Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
Type:
Application
Filed:
May 31, 2013
Publication date:
May 7, 2015
Applicant:
Universitatsstrasse 2
Inventors:
Edward H. Schuchman, Erich Gulbins, Anthony Futerman, Yael Pewzner-Jung