Patents Assigned to Universite de Lille 2
  • Process for preparing a pooled human platelet lysate, pooled human platelet lysate and its use for treating neurological disorders
    Patent number: 11744863
    Abstract: Process for preparing a heat-treated pooled human platelet lysate, said process comprising the steps of: a) Providing a pooled human platelet lysate (p HPL), b) Heat-treating the pooled human platelet lysate at a temperature of 50° C. to 70° C. during 20 to 40 minutes, c) Purifying the heat-treated pooled human platelet lysate of step b).
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: September 5, 2023
    Assignees: Centre Hospitalier Regional et Universitaire De Lille (CHRU), UNIVERSITE DE LILLE 2 DROIT ET SANTE, UNIVERSITE DU LITTORAL COTE D'OPALE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), TAIPEI MEDICAL UNIVERSITY
    Inventors: David Devos, Thierry Burnouf, Jean-christophe Devedjian, Ming-Li Chou, Flore Gouel
  • Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
    Patent number: 10844008
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 24, 2020
    Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)
    Inventors: Patricia Melnyk, Patrick Vermersch, Pascal Carato, Bénédicte Oxombre-Vanteghem, Héléne Zephir, Marion Donnier-Marechal
  • 1,4-bis(3-aminopropyl)piperazine derivative and its use
    Patent number: 10807958
    Abstract: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: October 20, 2020
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), UNIVERSITE DE LILLE 2 DROIT ET SANTE
    Inventors: Nicolas Sergeant, Luc Buee, Patricia Melnyk, Marion Gay, Nicolas Le Fur
  • Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same
    Patent number: 10772884
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: September 15, 2020
    Assignees: Alzprotect, Universite De Lille 2 Droit Et Sante, INSERM (Institut National De La Sante Et De La Recherche)
    Inventors: Stéphane Burlet, Cécilia Estrella, Mathieu Barrier, Patricia Melnyk, Nicolas Sergeant, Luc Buee, Philippe Verwaerde
  • Mitochondrial non-coding RNAs for predicting disease progression in heart failure and myocardial infarction patients
    Patent number: 10584383
    Abstract: The present invention relates to a method for predicting mortality of a test patient with chronic heart failure comprising based on detecting the expression level of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 1 to 8. The present invention also relates to a method for predicting cardiac remodeling after myocardial infarction in a test patient based on detecting the expression level of one or more lncRNAs selected from SEQ ID NOs 1 to 8.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: March 10, 2020
    Assignees: MEDIZINISCHE HOCHSCHULE HANNOVER, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), UNIVERSITÉ DE LILLE 2 (LILLE 2)—UNIVERSITY OF LAW AND HEALTH, CENTRE HOSPITALIER UNIVERSITAIRE LILLE (CHU), INSTITUT PASTEUR DE LILLE (IPL)
    Inventors: Thomas Thum, Regalla Kumarswamy, Florence Pinet, Christophe Bauters, Pascal De Groote
  • Light emitting system
    Patent number: 10561856
    Abstract: The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: February 18, 2020
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université de Lille 2 Droit et Santé, Centre Hospitalier Regional et Universitaire de Lille (CHRU)
    Inventors: Serge Mordon, Nacim Betrouni, Laurent Mortier
  • Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same
    Patent number: 10537569
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: January 21, 2020
    Assignees: ALZPROTECT, Universite de Lille 2 Droit et Saute, Inserm (Institut National De La Saute et de la Recherche Medicale
    Inventors: Stéphane Burlet, Cécilia Estrella, Mathieu Barrier, Patricia Melnyk, Nicolas Sergeant, Luc Buee, Philippe Verwaerde
  • Imidazol- or 1,2,4-triazol-derivatives and their use
    Patent number: 10323016
    Abstract: The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: June 18, 2019
    Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, INSTITUT PASTEUR DE LILLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Manuel Lassalle, Barbara Dubanchet
  • Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
    Patent number: 10179761
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: January 15, 2019
    Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)
    Inventors: Patricia Melnyk, Patrick Vermersch, Pascal Carato, Bénédicte Oxombre-Vanteghem, Hélène Zephir, Marion Donnier-Marechal
  • Pharmaceutical solution comprising dopamine for use in treating parkinson's disease
    Patent number: 10105326
    Abstract: The present invention is directed to pharmaceutical solution comprising at least dopamine for use in treating Parkinson's disease, wherein said pharmaceutical solution is kept under anaerobic conditions from its formulation to its administration.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: October 23, 2018
    Assignees: Centre Hospitalier Regional Et Universitaire De Lille (Chru), Universite De Lille 2 Droit Et Sante, Universite Du Littoral Cote D'Opale
    Inventors: David Devos, Caroline Moreau, Charlotte Laloux, Jean-christophe Devedjian
  • 1,4-bis(3-aminopropyl)piperazine derivative and its use
    Patent number: 10017476
    Abstract: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: July 10, 2018
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU), UNIVERSITE DE LILLE 2 DROIT ET SANTE
    Inventors: Nicolas Sergeant, Luc Buee, Patricia Melnyk, Marion Gay, Nicolas Le Fur
  • 2-oxo-3,4-dihydropyridine-5-carboxylates and their use
    Patent number: 9932309
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: April 3, 2018
    Assignees: Universite de Lille 2 Droit et Sante, Institut Pasteur de Lille, INSERM
    Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Sylvain Picon, Karen Aknin, Rajaa Boulahjar, Barbara Dubanchet
  • NOVEL 1,4-BIS(3-AMINOPROPYL)PIPERAZINE DERIVATIVE AND ITS USE
    Publication number: 20180072679
    Abstract: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.
