Patents Assigned to Universite de Montreal
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Publication number: 20230287070Abstract: Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. Novel tumor-specific antigens (TSAs) shared by a large proportion of AML cells are described herein. Most of the TSAs described herein derives from aberrantly expressed unmutated genomic sequences, such as intronic and intergenic sequences, which are not expressed in normal tissues. Nucleic acids, compositions, cells and vaccines derived from these TSAs are described. The use of the TSAs, nucleic acids, compositions, cells and vaccines for the treatment of leukemia such as AML is also described.Type: ApplicationFiled: March 15, 2021Publication date: September 14, 2023Applicant: UNIVERSITE DE MONTREALInventors: Claude Perreault, Pierre Thibault, Sebastien Lemieux, Gregory Ehx, Marie-Pierre Hardy
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Publication number: 20230165812Abstract: The present disclosure provides methods of treating cancer by silencing tumor-innervating sensory neurons. The methods include treating cancer by genetic ablation of ion channels (e.g., TRPV1 or NaV1.8), local pharmacological silencing or blockade of neuropeptide release from tumor-innervating nociceptor (e.g., with QX-314 and BoNT/a), as well as the antagonism of the CGRP receptor RAMP1 (e.g., with BIBN 4096).Type: ApplicationFiled: February 26, 2021Publication date: June 1, 2023Applicants: President and Fellows of Harvard College, Université de Montréal, Children's Medical Center CorporationInventors: Clifford J. Woolf, Sebastien Talbot, Bruce P. Bean
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Publication number: 20230158132Abstract: Acute lymphoblastic leukemia (ALL) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. Novel tumor-specific antigens (TSAs) specifically expressed by ALL cells are described herein. Most of the TSAs described herein derives from aberrantly expressed unmutated genomic sequences, such as intronic and intergenic sequences, which are not expressed in normal tissues. Nucleic acids, compositions, cells, antibodies and vaccines derived from these TSAs are described. The use of the TSAs, nucleic acids, compositions, antibodies, cells and vaccines for the treatment of leukemia such as ALL is also described.Type: ApplicationFiled: April 9, 2021Publication date: May 25, 2023Applicant: UNIVERSITE DE MONTREALInventors: Claude Perreault, Pierre Thibault, Marie-Pierre Hardy
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Publication number: 20230122855Abstract: Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.Type: ApplicationFiled: October 13, 2022Publication date: April 20, 2023Applicants: The Regents of the University of California, The Université de MontréalInventors: Aimee L. Edinger, Stephen Hanessian
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Publication number: 20230076854Abstract: A method for determining an optical system intended to equip a person on the basis of the adaptability of the person to a visual and/or proprioceptive modification of his environment, the method including a person visual behaviour parameter providing, during which a person visual behaviour parameter indicative of the visual behaviour of the person relative to a given state of the environment is provided; a reference value providing, during which a first value of the person visual behaviour parameter corresponding to a reference state of the environment is provided; a visual and/or proprioceptive modification providing, during which a visual and/or proprioceptive modification of the reference state of the environment is provided so as to define a modified state of the environment; and determining, during which an optical parameter of the optical system is determined based on the first value of the person visual behaviour parameter and on a second value of the person visual behaviour parameter associated with tType: ApplicationFiled: November 9, 2022Publication date: March 9, 2023Applicants: Essilor International, Universite de MontrealInventors: Guillaume GIRAUDET, Jocelyn FAUBERT, Rafael DOTI, Eduardo LUGO
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Publication number: 20230045357Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or ?-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.Type: ApplicationFiled: July 11, 2022Publication date: February 9, 2023Applicants: Université de Montréal, Bristol-Myers Squibb CompanyInventors: Eldon Scott PRIESTLEY, Samuel Kaye REZNIK, Edward H. RUEDIGER, James R. GILLARD, Oz Scott HALPERN, Wen JIANG, Jeremy RICHTER, Rejean RUEL, Sasmita TRIPATHY, Wu YANG, Xiaojun ZHANG
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Patent number: 11500224Abstract: A method for determining an optical system intended to equip a person on the basis of the adaptability of the person to a visual and/or proprioceptive modification of his environment, the method.Type: GrantFiled: August 30, 2018Date of Patent: November 15, 2022Assignees: Essilor International, Universite de MontrealInventors: Guillaume Giraudet, Jocelyn Faubert, Rafael Doti, Eduardo Lugo
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Patent number: 11493782Abstract: There is described a medical device for management of the axial length growth of an eye of a subject. The device comprises a central region having a first power, a transition region surrounding the central region, and a peripheral region surrounding the transition region and having a second power. The transition region has a width at most equal to 1.5 mm. The second power is chosen based on the first power to achieve a target net power, the target net power being the addition of the first power and the second power. The surface area of the central and peripheral regions is chosen as a function of the surface area of the pupil of the eye. Furthermore, the curve of power within the transition region is steep between the first power and the second power so that the transition region generates no optically usable power.Type: GrantFiled: November 23, 2018Date of Patent: November 8, 2022Assignee: Université de Montréal et al.Inventors: Patrick Simard, Jean Blanchard, Langis Michaud, Remy Marcotte-Collard
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Patent number: 11479530Abstract: Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.Type: GrantFiled: March 8, 2021Date of Patent: October 25, 2022Assignees: The Regents of the University of California, The Université de MontréalInventors: Aimee L. Edinger, Stephen Hanessian
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Publication number: 20220284303Abstract: A system simulating a decisional process in a mammal brain about characteristics of motions related to body gestures of a visually observed body through a simulated visual path is provided. The system includes an interface toward simulated neuronal structures, the interface at least converting luminous information of the observed body to an optic flow data stream conveying information related to the visually observed body and that can be processed in the simulated neuronal structures, the system being a feed-forward system and comprising hierarchically from the visual observation to the decision: the simulated visual path and its interface, a simulated local motion direction detection neuronal structure for the detection of motion directions with receptive fields, a simulated opponent motions detection neuronal structure, a simulated complex patterns detection neuronal structure, and a simulated motion pattern detection neuronal structure.Type: ApplicationFiled: August 3, 2020Publication date: September 8, 2022Applicants: UNIVERSITE DE MONTREAL, Essilor InternationalInventors: Jocelyn FAUBERT, Khashayar MISAGHIAN, Eduardo LUGO, Delphine TRANVOUEZ-BERNARDIN
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Publication number: 20220266017Abstract: A method for modulating a movement of a body part comprising: acquiring movement event data relating to the body part during a movement event, the movement event data including: a movement event parameter requiring modulation, a trigger value representative of a first time point in the movement event, and a target value representative of desired movement at a second, later, time point in the movement event; acquiring in real-time current movement data associated with a current movement event of the body part, the current movement data including current values of the movement event parameter; analyzing the current movement data to determine presence of the trigger value in the current movement event; and in response to identification of the trigger value in the current movement data, causing a brain stimulation assembly to apply a predetermined modulation signal to a brain motor region of the subject to cause the modulation of the body part towards the target value at the second time point in the current movemType: ApplicationFiled: July 30, 2020Publication date: August 25, 2022Applicant: UNIVERSITÉ DE MONTRÉALInventors: Marco Bonizzato, Marina Martinez
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Publication number: 20220263114Abstract: The invention concerns a solid polymer electrolyte comprising a polymer matrix comprising at least one ionic salt, the polymer matrix comprising at least one polyalkene carbonate, at least one second polymer different from the polyalkene carbonate polymer, and at least one alkene carbonate coming from the decomposition of the polyalkene carbonate. The present invention also concerns a method for preparing the solid polymer electrolyte and a battery comprising the solid polymer electrolyte.Type: ApplicationFiled: July 17, 2020Publication date: August 18, 2022Applicants: TotalEnergies SE, UNIVERSITE DE MONTREALInventors: David AYMÉ-PERROT, Mickaël DOLLÉ, David LEPAGE, Arnaud PRÉBÉ
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Publication number: 20220246922Abstract: The present invention relates to a composite electrode for a device storing electrical energy wherein said electrode comprises an electrode body and an electrode shell, wherein said body comprises at least one water-soluble polymer and wherein at least a part of said shell comprises a shell comprising at least one organic or organometallic material. The present invention also relates to a device storing electrical energy comprising said composite electrode and a process for preparing said composite electrode.Type: ApplicationFiled: June 3, 2020Publication date: August 4, 2022Applicants: TotalEnergies SE, UNIVERSITE DE MONTREALInventors: David AYME-PERROT, Jacopo PROFILI, Luc STAFFORD, Steeve ROUSSELOT, Mickaël DOLLE
