Abstract: The invention relates to novel compounds useful as ligands of actinides and which meet general formula (I) hereinafter: where: R1 and R2=H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; R3, R4, R5 and R6=H; a C1 to C12 hydrocarbon group; a monocyclic aryl or aryl-(C1 to C6)alkyl group; a —NR7R8 or —NR7COR8 group where R7=H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group, while R8=a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; an —OR9 or —SR9 group where R9=a C1 to C12 hydrocarbon group, a monocyclic C6 aryl or aryl-(C1 to C6)alkyl group. A further subject of the invention is a method for synthesizing these compounds and the uses thereof.
Type:
Grant
Filed:
March 28, 2012
Date of Patent:
July 7, 2015
Assignees:
Commissariat à l'énergie atomique et aux énergies alternatives, UNIVERSITE DE NANTES
Inventors:
Julia Bisson, Marie-Christine Charbonnel, Nathalie Boubals, Manuel Miguirditchian, Denis Guillaneux, Dominique Guillaumont, Cecile Marie, Didier Dubreuil, Muriel Pipelier, Virginie Blot
Abstract: The present invention concerns radioactive rhodium complexes, their preparation methods, and their use for the radiolabelling of biomolecules, especially monoclonal antibodies.
Type:
Application
Filed:
May 14, 2013
Publication date:
May 21, 2015
Applicants:
Institut National de la Sante et de la Recherche (INSERM), Chu Nantes, Universite de Nantes, Centre National de la Recherche Scientifique (C.N.R.S.), Universite d' Angers
Abstract: The present invention relates to novel melanoma antigen peptides and specific T lymphocytes directed to said peptides and the use thereof for treating melanoma.
Type:
Grant
Filed:
November 21, 2013
Date of Patent:
March 10, 2015
Assignees:
INSERM (Institut National de la Sante et de la Recherche Medicale), Universite de Nantes, Chu Nantes
Abstract: The invention relates to the use of monoclonal antibodies that only recognise the O-acetylated form of the GD2 ganglioside, or fragments of said antibody, for the diagnosis and the treatment of cancers in which the cells express the O-acetylated GD2, said antibody or said fragment recognising the O-acetylated GD2 molecules expressed by the tumoral cells and not recognising the GD2 molecules expressed at the surface of the peripheral nerves, in order to increase the specificity of the diagnosis and reduce the toxicity of the treatments. The invention also relates to artificially modified antibodies advantageously used for treating and diagnosing cancers in which the cells express the O-acetylated GD2.
Type:
Grant
Filed:
October 10, 2007
Date of Patent:
February 10, 2015
Assignee:
Universite de Nantes
Inventors:
Stéphane Birkle, Jean-Marie Mussini, Jacques Aubry, Jacques Barbet, Jean-Francois Chatal
Abstract: The present invention relates to an in vitro method for diagnosing the infectious state of an individual on the basis of a sample of white corpuscles arising from a biological specimen taken from an organ potentially infected by a pathogenic micro-organism of said individual, comprising at least the following two steps: i) measuring the mean cellular intensity of the autofluorescence of said sample, and ii) comparing the intensity measured in step i) with a control value, so as to determine the infectious state of said individual. The diagnostic method of the invention uses a routine optical material making it possible to work in wavelength regions which are compatible with the cellular autofluorescence, and thus constitutes a rapid, reliable and inexpensive aid for the diagnosis or monitoring of an infection in an individual.
Type:
Application
Filed:
March 22, 2012
Publication date:
February 5, 2015
Applicants:
UNIVERSITE DE NANTES, CHU NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SUD 11
Inventors:
Karim Asehnoune, Marie-Pierre Fontaine-Aupart, Sandrine Lecart, Antoine Monsel, Antoine Roquilly
Abstract: The invention relates to a method for preparing a colloidal nanoparticle solution, including: (a) dissolving a titanium-oxide precursor, referred to as a precursor, in one or more solvents, referred to as precursor solvents; and (b) chemically converting, preferably by means of hydrolysis, said titanium-oxide precursor and said precursor solvent into a colloidal-solution solvent so as to form titanium-oxide nanoparticles that are dispersed in the colloidal-solution solvent, said colloidal solution having a dynamic viscosity of between 4 and 54 cP at 20° C. and 101,325 Pa. The invention also relates to a colloidal titanium-oxide nanoparticle solution containing a dispersion of titanium-oxide nanoparticles in a solvent or system of solvents, the viscosity of which is between 4 and 54 cP, said solution being particularly obtainable according to the method of the invention, as well as to the uses thereof, in particular for preparing photovoltaic cells.
Type:
Application
Filed:
September 12, 2012
Publication date:
January 22, 2015
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE NANTES, Commissariat à l'énergie atomique et aux énergies alternatives, ARDEJE
Inventors:
Luc René Roger Brohan, Arkadiusz Michal Karpinski, Mireille Richard-Plouet, Solenn Berson, Stéphane Guillerez, Mickaël Barret, Jérôme Mourao
Abstract: Method for the preparation of a composite electrode and accumulator or battery including at least one composite electrode, the method includes a step of pouring a medium including at least one ionic liquid, a lithium, sodium or magnesium salt with at least one inorganic molecular precursor or a polymerizable monomer, the medium being in excess, and an in situ polycondensation or polymerization step.
Type:
Grant
Filed:
February 12, 2010
Date of Patent:
December 23, 2014
Assignees:
Centre National de la Recherche Scientifique, Universite Montpellier 2—Sciences et Techniques, Universite de Nantes
Inventors:
Jean Le Bideau, Jean-Baptiste Ducros, Dominique Guyomard, Patrick Soudan
Abstract: A method for hard surface deposition on aluminium metal parts of a turbine engine using MIG welding equipment which includes a pulsed current generator and pulsed filler metal wire feed, wherein the deposition is achieved using a filler metal wire whose composition is of the same nature as the composition of the aluminium alloy of the part to undergo hard surface deposition, with the pulsed metal wire feed and speed of deposition on the metal part of the turbine engine being adapted to carry out deposition without hot fissuring.
Type:
Application
Filed:
September 27, 2012
Publication date:
August 7, 2014
Applicants:
SNECMA, UNIVERSITÉ DE NANTES, UNIVERSITÉ PARIS SUD (UPS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Abstract: A generator of chaotic sequences of integer values is provided. The generator includes at least two discrete recursive filters at least of first-order, generating an output chaotic sequence of integer values, each recursive filter comprising means for implementing a nonlinear function connected via an exclusive-or gate to means for generating a perturbation sequence of integer values. The two filters are mounted in parallel. The chaotic sequence output from the generator is equal to an exclusive-or of the chaotic sequences output from the recursive filters, and in the means for implementing the nonlinear function includes a chaotic map.
Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.
Type:
Application
Filed:
June 4, 2012
Publication date:
June 12, 2014
Applicants:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CHU NANTES, UNIVERSITE DE NANTES
Inventors:
Pierre Weiss, Eva Mathieu, Jérôme Guicheux, Patricia Lemarchand
Abstract: A method is provided for extracting cellular compounds from micro-organisms. The method includes culturing the micro-organisms and extracting the cellular compounds from the micro-organisms. Each step is carried out in a continuous manner, wherein the extraction step is carried out separately from the culture step and in conditions of biocompatibility with the micro-organisms. The method further includes at least one step of recovering the cellular compounds and at least one step of recirculating the micro-organisms towards the culture step.
Type:
Grant
Filed:
April 22, 2008
Date of Patent:
May 6, 2014
Assignees:
Universite de Nantes, Centre National de la Recherche Scientifique (CNRS)
Inventors:
Jérémy Pruvost, Jack Legrand, Alain Foucault
Abstract: The present invention relates to novel melanoma antigen peptides and specific T lymphocytes directed to said peptides and the use thereof for treating melanoma.
Type:
Application
Filed:
November 21, 2013
Publication date:
March 27, 2014
Applicants:
INSERM (Institut National de la Sante et de la Recherche Medicale), Chu Nantes, Universite de Nantes
Abstract: The present invention lies in the field of new cancer therapies, more precisely in the field of antiangiogenic compounds. It notably concerns anti-Gb3 antibodies having specific CDR sequences, as well as the use of anti-Gb3 antibodies not coupled to a therapeutic molecule in the treatment of diseases associated with angiogenesis, such as solid tumors.
Type:
Application
Filed:
February 7, 2012
Publication date:
February 13, 2014
Applicants:
INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE, UNIVERSITE DE NANTES
Inventors:
François Paris, Stephane Birkle, Ariane Desselle, Jacques Aubry, Marie-Hélène Gaugler, Denis Cochonneau, Tanguy Chaumette
Abstract: The invention relates to novel compounds useful as ligands of actinides and which meet general formula (I) hereinafter: where: R1 and R2?H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; R3, R4, R5 and R6?H; a C1 to C12 hydrocarbon group; a monocyclic aryl or aryl-(C1 to C6)alkyl group; a —NR7R8 or —NR7COR8 group where R7?H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group, whilst R8=a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; an —OR9 or —SR9 group where R9=a C1 to C12 hydrocarbon group, a monocyclic C6 aryl or aryl-(C1 to C6)alkyl group. A further subject of the invention is a method for synthesizing these compounds and the uses thereof.