    Type: Application
    Filed: March 16, 2016
    Publication date: March 15, 2018
    Applicants: INSERM ( Institut National de la Sante et de la Recherche Medicale), CENTER HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU), UNIVERSITE DE LILLE 2 DROIT ET SANTE
    Inventors: Nicolas SERGEANT, Luc BUEE, Patricia MELNYK, Marion GAY, Nicolas LE FUR
  • Carboline compounds usable in the treatment of neurodegenerative diseases
    Patent number: 9714245
    Abstract: The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: July 25, 2017
    Assignees: ALZPROTECT, UNIVERSITE DE LILLE 2 DROIT ET SANTE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Patricia Melnyk, Pascal Carato, Stephane Burlet, Emilie Nguyen, Philippe Verwaerde, Nicolas Sergeant, Cecilia Estrella
  • Method for functionalizing surfaces for analyte detection
    Patent number: 9671397
    Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: June 6, 2017
    Assignees: Centre National De La Recherche Scientifique, Innobiochips, Universite De Lille 2 Droit Et Sante, Universite De Lille 1 Sciences Et Technologies
    Inventors: Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
  • METHOD FOR FUNCTIONALIZING SURFACES FOR ANALYTE DETECTION
    Publication number: 20130203629
    Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 8, 2013
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, UNIVERSITE DE LILLE 2 DROIT ET SANTE, INNOBIOCHIPS
    Inventors: Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
  • Compounds having a potentiating effect on the activity of ethionamide and uses thereof
    Patent number: 8338599
    Abstract: The present invention relates to the use of compounds with a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, for the preparation of a medicament for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to pharmaceutical compositions comprising them in combination with an antibiotic that is activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, to pharmaceutical compositions comprising them and to their use as medicaments, especially medicaments for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.
    Type: Grant
    Filed: July 4, 2007
    Date of Patent: December 25, 2012
    Assignees: Institut Pasteur de Lille, Centre National de la Recherche Scientifique, Universite de Lille 2, Universite du Droit et de la Sante, Institut National de la Sante et de la Recherche Medicale (Inserm)
    Inventors: Benoît Deprez, Nicolas Willand, Bertrand Dirie, Patrick Toto, Vincent Villeret, Camille Locht, Alain Baulard
  • COMPOUNDS HAVING A POTENTIATING EFFECT ON THE ACTIVITY OF ETHIONAMIDE AND USES THEREOF
    Publication number: 20110136823
    Abstract: The present invention relates to the use of compounds with a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, for the preparation of a medicament for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to pharmaceutical compositions comprising them in combination with an antibiotic that is activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, to pharmaceutical compositions comprising them and to their use as medicaments, especially medicaments for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.
    Type: Application
    Filed: July 4, 2007
    Publication date: June 9, 2011
    Applicants: Institut Pasteur De Lille, Centre National De La Recherche Scientifique, Universite De Lille 2, Universite Du Droit Et De La Sante, Institut National De La Sante Et De La Recherche Medicale (Inserm)
    Inventors: Benôit Deprez, Nicolas Willand, Dirie Bertrand, Toto Patrick, Villeret Vincent, Locht Camille, Baulard Alain
  • Antigen imitating extracellular areas of membrane proteins of type III produced from intracellular pathogenic micro-organisms, derived conformational antibodies and the use thereof
    Patent number: 7803378
    Abstract: An antigen derived from an intracellular pathogenic micro-organism characterized in that it comprises at least on peptidic fragment which essentially consists of the concatenation of sequences of at least two extracellular adjacent areas in the native structure of a membrane protein of type III of said intracellular pathogenic micro-organism, derived conformational antibodies and the application hereof.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: September 28, 2010
    Assignees: Centre National de la Recherche Scientifique, Universite de Rouen, Universite de Lille 2
    Inventor: Denis Tranchand-Bunel
  • In vitro diagnostic test for enterovirus infections
    Patent number: 7534558
    Abstract: The present invention is related to an in vitro diagnostic assay of enteroviruses, based on the revealing of an immunologic reaction of antigen-antibody recognition type, using antigens or epitopes thereof that do not induce antiviral neutralising antibodies but induce “facilitating” antibodies which increase the viral infection.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: May 19, 2009
    Assignees: Universite de Lille 2 Droit Et Sante, Centre Hospitalier Regional Universitaire de Lille (Chru de Lille)
    Inventors: Wassim Chehadeh, Didier Hober, Ahmed Bouzidi