Patents Assigned to Universite de la Mediterranee
  • Publication number: 20090123916
    Abstract: The present invention relates to complete rpoB genes, rpoB gene fragments SEQ. ID. no 9 to 32 and fragments of hypervariable sequences of said rpoB genes SEQ. ID. no 33 to 56 and 77 to 100, and to nucleic acid fragments of non-coding hypervariable sequences flanking the rpoB gene of sequences SEQ. ID. no 121 to 144 and 165 to 188, and also to oligonucleotides of species-specific sequences taken from said fragments of hypervariable sequences and to consensus oligonucleotides between the different species of Acinetobacter bacteria of sequences SEQ. ID. no 1 to 8 for the following 24 species: A. calcoaceticus (genomic species 1), A. baumannii (genomic species 2), genomic species 3, A. haemolyticus (genomic species 4), A. junii (genomic species 5), genomic species 6, A. johnsonii (genomic species 7), A. lwoffii (genomic species 8), genomic species 9, genomic species 10, genomic species 11, A. radioresistens (genomic species 12), genomic species 13, genomic species 16, A. schindleri, A. ursingii, A. baylyi, A.
    Type: Application
    Filed: March 16, 2006
    Publication date: May 14, 2009
    Applicants: UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE ll, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIQUE (NRS)
    Inventors: Bernard La Scola, Didier Raoult
  • Publication number: 20090104595
    Abstract: A method for determining sensitivity or resistance of isolates of HIV (human immunodeficiency virus) retroviruses to chemical molecules having an inhibiting activity on a viral protease or to therapeutic treatments based on inhibitors of the viral protease, including causing cell lysis of at least one yeast by expression of the retrovirus protease.
    Type: Application
    Filed: June 2, 2005
    Publication date: April 23, 2009
    Applicants: Universite de La Mediterranee, Centre National de La Recherche Scientifique- CNRS
    Inventors: Pablo Gluschankof, Didier Raoult, Najoua Ben M'Barek, Gilles Audoly
  • Publication number: 20090105131
    Abstract: The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-?2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-?2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.
    Type: Application
    Filed: July 18, 2008
    Publication date: April 23, 2009
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LA MEDITERRANEE AIX MARSEILLE II, SCHAFER-N, UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
    Inventors: GENEVIEVE ROUGON, Pascal Torregrossa, Melitta Schachner, Claus Schafer Nielsen
  • Patent number: 7417025
    Abstract: The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-?2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-?2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: August 26, 2008
    Assignees: Centre National de la Recherche Scientifique, Universite de la Mediterranee AIX-Marseille, Schafer-N, Universitaetsklinikum Hamburg-Eppendorf
    Inventors: Geneviève Rougon, Pascal Torregrossa, Melitta Schachner, Claus Schafer Nielsen
  • Patent number: 7399902
    Abstract: The present invention relates to a transgenic mouse which has integrated a reporter gene in the locus of the Cx40 gene, wherein said reporter gene is expressed in the different components of the cardiac conduction system (CCS) including the atrio-ventricular node (AVN). His bundle, bundle branches and Purkinje fibers.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: July 15, 2008
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de la Mediterranee (Aix-Marseille II)
    Inventors: Lucile Miquerol, Daniel Gros
  • Publication number: 20080146881
    Abstract: A retractor-retainer of intestines for celioscopic surgery, includes: a guide wire having a proximal portion consisting of a handle adapted to be connected to an operating table, an elongated distal portion designed to be introduced into the abdominal cavity during a celioscopic procedure; an elongated support mandrel along which is fixed a contention net, folded in such a way as to enable it to be deployed in situ; the distal end of the support mandrel and the distal portion of the guide wire being provided with complementary fast coupling elements; and an instrument for inserting the support mandrel and the contention net into the abdominal cavity and fixing it on the guide wire, the instrument including a barrel whereof at least the distal portion is hollow and dimensioned to receive the support mandrel and the contention net connected thereto.
    Type: Application
    Filed: December 21, 2005
    Publication date: June 19, 2008
    Applicants: PROTOMED, UNIVERSITE DE LA MEDITERRANEE, ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE
    Inventors: Yves Alimi, Frederic Mouret, Joachim Ramos Clamote
  • Patent number: 7166430
    Abstract: The invention concerns the total sequence of the Tropheryma whippelii bacteria rpoB gene, characterized in that it consists of the nucleotide sequence SEQ ID no. °9, and the nucleotide sequences derived from said sequence specific of the Tropheryma whippelii bacteria and their use as probe and primer.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: January 23, 2007
    Assignee: Universite de la Mediterranee (Aix-Marseille II)
    Inventors: Didier Raoult, Michel Drancourt
  • Publication number: 20060199182
    Abstract: The invention concerns a method for detecting by molecular identification a bacterium of one of the species of genus Streptococcus and four related genera Enterococcus, Gemella, Abiotrophia and Granulicatella which consists of using as probe or primer: the rpoB gene or gene fragment of one said bacterium of sequences SEQ ID no 1 to 3, or an oligonucleotide or mixture of oligonucleotides derived from sequences SEQ ID no 8 to 35, or in particular the oligonucleotides of sequences SEQ ID no 6 and 7.
    Type: Application
    Filed: November 4, 2003
    Publication date: September 7, 2006
    Applicants: Universite De La Mediterranee (Aix-Marseille II), Centre National De La Recherche Scientifique(CNRS)
    Inventors: Michel Drancourt, Didier Raoult
  • Publication number: 20060168674
    Abstract: The present invention relates to a transgenic mouse which has integrated a reporter gene in the locus of the Cx40 gene, wherein said reporter gene is expressed in the different components of the cardiac conduction system (CCS) including the atrio-ventricular node (AVN). His bundle, bundle branches and Purkinje fibers.
    Type: Application
    Filed: April 16, 2004
    Publication date: July 27, 2006
    Applicants: UNIVERSITE DE LA MEDITERRANEE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS
    Inventors: Lucile Miquerol, Daniel Gros
  • Patent number: 7060477
    Abstract: The invention concerns proteins of fungal origin having an epoxide hydrolase activity, such as those obtained in essentially pure form by extraction from fungi cells, or by culturing in host cells transformed by a nucleotide sequence coding for said fungal proteins. The invention also concerns the uses thereof, in particular for implementing methods for preparing enantiopure epoxides and/or diols.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: June 13, 2006
    Assignees: Centre National de la Recherche Scientifique, Universite de la Mediterranee
    Inventors: Michael Arand, Alain R. Archelas, Jacques Baratti, Roland Furstoss
  • Publication number: 20060058504
    Abstract: The present invention is directed to peptides comprising the sequence ASNKL (SEQ ID No. 1), inducing attraction of the axonal growth in presence of the semaphorin (Sema3A), L1 and NP-1 proteins and their use for the manufacture of a drug for neuronal/axonal regeneration or for treating neurodegenerative diseases. The present invention also includes a method for identifying a compound able to bind the NP-1, a method for identifying a compound able to revert the repulsory effect of Sema3A on the axonal growth from a suited cell, or methods to screen for molecules capable of blocking Sema3A-induced endocytosis.
    Type: Application
    Filed: April 18, 2003
    Publication date: March 16, 2006
    Applicants: Centre National de la Recherche Scientific (CNRS), Universite De La Mediterranee (ALX-Marseille II)
    Inventors: Genevieve Rougon, Valerie Castellani