Abstract: The present invention relates to a series of novel imidazo[1,2-?]pyrrolo[3,2-c]pyridines (or also named 6H-1,3a,6-Tri-aza-?y-indacenes) and derivatives thereof, according to formula: (I); The present invention also relates to processes for the preparation of imidazo[1,2-?]pyrrolo[3,2-c]pyridines, their use as. a, medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Bovine Viral Diarrhea virus (BVDV).

Abstract: This invention relates to riluzole for use in the treatment or prevention of adverse effects associated with the administration of anticancer agents having neurotoxic effects, such as, for example, platinum salts, taxanes and periwinkle alkaloids.

Abstract: The invention relates to a device for simulating the stomach of a monogastric mammal or of a human being that includes at least two compression chambers (C2, C3) connected together by an intermediate chamber. Each compression chamber (C2, C3) includes a piston (72, 73) adapted for urging the content of a compression chamber (C2, C3) towards the other compression chamber (C2, C3). The device includes means (20) capable of generating turbulent flow of the device content when passing through the intermediate chamber (C8). The intermediate chamber (C8) is formed in an intermediate block (8) provided with an access means (11a, 12, 16) for supplying products (12) and/or tapping the content of the device at any moment of the operation cycle thereof.

Abstract: A compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4) alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (?) or (?): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6) alkenyl group or a group of formula (y): wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a —NO2 group, a —NR5R6 group, a N+R5R6R7X? group, or a —OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.

Abstract: A method of using L-citrulline of the formula (I) for preparing a cosmetic composition, a food or nutraceutic composition or a pharmaceutical composition for treating diseases related to an increase in protein carbonylation, in particular for treating neurodegenerative diseases such as Alzheimer's or Parkinson's disease.

Abstract: The present invention relates to a series of novel imidazo[1,2-?]pyrrolo[3,2-c]pyridines (or also named 6H-1,3a,6-Tri-aza-?y-indacenes) and derivatives thereof, according to formula: (I); The present invention also relates to processes for the preparation of imidazo[1,2-?]pyrrolo[3,2-c]pyridines, their use as. a, medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Bovine Viral Diarrhea virus (BVDV).

Abstract: The present invention relates to the use of a compound of formula (I): in which R1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.

Abstract: A system for representation and analysis of pressure variables in a patient including a plurality of pressure sensors; a signal processor connected to process signals emitted by the sensors, wherein the process comprises a multiplicity of inputs for receiving analog signals from the sensors, wherein each input is connected to a sampling circuit providing a digital signal used by a calculator for performing processing steps comprising: resampling displayed or recorded signals, analyzing the frequency of sampled signals in relation to a range of target frequencies recorded in a memory, for the display and recording of temporal variations of the signals corresponding to slow waves of the signals, and determination of temporal shifts between the slow waves corresponding to two distinct inputs; and a display that shows variations in the signals.

Abstract: A method of analyzing biological pressure signals in a patient including obtaining arterial blood pressure, cerebral blood flow rate and intracranial pressure signals from the patient, and analyzing frequencies of the signals in relation to a range of target frequencies corresponding to at least one of type-B slow waves, infra-B waves and ultra-B waves; and an apparatus for analyzing biological pressure signals in a patient including an acquisition module, located adjacent to the patient and having input channels that receive signals from an arterial blood pressure (ABP) sensor, a cerebral blood flow rate (CBF) sensor, and an intracranial pressure (ICP) sensor; an analysis module that performs frequency analysis of the signals from a target frequency selected from the group consisting of type B slow waves corresponding to a frequency between 8×10?3 hertz and 50×10?3 hertz, infra-B waves corresponding to a frequency lower than 8×10?3 hertz, and ultra-B waves corresponding to a frequency including between 50×10

Abstract: The invention concerns a method for detecting micro-organisms constituting a flora of micro-organisms, whereof at least part of the elements has a common operon. The invention is characterised in that it consists in identifying the elements of said flora by studying the intergenetic sequence of said operon, and the support exhibiting nucleic acids capable of hybridizing said intergenetic sequence.