Abstract: The present invention relates to a method for prediction of response to cardiovascular regeneration comprising the use of biomarkers. Further, the present invention relates to a combination of the biomarkers for use in a method for prediction of response to cardiovascular regeneration, a computer device to perform a method according to the present invention and a device adapted for carrying out the inventive method.

Abstract: The present invention relates to a method for prediction of response to disease therapy, in particular to tissue regeneration, preferably to cardiovascular regeneration, comprising the use of a biomarker. Further, the present invention relates to a combination of biomarkers for use in a method for prediction of response to disease therapy, in particular to tissue regeneration, preferably to cardiovascular regeneration, a computer device to perform a method according to the present invention and a device adapted for carrying out the inventive method.

Abstract: The present invention relates to L-arabino-oligosaccharides, in particular synthetically produced L-arabino-oligosaccharides and their uses for the prophylaxis of allergic reactions in mammals.

Abstract: A device for producing a 3D-printed active substance-releasing system with active substance depots, such that a radiation source in operation causes a polymerisation of a layer of the base material on the construction platform and that an inkjet printhead incorporates an active substance mixture, which has at least one active substance, into the base material in a locationally selective manner. A trough is provided, in which a base material and a construction platform are arranged, and polymerising selected regions of a layer of the base material on the construction platform and introducing, by means of an inkjet printing method, an active substance mixture, which has at least one active substance, into the base material and/or polymerised base material in a locationally selective manner in order to thereby create active ingredient depots in the active ingredient-releasing system.

Abstract: The invention relates to composite materials based on tungsten carbide and comprising gold, palladium and/or platinum and to a method for producing said composite materials by sintering. By means of the FAST method, hard and biocompatible WC/(Au, Pd, Pt) composite materials can be produced, inter alia for use as coatings on tools and prostheses and as solid bodies in, for example, blood pumps.

Abstract: The present invention relates to a method for prediction of response to cardiovascular regeneration comprising the use of biomarkers. Further, the present invention relates to a combination of the biomarkers for use in a method for prediction of response to cardiovascular regeneration, a computer device to perform a method according to the present invention and a device adapted for carrying out the inventive method.

Abstract: The invention relates to a welding assembly for the permanent joining of a first tubular component with a second component along a two- or three-dimensional intersection curve, along which both components contact, comprising a securing assembly for detachably securely joining on a tubular end of the first component facing away from the intersection curve, a manipulator unit mounted directly or indirectly on the securing assembly such that it can pivot about a tube longitudinal axis assigned to the first component. The manipulator unit has a freely positionable manipulator end, with a welding tool attached to the freely positionable manipulator end. The securing assembly comprises a clamping module that can at least partially be introduced into the tubular end of the first component on the end side and in an axial manner.

Abstract: The present invention relates to SH2B adapter protein 3 (SH2B3) for use as a diagnostic marker. Further, the present invention relates to a method for the determination of SH2B3 gene expression.

Abstract: The invention relates to an articulated arm robot for handling a payload, comprising a robot arm (R), which is attached to a base (1) that can be rotated about a first axis (A1), and at least two arm elements (2 and 3), which are arranged to form a kinematic chain and a first arm element (2) is mounted on the base (1) to pivot about a second axis (A2) that is oriented orthogonally relative to the first axis and a second arm element (3) which is attached to the first arm to be pivotal manner about a third axis (A3) that is oriented parallel to the second axis (A2).

Abstract: A device for in situ milling of joint surfaces, including a milling device and a joint clamping device. The joint clamp device is designed to be inserted between two joint components forming a joint, particularly bones, and for pushing the joint components apart with a predetermined or adjustable tension, wherein the joint clamping device includes a recess in which the milling device can be inserted, wherein the milling device includes a face milling cutter.

Abstract: The invention relates to a method for the sequence-specific analysis of nucleic acids in a sample in which the nucleic acid is present at least partially as a double strand, which method uses electrochemical detection methods (e.g. with [OsO4(bipy)]). In particular, the methods comprise steps in which the at least partially double-stranded nucleic acid strands are converted by thermal denaturation to single strands which are termed target strands, and at least one nucleic acid strand designated protective strand is added, which protective strand can hybridize with a target strand, in order to form partial double-stranded segments, wherein the protective strands are shorter than the target strands, wherein the temperature of the sample is rapidly lowered to a temperature of below 5° C., preferably below 0° C.

