Abstract: Method for preparing a peptide assembly of n fragments and n?1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci?1-Ai- . . . -Cn?1-An??(I) in which A1, A2, A3, . . . Ai . . . , An are peptide fragments, C1, C2, C3 . . . Ci?1 . . . Cn?1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.
Type:
Grant
Filed:
February 15, 2012
Date of Patent:
September 11, 2018
Assignees:
Centre National de la Recherche Scientifique, Universite de Lille 1 Sciences et Technologies
Inventors:
Oleg Melnyk, Nathalie Ollivier, Reda Mhidia, Julien Dheur
Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.
Type:
Grant
Filed:
July 25, 2014
Date of Patent:
March 20, 2018
Assignees:
INSERM (Institut National de la Sante et de la Recherche Medicale), Universite de Droit et de la Sante de Lille 2, Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Lille, Universite de Lille 1 Sciences et Technologies, ETH Zurich, Universidad de la Republica
Inventors:
Wolf-Dietrich Hardt, Patrick Kaiser, Jean-Claude Sirard, Christophe Carnoy, Delphine Fougeron, Jose Alejandro Chabalgoity, Natalia Munoz
Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.
Type:
Grant
Filed:
October 11, 2011
Date of Patent:
June 6, 2017
Assignees:
Centre National De La Recherche Scientifique, Innobiochips, Universite De Lille 2 Droit Et Sante, Universite De Lille 1 Sciences Et Technologies
Inventors:
Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
Abstract: The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with iNKT cell agonists.
Type:
Application
Filed:
October 1, 2013
Publication date:
August 13, 2015
Applicants:
INSERM (Institut National de la Santé et de la Recherche Médicale), INSTITUT PASTEUR DE LILLE, UNIVERSITÉ DE LILLE 1 - SCIENCES ET TECHNOLOGIES, UNIVERSITÉ DU DROIT ET DE LA SANTÉ LILLE 2, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Abstract: A process for the preparation by ethylene polymerization of at least one dialkyl magnesium compound of formula R—(CH2—CH2)n—Mg—(CH2—CH2)m—R? in which R and R?, identical or different, represent aryl, benzyl, allyl or alkyl groups and in which the integers n and m, identical or different, represent average —CH2—CH2— chain formation numbers greater than 1, the process including a single stage of mixing the following components: at least one ligand or one ligand precursor, at least one rare earth salt, at least one dialkyl magnesium compound of formula R—Mg—R?, and ethylene, in a medium allowing contact between the components of the above mixture.
Type:
Application
Filed:
July 20, 2012
Publication date:
July 17, 2014
Applicant:
UNIVERSITE DE LILLE 1 SCIENCE ET TECHNOLOGIES
Inventors:
Thomas Chenal, Andre Mortreux, Marc Visseaux
Abstract: Method for preparing a peptide assembly of n fragments and n?1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci?1-Ai- . . . -Cn?1-An ??(I) in which A1, A2, A3, . . . Ai . . . An are peptide fragments, C1, C2, C3 . . . Ci?1 . . . Cn?1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.
Type:
Application
Filed:
February 15, 2012
Publication date:
December 12, 2013
Applicants:
UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Oleg Melnyk, Nathalie Ollivier, Reda Mhidia, Julien Dheur
Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.
Type:
Application
Filed:
October 11, 2011
Publication date:
August 8, 2013
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, UNIVERSITE DE LILLE 2 DROIT ET SANTE, INNOBIOCHIPS
Inventors:
Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
Abstract: The use of extract of leeches' saliva as anti-bacterial agent for the manufacture of different compositions, such as a pharmaceutical composition, a cosmetic composition or a cleaning product.
Type:
Application
Filed:
October 15, 2010
Publication date:
October 4, 2012
Applicants:
UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE