Patents Assigned to UNIVERSITE D'AVIGNON
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Patent number: 12168224Abstract: The present invention relates to an optically pure (+) or (?) enantiomer of a ruthenium complex having formula (I) as well as the preparation method of said enantiomer, and uses thereof as catalyst, in particular in asymmetric olefin metathesis.Type: GrantFiled: July 8, 2021Date of Patent: December 17, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ D'AIX-MARSEILLE, UNIVERSITE DE RENNES 1, INSTITUT NATIONAL DES SCIENCES APPLIQUÉES, ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE RENNES, UNIVERSITY OF CALIFORNIA, SAN DIEGOInventors: Rodolphe Jazzar, Guy Bertrand, François Vermersch, Nicolas Vanthuyne, Jennifer Morvan, Marc Mauduit
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Publication number: 20240399143Abstract: The deep brain stimulation system has at least four stimulation pairs of electrodes. Each stimulation pair of electrodes provides an electric stimulation at a carrier frequency. The mean value between the carrier frequency of any first stimulation pair of electrodes and the carrier frequency of any second stimulation pair of electrodes defines a first mean carrier frequency. The mean value between the carrier frequency of any third stimulation pair of electrodes and the carrier frequency of any fourth stimulation pair of electrodes defines a second mean carrier frequency. The difference between the first and second mean carrier frequencies is equal to or greater than 200 Hz.Type: ApplicationFiled: October 14, 2022Publication date: December 5, 2024Applicants: UNIVERSITE D'AIX-MARSEILLE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Emma Acerbo, Boris Botzanowski, Florian Missey, Adam Williamson
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Publication number: 20240389587Abstract: A phytopharmaceutical method for treating a plant organ affected by a phytopathogenic fungal strain. The method includes the steps of applying on the plant organ a composition including at least one xanthone UPR (Unfolded Protein Response) inhibitor, preferably, an IRE-1 (Inositol-Requiring Enzyme 1) inhibitor, in a sub-effective amount. Also, a phytopharmaceutical composition including at least one UPR (Unfolded Protein Response) inhibitor in a sub-effective amount.Type: ApplicationFiled: November 30, 2022Publication date: November 28, 2024Applicants: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (INRAE), AGROCAMPUS OUEST (Institut national supérieur des sciences agronomiques, agro-alimentaires,, UNIVERSITÉ D'ANGERSInventors: Nelly BATAILLÉ-SIMONEAU, Thomas CHARPENTIER, Thomas GUILLEMETTE, Anne-Marie LE RAY, Pascal RICHOMME-PENIGUEL, Philippe SIMONEAU, Guillaume VIAULT
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Patent number: 12152317Abstract: The invention relates to Variable Domain of Camelid Heavy Chain-only (VHH) molecules which bind TfR and the uses thereof e.g., to transport molecules of pharmaceutical or diagnostic interest into cells and in organs, in pathological conditions including cancer.Type: GrantFiled: January 8, 2020Date of Patent: November 26, 2024Assignees: VECT-HORUS, UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Romy Cohen, Marion David, Michel Khrestchatisky
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Patent number: 12146160Abstract: The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells play a central role in peripheral tolerance and thus critically prevent the development of autoimmune and inflammatory disorders. The inventors showed that Foxp3+CD4+ Tregs express high levels of LT?, which negatively regulates their immunosuppressive signature. The inventors have demonstrated that the adoptive transfer of Tregs previously incubated with soluble lymphotoxin-? receptor in mice protects from dextran sodium sulfate (DSS)-induced colitis. Thus, the number of cells to be injected in adoptive transfer may be reduced and a transfection or transduction step avoided, which represents a technical facilitation.Type: GrantFiled: May 13, 2020Date of Patent: November 19, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventor: Magali Irla
