Patents Assigned to Universite de Caen
  • Publication number: 20230322804
    Abstract: The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.
    Type: Application
    Filed: June 2, 2023
    Publication date: October 12, 2023
    Applicants: BIOMÉRIEUX, UNIVERSITÉ DE CAEN NORMANDIE
    Inventors: Sylvain URSUEGUI, Alain LAURENT, Ali LAAYOUN, Frédéric FABIS
  • Patent number: 11756194
    Abstract: Computer-implemented process on an image of a biological sample The present invention relates to a computer-implemented process to automatically analyze a digital image (103) of abiological sample (101). The process involves a change (203) from a first color space to a second color space. Then, fits are performed taking into account several dimensions of the second color space to classify pixels.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: September 12, 2023
    Assignees: Vilniaus Universitetas;, Universite De Caen Normandie, Institut National De La Sante Et De La Recherche Medicale, Centre Regional Francois Baclesse
    Inventors: Laurent Poulain, Arvydas Laurinavicius, Benoît Plancoulaine, Nicolas Elie
  • Patent number: 11739105
    Abstract: The present invention relates to a compound of formula (I) below: in which: R1 represents, in particular, an alkylene group comprising from 1 to 6 carbon atoms; R2 and R3 are, in particular, H; n is 0, 1, 2 or 3; and R4 is chosen from the group consisting of: NO2, ORa, SRa and NRaRb, wherein Ra and Rb are as defined above; R5 and R6, identical or different, represent an alkyl or alkoxy group comprising from 1 to 6 carbon atoms; and R7, R8 and R9, identical or different, represent an alkyl group comprising from 2 to 6 carbon atoms.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: August 29, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIE
    Inventors: Mohamad El Roz, Sami Lakhdar, Igor Telegeiev
  • Patent number: 11713280
    Abstract: A field of thermal treatment of ceramic materials is provided, and relates to a method for thermal treatment of a solid ceramic part in a microwave cavity, the direction of the electrical field E being substantially uniform in an empty cavity, comprising the steps that consist of placing, in the cavity, at least one ceramic part surrounded by at least one first susceptor with dimensions, material and arrangement configured to emit infrared radiation, each first susceptor including at least one first main surface, each first main surface being an adjusted surface in which the cone distances are parallel to the electrical field E, and of emitting the microwaves into the cavity.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: August 1, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIE, ECOLE NATIONALE SUPERIEURE D'INGENIEURS CAEN, UNIVERSITE POLYTECHNIQUE HAUTS-DE-FRANCE, ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DE METHODES ET PROCESSUS INDUSTRIELS-ARMINES
    Inventors: Sylvain Marinel, Etienne Savary, François-Xavier Lefevre, Jérôme Lecourt, Sébastien Saunier, Pauline Chanin-Lambert
  • Patent number: 11708375
    Abstract: The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: July 25, 2023
    Assignees: BIOMÉRIEUX, UNIVERSITÉ DE CAEN NORMANDIE
    Inventors: Sylvain Ursuegui, Alain Laurent, Ali Laayoun, Frédéric Fabis
  • Publication number: 20230116369
    Abstract: The present application relates to novel mixed compounds based on oxides and sulfides, and the use thereof as a solid electrolyte, with improved sulfide stability. The application further relates to electrochemical elements and lithium batteries containing such electrolytes.
    Type: Application
    Filed: March 23, 2021
    Publication date: April 13, 2023
    Applicants: SAFT, Centre national de la recherche scientifique, ECOLE NATIONALE SUPERIEURE D INGENIEURS DE CAEN, UNIVERSITE DE CAEN NORMANDIE
    Inventors: Vincent PELE, Nadège ROUMEGOUS, Christian JORDY, Valérie PRALONG
  • Patent number: 11606857
    Abstract: The method for determining a quality factor of an accelerating superconducting cavity of a particle accelerator, in particular a linear particle accelerator, the method includes determining a heat load to which a cryomodule having the accelerating cavity and a bath of cryogenic fluid is subjected, then determining a quality factor based on the determination of the heat load during the operation of the particle accelerator.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: March 14, 2023
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIE
    Inventors: Adrien Vassal, Patrick Bonnay, François Bonne, Adnan Ghribi
  • Patent number: 11474099
    Abstract: The invention relates to a novel method for diagnosing the sulfur nutrition state of a plant by measuring the content of certain mineral nutrients in the leaves.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: October 18, 2022
    Assignees: AGRO INNOVATION INTERNATIONAL, UNIVERSITE DE CAEN BASSE NORMANDIE
    Inventors: Elise Sorin, Mustapha Arkoun, Florence Cruz, Jean-Claude Yvin, Anne Maillard, Sylvain Diquelou, Philippe Etienne, Alain Ourry
  • Patent number: 11446626
    Abstract: The present invention relates to a method for the preparation of a colloidal aqueous suspension of stable zeolite nanocrystals having framework structures comprising at least one cation selected from Gd, Fe, Cu and Ce, said structures being loaded with a gas selected from O2, CO2 and mixtures thereof, to the colloidal aqueous suspension of zeolite nanocrystals obtained by such a process, and to the use of said suspension in therapy, more particularly in cancer therapy and hypoxia-related diseases and/or in diagnosis.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: September 20, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIE
    Inventors: Samuel Valable, Svetlana Mintova Lazarova, Clément Anfray, Valentin Valtchev, Omar Touzani, Myriam Bernaudin
  • Patent number: 11278609
    Abstract: Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: March 22, 2022
    Assignees: KLINIKUM DER UNIVERSITÄT MÜNCHEN, UNIVERSITE DE CAEN BASSE-NORMANDIE
    Inventors: Johannes Hübner, Axel Hartke, Luis Felipe Romero Saavedra
  • Publication number: 20210408756
    Abstract: An active laser medium for emitting a light beam by laser effect includes an X—F2-doped crystal, wherein X is a chemical element from the alkaline-earth family and F is fluorine. The crystal is doped with trivalent ions including: a first category of optically active dopant ions, in which each dopant ion is an ion of a first rare earth; and a second category of optically inactive dopant ions, referred to as buffer ions, in which each dopant ion is an ion of a rare earth different from the first rare earth. The second category of dopant ions has at least ions of a second rare earth and ions of a third rare earth, different from one another. The invention provides an active laser medium that can be used to obtain both a desired emission spectrum shape and a high thermal conductivity.
    Type: Application
    Filed: October 30, 2019
    Publication date: December 30, 2021
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE DE CAEN NORMANDIE, ENSICAEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Patrice CAMY, Alain BRAUD, Jean-Louis DOUALAN, Abdel BENAYAD, Jean-Paul GOOSSENS
  • Publication number: 20210337789
    Abstract: The invention concerns derivatives of m-guaiacol, their preparation and their uses as biocides, in particular as antibacterials or disinfectants.
    Type: Application
    Filed: July 2, 2019
    Publication date: November 4, 2021
    Applicants: Universite de Caen Normandie, LABEO
    Inventors: Sylvain Rault, Christophe Rochais, Stéphane Lemaitre, Feng Xiao, Peggy Suzanne, Patrick Dallemagne, Sophie Castagnet, Albertine Leon-Seck
  • Publication number: 20210269883
    Abstract: The present disclosure relates to the identification of a biomarker, consisting in a circulating miRNA, suitable for use in the diagnosis and prognosis of high-grade serous ovarian carcinoma (HGSOC), and to diagnostic kits for use in such diagnosis.
    Type: Application
    Filed: July 4, 2019
    Publication date: September 2, 2021
    Applicants: UNIVERSITE DE CAEN NORMANDIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE REGIONAL FRANCOIS BACLESSE, UNIVERSITE GRENOBLE ALPES
    Inventors: Nicolas VIGNERON, Christophe DENOYELLE, Laurent POULAIN, Jean-Paul ISSARTEL, Bernard LAMBERT, Matthieu MERYET-FIGUIERE, Mégane VERNON, Audrey GUTTIN
  • Patent number: 11065230
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of systemic mastocytosis. The inventors showed the effect of KPT-251 treatment on SCF-dependent human Mast cell (MC) line without KIT mutation (WT ROSA) and on two factor-independent MC lines with KIT mutations : ROSA ? 417-419 insY and ROSA D816V. KPT is a Selective Inhibitor of Nuclear Export (SINE) that specifically inhibits the activity of the exportin-1 (XPO1). KPT-251 treatment induces minimal toxicity in non-cancerous hematopoietic cells both in vitro and in vivo. In particular, the present invention relates a method of treating systemic mastocytosis in patient in need thereof comprising administering to the patient a therapeutically effective amount of a XPO1 inhibitor.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: July 20, 2021
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), FONDATION IMAGINE, UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE CAEN NORMANDIE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE CAEN
    Inventors: Olivier Hermine, Flavia Guillem, Gandhi Damaj, Sophia Ladraa
  • Publication number: 20210121432
    Abstract: Bambuterol for the Treatment of Alzheimer's Disease Bambuterol or the pharmaceutically acceptable salt thereof is used in an effective amount to treat Alzheimer's disease. The compound is administered intranasal, or through oral or intravenous routes and under an appropriate formulation for getting around the blood brain barrier, wherein it may do one more of preventing, slowing the progression of, or reversing Alzheimer's disease.
    Type: Application
    Filed: April 16, 2019
    Publication date: April 29, 2021
    Applicant: Université de Caen Normandie
    Inventors: Christophe ROCHAIS, Patrick DALLEMAGNE, Anne-Claire GROO, Aurélie MALZERT-FRÉON
  • Patent number: 10828215
    Abstract: Disclosed is a handling system that makes it possible to place a wheeled sleeping unit, particularly a hospital bed, in a high position for a maintenance operation. The system includes a supporting device that is slidably mounted along a guide assembly and is provided with a receiving assembly that is hinged onto one or more vertical slidable portions of the device that are adjacent to a raising area. A sleeping unit can be placed in the area, above a lifting portion defined by the receiving assembly, and a longitudinal side of the unit can be positioned against an abutment surface of the assembly. The receiving assembly includes a holding element that fits into the top of the unit so as to lock the positioning of the unit in the receiving assembly, which makes it possible to change the orientation of the unit after a raising phase.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: November 10, 2020
    Assignees: UNIVERSITE DE CAEN, CENTRE HOSPITALIER PUBLIC DU COTENTIN
    Inventors: Yannick Guhel, Jean-Pierre Guillerm, Mickaël Besnard
  • Patent number: 10647584
    Abstract: Some embodiments are directed to a method for the preparation of defect-free nanosized synthetic zeolite materials, to the defect-free nanosized synthetic zeolite materials, to stable colloidal suspensions of the defect-free synthetic zeolite materials, and to the use of the defect-free nanosized synthetic zeolite materials and the stable colloidal suspensions in various applications.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: May 12, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NATIONALE SUPÉRIEURE D'INGÉNIEURS DE CAEN, UNIVERSITÉ DE CAEN / UNIVERSITÉ DE BASSE-NORMANDIE
    Inventors: Svetlana Mintova Lazarova, Siddulu Naidu Talapaneni, Julien Grand, Jean-Pierre Gilson
  • Publication number: 20200137869
    Abstract: The method for determining a quality factor of an accelerating superconducting cavity of a particle accelerator, in particular a linear particle accelerator, the method includes determining a heat load to which a cryomodule having the accelerating cavity and a bath of cryogenic fluid is subjected, then determining a quality factor based on the determination of the heat load during the operation of the particle accelerator.
    Type: Application
    Filed: October 24, 2019
    Publication date: April 30, 2020
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CAEN NORMANDIE
    Inventors: Adrien Vassal, Patrick Bonnay, François Bonne, Adnan Ghribi
  • Publication number: 20190375763
    Abstract: The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.
    Type: Application
    Filed: July 13, 2017
    Publication date: December 12, 2019
    Applicants: BIOMÉRIEUX, UNIVERSITÉ DE CAEN NORMANDIE
    Inventors: Sylvain URSUEGUI, Alain LAURENT, Ali LAAYOUN, Frédéric FABIS
  • Publication number: 20190339259
    Abstract: The invention relates to a novel method for diagnosing the sulfur nutrition state of a plant by measuring the content of certain mineral nutrients in the leaves.
    Type: Application
    Filed: February 3, 2017
    Publication date: November 7, 2019
    Applicants: Agro Innovation International, Universite de Caen Basse Normandie
    Inventors: Elise SORIN, Mustapha ARKOUN, Florence CRUZ, Jean-Claude YVIN, Anne MAILLARD, Sylvain DIQUELOU, Philippe ETIENNE, Alain OURRY