Abstract: A system for characterizing a pulse of electromagnetic radiation by time-resolved optical gating, which includes an interference-forming device which is adapted for superimposing four parts of the pulse. The system also includes a matrix image sensor which selectively captures, based on two-photon absorptions, an interference pattern formed by the pulse. The system allows obtaining the pulse shape completely and accurately, and is particularly suitable for characterizing ultrashort pulses. Also, the two-photon absorption can be produced in the matrix image sensor, or replaced by optical frequency doubling which is produced by an SHG crystal plate.

Abstract: A steel having high mechanical properties, characterized in that it has the following composition by weight: 12% to 25 % Nickel; 7.4% to 20 % Cobalt; 3% to 11% Molybdenum; 0.2% to 2.21% addition elements, the remainder being iron, the structure of the material including a combination of fine grains and ultrafine grains, the so-called fine grains having a grain size of between 1.2 micrometers and 3 micrometers and the so-called ultrafine grains having a grain size of between 0.2 and 1 micrometer, the proportion of ultrafine grains being between 55 % and 65 %, and a process for manufacturing the steel.

Abstract: The present invention relates to the use of 2-phenylbutyric acid, or 3-phenylbutyric acid, or 4-phenylbutyric acid, or one of their salts, or one of their combinations, to combat cryptogamic diseases caused by fungi and oomycetes. The present invention also relates to the use of these compounds and these combinations as fungicidal or fungistatic agents for the prevention or the curative treatment of cryptogamic diseases.

Abstract: A compound of formula I: wherein A is present or absent; X1, X2, X3 and X4 are, independently from each other, an alkyl; Y1, Y2, Y3 and Y4 are independently from each other a C1-C10 alkyl, -Z1, Z2, Z3 and Z4 are independently from each other a C1-C5 linear alkyl; R1 is a group allowing to carry out bioorthogonal reactions; and R2 is group including a N.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of diseases mediated by the NRP-1/OBR complex signaling pathway. In particular, the present invention relates to a method for treating a disease selected from the group consisting of cancers, obesity and obesity related diseases, anorexia, autoimmune diseases and infectious diseases in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of the NRP-1/OBR signaling pathway.

Abstract: Disclosed is a family of corroles for their use in the treatment of an infection by poxvirus.

Abstract: A method for frequency-converting a source optical signal in order to produce a useful optical signal, by mixing a plurality of waves, implements a plurality of waveguides that are coupled together. Individual parameter values of the waveguides, as well as at least one coupling parameter, are selected so as to obtain the useful signal with a high intensity. Such a method for producing the useful signal is suitable for a spectroscopic application, in particular a molecular spectroscopy application.

Abstract: The invention relates to a method for acquiring an image by an imager (20) comprising a matrix of pixels configured to generate an electric response when exposed to an incident light flux travelling through an optical path (21) in which is arranged a wavefront correction element (22), comprising the following steps: 1) initiating the exposure of the pixels to the incident light flux; 2) for a plurality of iterations during the exposure: 2.1) non-destructive reading of the electric responses of pixels of a region of interest; 2.2) determining an evolution of the spatial distribution of pixels in logarithmic mode previous iteration with respect to the previous iteration; 2.3) based on said evolution, establishing a command for the wavefront correction element (22) in order to correct the wavefront; 2.4) configuring the wavefront correction element, 3) reading the electric responses of the pixels resulting in an image.

Abstract: Disclosed is a family of corroles for its use in the treatment of an infection by human herpesvirus, especially in the treatment of an infection by human cytomegalovirus.

Abstract: The present invention relates to a novel process for biological detection of mycobacteria via electrochemical analysis methods of the catalytic activity of antigen 85.

Abstract: A method for frequency-converting a source optical signal in order to produce a useful optical signal, by mixing a plurality of waves, implements a plurality of waveguides that are coupled together. Individual parameter values of the waveguides, as well as at least one coupling parameter, are selected so as to obtain the useful signal with a high intensity. Such a method for producing the useful signal is suitable for a spectroscopic application, in particular a molecular spectroscopy application.

Abstract: A modular tetrazine platform, can be used as diagnostic, theragnostic agent and/or medicinal product. An inverse electron demand Diels-Alder reaction can be used for synthesizing bifunctionalized tetrazines, which can be obtained from monofunctionalised tetrazines.

Abstract: Compounds of the general structure (I), which includes: a radioactive entity, which is a beta-energy emitter that produces Cherenkov radiation, a fluorophore that absorbs electromagnetic radiation of a wavelength ? ranging from 300 nm to 500 nm; a fluorophore which emits electromagnetic radiation of a wavelength ? ranging from 650 nm to 950 nm and/or is a photosensitizer which produces reactive oxygen species ROSs; and a vector entity, which may be present or absent. Also, the use of these compounds for an application for near-infrared Cherenkov luminescence imaging and/or for the treatment of deep biological tissues by Cherenkov dynamic phototherapy.

Abstract: A composition including an extract of Moricandia for the use thereof in the prevention and/or treatment of metabolic diseases related to impaired glucose tolerance and/or insulin resistance. Also a composition including an extract of Moricandia for the use thereof in the prevention of weight gain, in particular of body fat.

Abstract: High dynamic range (HDR) images are generated on the basis of a plurality of images obtained by non-destructive reading of an image sensor, called NDRO images. An HDR image generation method includes: the determination of a criterion of desired quality for the HDR image; at least two non-destructive readings of the sensor delivering at least two successive NDRO images; the selection, as a function of the criterion of desired quality, of the first and of the last NDRO image to be used to generate the HDR image; the generation of the HDR image on the basis of information extracted from a series of successive NDRO images starting with the first and terminating with the last NDRO image to be used; the storage of a single image at one and the same time throughout the entire HDR generation phase.

Abstract: In the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds, a process for the synthesis of compound of formula (I). This process is especially useful to obtain chiral bulky phosphorus compounds. The present invention also relates to compounds of formula (VII), (VIII), (IX) and (X) and their processes of manufacturing starting from a compound of formula (I).

Abstract: The present invention relates to a process for the synthesis of 3,6 functionalized 1,2,4,5-tetrazine compounds.

Abstract: An electrochemical method is provided for in-vitro determination of the presence of bacteria producing lactamases, in a sample that may contain such bacteria.

Abstract: The present invention relates to agents capable of inhibiting the binding between Leptin and Neuropilin-1 (NRP1) and uses thereof in the therapeutic field.

Abstract: An acoustic analysis device based on atomic force microscopy for the volume analysis of an organic or inorganic sample includes a support on which the sample is immobilized, and an atomic force microscopy lever having a free end provided with a part that interacts with an upper face of the sample and scans said upper face, one or at least two of the independent piezoelectric actuators supplying ultrasonic waves with interferential coupling, and acoustic measurement and analysis bodies associated with the atomic force microscopy lever. The support is a total reflection prism to which the piezoelectric actuators are applied, and the piezoelectric actuators are applied in determined positions on said prism in order to define determined angles of excitation of the ultrasonic waves.