Abstract: Compositions for use in the prevention and/or treatment of at least one adverse effect of a chemotherapy in the treatment of cancer are disclosed. The compositions have N-acetylcysteine (NAC) and vitamin B12 and/or a combination of vitamins B1, B2 and B3. Methods of treatment of chemo-induced nociceptive and/or neuropathic pain by administering such compositions are also disclosed.

Abstract: A method for tracking the activity of animals confined in a facility including at least one cage, a plurality of antennae arranged underneath the at least one cage, an RFID reader to which the plurality of antennae are connected, a computer capable of controlling transmission and reception by the RFID reader, and an RFID tag to be fitted to an animal confined in the cage, the method including that the following steps are carried out:—the animal is fitted with the tag,—the RFID reader generates the transmission of an electromagnetic wave at the plurality of antennae,—the RFID reader identifies which antenna(e) has/have received the response transmitted by the tag,—the computer analyses over a given period which antennae have received a signal transmitted by the tag, thus determining the consecutive positions of the animal.

Abstract: A quantum simulator to simulate an evolution of a solution of a complex nonlinear equation. The quantum simulator includes a first wavelength-tunable laser configured to emit light with a tunable central wavelength; a vapor cell comprising a gas of atoms or molecules at a given temperature; a beam shaper unit arranged between the wavelength-tunable laser and the vapor cell and configured to modify the phase and/or the amplitude of the emitted light. The vapor cell is configured to receive light at the output of the beam shaper unit so that the light interacts with the gas to produce an output light; the interaction mapping the complex nonlinear equation with given initial conditions and coefficient data of the complex nonlinear equation.

Abstract: A method for determining the level of inorganic pyrophosphate (PPi) in a biological sample, including the steps of: a) a measurement of the concentration of PPi in a first fraction of the biological sample, using an assay based on enzymatic reaction, b) a measurement of the concentration of PPi in a second fraction of the biological sample, using an assay based on ionic chromatography, and c) a comparison of the value measured in step a) and the value measured in step b), and assessing if the difference is above a pre-determined threshold. If the difference between the values measured respectively in step a) and in step b) is lower than or equal to the pre-determined threshold, the concentration of PPi in the biological sample is determined as the mean of the values measured in step a) and in step b).

Abstract: A beam-steering device (BSD) including a dielectric substrate (DS) and a cover window (DCW), both transparent; a plurality of transparent conducting rails (VEL), extending parallel to each other between the dielectric surfaces, dividing a space between the substrates into a plurality of elongated cells (LC0-LC3); a nematic liquid crystal (LC) filling the elongated cells; and a plurality of electrical interconnections (ELI) suitable to apply an electric potential (V0-VN) to each one of the conducting rails. The pitch P of the conducting rails is smaller than an optical wavelength ?; and the height H of the conducting rails is at least equal to ?/?n, ?n being the birefringence of the liquid crystal at the optical wavelength.

Abstract: The present invention relates to a compound of general formula (I), wherein R1 is OCH2CH2OCH3 or OCH3, R?1 is H or OH, R2 is Cl, F, Br or I, with the proviso that when: R1 is OCH2CH2OCH3 then R?1 is H, R1 is OCH3 then R?1 is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.

Abstract: An optical imaging system including a transmitter unit and a receiver unit. The transmitter unit includes a light-emitting source generating at least one first optical beam at a given wavelength; a light modulator, associated with a first field of view, detects the at least one first optical beam in a first deflection direction within the first field of view to generate a first deflected beam, by applying an external control signal; and a transmissive deflecting device, associated with a second field of view and including a two-dimensional arrangement of deflecting cells, each of the deflecting cells being reachable by the first deflected beam and being associated with an elementary field of view, the transmissive deflecting device generating at least one second deflected beam from the first deflected beam using an operational deflecting cell of the plurality of deflecting cells that receives the first deflected beam.

Abstract: The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the treatment of cancer or inflammatory diseases.

Abstract: A heptane composition obtained from a plant source is described, wherein the plant source comprises Commiphora wildii and wherein the heptane composition is obtained by a process of extraction comprising hydrodistilling or steam distilling a resin of Commiphora wildii to obtain an essential oil. A method of using the heptane composition as a solvent for extracting one or more natural products is also described.

Abstract: The present invention relates to novel plants displaying an improved resistance to nematodes. The present invention also relates to seeds and parts of said plants. The present invention further relates to methods of making and using such seeds and plants. The present invention also relates to a novel SmD1 allele, which results in a modified SmD1 protein associated with such improved resistance to nematodes.

Abstract: Systems for inspecting a surface of an optical wave originating from an optical device are provided. The optical device includes an exit pupil, and the inspection system includes an optical measuring head and a computer for processing the images from said optical measuring head. The optical measuring head includes a density gradient filter, the density varying periodically in the two directions in space, a matrix frame having at least four identical lenses of square shape of the same focal length and being arranged symmetrically, and a photodetector array, each of the four lenses forming an image of the pupil in the plane of this array. The image processing computer includes computing means for computing the partial derivatives ? ? ? x ? ( x , y ) and ? ? ? y ? ( x , y ) of the wave surface ?(x, y) in the plane of the exit pupil.

Abstract: The method for the in vitro or ex vivo amplification of stem cells of brown or beige adipocytes includes: extracting (i) a stromal vascular fraction from human adipose tissue including endothelial cells of the vascular network of human adipose tissue and stem cells of brown or beige human adipose tissue and (ii) an extracellular matrix of the human adipose tissue, the extracellular matrix including endothelial cells of the vascular network of human adipose tissue, stem cells of brown or beige human adipose tissue and collagen; mixing the stromal vascular fraction and the extracellular matrix; and culturing the mixture obtained, in suspension, in a culture medium.

Abstract: The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to treat skeletal growth regardation disorders, such as achondroplasia.

Abstract: Modulation of neural signaling of a pancreas-related sympathetic nerve is capable of improving glycaemic control by inhibiting T cell activation or migration to the pancreas, and hence providing a way of treating or preventing type 1 diabetes.

Abstract: The present disclosure relates to biguanide derivatives of formula (I) and their rearrangement products. The present disclosure also relates to the use of these compounds in a method for treating cancer, in particular melanoma.

Abstract: The method for tin vitro or ex vivo amplification of human adipose tissue stem cells includes: —extracting a stromal vascular fraction of a human adipose tissue including endothelial cells of the human adipose tissue vascular network and human adipose tissue stem cells, and an extracellular matrix of the human adipose tissue, the extracellular matrix including endothelial cells of the human adipose tissue vascular network, human adipose tissue stem cells and collagen; —mixing the stromal vascular fraction and the extracellular matrix; and—culturing the mixture obtained in the preceding step, in suspension, in a culture medium.

Abstract: The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to treat skeletal growth regardation disorders, such as achondroplasia.

Abstract: The invention relates to an in vitro or ex vivo method for differentially diagnosing a bipolar disorder and a major depressive disorder in a human patient in a need thereof presenting depressive symptoms, comprising the following steps: providing a biological sample from said patient; determining, from said biological sample, the abundance of at least one of the following cytokines TNF-?, IFN-?, IL-6, IL-10, IL-12p40, IL-15, IL-16, IL-17A and IL-27; and diagnosing a bipolar disorder or a major depressive disorder from the determination of the abundance of the at least one of the following cytokines TNF-?, IFN-?, IL-6, IL-10, IL-12p40, IL-15, IL-16, IL-17A and IL-27.

Abstract: The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to treat skeletal growth retardation disorders, such as achondroplasia.

Abstract: The present invention relates to the identification of proteins of the WNT signaling pathway as therapeutic targets of pigmentation disorder and as biomarkers of pigmentation status. The invention in particular relates to products and methods for treating a hypopigmentation disorder. The invention also relates to products and methods for detecting, diagnosing, staging or monitoring the course of hypopigmentation disorder and is particularly suited for human subjects.