Patents Assigned to Universite de Caen
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Publication number: 20230322804Abstract: The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.Type: ApplicationFiled: June 2, 2023Publication date: October 12, 2023Applicants: BIOMÉRIEUX, UNIVERSITÉ DE CAEN NORMANDIEInventors: Sylvain URSUEGUI, Alain LAURENT, Ali LAAYOUN, Frédéric FABIS
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Patent number: 11756194Abstract: Computer-implemented process on an image of a biological sample The present invention relates to a computer-implemented process to automatically analyze a digital image (103) of abiological sample (101). The process involves a change (203) from a first color space to a second color space. Then, fits are performed taking into account several dimensions of the second color space to classify pixels.Type: GrantFiled: June 27, 2019Date of Patent: September 12, 2023Assignees: Vilniaus Universitetas;, Universite De Caen Normandie, Institut National De La Sante Et De La Recherche Medicale, Centre Regional Francois BaclesseInventors: Laurent Poulain, Arvydas Laurinavicius, Benoît Plancoulaine, Nicolas Elie
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Patent number: 11739105Abstract: The present invention relates to a compound of formula (I) below: in which: R1 represents, in particular, an alkylene group comprising from 1 to 6 carbon atoms; R2 and R3 are, in particular, H; n is 0, 1, 2 or 3; and R4 is chosen from the group consisting of: NO2, ORa, SRa and NRaRb, wherein Ra and Rb are as defined above; R5 and R6, identical or different, represent an alkyl or alkoxy group comprising from 1 to 6 carbon atoms; and R7, R8 and R9, identical or different, represent an alkyl group comprising from 2 to 6 carbon atoms.Type: GrantFiled: November 16, 2018Date of Patent: August 29, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIEInventors: Mohamad El Roz, Sami Lakhdar, Igor Telegeiev
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Patent number: 11713280Abstract: A field of thermal treatment of ceramic materials is provided, and relates to a method for thermal treatment of a solid ceramic part in a microwave cavity, the direction of the electrical field E being substantially uniform in an empty cavity, comprising the steps that consist of placing, in the cavity, at least one ceramic part surrounded by at least one first susceptor with dimensions, material and arrangement configured to emit infrared radiation, each first susceptor including at least one first main surface, each first main surface being an adjusted surface in which the cone distances are parallel to the electrical field E, and of emitting the microwaves into the cavity.Type: GrantFiled: October 20, 2017Date of Patent: August 1, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIE, ECOLE NATIONALE SUPERIEURE D'INGENIEURS CAEN, UNIVERSITE POLYTECHNIQUE HAUTS-DE-FRANCE, ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DE METHODES ET PROCESSUS INDUSTRIELS-ARMINESInventors: Sylvain Marinel, Etienne Savary, François-Xavier Lefevre, Jérôme Lecourt, Sébastien Saunier, Pauline Chanin-Lambert
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Patent number: 11708375Abstract: The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.Type: GrantFiled: July 13, 2017Date of Patent: July 25, 2023Assignees: BIOMÉRIEUX, UNIVERSITÉ DE CAEN NORMANDIEInventors: Sylvain Ursuegui, Alain Laurent, Ali Laayoun, Frédéric Fabis
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Publication number: 20230116369Abstract: The present application relates to novel mixed compounds based on oxides and sulfides, and the use thereof as a solid electrolyte, with improved sulfide stability. The application further relates to electrochemical elements and lithium batteries containing such electrolytes.Type: ApplicationFiled: March 23, 2021Publication date: April 13, 2023Applicants: SAFT, Centre national de la recherche scientifique, ECOLE NATIONALE SUPERIEURE D INGENIEURS DE CAEN, UNIVERSITE DE CAEN NORMANDIEInventors: Vincent PELE, Nadège ROUMEGOUS, Christian JORDY, Valérie PRALONG
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Patent number: 11606857Abstract: The method for determining a quality factor of an accelerating superconducting cavity of a particle accelerator, in particular a linear particle accelerator, the method includes determining a heat load to which a cryomodule having the accelerating cavity and a bath of cryogenic fluid is subjected, then determining a quality factor based on the determination of the heat load during the operation of the particle accelerator.Type: GrantFiled: October 24, 2019Date of Patent: March 14, 2023Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIEInventors: Adrien Vassal, Patrick Bonnay, François Bonne, Adnan Ghribi
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Patent number: 11474099Abstract: The invention relates to a novel method for diagnosing the sulfur nutrition state of a plant by measuring the content of certain mineral nutrients in the leaves.Type: GrantFiled: February 3, 2017Date of Patent: October 18, 2022Assignees: AGRO INNOVATION INTERNATIONAL, UNIVERSITE DE CAEN BASSE NORMANDIEInventors: Elise Sorin, Mustapha Arkoun, Florence Cruz, Jean-Claude Yvin, Anne Maillard, Sylvain Diquelou, Philippe Etienne, Alain Ourry
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Patent number: 11446626Abstract: The present invention relates to a method for the preparation of a colloidal aqueous suspension of stable zeolite nanocrystals having framework structures comprising at least one cation selected from Gd, Fe, Cu and Ce, said structures being loaded with a gas selected from O2, CO2 and mixtures thereof, to the colloidal aqueous suspension of zeolite nanocrystals obtained by such a process, and to the use of said suspension in therapy, more particularly in cancer therapy and hypoxia-related diseases and/or in diagnosis.Type: GrantFiled: August 7, 2018Date of Patent: September 20, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIEInventors: Samuel Valable, Svetlana Mintova Lazarova, Clément Anfray, Valentin Valtchev, Omar Touzani, Myriam Bernaudin
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Polypeptides derived from and their use for vaccination and the generation of therapeutic antibodies
Patent number: 11278609Abstract: Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.Type: GrantFiled: February 25, 2015Date of Patent: March 22, 2022Assignees: KLINIKUM DER UNIVERSITÄT MÜNCHEN, UNIVERSITE DE CAEN BASSE-NORMANDIEInventors: Johannes Hübner, Axel Hartke, Luis Felipe Romero Saavedra -
Publication number: 20210408756Abstract: An active laser medium for emitting a light beam by laser effect includes an X—F2-doped crystal, wherein X is a chemical element from the alkaline-earth family and F is fluorine. The crystal is doped with trivalent ions including: a first category of optically active dopant ions, in which each dopant ion is an ion of a first rare earth; and a second category of optically inactive dopant ions, referred to as buffer ions, in which each dopant ion is an ion of a rare earth different from the first rare earth. The second category of dopant ions has at least ions of a second rare earth and ions of a third rare earth, different from one another. The invention provides an active laser medium that can be used to obtain both a desired emission spectrum shape and a high thermal conductivity.Type: ApplicationFiled: October 30, 2019Publication date: December 30, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE DE CAEN NORMANDIE, ENSICAEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Patrice CAMY, Alain BRAUD, Jean-Louis DOUALAN, Abdel BENAYAD, Jean-Paul GOOSSENS
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Publication number: 20210337789Abstract: The invention concerns derivatives of m-guaiacol, their preparation and their uses as biocides, in particular as antibacterials or disinfectants.Type: ApplicationFiled: July 2, 2019Publication date: November 4, 2021Applicants: Universite de Caen Normandie, LABEOInventors: Sylvain Rault, Christophe Rochais, Stéphane Lemaitre, Feng Xiao, Peggy Suzanne, Patrick Dallemagne, Sophie Castagnet, Albertine Leon-Seck
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Publication number: 20210269883Abstract: The present disclosure relates to the identification of a biomarker, consisting in a circulating miRNA, suitable for use in the diagnosis and prognosis of high-grade serous ovarian carcinoma (HGSOC), and to diagnostic kits for use in such diagnosis.Type: ApplicationFiled: July 4, 2019Publication date: September 2, 2021Applicants: UNIVERSITE DE CAEN NORMANDIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE REGIONAL FRANCOIS BACLESSE, UNIVERSITE GRENOBLE ALPESInventors: Nicolas VIGNERON, Christophe DENOYELLE, Laurent POULAIN, Jean-Paul ISSARTEL, Bernard LAMBERT, Matthieu MERYET-FIGUIERE, Mégane VERNON, Audrey GUTTIN
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Patent number: 11065230Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of systemic mastocytosis. The inventors showed the effect of KPT-251 treatment on SCF-dependent human Mast cell (MC) line without KIT mutation (WT ROSA) and on two factor-independent MC lines with KIT mutations : ROSA ? 417-419 insY and ROSA D816V. KPT is a Selective Inhibitor of Nuclear Export (SINE) that specifically inhibits the activity of the exportin-1 (XPO1). KPT-251 treatment induces minimal toxicity in non-cancerous hematopoietic cells both in vitro and in vivo. In particular, the present invention relates a method of treating systemic mastocytosis in patient in need thereof comprising administering to the patient a therapeutically effective amount of a XPO1 inhibitor.Type: GrantFiled: September 15, 2017Date of Patent: July 20, 2021Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), FONDATION IMAGINE, UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE CAEN NORMANDIE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE CAENInventors: Olivier Hermine, Flavia Guillem, Gandhi Damaj, Sophia Ladraa
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Publication number: 20210121432Abstract: Bambuterol for the Treatment of Alzheimer's Disease Bambuterol or the pharmaceutically acceptable salt thereof is used in an effective amount to treat Alzheimer's disease. The compound is administered intranasal, or through oral or intravenous routes and under an appropriate formulation for getting around the blood brain barrier, wherein it may do one more of preventing, slowing the progression of, or reversing Alzheimer's disease.Type: ApplicationFiled: April 16, 2019Publication date: April 29, 2021Applicant: Université de Caen NormandieInventors: Christophe ROCHAIS, Patrick DALLEMAGNE, Anne-Claire GROO, Aurélie MALZERT-FRÉON
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Patent number: 10828215Abstract: Disclosed is a handling system that makes it possible to place a wheeled sleeping unit, particularly a hospital bed, in a high position for a maintenance operation. The system includes a supporting device that is slidably mounted along a guide assembly and is provided with a receiving assembly that is hinged onto one or more vertical slidable portions of the device that are adjacent to a raising area. A sleeping unit can be placed in the area, above a lifting portion defined by the receiving assembly, and a longitudinal side of the unit can be positioned against an abutment surface of the assembly. The receiving assembly includes a holding element that fits into the top of the unit so as to lock the positioning of the unit in the receiving assembly, which makes it possible to change the orientation of the unit after a raising phase.Type: GrantFiled: October 19, 2016Date of Patent: November 10, 2020Assignees: UNIVERSITE DE CAEN, CENTRE HOSPITALIER PUBLIC DU COTENTINInventors: Yannick Guhel, Jean-Pierre Guillerm, Mickaël Besnard
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Patent number: 10647584Abstract: Some embodiments are directed to a method for the preparation of defect-free nanosized synthetic zeolite materials, to the defect-free nanosized synthetic zeolite materials, to stable colloidal suspensions of the defect-free synthetic zeolite materials, and to the use of the defect-free nanosized synthetic zeolite materials and the stable colloidal suspensions in various applications.Type: GrantFiled: October 22, 2015Date of Patent: May 12, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NATIONALE SUPÉRIEURE D'INGÉNIEURS DE CAEN, UNIVERSITÉ DE CAEN / UNIVERSITÉ DE BASSE-NORMANDIEInventors: Svetlana Mintova Lazarova, Siddulu Naidu Talapaneni, Julien Grand, Jean-Pierre Gilson
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Publication number: 20200137869Abstract: The method for determining a quality factor of an accelerating superconducting cavity of a particle accelerator, in particular a linear particle accelerator, the method includes determining a heat load to which a cryomodule having the accelerating cavity and a bath of cryogenic fluid is subjected, then determining a quality factor based on the determination of the heat load during the operation of the particle accelerator.Type: ApplicationFiled: October 24, 2019Publication date: April 30, 2020Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIEInventors: Adrien Vassal, Patrick Bonnay, François Bonne, Adnan Ghribi
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Publication number: 20190375763Abstract: The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.Type: ApplicationFiled: July 13, 2017Publication date: December 12, 2019Applicants: BIOMÉRIEUX, UNIVERSITÉ DE CAEN NORMANDIEInventors: Sylvain URSUEGUI, Alain LAURENT, Ali LAAYOUN, Frédéric FABIS
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Publication number: 20190339259Abstract: The invention relates to a novel method for diagnosing the sulfur nutrition state of a plant by measuring the content of certain mineral nutrients in the leaves.Type: ApplicationFiled: February 3, 2017Publication date: November 7, 2019Applicants: Agro Innovation International, Universite de Caen Basse NormandieInventors: Elise SORIN, Mustapha ARKOUN, Florence CRUZ, Jean-Claude YVIN, Anne MAILLARD, Sylvain DIQUELOU, Philippe ETIENNE, Alain OURRY