Abstract: The spatial center of mass and a mass of an object can be determined by orientating the suspended object in at least two different spatial positions and measuring the orientation of the object in each of the different spatial positions the forces acting on the suspension devices because of the suspended object, the forces acting on the suspension devices being resolved into three independent force components. A center of area of the object and the associated force effect lines are determined for each of the at least two spatial positions, the center of area of the respective spatial position being determined with an inclined tension compensation of the suspension devices. The spatial center of mass is determined by superimposing at least two force effect lines.

Abstract: A composition for the adhesive bonding and/or fixing of biological and/or synthetic tissues includes the components: a) a nitrogen-functionalized polysaccharide; and b) a terminally functionalized oligolactone.

Abstract: An implantable system for determining the accommodation requirement in an artificial accommodation system by optical measurement of the pupil diameter and the surrounding luminance, including at least one optical system, at least one data acquisition system that does not contact the ciliary muscle and measures a diameter of the pupil and luminance around at least one eye as a physical control signal for the accommodation requirement, at least one data processing system for generating an actuating signal for the optical system from the detected physical control signals or for the purpose of switching to the standby mode, at least one energy supply system, and at least one fixing system. The system has one sensor or a plurality of sensors with sensor elements for measuring the pupil diameter and the surrounding luminance.

Abstract: The invention relates to a prosthesis for replacing a joint connection, wherein like magnetic fields from the condyle 10, socket 12 and joint collar 14 overlap in such a way that the repulsive forces generate a suspended state of the condyle 10 in the bearing and the damping effect is maximized. The invention is also directed to a method for replacing a bone junction in a mammal, wherein the prosthesis is fastened to the articular bone and repulsive forces generate a levitated state of the condyle 10 under load.

Abstract: The invention relates to a method of labelling and analysing nucleic acids. More specifically, the invention relates to a method of analysing nucleic acids, which comprises contacting the nucleic acids to be detected, which are in the form of single-stranded nucleic acid strands partially (i.e. over a part of the total length of the nucleic acid strands) hybridized with protective strands, with substances which specifically react with nucleobases of the single-stranded sections of the nucleic acid strands, and which are capable of subsequently participating in a reversible redox reaction in electroanalytical processes known to the skilled worker.

Abstract: A device for in situ milling of joint surfaces, including a milling device (20, 24) and a joint clamping device (10). The joint clamp device (10) is designed to be inserted between two joint components forming a joint, particularly bones (1, 3), and for pushing the joint components (1, 3) apart with a predetermined or adjustable tension, wherein the joint clamping device (10) includes a recess (11) in which the milling device (20, 24) can be inserted, wherein the milling device (20, 24) includes a face milling cutter (21).

Abstract: The invention relates to an insufflator with a supply connection (22) and a delivery connection (14) and a pressure and flow measuring device arranged between said connections (14, 22) for determining measured quantities characterizing a gas pressure at a delivery connection and a gas volume flow at the delivery connection. The pressure and flow measuring device comprises a multilayer board (20) which comprises on its interior at least one flow channel (26) that is connected at its input to the supply connection (22) and at its output (8) to the delivery connection (14). Arranged on the board (20) are pressure measurement sensors (32, 34) and electronic components (4, 6) for the wiring of the pressure measurement sensors.

Abstract: The present invention relates to a combination, in particular for the adhesive bonding and/or fixing of biological and/or synthetic tissues, wherein the combination comprises the components a) a nitrogen-functionalized polysaccharide and b) a terminally functionalized oligolactone.

Abstract: The spatial center of mass and a mass of an object can be determined by orientating the suspended object in at least two different spatial positions and measuring the orientation of the object in each of the different spatial positions the forces acting on the suspension devices because of the suspended object, the forces acting on the suspension devices being resolved into three independent force components. A center of area of the object and the associated force effect lines are determined for each of the at least two spatial positions, the center of area of the respective spatial position being determined with an inclined tension compensation of the suspension devices. The spatial center of mass is determined by superimposing at least two force effect lines.