Patents Assigned to Universite de Montreal
  • Patent number: 10954194
    Abstract: The invention relates to a method of treating a subject who has cancer or a non-malignant tumor, the method comprising administering a therapeutically effective amount of a 18-20 member bi-polycyclic compound to the subject.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: March 23, 2021
    Assignees: Haro Pharmaceuticals Inc., The Royal Institution for the Advancement of Learning/ McGill University, Universite De Montreal
    Inventors: David Bettoun, Eduardo Martinez, James Gleason, Sylvie Mader, Shuo Xing
  • Patent number: 10877036
    Abstract: Resonance energy transfer (RET)- or protein-fragment complement assay (PCA)-based biosensors useful for assessing the activity of G-proteins are described. These biosensors are based on the competition between the G? subunit and a G?? interacting protein (?? IP) for the binding to the G?? dimer. These biosensors comprises (1) a ?? IP and (2) a G? or G? protein; a GPCR; or a plasma membrane targeting domain, fused to suitable RET or PCA tags. Methods using such biosensors for different applications, including the identification of agents that modulates G-protein activity or for the characterization of GPCR signaling/regulation, such as G-protein preferences and activation profiles of GPCRs, are also described.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: December 29, 2020
    Assignee: UNIVERSITÉ DE MONTRÉAL
    Inventors: Michel Bouvier, Christian Le Gouill, Mireille Hogue, Viktoriya Lukasheva
  • Publication number: 20200348536
    Abstract: A method for determining an optical system intended to equip a person on the basis of the adaptability of the person to a visual and/or proprioceptive modification of his environment, the method.
    Type: Application
    Filed: August 30, 2018
    Publication date: November 5, 2020
    Applicants: Essilor International, Universite de Montreal
    Inventors: Guillaume GIRAUDET, Jocelyn FAUBERT, Rafael DOTI, Eduardo LUGO
  • Patent number: 10822343
    Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: November 3, 2020
    Assignees: Bristol-Myers Squibb Company, Université de Montréal
    Inventors: Jacques Banville, Roger Remillard, Edward H. Ruediger, Daniel H. Deon, Marc Gagnon, Laurence Dube, Julia Guy, Eldon Scott Priestley, Shoshana L. Posy, Brad D. Maxwell, Pancras C. Wong, R. Michael Lawrence, Michael M. Miller
  • Publication number: 20200323923
    Abstract: The invention relates to compounds as described herein and pharmaceutical compositions containing them. Also, the invention relates to methods for expanding stem cells and/or progenitor cells and methods for treating a hematopoietic disorder/malignancy, an autoimmune disease and/or an inherited immunodeficient disease.
    Type: Application
    Filed: November 1, 2018
    Publication date: October 15, 2020
    Applicant: UNIVERSITE DE MONTREAL
    Inventors: Bruno SIMONEAU, Yves CHANTIGNY, Jonathan YEH, Guy SAUVAGEAU, Anne MARINIER
  • Patent number: 10792154
    Abstract: A limb sparring system for replacing a portion of a radius, the radius being adjacent to an ulna, the system comprising a cutting guide including a cut guiding portion for guiding a saw when making a predetermined cut in the radius to excise the portion of the radius, an opposed ulnar mounting portion mountable to the ulna, and a linking portion extending therebetween; and an endoprosthesis configured for replacing the portion of the radius after the portion of the radius has been excised. When the cutting guide is operatively mounted to the radius and ulna, the cut guiding portion and the ulnar mounting portion engage respectively the radius and the ulna in a predetermined spatial relationship relative thereto.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: October 6, 2020
    Assignees: SOCOVAR, L.P., Colorado State University Research Foundation, Universite de Montreal
    Inventors: Vladimir Brailovski, Yvan Petit, Bertrand Lussier, Bernard Seguin, Martin Brummund, Anatolie Timercan
  • Publication number: 20200306213
    Abstract: Compounds, compositions and their use in the treatment or prevention of symptoms of Lowe Syndrome and Dent disease 2 are described, for instance, the use of such compounds in the treatment of Lowe Syndrome and Dent disease 2, or in the treatment or prevention of at least one symptom associated therewith.
