Patents Assigned to Universite de Droit de la La Sante de Lille 2
  • ENPP1 (PC-1) GENE HAPLOTYPE ASSOCIATED WITH THE RISK OF OBESITY AND TYPE 2 DIABETES AND THEIR APPLICATIONS
    Publication number: 20120009592
    Abstract: The present invention is directed to a method for determining if a subject is at increased risk to develop obesity or pathology related to obesity by determining the presence of a haplotype comprising three specific SNPs in a DNA or RNA sample of this subject and/or an elevated serum ENPP1 protein concentration. The present invention also relates to a kit and to an isolated nucleic sequence, vector or recombinant cell comprises said ENPP1 gene haplotype. The invention further comprises a method for selecting a compound for the treatment or the prevention of obesity or pathology related to obesity and a method for determining the efficacy of a drug to reduce the risk of obesity or pathology related to obesity in a patient.
    Type: Application
    Filed: August 3, 2011
    Publication date: January 12, 2012
    Applicants: Universite de Droit de la La Sante de Lille 2, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Philippe Froguel, David Meyre, Christian Dina, Philippe Boutin
  • ENPP1 (PC-1) gene haplotype associated with the risk of obesity and type 2 diabetes and their applications
    Patent number: 8017324
    Abstract: The present invention is directed to a method for determining if a subject is at increased risk to develop obesity or pathology related to obesity by determining the presence of a haplotype comprising three specific SNPs in a DNA or RNA sample of this subject and/or an elevated serum ENPP1 protein concentration. The present invention also relates to a kit and to an isolated nucleic sequence, vector or recombinant cell comprises said ENPP1 gene haplotype. The invention further comprises a method for selecting a compound for the treatment or the prevention of obesity or pathology related to obesity and a method for determining the efficacy of a drug to reduce the risk of obesity or pathology related to obesity in a patient.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: September 13, 2011
    Assignees: Centre National de la Recherche Scientifique, Universite de Droit de la La Sante de Lille 2
    Inventors: Philippe Froguel, David Meyre, Christian Dina, Philippe Boutin