Type:
Application
Filed:
March 28, 2012
Publication date:
January 30, 2014
Applicants:
UNIVERSITE DE NANTES, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENE ALT
Inventors:
Julia Bisson, Marie-Christine Charbonnel, Nathalie Boubals, Manuel Miguirditchian, Denis Guillaneux, Dominique Guillaumont, Cecile Marie, Didier Dubreuil, Muriel Pipelier, Virginie Blot
Abstract: The present invention concerns a pharmaceutical composition comprising at least one agonist of at least one Toll Like receptor (TLR) chosen from TLR 4 and 9, for use in the prophylactic treatment of septic complications of post-traumatic systemic immunodepression in a patient who has suffered one or more severe traumatic injuries and is hospitalized in particular in an intensive care unit. Preferably, said TLR 4 agonist is monophosphoryl lipid A (MPLA) or deacylated 3-O-monophosphoryl lipid A (3D-MPLA) and said TLR 9 agonist is a CpG oligodeoxynucleotide (CpG ODN).
Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).
Type:
Grant
Filed:
March 3, 2010
Date of Patent:
January 7, 2014
Assignees:
Graftys, Universite de Nantes, Centre National de la Recherche Scientifique (C.N.R.S.)
Inventors:
Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
Abstract: The present invention concerns a composition useful as bone substitute comprising one or more calcium-phosphate compounds in association with an analgesic. It also refers to a preparation process of said composition, a preparation process of a drug-combined device comprising said composition, the drug combined device thus obtained, a kit comprising said composition and the use of said composition for the preparation of a drug-combined device useful for filling a bony defect caused in the iliac crest by collection of auto-graft bone, as a scaffold for tissue engineering and to produce a dental or bony implant.
Type:
Application
Filed:
September 3, 2013
Publication date:
January 2, 2014
Applicants:
Graftys, Ecole Nationale Veterinaire de Nantes, Universite de Nantes
Abstract: The invention provides chondrogenic differentiation media comprising chondrogenic growth factors and low-molecular-weight sulfated polysaccharide derivatives of marine native exopolysaccharides (EPS) excreted by mesophilic marine bacteria from deep-sea hydrothermal environments. The invention relates to methods for inducing chondrogenic differentiation in pluripotent or multipotent cells, to cartilage tissues obtained by such methods, and to the use of such cartilage tissues for therapeutic purposes.
Type:
Application
Filed:
March 16, 2012
Publication date:
December 19, 2013
Applicants:
Institut National de la Sante et de Ia Recherche Medicale, UNIVERSITE DE NANTES, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER
Abstract: The present invention relates to a method for detecting the presence or the absence, and optionally quantifying and/or isolating, antigen-specific peripheral blood mononuclear cells. This method, which involves flow cytometry, is based on the use of a fluorescently-labeled antibody specifically recognizing peripheral blood mononuclear cells, and of fluorescently-labeled beads coated with at least one antigen that is specifically recognized by antigen-specific peripheral blood mononuclear cells. The method according to the invention is for example useful for diagnosing immune disorders such as transplant rejections and autoimmune disorders.
Type:
Application
Filed:
June 17, 2011
Publication date:
July 11, 2013
Applicants:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CHU NANTES, UNIVERSITE DE NANTES
Inventors:
Jean Paul Soulillou, Sophie Brouard, Ahmed Akl
Abstract: The invention relates to a photoreactor (1) comprising a contained reaction chamber (15), wherein the chamber (15) is separated from the exterior by a light-capturing wall (11) and another wall (12), the capturing wall and the other wall being parallel to one another; characterized in that the photoreactor (1) additionally comprises a thermal valve (13) placed against the other wall (12) for passively controlling the increase in heat inside the chamber (15) due to the radiation passing through the capturing wall (11) in order to maintain the temperature in at least one part of the chamber (15) under a threshold temperature (Ts), the thermal valve (13) being made of a phase-change material.
Type:
Application
Filed:
September 13, 2011
Publication date:
July 11, 2013
Applicants:
Universite de Nantes, Centre National de la Recherche Scientifique (CNRS
Inventors:
Vincent Goetz, Jeremy Pruvost, Jack Legrand, Gael Plantard