    Type: Application
    Filed: September 27, 2018
    Publication date: October 1, 2020
    Applicants: Université de Montréal, The University of Manchester, Centre National De La Recherche Scientifique, Sorbonne Université, Institut Pasteur
    Inventors: Sébastien CARRENO, Khaled Ben El Kadhi, Arnaud Echard, Clothilde Cauvin, Martin Lowe
  • Patent number: 10752591
    Abstract: The invention relates to a method of inhibiting loss of muscle mass or muscle function in a subject in need thereof, or a method of treating miofibers ex vivo, the method comprising administering a therapeutically effective amount of a 18-20 member bi-polycyclic compound to the subject or to the miofibers.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: August 25, 2020
    Assignees: Haro Pharmaceuticals Inc., The Royal Institution for the Advancement of Learning/McGill University, Universite De Montreal
    Inventors: David Bettoun, Eduardo Martinez, James Gleason, Sylvie Mader, Shuo Xing
  • Publication number: 20200214926
    Abstract: The application relates to a method for adapting the visual and/or visual-motor behavior of a person, including: providing an optical parameter and a person visual parameter; providing a target value; modifying a visual and/or visual motor behavior; assessing a person visual parameter; determining a suitable visual and/or visual-motor behavior; and adapting the visual and/or visual-motor behavior of the person.
    Type: Application
    Filed: October 2, 2018
    Publication date: July 9, 2020
    Applicants: Essilor International, Universite de Montreal
    Inventors: Bjorn DROBE, Jocelyn FAUBERT, Guillaume GIRAUDET
  • Publication number: 20200188361
    Abstract: A method for treating acute myeloid leukemia (AML), such as poor risk AML, by administering to a subject in need thereof an effective amount of a mitochondrial activity inhibitor, for example a class A electron transport chain (ETC) complex I inhibitor such as Mubritinib or a pharmaceutically acceptable salt thereof, is disclosed. The AML to be treated may be characterized by certain features, such as high level of expression of one or more Homeobox (HOX)-network genes, high and/or low expression of specific genes, the presence of one or more cytogenetic or molecular risk factors such as intermediate cytogenetic risk, Normal Karyotype (NK), mutated NPM1, mutated CEBPA, mutated FLT3, mutated DNMT3A, mutated TET2, mutated IDII1, mutated IDII2, mutated RUNX1, mutated WT1, mutated SRSF2, intermediate cytogenetic risk with abnormal karyotype (intern(abnK)), trisomy 8 (+8) and/or abnormal chromosome (5/7), and/or a high leukemic stem cell (LSC) frequency.
    Type: Application
    Filed: January 24, 2020
    Publication date: June 18, 2020
    Applicant: UNIVERSITE DE MONTREAL
    Inventors: Guy Sauvageau, Irene Baccelli
  • Publication number: 20200126534
    Abstract: A speech recognition method and apparatus, including implementation and/or training, are disclosed. The speech recognition method includes obtaining a speech signal, and performing a recognition of the speech signal, including generating a dialect parameter, for the speech signal, from input dialect data using a parameter generation model, applying the dialect parameter to a trained speech recognition model to generate a dialect speech recognition model, and generating a speech recognition result from the speech signal by implementing, with respect to the speech signal, the dialect speech recognition model. The speech recognition method and apparatus may perform speech recognition and/or training of the speech recognition model and the parameter generation model.
    Type: Application
    Filed: October 18, 2019
    Publication date: April 23, 2020
    Applicants: Samsung Electronics Co., Ltd., Universite De Montreal
    Inventors: Sanghyun YOO, Yoshua BENGIO, Inchul SONG
  • Patent number: 10584159
    Abstract: Bioluminescence resonance energy transfer (BRET) biosensors for assessing the intracellular localization, internalization and trafficking into cellular compartments of proteins such as receptors, and other biomolecules such as second messengers, are disclosed. These biosensors, which are dependent on the concentration/density of the BRET donor and acceptor in cellular compartments rather that specific protein-protein interactions, use a Renilla GFP/Luc BRET pair, which allows the robust and reproducible monitoring of protein trafficking/localization, with a sensitivity compatible with high-throughput screening (HTS). The use of these biosensors for various applications, including assessing/monitoring protein endocytosis, recycling and intracellular trafficking, receptor maturation/rescue by pharmacological chaperones, various endocytosis/exocytosis processes, activation/inhibition, as well as biomolecule concentration/density in different cellular compartments, is also disclosed.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: March 10, 2020
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Université de Montréal
    Inventors: Stéphane Alain Laporte, Yoon Namkung, Michel Bouvier, Christian Le Gouill, Mireille Hogue, Viktoriya Lukasheva, Hiroyuki Kobayashi, Denis Deblois, Étienne Durette
  • Patent number: 10501802
