzymes and the study of their activity and effects.Type: ApplicationFiled: October 8, 2012Publication date: September 25, 2014Applicant: UNIVERSITAT DE LES ILLES BALEARSInventors: Pablo Vicente Escribá Ruiz, Gwndolyn Barceló Coblijn, María Laura Martín, Silvia Terés Jiménez, María Antònia Noguera Salvà, Xavier Busquets Xaubet, David López Jiménez, Maitane Ibarguren Aizpitarte, José Javier Soto Salvador, Miguel Yus Astiz
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Patent number: 8778912Abstract: This invention relates to a composition that comprises inositol phosphates and/or bisphosphonates, and to the use thereof to prevent the loss of substances of biological interest in the body of patients subjected to dialysis and to maintain sufficient physiological levels of said substances to regulate physiological and/or pathological processes, these substances being inhibitors of pathological crystallization.Type: GrantFiled: May 14, 2009Date of Patent: July 15, 2014Assignee: Universitat de les Illes BalearsInventors: Félix Grases Freixedas, Joan Perello Bestard, Fernando Tur Espinosa, Antonia Costa Bauza, Rafael M. Prieto Almirall, Isabel Gomila Muñiz
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Publication number: 20140056994Abstract: The invention relates to a fixed-dose association of phytate and zinc in synergic proportions for use in the treatment of crystallization of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallization of hydroxyapatite in humans.Type: ApplicationFiled: February 19, 2013Publication date: February 27, 2014Applicant: Universitat De Les Illes BalearsInventor: Universitat De Les Illes Balears
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Patent number: 8427559Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?) of the learning zone, evaluating a distance (d,d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.Type: GrantFiled: June 22, 2012Date of Patent: April 23, 2013Assignees: France/Ecole Normale Seperieure de Cachan, France and Universitat de les Illes Balears, Centre National de la Recherche Scientifique-CNRSInventors: Jean-Michel Morel, Bartomeu Coll, Antonio Buades
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Patent number: 8377909Abstract: The present invention relates to the use of myo-inositol hexaphosphate or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention or treatment of a disease associated with the dissolution of crystals of calcium salts, in particular osteoporosis. These compounds may be utilized in the manufacture of functional foods, dietetic supplements, vitamin supplements, nutritional supplements, food supplements, or phytotherapeutic products having properties of inhibition of dissolution of crystals of calcium salts.Type: GrantFiled: May 30, 2007Date of Patent: February 19, 2013Assignee: Universitat de les Illes BalearsInventors: Felix Grases Freixedas, Pilar Sanchis Cortes, Antonia Costa-Bauza, Joan Perello Bestard, Rafael Mara Prieto Almirall, Bernat Isern Amengual, Ramon Garcia Gonzalez
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Publication number: 20120268623Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?) of the learning zone, evaluating a distance (d,d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.Type: ApplicationFiled: June 22, 2012Publication date: October 25, 2012Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, FRANCE AND UNIVERSITAT DE LES ILLES BALEARS, FRANCE/ECOLE NORMALE SUPERIEURE DE CACHANInventors: Jean-Michel MOREL, Bartomeu COLL, Antonio BUADES
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Patent number: 8253825Abstract: The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC?,) of the learning zone, evaluating a distance (d, d?,) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f?2,), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.Type: GrantFiled: April 13, 2005Date of Patent: August 28, 2012Assignees: France/Ecole Normale Superieure de Cachan, France and Universitat de les Illes Balears, Centre National de la Recherche Scientifique-CNRSInventors: Jean-Michel Morel, Bartomeu Coll, Antonio Buades
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Publication number: 20100267630Abstract: The present invention is addressed to the use of leptin, a fragment of leptin or a mimetic product of leptin action, in the preparation of a pharmaceutical composition, a food composition and/or a nutritional supplement for the prevention of unhealthy food habits and/or cardiovascular disorders during adulthood.Type: ApplicationFiled: June 20, 2008Publication date: October 21, 2010Applicant: UNIVERSITAT DE LES ILLES BALEARSInventors: Andreu Palou Oliver, Catalina Picó Segura, Paula Oliver Vara, Teresa Priego Cuadra, Juana Sánchez Roig, Mariona Palou March, Aixa Tobaruela Arbona