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Patent number: 12144896Abstract: The treatment of cancer using platinum-based compounds includes certain drawbacks such as biocompatibility, loading efficacy, leakage of drugs during storage and in the bloodstream, more particularly due to the nature of the nanocarriers for platinum delivery. A nanosystem that allows improving platinum-based drug in vivo performance, kinetics and efficacy. In particular, nanoparticles useful as drug delivery system, these nanoparticles being formed from at least: (a) platinum-based drug, (b) poly-L-arginine, and (c) hyaluronic acid. Particularly, these nanoparticles have been tested in terms of entrapment efficiency and also carried out in vitro experiments in 2D cell culture (viability studies on B6KPC3, A549 and HT-29 cells) and 3D cell model (spheroids made of HTC-116) and in vivo experiments (by injecting intravenously to mice the nanoparticles or comparative oxaliplatin solution) to prove their efficiency.Type: GrantFiled: September 16, 2019Date of Patent: November 19, 2024Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, UNIVERSITE D'ANGERS, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERSInventors: Giovanna Lollo, Jean-Pierre Benoit, Marie Brachet-Botineau
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Publication number: 20240376065Abstract: The instant invention relates to thionolactone compounds useful as comonomers to introduce weak bonds for polymer degradation or functionalization. The invention is also directed to processes for the preparation of said compounds, notably by thionation of the corresponding lactones. The invention is furthermore directed to uses of said thionolactones as comonomers, copolymers made from these comonomers, and processes for the preparation of said copolymers.Type: ApplicationFiled: July 21, 2022Publication date: November 14, 2024Applicants: SPECIALTY OPERATIONS FRANCE, Université d'Aix-Marseille, Centre National de la Recherche ScientifiqueInventors: Pierre-Emmanuel Dufils, Christopher Mark Plummer, David James Wilson, Didier Gigmes, Yohann Guillaneuf
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Publication number: 20240360396Abstract: The preparation of a microstructured scaffold corresponding to a biocompatible membrane-type support material for cell culture, and a composition that includes the microstructured scaffold and cells, in particular photoreceptors. Also, the preparation of an implantable graft for the treatment of diseases of the retinal pigment epithelium and the neural retina.Type: ApplicationFiled: July 21, 2022Publication date: October 31, 2024Applicants: CENTRE D'ETUDE DES CELLULES SOUCHES, UNIVERSITE D'EVRY VAL D'ESSONNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS-SACLAYInventors: Christelle MONVILLE, Elise HERARDOT, Karim BEN M'BAREK, Frédéric HAMOUDA
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Patent number: 12131914Abstract: A method for processing a substrate that includes: loading the substrate in a plasma processing chamber; performing a cyclic plasma etch process including a plurality of cycles, where each cycle of the plurality of cycles includes: generating a first plasma from a first gas mixture including a fluorosilane and oxygen; performing a deposition step by exposing the substrate to the first plasma to form a passivation film including silicon and fluorine; generating a second plasma from a second gas mixture including a noble gas; and performing an etch step by exposing the substrate to the second plasma.Type: GrantFiled: November 9, 2021Date of Patent: October 29, 2024Assignees: Tokyo Electron Limited, Université d'OrleansInventors: Du Zhang, Hojin Kim, Shigeru Tahara, Kaoru Maekawa, Mingmei Wang, Jacques Faguet, Remi Dussart, Thomas Tillocher, Philippe Lefaucheux, Gaëlle Antoun
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Patent number: 12125594Abstract: The method for determining an onset time and an excitability of a brain region that is not observed as recruited or not recruited in a seizure activity of an epileptic patient brain includes: providing a dynamical model of a propagation of an epileptic seizure in the brain networks; providing a statistical model which defines the probability of generating sets of observations of the state of the brain networks by said dynamical model; training the dynamical model of the propagation of an epileptic seizure using the statistical model and the data set of observations of the training cohort; and inverting the trained dynamical model and inferring the onset time and excitability of a third region from the onset time that is observed for the first and second regions using the statistical model.Type: GrantFiled: July 22, 2020Date of Patent: October 22, 2024Assignees: UNIVERSITÉ D'AIX MARSEILLE (AMU), INSTIT NAT DE LA SANTÉ ET DE LA RECHERCHE MÉDICALEInventors: Viktor Jirsa, Viktor Sip
