Abstract: The present invention relates to a solid or liquisolid formulation comprising corallopyronin A, wherein the formulation comprises an amorphous solid dispersion of corallopyronin A embedded in a water-soluble polymer or corallopyronin A loaded onto porous silica.
Inventors:
Karl G. WAGNER, Anna Katharina KROME, Achim HÖRAUF, Gabriele M. KÖNIG, Kenneth Michael PFARR, Andrea SCHIEFER, Stefan KEHRAUS, Marc Peter HÜBNER
Abstract: A method for the exchange of electrical energy between at least two moving, electrically powered vehicles, comprising the steps: providing a first and a second electrically powered vehicle, having a respective electrical energy store, the energy store of the first and the second vehicle can emit or receive electrical energy, and the first and second vehicles move or are to be moved along a first or second route; changing the first and second routes in such a way that both changed routes coincide along a route section; steering the first and second vehicle along the changed first and second route in such a way that both the vehicles move along the coinciding route section at a distance to one another that is smaller than a predefined maximum distance; and transferring electrical energy from the energy store of the first vehicle to the energy store of the second vehicle.
Abstract: The present invention relates to human tissue kallikrein 7 (KLK7) selective inhibitor compounds, combinations including these compounds, process to obtain the referred compounds, and methods of using the same. The present invention belongs to the field of chemistry, pharmacology and medicine.
Type:
Application
Filed:
May 14, 2021
Publication date:
June 15, 2023
Applicants:
Fundação Universidade Federal do ABC - UFABC, Technische Universität Braunschweig
Inventors:
Luciano PUZER, Ana Flávia SANTARINE LAUREANO, Daniele RIBEIRO DE ARAÚJO, Michael HUST
Abstract: A method for determining a property of at least one particle (P) in a medium (M), comprising: emitting a coherent light beam (6) to irradiate a sample (5) of the medium (M); recording an interference image (10) of a first part of the light beam (6) scattered by the at least one particle (P) and a second part of the light beam (6) not scattered by particles (P); computing (S1), for positions (13) within the sample (5), an electric field (E1) of the first part from the interference image (10); generating (S2) a representation (16) comprising for each position (13), a phase value (?), determined from the computed electric field (E1) and from an estimated electric field (E2) of the second part, and an intensity value (I), determined from the intensity (I1) of the first part and from the phase value (?); and determining (S3), therefrom, said property.
Type:
Application
Filed:
April 29, 2021
Publication date:
June 15, 2023
Applicant:
Universität für Bodenkultur Wien
Inventors:
Petrus Dominicus Joannes VAN OOSTRUM, Erik Olof REIMHULT
Abstract: The device for locating cardiac arrhythmias comprises a three-dimensional reconstruction of the patient's torso and a number of surface electrodes, wherein the three-dimensional reconstruction of the patient's torso is generated through a number of images obtained by means of at least one camera. In particular, the device comprises elements for locating the surface electrodes, which detect the position of the electrodes with respect to the patient's torso, and data processing elements that generate, on the basis of the three-dimensional reconstruction and the position of the electrodes, a surface electrocardiographic map, and said surface electrocardiographic map has a number of data corresponding to readings of the surface electrodes related to areas of the three-dimensional reconstruction.
Type:
Grant
Filed:
October 29, 2015
Date of Patent:
June 13, 2023
Assignees:
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON, UNIVERSITAT POLITECNICA DE VALENCIA
Inventors:
Andreu Martinez Climent, Felipe Atienza Fernandez, Angel Arenal, Francisco Fernandez Aviles, Maria S. Guillem Sanchez
Abstract: A safety system is provided for a machine tool which has a frame and a tool. The safety system has a clamping device and a motion device. The clamping device is movable by the motion device from a working position, in which the tool is extended and can be used for working, to a safety position, in which the tool is retracted. The motion device has a first magnetic means connected to or arranged on the tool and a second magnetic means connected to or arranged on the frame, such that movement of the tool by the motion device from the working position to the safety position can be triggered and/or at least partially performed by magnetic force.
Type:
Grant
Filed:
November 18, 2019
Date of Patent:
June 13, 2023
Assignees:
Felder KG, Technische Universität Wien
Inventors:
Thomas Weiler, Helmut Caudr, Friedrich Bleicher
Abstract: The present invention relates to a single-use test-strip for the quantitative determination of sodium concentration and creatinine concentration and for the subsequent determination of their ratio, and to a non-invasive point-of-care (POC) device for detecting sodium depletion and/or sodium overload in a patient's body. Furthermore, the present invention relates to a method for simultaneously and quantitatively determining sodium concentration and creatinine concentration in a patient's urine sample and to a method of detecting sodium depletion and/or sodium overload in a patient's body.
Type:
Grant
Filed:
March 20, 2018
Date of Patent:
June 13, 2023
Assignees:
UNIVERSITÄT INNSBRUCK, MEDIZINISCHE UNIVERSITÄT INNSBRUCK
Inventors:
Peter Heinz-Erian, Gerda Laura Fuhrmann
Abstract: The invention relates to a connecting device (3) for mounting a wooden construction element (1), in particular in the form of a panel or beam, on a support (2a), wherein the connecting device (3) has a mounting node (4), which is designed for mounting the connecting device (3) on the support (2a), and a coupling arrangement (5), which is connected to the mounting node (4) and which, in the installed state, while projecting from the mounting node (4) on an upper side (1a) of the wooden construction element (1) can be connected to the latter by fastening members (7), which at least partially pass through the wooden construction element (1), wherein the mounting node (4) and the coupling arrangement (5) are each produced from a material which has a higher strength than that of the wooden construction element (1). The invention further relates to a wooden construction arrangement having a connecting device (3) according to the invention and to a structure having such a wooden construction arrangement.
Abstract: The disclosure relates to a drive device (V) for producing a translational motion of a movable tappet (8) by means of an electromagnetic rotating machine. The drive device includes an inner rotor (4) and an outer coaxial stator (5) and has a movement-thread pair integrated coaxially in the stator. The movement-thread pair comprising a lead screw (6), which is coupled to the rotor for conjoint rotation, and a threaded nut (7), which is linearly guided in a stator sleeve (2) in a rotationally fixed manner and is rigidly coupled to the tappet. The rotor is guided for rotation around the stator and a torque being transferred from the rotor to the lead screw by means of a thin-walled flange (10). A rotational fixation (11) of the threaded nut in the cavity of the stator sleeve is provided as a result of interlocking joining of the two.
Abstract: The invention provides conjugates of cyclic peptides as ligands for cellular surface receptors, in particular, as ligands for ?v?6-integrin. The conjugates further contain effector moieties and are suitable for use as therapeutic agent, diagnostic agent, agent for imaging, targeting moiety and as biomolecular research tool. The invention specifically relates to the use of conjugates with signalling moieties or radionuclides for in-vivo addressing of ?v?6-integrin.
Type:
Application
Filed:
March 12, 2021
Publication date:
June 8, 2023
Applicant:
Technische Universität München
Inventors:
Johannes Notni, Neil Quigley, Katja Steiger
Abstract: The invention relates to the use of a recombinant porcine adeno-associated virus (AAV) vector comprising a peptide-modified porcine AAV serotype 1 (AAVpol) capsid in gene therapy of muscle and/or central nervous system (CNS) disorders, in particular neuromuscular diseases such as genetic neuromuscular diseases.
Type:
Application
Filed:
April 28, 2021
Publication date:
June 8, 2023
Applicants:
Genethon, Universität Heidelberg, Universite d'Evry val d'Essonne, Institut National de la Santé et de la Recherche Médicale
Inventors:
Ana Buj Bello, Edith Renaud-Gabardos, Dirk Grimm, Jonas Weinmann
Abstract: The invention relates to a modular pulse source consisting of a main module and at least one additional module which are connected in series to each other in the sense of two-terminal circuits. The modules each comprise an energy storage device. The energy storage device of the main module is initially charged by a charging circuit. A stimulation coil is connected at the two ends of the series connection and as a result of a voltage pulse delivered by the chain of modules generates a magnetic field which in turn causes an induced electrical pulse or a respective electric field.
Abstract: The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.
Abstract: The particle sensor device comprises a substrate, a photodetector, a dielectric on or above the substrate, a source of electromagnetic radiation, and a through-substrate via in the substrate. The through-substrate via is exposed to the environment, in particular to ambient air. A waveguide is arranged in or above the dielectric so that the electromagnetic radiation emitted by the source of electromagnetic radiation is coupled into a portion of the waveguide. A further portion of the waveguide is opposite the photodetector, so that said portions of the waveguide are on different sides of the through-substrate via, and the waveguide traverses the through-substrate via.
Type:
Grant
Filed:
December 13, 2018
Date of Patent:
June 6, 2023
Assignees:
AMS AG, TECHNISCHE UNIVERSITÄT GRAZ
Inventors:
Jochen Kraft, Georg Röhrer, Fernando Jesus Castano Sanchez, Anderson Pires Singulani, Paul Maierhofer
Abstract: The present invention relates to a liquisolid pharmaceutical formulation comprising a porous carrier and an active pharmaceutical ingredient loaded onto a surface of the porous carrier, wherein the active pharmaceutical ingredient is dispersed in propylene carbonate or a mixture of propylene carbonate and a further solvent and the dispersion of the active pharmaceutical ingredient and propylene carbonate or a mixture of propylene carbonate and a further solvent is loaded onto the external surface and the internal surface located inside the pores of the porous carrier thereby forming a liquisolid system, and to a process for manufacturing such a liquisolid pharmaceutical formulation.
Abstract: The invention relates to a method and a computer program for estimating a bilirubin level of a neonate, composed of the steps of: Acquiring a series of bilirubin levels estimated at different time points from a sample obtained from a neonate, Acquiring a plurality of covariates from the neonate, each composed of an information about a neonatal property, Providing a pre-defined bilirubin model function, wherein the bilirubin model function is configured to describe a time course of a bilirubin level of a neonate, Determining a plurality of model parameters of the bilirubin model function, wherein each model parameter is estimated from at least one covariate of the plurality of covariates and an associated population model parameter, Determining from the series of acquired bilirubin levels and the bilirubin model function with the determined model parameters an expected bilirubin level of the neonate for a time particularly later than a lastly acquired bilirubin level of the series of bilirubin levels.
Type:
Grant
Filed:
March 15, 2022
Date of Patent:
May 30, 2023
Assignee:
UNIVERSITÄT BASEL
Inventors:
Gilbert Koch, Sven Wellmann, Marc Pfister, Severin Kasser, Melanie Wilbaux
Abstract: A method for the diagnosis of systemic lupus erythematosus (SLE) based on an interfacial process of antigen-antibody molecular recognition, specifically between anti-Ro52 and Ro52 protein, in a piezoelectric resonator, for application in the diagnosis of autoimmune diseases such as SLE.
Type:
Grant
Filed:
June 29, 2018
Date of Patent:
May 30, 2023
Assignees:
UNIVERSITAT POLITECNICA DE VALENCIA, INSTITUTO DE INVESTIGACION SANITARIA LA FE—FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO Y POLITECNICO LA FE DE LA COMUNIDAD VALENCIANA, UNIVERSITAT DE VALENCIA ESTUDI GENERAL
Inventors:
Noelle Marine Do Nascimento, David Gimenez Romero, Sergi Benat Morais Ezquerro, Angel Maquieira Catala, Augusto Miguel Juste Dolz, Elena Grau Garcia, Rosa Puchades Pla, Jose Andres Roman Iborra
Abstract: The invention relates to an apparatus and to a method for establishing a connection having material continuity or having material continuity and shaping matching or for separating such a connection of at least one metal or ceramic component and of a component formed from or by a thermoplastic polymer in which the components to be joined together can be pressed together by a pressing device having a counterholder and a plunger. A heating device is present at the plunger and/or at the counterholder or acts there.
Type:
Grant
Filed:
March 14, 2017
Date of Patent:
May 30, 2023
Assignees:
FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V., TECHNISCHE UNIVERSITAT DRESDEN
Inventors:
Maurice Langer, Annett Klotzbach, Robert Pautzsch
Abstract: The invention relates to a method for selecting a sequence set from a library of expressed nucleic acid sequences, wherein cells are provided, each cell comprises an expressed nucleic acid sequence expressed as a target protein. The cells are encapsulated by treating them with a cationic polysaccharide and subsequently treating them with an anionic polysaccharide, yielding encapsulated cells, perforating the membrane of the encapsulated cells, yielding solubilized compartments, contacting them with a ligand to said target protein, the ligand bearing a detectable label, and selecting a subset of solubilized compartments as a function of detectable label and isolating the expressed nucleic acid sequences from the selection as a selected sequence set.
Abstract: The present invention provides a method for determining the resistance of a microorganism to a drug by detecting at least a transcript of a drug resistance gene from a microorganism in a biological sample, the method comprising the steps of: (i) lysing the cells by means of a chemical or a mechanical method, thereby obtaining a lysate and cell debris; (ii) obtaining a ribosome-antibody complex from the lysate using an antibody or a fragment thereof which binds specifically to a microorganism-ribosomal protein; (iii) purifying the mRNA associated to the ribosome-antibody complex by means of a nucleic acid extraction method; and (iv) submitting the resulting mRNA to a specific gene detection method, thereby identifying the at least one drug resistance gene transcript of the biological sample.
Type:
Application
Filed:
April 11, 2019
Publication date:
May 25, 2023
Applicant:
UNIVERSITAT AUTONOMA DE BARCELONA
Inventors:
Albert QUINTANA ROMERO, Elisenda SANZ IGLESIAS