Abstract: The invention relates to novel peptide-silane “hybrid block” molecules, to the synthesis thereof and to the use of same for producing novel peptide-silica hybrid materials that can be used in various applications.

Abstract: The disclosure relates to a method for the synthesis of a compound of the following formula (I) in which: R1 and R2 are independently an N-protective group; R3 is a hydrogen atom, a C1-C6 alkyl group, a C1-C6 arylalkyl group, a C2-C6 alkenyl group, or a alkoxycarbonylalkyl group; Y is a —C(HR4)- group in which R4 is a hydrogen atom, a C1-C6 alkyl group, an aryl group, a C1-C6 arylalkyl group, or a C2-C6 alkenyl group; or an orthophenylene group.

Abstract: Imidazo[1,2-a]quinoxaline compounds for the treatment of cancers as well as pharmaceutical compositions that include these compounds and their uses in therapy.

Abstract: Phosphorus-calcium-strontium compound of formula (I); method for preparing same; composition for the extemporaneous preparation of a cement comprising a solid phase (SP) and a liquid phase (LP), wherein the solid phase comprises a mixture of inorganic compounds of formula (II); use as an endodontic cement.

Abstract: The invention relates to the use of oligomers having constrained dipeptide or tripeptide motifs as agents for the vectorization of active ingredients.

Abstract: The invention relates to a dipeptide conjugate having general formula I, AA2-AA1-NH2, wherein A represent the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic radical at C1-C24, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, and/or which can comprise a phenyl group or lipoic acid or the reduced form thereof, dihydrolipoic acid or N-lipoyllysine; and AA1 and AA2 represent identical or different amino acids which are selected from the group containing Ala, Asn, Cys, Gln, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Asp, Glu, Arg, His, Lys, Orn, Dap, Dab, the corresponding homo-amino acids and the corresponding beta-amino acids in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.

Abstract: This invention is based on the identification of the role played by the receptor mX on certain insects through the behavior evinced in the taste sensory reactions of these insects. The invention addresses the use of the modulators on the mX receptor, such as L-canavanine and/or a mix of arginine and calcium and/or N-methyl-L-arginine (NMA) which are used to prepare a compound with repellent or attractive qualities with regard to certain insects. The invention also concerns the use of an mX insect receptor as a target for the identification of repellent substances regarding at least some insects.

Abstract: The invention relates to a tripeptide conjugate having general formula I, A-AA1-AA2-AA3-NH2, wherein A represents the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic radical at C1-C24, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, lipoic acid or the reduced form thereof, dihydrolipoic acid, N-lipoyllysine, or phenylbutyric acid; and AA1, AA2 and AA3, which may be identical or different, represent independently of each other an amino acid selected from His, Phe, Ala, Arg, Lys, Orn, Trp, Nap, Tpi and Tic, on the condition that at least one of AA1, AA2 or AA3 represent Phe, preferably Dphe in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.

Abstract: The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

Abstract: The disclosure relates to a method for the synthesis of a compound of the formula (I) in which: n is an integer higher than or equal to 1; Rb and each Rn are independently a hydrogen atom, a C1-C6 arylalkyl group or a C1-C6 alkyl group substituted or not by an aryl group, —COOH, C1-C6, —COO-(alkyl), —CONH2, —SH, heteroaryl, —NH2, —NHC(NH)(NH2), C1-C6-s-(alkyl), —OH or phenol; Ra is a N-protective group; Rc is a ORd group in which Rd is a C1-C6 alkyl group or a NReRf group in which Re and Rf Re independently an N-protective group.

Abstract: The invention relates to a peptide of formula W-DPhe-Arg-Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a monocarboxylic acid of general formula HOOC—R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C1-C24 radical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg.

Abstract: This invention is based on the identification of the role played by the receptor mX on certain insects through the behavior evinced in the taste sensory reactions of these insects. The invention addresses the use of the modulators on the mX receptor, such as L-canavanine and/or a mix of arginine and calcium and/or N-methyl-L-arginine (NMA) which are used to prepare a compound with repellent or attractive qualities with regard to certain insects. The invention also concerns the use of an mX insect receptor as a target for the identification of repellent substances regarding at least some insects.

Abstract: The invention relates to a process for immobilizing acidic or electrophilic compounds in a solution. The process is characterized in that it consists in bringing a crosslinked polyimine, which is insoluble in the medium and in which the imino groups are —NH-groups, into contact with said compounds and in then separating, by filtration, the modified polyimine obtained. The crosslinked polyimine comprises linear segments composed of —HN—R1—NH—R2—Ar—R3-units in which R1, R2 and R3 are identical or different alkylene or alkenylene groups and Ar represents an aromatic group. The process is of use for fixing undesirable compounds or for purifying acidic compounds.

Abstract: The invention relates to a peptide of formula W-DPhe-Arg-Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a nionocarboxylic acid of general formula HOOC—R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C1-C24 radical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg.