Patents Assigned to UNIVERSITE DE NICE SOPHIA ANTIPOLIS-GRAND CHÂTEAU
  • Alpha-cell re-generation combined with conversion to beta cells
    Patent number: 10610504
    Abstract: The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: April 7, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NICE SOPHIA ANTIPOLIS-GRAND CHÂTEAU
    Inventors: Jacob Hecksher-Sørensen, Patrick Collombat