Abstract: A composition comprises an aqueous dispersion of particles (p) of mean hydrodynamic diameter between 50 and 5000 nm. The particles contain (A) polymers based on cyclodextrin units, comprising on average at least four cyclodextrin units within their structure; and (B) macromolecules of polysaccharides comprising groups G capable of forming inclusion complexes with the cyclodextrins present in the structure of the polymers (A), with an average number of groups G per polysaccharide macromolecule at least equal to three. The compounds (A) and (B) are water-soluble in the isolated state. A method is also provided which relates to the preparation of these compositions, as well as their use in order to achieve the encapsulation of compounds such as active substances.
Type:
Grant
Filed:
July 1, 2003
Date of Patent:
March 23, 2010
Assignees:
Centre National de la Recherche Scientifique (C.N.R.S.), Universite de Paris 11 - Paris SUD
Inventors:
Ruxandra Gref, Catherine Amiel, Bernard Sebille, Patrick Couvreur
Abstract: A vacuum magnetic ion trap includes an assembly forming a permanent magnet including at least two magnetized structures (30, 32) in the form of hollow cylinders, one convergent radial structure, magnetized along a convergent radial direction, and one divergent radial structure, magnetized along a divergent radial direction, the convergent and divergent radial magnetized structures (30, 32) being arranged along a common longitudinal axis (XX?) The trap also includes a sealed chamber (4) containing anion confinement cell (8) fixed between the at least two magnetized structures (30, 32) and including at least two trapping electrodes (10) connectable to a voltage generator (12).
Type:
Grant
Filed:
August 2, 2005
Date of Patent:
August 11, 2009
Assignees:
Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie-Paris VI, Universite de Paris 11 - Paris Sud
Inventors:
Michel Heninger, Joël Lemaire, Gérard Mauclaire, Pierre Boissel
Abstract: The invention relates to the use of 8-hydroxyquinoline 7-carboxylic acid derivatives in order to produce integrase-inhibiting medicaments, capable of blocking viral replication in the stages preceding integration, and if appropriate at the level of this integration stage, these medicaments being usable for the treatment of retroviral pathologies, in particular for the treatment of AIDS.
Type:
Grant
Filed:
May 15, 2003
Date of Patent:
January 20, 2009
Assignees:
Bioalliance Pharma SA, Institut Gustave Roussy, Centre National de la Recherche Scientifique (C.N.R.S.), Inserm, Universite de Paris 11- Paris Sud