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Patent number: 12120892Abstract: The application relates to organic-inorganic hybrid perovskites of formula (I): [(A)1?2.48p?b(B)3.48p+b](1+2p?y)/1+p)(Pb)1?p?m(M)m(X1)3?y?q(X2)q(I), and perovskite photovoltaic cells comprising the same.Type: GrantFiled: July 19, 2018Date of Patent: October 15, 2024Assignees: UNIVERSITÉ D'ANGERS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), CHIMIE PARISTECHInventors: Nicolas Mercier, Antonin Leblanc, Thierry Pauporté
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Patent number: 12091541Abstract: A solid organic material comprising at least one amphiphilic block copolymer of the methacrylic type, the block copolymer being dispersed in a polymer matrix, the block copolymer having a number-average molar mass (Mn) greater than or equal to 20 000 g/mol; a method for preparing said solid organic material; use of said solid organic material for antibacterial, antimicrobial, antiviral, anti-inflammatory and/or antifungal applications; a medical device comprising said solid organic material.Type: GrantFiled: July 6, 2018Date of Patent: September 17, 2024Assignees: Centre national de la recherche scientifique, UNIVERSITÉ D'AIX MARSEILLE, Ecole Centrale de MarseilleInventors: Didier Gigmes, Yohann Guillaneuf, Catherine Guillaneuf, Marc René Sauveur Maresca, Cédric Ysacco
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Patent number: 12079997Abstract: A method for determining a contour of the representation, on a photo of an object made up of one or several elements, referred to as an “actual contour.” The method includes the following steps: 1) application of a first treatment to the photo so as to obtain a first image representing a first contour of the object; 2) application of a second treatment to the photo so as to obtain a second image representing a second contour of the object; 3) association, according to a predetermined association algorithm, of each point of the second contour with a point of the first respective contour, then removal of the points of the first contour that have not been associated with a point of the second contour, the first image then representing a corrected contour of the object.Type: GrantFiled: February 21, 2020Date of Patent: September 3, 2024Assignees: DENTAL MONITORING, UNIVERSITE D'ORLEANSInventors: Van Trung Pham, Yves Lucas, Sylvie Treuillet, Laurent Debraux
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Patent number: 12077744Abstract: The invention describes a device (10) for dispensing microbubbles (30) for cell sonoporation, comprising: a tube configured to receive a vial (20) containing a solution (26) of microbubbles (30), at least two catheters (11, 12) arranged inside the tube and opening into the vial (20) when the latter is received by the tube, wherein, when the first catheter (11) is connected to a first air injection source, air can be injected into the vial (20) via the first catheter so as to generate an overpressure therein, the microbubbles (30) contained in the vial (20) entering the second catheter (12) and moving toward its second end (122). The invention also relates to a sonoporation device, a sonoporation process and a computer program product.Type: GrantFiled: September 18, 2019Date of Patent: September 3, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'ORLEANSInventors: Anthony Delalande, Matthias Lebertre, Michaël Delalande, Chantal Pichon
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Patent number: 12064470Abstract: The present invention relates to the activation of FGF10 signaling pathway for use in the treatment of a heart disease.Type: GrantFiled: November 16, 2018Date of Patent: August 20, 2024Assignees: UNIVERSITE D'AIX-MARSEILLE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventor: Francesca Nadège Joëlle Rochais
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Patent number: 12065124Abstract: Disclosed is a method for controlling a hybrid vehicle power train, including a thermal drive chain and an electric drive chain, the electric drive chain including a traction battery, a voltage modulator, an inverter, first and second electrical machines. The voltage modulator is designed to modulate a supply voltage of an electric current from the traction battery to the first and second electrical machines. The method includes: a step of analytically calculating an optimal supply voltage using a mathematical expression that corresponds to the resolution of an equation expressed as ? P b ? a ? t ? U e = 0 , where Ue is the supply voltage, Pbat is the electrical power supplied by the traction battery, and where the electrical power supplied by the traction battery is expressed as a quadratic function of the supply voltage; and a step of controlling the voltage modulator in such a way that it outputs the optimal supply voltage.Type: GrantFiled: July 9, 2019Date of Patent: August 20, 2024Assignees: RENAULT S.A.S., UNIVERSITE D'ORLEANSInventors: Guillaume Colin, Souad Hadj-Said, Ahmed Ketfi-Cherif
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Patent number: 12055471Abstract: The present description relates according to a first aspect to a method for measurement of optical properties of at least one particle in a sample (10) and permits, for example, quantitative determination of the complex dipolar polarizability of at least one particle present in a sample. The optical characterization method comprises the illumination of said sample (10) using a light beam, the sample (10) being positioned in the object space of an optical system (120); the acquisition of at least one phase image and at least one intensity image of said at least one particle illuminated by the light beam, the acquisition being carried out in an analysis plane arranged in the image space of the optical system (120); and the determination of at least one optical property of said at least one particle from said at least one phase image and at least one intensity image.Type: GrantFiled: August 26, 2020Date of Patent: August 6, 2024Assignees: Centre national de la recherche scientifique, Université d'Aix-Marseille, CENTRALE MARSEILLEInventors: Samira Khadir, Guillaume Baffou, Serge Monneret
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Patent number: 12049500Abstract: The present invention relates to antibodies having specificity to Nectin-4 and uses thereof.Type: GrantFiled: March 31, 2022Date of Patent: July 30, 2024Assignees: EMERGENCE THERAPEUTICS GmbH, UNIVERSITE D'AIX-MARSEILLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), INSTITUT JEAN PAOLI & IRENE CALMETTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS-Inventors: Jack Elands, Florence L'Hospice, Xavier Préville, Daniel Olive, Marc Lopez
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Publication number: 20240241274Abstract: A method for manufacturing a detector of a first and a second incident ionizing radiation including determining the abscissa em of a point of intersection between a first and a second curve, with the first and second curves representing the evolution of the number of photons or electrical charges generated per second by a transducing material as a function of the total thickness of an amplifying material when the transducing material is irradiated, through this thickness of transducing material, by the first and second incident ionizing radiation, respectively; then selecting the total thickness of amplifying material between 0.9 em and 1.1 em and producing the detector with the selected thickness of amplifying material.Type: ApplicationFiled: January 24, 2022Publication date: July 18, 2024Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX MARSEILLE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INSTITUT JEAN PAOLI & IRENE CALMETTES CENTRE REGIONAL DE LUTTE CONTRE LE CANCERInventors: Julien DARREON, Sree Bash Chandra DEBNATH, Didier TONNEAU, Carole FAUQUET, Agnès TALLET
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Patent number: 12037976Abstract: A wind farm/park having a plurality of spatially distributed wind turbines, including at least one upstream wind turbine and at least one downstream wind turbine. Each wind turbine includes a rotor with at least two blades. At least one downstream wind turbine is affected under certain wind conditions by a wake region generated by the upstream wind turbine and containing helical vortex structures formed at the tip of the blades of the upstream wind turbine. A geometry or configuration of one or more of the rotor blades of the upstream wind turbine is different from a geometry or configuration of the other blade(s) of the upstream wind turbine thereby creating a fixed asymmetry in the blade configuration so as to accelerate destruction of vortices in the wake of the rotor of the upstream wind turbine by exciting a natural instability of the blade tip vortices.Type: GrantFiled: October 8, 2021Date of Patent: July 16, 2024Assignees: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRALE MARSEILLE, DANMARKS TEKNISKE UNIVERSITET (DTU)Inventors: Thomas Leweke, Jens Sorensen