Patents Assigned to Universite de Lille 2, Universite du Droit et de la Sante
  • Compounds having a potentiating effect on the activity of ethionamide and uses thereof
    Patent number: 8338599
    Abstract: The present invention relates to the use of compounds with a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, for the preparation of a medicament for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to pharmaceutical compositions comprising them in combination with an antibiotic that is activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, to pharmaceutical compositions comprising them and to their use as medicaments, especially medicaments for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.
    Type: Grant
    Filed: July 4, 2007
    Date of Patent: December 25, 2012
    Assignees: Institut Pasteur de Lille, Centre National de la Recherche Scientifique, Universite de Lille 2, Universite du Droit et de la Sante, Institut National de la Sante et de la Recherche Medicale (Inserm)
    Inventors: Benoît Deprez, Nicolas Willand, Bertrand Dirie, Patrick Toto, Vincent Villeret, Camille Locht, Alain Baulard
  • COMPOUNDS HAVING A POTENTIATING EFFECT ON THE ACTIVITY OF ETHIONAMIDE AND USES THEREOF
    Publication number: 20110136823
    Abstract: The present invention relates to the use of compounds with a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, for the preparation of a medicament for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to pharmaceutical compositions comprising them in combination with an antibiotic that is activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, to pharmaceutical compositions comprising them and to their use as medicaments, especially medicaments for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.
    Type: Application
    Filed: July 4, 2007
    Publication date: June 9, 2011
    Applicants: Institut Pasteur De Lille, Centre National De La Recherche Scientifique, Universite De Lille 2, Universite Du Droit Et De La Sante, Institut National De La Sante Et De La Recherche Medicale (Inserm)
    Inventors: Benôit Deprez, Nicolas Willand, Dirie Bertrand, Toto Patrick, Villeret Vincent, Locht Camille, Baulard Alain