Patents Assigned to UNIVERSITAT DE VALÈNCIA
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Patent number: 11933676Abstract: The present invention relates to a microscope for quantitative measurements of the wavefront, comprising: means for the illumination of a sample (T); an objective lens (2); an ordered two-dimensional arrangement of lenses (3), with a spacing p? greater than 500 ?m and a relative aperture of less than 10; an image sensor (4) located in a capture space (Ec) to receive the light scattered by the sample (T), and to acquire spatial and angular information on the object wavefront associated therewith; and a computational entity to perform a computational reconstruction of the object wavefront from the spatial and angular information. Other aspects of the invention relate to a method, a computer program and a product incorporating the same, adapted for the performance of the functions of the computational entity of the microscope, as well as to a module and a kit for a microscope.Type: GrantFiled: February 14, 2020Date of Patent: March 19, 2024Assignee: UNIVERSITAT DE VALÈNCIAInventors: Manuel Martínez Corral, Genaro Saavedra Tortosa, Emilio Sánchez Ortiga, Peter Török
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Patent number: 11815455Abstract: The invention relates to a diffractive device for chemical and biological analysis based on structured receptors on waveguides, which comprises: a waveguide and a recognition element consisting of a grating with receptors arranged on the waveguide and are intended to interact with target compounds present in a sample; and a radiation source that emits an incident beam propagated through the waveguide, interacting with the recognition element and being diffracted according to Bragg's law, thereby generating a reflected beam and a transmitted beam, which are collected by optical analyzers that record parameters of the reflected beam and of the transmitted beam, enabling multiple analyses to be conducted in a simple, fast, 15 sensitive and quantitative manner, label-free and in real time.Type: GrantFiled: July 6, 2020Date of Patent: November 14, 2023Assignees: UNIVERSITAT POLITECNICA DE VALENCIA, UNIVERSITAT DE VALENCIAInventors: José Miguel Avellá Oliver, Ángel Maquieira Catala, Augusto Miguel Juste Dolz, Maria Estrella Fernández Sánchez, Daniel Pastor Abellán, Pascual Muñoz Muñoz, Martina Delgado Pinar, Miguel Vicente Andrés Bou
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Publication number: 20230346769Abstract: Use of simple acyclic polyamines for the treatment of parasites of the family Trypanosomatidae The present invention provides the use of certain single acyclic polyamines of Formula (I), attached to heterocycles, for the treatment of leishmaniasis and trypanosomiasis. All the compounds studied show antiparasitic activity against Leishmania species, comparable or superior to that of the active ingredient of the drug commonly used to treat this disease, but with a macrophage toxicity similar to or, in most cases, lower than that of the commercial reference compound, and with higher selectivity indices against strains representative of the three clinical forms of the disease: cutaneous, mucocutaneous and visceral. The compounds show ability to inhibit parasite superoxide dismutase, generally at concentrations lower than those required to inhibit human superoxide dismutase. All this supports its usefulness for treating leishmaniasis and also trypanosomiasis.Type: ApplicationFiled: July 9, 2021Publication date: November 2, 2023Applicants: Universidad De Granada, Universitat De ValènciaInventors: Enrique Gargía-España Monsonís, María Paz Clares García, Estefanía Delgado Pinar, Clotilde Marín Sánchez, Manuel Sánchez Moreno, Rubén Martín Escolano, Álvaro Martín Montes
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Patent number: 11796689Abstract: A device for detecting photons and charged particles includes a first photon-detecting panel, which causes a Compton scattering of incident radiation with charged particles, such that the wavelength thereof increases, losing part of their energy, generating a signal. A central charged particle-detecting panel, following the first photon-detecting panel on a side opposite that of the incident radiation, identifies charged particles generated in the first photon-detecting panel, generating a signal. A second photon-detecting panel, follows the central charged particle-detecting panel on a side opposite that of the first photon-detecting panel. Scattered photons and/or charged particles are generated in the first photon-detecting panel interact, generating a signal.Type: GrantFiled: November 4, 2020Date of Patent: October 24, 2023Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, UNIVERSITAT DE VALENCIAInventors: Gabriela Dolores Llosá Llácer, Carlos Lacasta Llácer, John Barrio Toala
