Patents Assigned to UNIVERSITE D'AIX MARSEILLE (AMU)
  • Publication number: 20230036464
    Abstract: The method of optimizing an intracranial implantation scheme of a set of electroencephalographic electrodes for identification of an epileptogenic zone in an epileptic patient’s brain includes: - providing a model of the epileptogenic zone and a model of the propagation of an epileptic discharge from the epileptic zone to a propagation zone, and loading the models in a computerized platform personalized according to the patient’s brain; - providing at least one hypothesis of the localization of the epileptogenic zone in the patient brain; - for the at least hypothesis of the localization of the epileptogenic zone, simulating, in the personalized computerized patient’s brain, epileptic seizures, and determining, for the hypothesis and epileptic seizures, a network of propagation zones; - for a plurality of intracranial implantation schemes of the electroencephalographic electrodes, obtaining, using the personalized computerized patient’s brain, simulated electroencephalographic signals activity to be measured
    Type: Application
    Filed: January 22, 2021
    Publication date: February 2, 2023
    Applicants: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: Viktor Jirsa, Kenza El Houssaini, Huifang Wang
  • Publication number: 20220369618
    Abstract: The disclosure relates to an apparatus and a system for testing the cognitive ability of a rodent, comprising a testing chamber, a retarding zone connected to the entrance chamber and including at least one obstacle configured to slow down the rodent's movement to the entrance chamber, and an optional transfer chamber connected to the entrance chamber via the retarding zone for transfer of the rodent to and from an area external to the apparatus. The testing chamber comprises an entrance chamber, a plurality of corridors each connected to the entrance chamber via a corridor's first end portion, and at least one odor diffuser for diffusing odors in the plurality of corridors.
    Type: Application
    Filed: October 22, 2020
    Publication date: November 24, 2022
    Applicants: Université d'Aix Marseille (AMU), Centre National de la Recherche Scientifique
    Inventors: François Silvio Paul Hubert Roman, Guy Pierre Roger Escoffier
  • Patent number: 11428924
    Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: August 30, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Centrale de Marseille (ECM), Université d'Aix-Marseille (AMU)
    Inventors: Hervé Rigneault, Esben Ravn Andresen, Siddarth Sivankutty
  • Publication number: 20220266505
    Abstract: The method for manufacturing a three-dimensional object or for modifying the surface state of a preformed object by local polymerisation of monomers or oligomers, the polymerisation being initiated by mono-photon or multi-photon absorption in an area to be polymerised, includes: —introducing into a vessel with light-transparent walls a reaction medium comprising polymerisable monomers or oligomers, a polymerisation inhibitor, an indicator of the amount of the inhibitor and a photochemical polymerisation initiator; —initiating the polymerisation of the monomers or oligomers; —indicating the amount of inhibitor present in the reaction medium; —controlling the amount of light emitted by the irradiation system relative to the amount of inhibitor indicated by the indicator; and —switching to a following zone to be polymerised by moving the object and/or the focused light beam.
    Type: Application
    Filed: July 22, 2020
    Publication date: August 25, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX-MARSEILLE (AMU), ECOLE CENTRALE DE MARSEILLE
    Inventors: Claude Amra, Jean-Claude André, Laurent Gallais-During, Myriam Zerrad
  • Publication number: 20220262515
    Abstract: The method for determining an onset time and an excitability of a brain region that is not observed as recruited or not recruited in a seizure activity of an epileptic patient brain includes: providing a dynamical model of a propagation of an epileptic seizure in the brain networks; providing a statistical model which defines the probability of generating sets of observations of the state of the brain networks by said dynamical model; training the dynamical model of the propagation of an epileptic seizure using the statistical model and the data set of observations of the training cohort; and inverting the trained dynamical model and inferring the onset time and excitability of a third region from the onset time that is observed for the first and second regions using the statistical model.
    Type: Application
    Filed: July 22, 2020
    Publication date: August 18, 2022
    Applicants: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: Viktor Jirsa, Viktor Sip
  • Publication number: 20220249167
    Abstract: The method of identifying a potentially surgically operable target zone in an epileptic patient's brain includes: providing a computerized platform modelling various zones of a primate brain and connectivity between said zones; providing a model of an epileptogenic zone and a model of the propagation of an epileptic discharge from an epileptic zone to a propagation zone; obtaining a patient's personalized computerized platform; deriving the potential target zones based on modularity analysis; evaluating the target zones' effectiveness by simulating epileptic seizures propagation in the personalized patient's computerized platform; evaluating the target zones' safety by simulating spatiotemporal brain activation patterns in a defined state condition and comparing the simulated spatiotemporal brain activation patterns obtained before removal of the target zone with the spatiotemporal brain activation patterns obtained after removal of the target zone; identifying the target zones which satisfy both effectivenes
    Type: Application
    Filed: May 27, 2020
    Publication date: August 11, 2022
    Applicants: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: Sora An, Viktor Jirsa
  • Publication number: 20220039736
    Abstract: The invention relates to modulating epileptogenicity in a brain of an epileptic patient. The method according to the invention comprises the steps of: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading said models in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in said data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing said at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 10, 2022
    Applicants: UNIVERSITE D'AIX MARSEILLE (AMU), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (AP-HM), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Viktor Jirsa, Christophe Bernard, Fabrice Bartolomei, Maxime Guye
  • Patent number: 11191476
    Abstract: The method of modulating epileptogenicity in a brain of an epileptic patient includes: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading the model in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in the data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing the at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: December 7, 2021
    Assignees: UNIVERSITE D'AIX MARSEILLE (AMU), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE (AP-HM), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Viktor Jirsa, Christophe Bernard, Fabrice Bartolomei, Maxime Guye
  • Publication number: 20210285967
    Abstract: The invention relates to an in vitro or ex vivo method for differentially diagnosing a bipolar disorder and a major depressive disorder in a human patient in a need thereof presenting depressive symptoms, comprising the following steps: providing a biological sample from said patient; determining, from said biological sample, the abundance of at least one of the following cytokines TNF-?, IFN-?, IL-6, IL-10, IL-12p40, IL-15, IL-16, IL-17A and IL-27; and diagnosing a bipolar disorder or a major depressive disorder from the determination of the abundance of the at least one of the following cytokines TNF-?, IFN-?, IL-6, IL-10, IL-12p40, IL-15, IL-16, IL-17A and IL-27.
    Type: Application
    Filed: October 4, 2019
    Publication date: September 16, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX-MARSEILLE (AMU), UNIVERSITÉ CÔTE D'AZUR, ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE (AP-HM), SORBONNE UNIVERSITE, UNIVERSITE DE MONTPELLIER, CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
    Inventors: Wafa Bel Haj Ali, El Chérif Ibrahim, Raoul Belzeaux, Lionel Fillatre, Nicolas Glaichenhaus, Philippe Courtet, Emanuela Martinuzzi, Susana Do Carmo Pinto Barbosa
  • Publication number: 20210123916
    Abstract: The invention relates to a method for diagnosing a cancer in a mammal in a need thereof. The method comprises the following steps: collecting a biological sample from said mammal; determining, from said biological sample, if the ADAMTSL5 gene is overexpressed; diagnosing a cancer from the determination of the overexpression of said gene. It also relates to a kit for determining an overexpression of the ADAMTSL5 gene in a biological sample obtained from a mammal, to a pharmaceutical composition comprising an agent targeting ADAMTSL5 or the ADAMTSL5 pathway as well as a pharmaceutically acceptable carrier for use in the treatment of a cancer, and to a use of an ADAMTSL5 mRNA or protein as a biomarker of cancer.
    Type: Application
    Filed: March 29, 2019
    Publication date: April 29, 2021
    Applicants: UNIVERSITE D'AIX-MARSEILLE (AMU), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Flavio Maina, Maria Arechederra, Rosanna Dono, Timothy Mead, Suneel Apte
  • Publication number: 20210063511
    Abstract: The invention relates to a material for use as a pad in high field and/or very high field magnetic resonance imaging instrument, comprising at least one polar solvent having a melting point of 14° C. to 50° C., a dispersant and a dielectric charge. The invention relates also to a pad used in field of high field and/or very high field magnetic resonance imaging made of at least such a material.
    Type: Application
    Filed: March 27, 2019
    Publication date: March 4, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, ECOLE CENTRALE DE MARSEILLE, UNIVERSITE D'AIX-MARSEILLE (AMU)
    Inventors: Abdeddaim Redha, Anne-Lise Adenot-Engelvin, Marc Dubois, Stefan Enoch, Nicolas Mallejac, Zo Raolison, Pierre Sabouroux, Alexandre Vignaud
  • Publication number: 20210038682
    Abstract: The invention relates to a modulator of small conductance calcium activated K+ channels of the vestibular nuclei cells for use in the treatment of a lesional vestibular disorder in a patient in need thereof, and to a pharmaceutical composition comprising such modulator, for such a use.
    Type: Application
    Filed: March 13, 2019
    Publication date: February 11, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX-MARSEILLE (AMU)
    Inventors: Brahim Tighilet, Christian Chabbert, Christiane Mourre, David Pericat, Jacques Léonard
  • Publication number: 20210018744
    Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres.
    Type: Application
    Filed: April 4, 2017
    Publication date: January 21, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Universite d'Aix-Marseille (AMU), Ecole Centrale de Marseille (ECM)
    Inventors: Hervé Rigneault, Esben Ravn Andresen, Siddarth Sivankutty
  • Publication number: 20200345275
    Abstract: The invention relates to a method for automatic and continuous measurement of a sedation state of a patient in an intensive care unit. The method according to the invention comprises the following steps: providing signals representative of the condition of the patient, said signals comprising cardio-circulatory signals, signals representative of the respiratory activity and signals representative of the motor activity of the patient; and determining a global index representative of the sedation state of the patient.
    Type: Application
    Filed: January 25, 2019
    Publication date: November 5, 2020
    Applicants: UNIVERSITE D'AIX-MARSEILLE (AMU), ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (AP-HM), INSTITUT FRANCAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS DE L'AMENAGEMENT ET DES RESEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Harold Noble Ibouanga-Kipoutou, Salah Boussen, Kouider Nacer M'Sirdi, Pierre-Jean Arnoux, Nicolas Bruder, Michel Behr
  • Publication number: 20200025763
    Abstract: The invention concerns a method and a system for diagnosing a pathology in a mammal in need thereof. The method according to the invention comprises the following steps: collecting a blood, blood plasma or blood serum sample from said mammal, said biological sample comprising a protein mixture; obtaining an optical thermal denaturation profile of said biological sample; comparing said optical thermal denaturation profile of said biological sample with an optical thermal denaturation reference profile; and diagnosing the pathology.
    Type: Application
    Filed: December 21, 2017
    Publication date: January 23, 2020
    Applicants: UNIVERSITE D'AIX MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: Philipp Tsvetkov, François Devred
  • Publication number: 20190254585
    Abstract: The invention relates to modulating epileptogenicity in a brain of an epileptic patient. The method according to the invention comprises the steps of: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading said models in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in said data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing said at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.
    Type: Application
    Filed: July 18, 2016
    Publication date: August 22, 2019
    Applicants: UNIVERSITE D'AIX MARSEILLE (AMU), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (AP-HM), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Viktor Jirsa, Christophe Bernard, Fabrice Bartolomei, Maxime Guye
  • Publication number: 20190029550
    Abstract: The invention relates to a method for automatically detecting elements of interest in electrophysiological signals, and to a detector for implementing such a method. The method according to the invention comprises steps in which: electrophysiological signals are delivered; a whitened time-frequency representation of said electrophysiological signals is produced; a threshold is set; this threshold is applied to the whitened time-frequency representation; and, in the whitened time-frequency representation, local maxima that are higher than or equal to the applied threshold are detected.
    Type: Application
    Filed: February 28, 2017
    Publication date: January 31, 2019
    Applicants: UNIVERSITÉ D'AIX-MARSEILLE (AMU), INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE (AP-HM)
    Inventors: Nicolas Roehri, Christian George Benar, Fabrice Bartolomei