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Patent number: 11348572Abstract: A speech recognition method includes obtaining an acoustic sequence divided into a plurality of frames, and determining pronunciations in the acoustic sequence by predicting a duration of a same pronunciation in the acoustic sequence and skipping a pronunciation prediction for a frame corresponding to the duration.Type: GrantFiled: July 18, 2018Date of Patent: May 31, 2022Assignees: Samsung Electronics Co., Ltd., UNIVERSITE DE MONTREALInventors: Inchul Song, Junyoung Chung, Taesup Kim, Sanghyun Yoo
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Publication number: 20220121040Abstract: A method for determining a design of a progressive lens intended to be worn by a future wearer, the progressive lens comprising a front surface and a back surface, at least one of the front surface and the back surface comprising a progression profile on its general spherical shape, said at least one progression profile defining a meridian line extending from a distance-vision point to a near-vision point, said meridian line comprising a vertical portion passing through the distance-vision point and an inclined portion passing through the near-vision point, the vertical portion and the inclined portion forming an angle between them, the method including obtaining first data representative of a first measurement of a first postural instability of the future wearer when seeing a visual pattern moving along an mediolateral direction, and determining a reparation between the first progression profile and the second progression profile based on the first data.Type: ApplicationFiled: November 27, 2019Publication date: April 21, 2022Applicants: Essilor International, UNIVERSITE DE MONTREALInventors: Delphine TRANVOUEZ-BERNARDIN, Jocelyn FAUBERT, Guillaume GIRAUDET
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Publication number: 20220026741Abstract: A method for determining a design of a progressive lens intended to be worn by a future wearer, the progressive lens comprising a front surface and a back surface, at least one of the front surface and the back surface comprising a progression profile on its general spherical shape, said at least one progression profile defining a meridian line extending from a distance-vision point to a near-vision point, said meridian line comprising a vertical portion passing through the distance-vision point and an inclined portion passing through the near-vision point, the vertical portion and the inclined portion forming an angle between them, the method comprising obtaining first data representative of a first measurement of a first postural instability of the future wearer when seeing at a visual pattern moving along an anterior-posterior direction, and determining the angle of the inclined portion based on the first data.Type: ApplicationFiled: November 27, 2019Publication date: January 27, 2022Applicants: Essilor International, UNIVERSITE DE MONTREALInventors: Delphine TRANVOUEZ-BERNARDIN, Jocelyn FAUBERT, Guillaume GIRAUDET
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Publication number: 20220011596Abstract: A system and method for determining an adapted ophthalmic device for a wearer, the method including acquiring a set of parameters values relating to the wearer, determining at least a task to be performed by the wearer involving visual exploration, using a computing system, determining a value of a criterion assessing an efficiency of the wearer's visual exploration strategy for the task, and determining an optical design of an ophthalmic device to be worn by a wearer according to the determined value of the criterion.Type: ApplicationFiled: October 9, 2019Publication date: January 13, 2022Applicants: Essilor International, UNIVERSITE DE MONTREALInventors: Delphine BERNARDIN, Jocelyn FAUBERT, Romain CHAUMILLON, Eduardo LUGO, Sergio MEJIA ROMERO
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Publication number: 20210322509Abstract: A method for preventing or reducing the risk of perinatal or neonatal morbidity and mortality caused by antenatal inflammation in humans is described. This method is based on the administration of a compound of formula I or a pharmaceutically acceptable salt thereof: to an expectant human mother suffering from antenatal fetal inflammation. The method prevents or reduces the risk of organ damages, including brain, lung and intestinal damages, and sequelae therefrom, in the neonates, as well as the risk of neonatal death.Type: ApplicationFiled: June 30, 2021Publication date: October 21, 2021Applicants: CHU SAINTE-JUSTINE, UNIVERSITÉ DE MONTRÉAL, THE UNIVERSITY OF ADELAIDEInventors: Sylvain CHEMTOB, Christiane QUINIOU, Sarah Anne ROBERTSON, Mathieu NADEAU-VALLÉE, William D. LUBELL, David OLSON, Peck Yin CHIN, Sylvie GIRARD, Doan-Ngoc DUC
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Publication number: 20210261583Abstract: Small molecules compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.Type: ApplicationFiled: June 14, 2019Publication date: August 26, 2021Applicants: The Regents of the University of California, Universite de MontrealInventors: Aimee Edinger, Stephen Hanessian
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Publication number: 20210261504Abstract: Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.Type: ApplicationFiled: March 8, 2021Publication date: August 26, 2021Applicants: The Regents of the University of California, The Université de MontréalInventors: Aimee L. Edinger, Stephen Hanessian