    Abstract: Methods for the diagnosis of leukemias, and more specifically AML, such as MLL-AF9 AML, in a subject, based on the assessment of the expression or activity of one or more of the genes listed in Tables 1 and 2 are disclosed. The use of antibodies or antigen-binding fragments thereof that bind to one or more of proteins showing preferential expression at the cell surface of AML leukemic cells for treating AML is also disclosed.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: December 10, 2019
    Assignees: UNIVERSITE DE MONTREAL, UNIVERSITÉ LAVAL
    Inventors: Brian Thomas Wilhelm, Frederic Barabe
  • Patent number: 10428077
    Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: October 1, 2019
    Assignees: Bristol-Myers Squibb Company, Université de Montréal
    Inventors: Jacques Banville, Roger Remillard, Edward H. Ruediger, Daniel H. Deon, Marc Gagnon, Laurence Dube, Julia Guy, Eldon Scott Priestley, Shoshana L. Posy, Brad D. Maxwell, Pancras C. Wong, R. Michael Lawrence, Michael M. Miller
  • Patent number: 10414813
    Abstract: Novel minor histocompatibility antigens (MiHAs) are described. These novel MiHAs were selected based on two features: (i) they are encoded by loci with a minor allele frequency (MAF) of at least 0.05; and (ii) they have adequate tissue distribution. Compositions, nucleic acids and cells related to these novel MiHAs are also described. The present application also discloses the use of these novel MiHAs, and related compositions, nucleic acids and cells, in applications related to cancer immunotherapy, for example for the treatment of hematologic cancers such as leukemia.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: September 17, 2019
    Assignees: UNIVERSITÉ DE MONTRÉAL, RSEM, LIMITED PARTNERSHIP
    Inventors: Claude Perreault, Diana Paola Granados, Jean-Sébastien Delisle, Pierre Thibault, Sébastien Lemieux
  • Patent number: 10377632
    Abstract: There is provided a process for producing LiMXO4, comprising the steps of reacting a source of lithium, a source of M, and a source of X together, in a melted state at a reaction temperature between 900 to 1450 C, in the presence of an excess of (A) a solid-solid reducing couple having an oxygen partial process at equilibrium (pO2) comprised between 10?8 and 10?15 atm at said reaction temperature according to an Ellingham-Richardson diagram for oxides, or (B) one component of the solid-solid reducing couple together with a gas-gas reducing couple having an oxygen partial pressure equilibrium (pO2) between 10?8 and 10?15 atm at said reaction temperature according to an Ellingham-Richardson diagram of oxides, and under thermic equilibrium and thermodynamic equilibrium. There is also provided a LiMXO4 melt-solidified product free from off-composition impurities.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: August 13, 2019
    Assignees: JOHNSON MATTHEY PUBLIC LIMITED COMPANY, UNIVERSITÉ DE MONTRÉAL, LA CORPORATION DE L'ÉCOLE POLYTECHNIQUE DE MONTRÉAL
    Inventors: Michel Gauthier, Patrice Chartrand, Majid Talebi-Esfandarani, Pierre Sauriol, Mickael Dollé, Jasmin Dufour, Guoxian Liang
  • Patent number: 10377715
    Abstract: The invention relates to 18-20 member bi-polycyclic compounds, methods of making these compounds, and methods of using them in treating hyperproliferative disorders (e.g., cancer) and non-malignant tumors; promoting muscle formation; inhibiting muscle degeneration or the loss of muscle mass or muscle function; and myofibers ex vivo.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: August 13, 2019
    Assignees: Haro Pharmaceuticals Inc., The Royal Institution for the Advancement of Learning/ McGill University, Universite De Montreal
    Inventors: David Bettoun, Eduardo Martinez, James Gleason, Sylvie Mader, Shuo Xing
  • Patent number: 10342554
    Abstract: A cutting guide for guiding a cut in a radius, the radius being adjacent to an ulna, the cutting guide comprising: a cut guiding portion, an opposed ulnar mounting portion and a linking portion extending therebetween; the cutting guide being delimited by a cutting guide peripheral surface defining a bone facing portion, the bone facing portion being contoured to match the shape of the radius and ulna.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: July 9, 2019
    Assignees: SOCOVAR, L.P., Colorado State University Research Foundation, Universite de Montreal
    Inventors: Vladimir Brailovski, Yvan Petit, Bertrand Lussier, Bernard Seguin, Martin Brummund, Anatolie Timercan
  • Patent number: 10342817
    Abstract: The present invention relates to pharmaceutical compositions and combination therapies for treating patients having a neoplasm or a proliferative disorder, the combination comprises ribavirin, GDC-0449 and a chemotherapeutic agent, wherein said combination therapy overcomes resistance developed in patients during anti-neoplastic treatment. The present invention also provides a combination therapy for treating patients having leukemia.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: July 9, 2019
    Assignee: Universite de Montreal
    Inventors: Katherine Borden, Hiba Zahreddine, Biljana Culjkovic Kraljacic
  • Patent number: 10336747
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: July 2, 2019
    Assignee: UNIVERSITÉ DE MONTRÉAL
    Inventors: Guy Sauvageau, Yves Gareau, Rejean Ruel, Stephane Gingras, Iman Fares