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Patent number: 11787824Abstract: The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure. The invention also relates to methods for obtaining them with high yields, in addition to their uses in the generation of solar fuels, photoactivated degradation, photoreduction of CO2, heterogeneous catalysis, as a component or part of an electronic component and/or as a porous or photoactive coating for controlling pollutants, inter alia.Type: GrantFiled: May 23, 2019Date of Patent: October 17, 2023Assignees: Universitat de València, Universidad de GranadaInventors: Carlos Marti Gastaldo, Javier Castells Gil, Natalia Muñoz Padial
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Patent number: 11740245Abstract: The present invention proposes a novel method for the detection of circulating histones H3 and H2B in plasma from sepsis or septic shock (SS) patients, based on mass spectrometry-based methods, in particular based on multiple reaction monitoring targeted mass spectrometry (MRM-MS). Such methods allow quantification of histones using an internal standard and show strong specificity and sensitivity values.Type: GrantFiled: November 6, 2017Date of Patent: August 29, 2023Assignees: Centro de Investigación Biomédica en Red (CIBER-ISCIII), Fundación INCLIVA, Universitat de Valencia Estudi GeneralInventors: José Luis García Giménez, Carlos Romá Mateo, Federico V. Pallardó Calatayud
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Patent number: 11730751Abstract: Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.Type: GrantFiled: May 16, 2018Date of Patent: August 22, 2023Assignees: UNIVERSITAT DE VALÈNCIA-ESTUDI GENERAL, FUNDACIÓN UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR, Elysium Health, Inc.Inventors: José Maria Estrela Ariguel, José Enrique De La Rubia Orti, Ryan Dellinger
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Patent number: 11662347Abstract: A method for the diagnosis of systemic lupus erythematosus (SLE) based on an interfacial process of antigen-antibody molecular recognition, specifically between anti-Ro52 and Ro52 protein, in a piezoelectric resonator, for application in the diagnosis of autoimmune diseases such as SLE.Type: GrantFiled: June 29, 2018Date of Patent: May 30, 2023Assignees: UNIVERSITAT POLITECNICA DE VALENCIA, INSTITUTO DE INVESTIGACION SANITARIA LA FE—FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO Y POLITECNICO LA FE DE LA COMUNIDAD VALENCIANA, UNIVERSITAT DE VALENCIA ESTUDI GENERALInventors: Noelle Marine Do Nascimento, David Gimenez Romero, Sergi Benat Morais Ezquerro, Angel Maquieira Catala, Augusto Miguel Juste Dolz, Elena Grau Garcia, Rosa Puchades Pla, Jose Andres Roman Iborra
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Patent number: 11604343Abstract: The invention relates to a plenoptic ocular device intended to be coupled in an ocular port of an optical instrument configured to generate a real image of a sample on a focal plane situated in a region close to said ocular port, said plenoptic ocular device being configured to capture said real image, generate a set of elemental images and send them to recording means with spatial discretisation which in turn comprises communication means configured to transmit the set of elemental images to external image processing means.Type: GrantFiled: August 8, 2019Date of Patent: March 14, 2023Assignee: Universitat De ValenciaInventors: Manuel Martinez Corral, Genaro Saavedra Tortosa, Gabriele Scrofani, Angel Tolosa Ruiz, Jorge Garcia Sucerquia
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Patent number: 11202794Abstract: Modulation of microRNAs against myotonic dystrophy type 1 and antagonists of microRNAs therefor. The invention provides the use of inhibitors of microRNAs repressors of MBNL1 and/or MBNL2 genes for the manufacture of a medicinal product for the treatment of myotonic dystrophy 1. Inhibiting these microRNAs allows to increase the endogenous levels of the corresponding proteins MBNL1 and/or MBNL2, thereby alleviating symptoms of the disease, especially when inhibiting repressors that are expressed in the main affected organs: skeletal muscle, heart or organs of the central nervous system. The inhibition of the microRNAs miR-23b-3p and miR-218-5p is preferred. It also provides oligoribonucleotide or oligoribonucleotide analogue antagonists suitable therefor, preferably antagomiRs directed against the microRNAs mentioned with chemical modifications that enhance their interaction with the target, their stability in vivo and their ability to penetrate into the cells and distribute throughout tissues and organs.Type: GrantFiled: September 19, 2017Date of Patent: December 21, 2021Assignees: UNIVERSITAT DE VALENCIA, AUM LIFETECH, INC.Inventors: Rubén D. Artero Allepuz, María Beatriz LlamusíTroisi, Estefanía Cerro Herreros, Juan M. Fernández Costa, Veenu Aishwarya, Thorleif Møller
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Patent number: 11154409Abstract: A percutaneous collar is made up of a central rigid ring and a flexible mesh inside a microporous silicone disc. The volume of the disc has a three-dimensional network of interconnected micropores forming microchannels connecting both external faces of the disc through the external micropores to the internal flexible mesh wherein the flexible mesh is formed by crossed longitudinal and radial elements or plates which form a plurality of holes.Type: GrantFiled: August 1, 2017Date of Patent: October 26, 2021Assignees: UNIVERSITAT POLITÉCNICA DE VALÈNCIA, UNIVERSITAT DE VALÈNCIA, FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL CLÍNICO DE LA COMUNIDAD VALENCIANA (INCLIVA)Inventors: José Expósito Ollero, Ana Vallés Lluch, José Albelda Vitoria, Juan Victor Hoyos Fuentes, Antonio Silvestre Muñoz
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Patent number: 11129544Abstract: A system and method are presented for use in monitoring one or more conditions of a subject's body. The system includes a control unit which includes an input port for receiving image data, a memory utility, and a processor utility. The image data is indicative of data measured by a pixel detector array and is in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern. The memory utility stores one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body. The processor utility is configured and operable for processing the image data to determine one or more corresponding body conditions; and generating output data indicative of the corresponding body conditions.Type: GrantFiled: August 22, 2019Date of Patent: September 28, 2021Assignees: BAR ILAN UNIVERSITY, UNIVERSITAT DE VALENCIAInventors: Zeev Zalevsky, Javier Garcia, Vicente Mico, Michael Belkin, Yevgeny Beiderman, Israel Margalit
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Patent number: 11054415Abstract: The present invention relates to bioconjugates and labeled derivatives of anatoxin-a, at different positions of the molecule, suitable for producing antibodies with high affinity and specificity for anatoxin-a. At the same time, the present invention also relates to the use of bioconjugates of anatoxin-a and labeled derivatives of anatoxin-a as assay antigens. Moreover, the present invention also relates to methods for analyzing, concentrating and extracting anatoxin-a using the antibodies obtained, sometimes together with assay antigens which are bioconjugates or labeled derivatives. This invention also provides a kit for analyzing anatoxin-a which comprises antibodies against this cyanotoxin sometimes together with assay antigens which are bioconjugates or labeled derivatives of anatoxin-a.Type: GrantFiled: September 21, 2016Date of Patent: July 6, 2021Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, UNIVERSITAT DE VALÈNCIAInventors: Antonio Abad Fuentes, Josep Vicent Mercader Badia, Antonio Abad Somovilla, Consuelo Agulló Blanes, Guillermo Quiñones Reyes
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Patent number: 11022705Abstract: The present invention relates to a system (10) and method for the volumetric and isotopic identification of the spatial distribution of ionizing radiation from point or extensive radioactive sources (3) in radioactive surroundings. More specifically, this system (10) comprises a gamma radiation detector (2) and an optical transducer (1) joined to each other and linked to a control unit to detect the absolute position of radioactive sources (3) relative to a visual reference located in the radioactive surroundings, and to determine the radioactive activity of the sources, that is to say it detects the isotope composition of the radioactive sources (3).Type: GrantFiled: February 1, 2018Date of Patent: June 1, 2021Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), UNIVERSITÄT DE VALENCIA, EMPRESA NACIONAL DE RESIDUOS RADIOACTIVOS, S.A. (ENRESA)Inventors: Jorge Agramunt Ros, Francisco Albiol Colomer, Alberto Corbi Bellot, Luis Caballero Ontanaya, César Domingo Pardo, Alberto Albiol Colomer
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Patent number: 10975435Abstract: The present invention provides a method for diagnosing or detecting Idiopathic Scoliosis, in particular AIS, as well as a method for prognosticating this disease in a human subject.Type: GrantFiled: June 16, 2016Date of Patent: April 13, 2021Assignees: CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED (CIBER), HOSPITAL UNIVERSITARIO Y POLITÉCNICO LA FE, UNIVERSITAT DE VALÈNCIAInventors: Jose Luis Garcia Gimenez, Teresa Bas Hermida, Federico Vicente Pallardo Calatayud, David Hervas Marin, Salvador Mena Molla
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Patent number: 10672145Abstract: Device for extracting three-dimensional information from radiographic images of an object; process for calibrating said device; and process for generating said radiographic images includes an X-ray emitter and an X-ray sensor. A contour sensor represents contour points of an object by means of the radiation emitted or reflected by the object. The device also has a calibration framework with X-ray markers, and contour markers. The processes are based on taking contour and X-ray images of the calibration framework, first without an object of study and subsequently with one, taking into account the information provided by the markers, and the fact that the contour sensor is placed in the same manner with respect to the X-ray emitter in all the images taken.Type: GrantFiled: March 29, 2016Date of Patent: June 2, 2020Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), UNIVERSITAT DE VALENCIAInventors: Francisco Javier Albiol Colomer, Alberto Corbi Bellot, Celso Bellot Romero, Alberto Albiol Colomer
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Patent number: 10665800Abstract: The present invention relates to a method for producing a solid solar cells, including the steps of providing a hole collector layer, applying a conductive layer onto the hole collector layer, applying an electron blocking layer onto the conductive layer, applying a sensitizer layer onto the electron blocking layer, applying a hole blocking layer onto the sensitizer layer, and providing a current collector and/or a metal layer or a conductor. The sensitizer layer including an organic-inorganic perovskite is applied by co-deposition of one or more sublimated divalent or trivalent salts and of one or more sublimated organic ammonium salts to obtain the organic-inorganic perovskite. The invention also relates to solid state solar cells, wherein the charge flow is inverted compared to the charge flow in a solar cell of conventional architecture and/or obtained by the above method.Type: GrantFiled: September 5, 2014Date of Patent: May 26, 2020Assignees: Ecole Polytechnique Federate de Lausanne (EPFL), Universitat de ValenciaInventors: Mohammad Khaja Nazeeruddin, Michael Graetzel, Hendrik Jan Bolink, Olga Malinkiewicz, Alejandra Soriano Portillo
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Patent number: 10577266Abstract: The present invention refers to an anaerobic process with filtration procedure for wastewater treatment at room temperature, that comprises: continuously feeding at least one anaerobic reactor, with previously sieved wastewater and feeding biodegradable organic waste—BOW—also previously sieved, said reactor being coupled to at least one gasified filtration membrane, with recirculation of biogas from the reactor, carrying out the anaerobic digestion of the organic fraction contained in the mixture of wastewater and the BOW, in the reactor, obtaining a treated mixture and filtering the mixture treated in the reactor, in at least one filtration tank through the gasified membrane under conditions such that the relationship between the biogas recirculated per square meter of membrane, and time unit, and the wastewater filtered—SGDp—is the minimum value allowed by the solid concentration in a treatment plant.Type: GrantFiled: March 30, 2017Date of Patent: March 3, 2020Assignees: FCC AQUALIA, S.A., UNIVERSITAT POLITÈCNICA DE VALÈNCIA, UNIVERSITAT DE VALÈNCIA ESTUDI GENERALInventors: Frank Rogalla, Jose Ramón Vázquez Padín, Emérita Jiménez Douglas, Freddy Durán Pinzón, Aurora Seco Torrecillas, Alberto Bouzas Blanco, Josep Ribes Bertomeu, María Victoria Ruano García, Joaquín Serralta Sevilla, Ángel Robles Martínez, Juan Bautista Giménez García, José Ferrer Polo
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Patent number: 10568670Abstract: Intramedullary fixation device, having an intramedullary rod (2) which is provided for insertion thereof into a bone (1) and consists of a central screw (4) having a first free end comprising a stopper (7) and a second free end with a pre-tensioning nut (8), an alternating series of expanders (3) and bolts (5) being arranged in between, the bolt surfaces in contact with the expanders (3) having a wedge shape. The bolts (5) or expanders (3) may have no, or one or more variations in the dimensions of the different geometric parameters, in accordance with the adjacent expanders, along the length of the implant, and the central screw (4) may have a variable cross section. The device may have different additional components, such as an osteotomic base (9) for fixation of the musculature. The device promotes maximum nailing limited between these elements and produces a controlled peripheral radial deformation.Type: GrantFiled: September 18, 2017Date of Patent: February 25, 2020Assignees: UNIVERSITAT POLITECNICA DE VALENCIA, UNIVERSITAT DE VALÈNCIA, FOUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNIDAD VALENCIANA (INCLIVA)Inventors: Jose Exposito Ollero, Jose Albelda Vitoria, Juan Victor Hoyos Fuentes, Ana Valles Lluch, Antonio Silvestre Munoz
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Patent number: 10544083Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.Type: GrantFiled: February 8, 2018Date of Patent: January 28, 2020Assignee: Universitat de ValènciaInventors: Juan Saus, Santos Fustero, Juan F. Sanz-Cervera, Enrique Pérez-Payá, Raül Blasco, Francisco Revert-Ros, Fernando Revert