Abstract: The invention relates to a curable resin that represents an excellent substitute for phenolic resins and is therefore able to replace phenolic resins in all applications in which they are used. Said resin is characterised in that it comprises: (1) at least one prepolymer resulting from the prepolymerisation of a compound A comprising at least one aromatic or heteroaromatic ring, a first group —O—CH2-C?CH and at least one second group selected from the groups —O—CH2-C?CH2 and —CH2-CH?CH2, said groups being carried by the at least one aromatic or heteroaromatic ring; and (2) a compound B comprising at least two thiol groups (—SH). The invention also relates to a material obtained by curing said curable resin, and in particular to an ablative composite material. The invention further relates to a material obtained by curing said curable resin.

Abstract: A sizing composition for reinforcing fibres is provided which makes it possible to improve the adhesion of these fibres with respect to an organic matrix that forms, with them, a part made of a composite material and that results from the chain transfer polymerization of a curable resin. The sizing composition includes a polybutadiene prepolymer comprising at least two epoxide functions, a cross-linking agent comprising at least two reactive functions, at least one of which is a thiol function; and a catalyst comprising at least one tertiary amine function.

Abstract: Method for retrieving data entered during a server connection, the server having access to a memory including a generated hashed word of a first input data, which corresponds to the data modified by a processing function, the capacity of the hashed word being lower than a predefined capacity, a generated security key of a second input data, which corresponds to the data modified by a processing function, the capacity of the security key being equal to the difference between the predefined capacity and the hashed word capacity, the security key not being stored, method wherein: —after a request to retrieve the data, the hashed word and the security key are concatenated in order to reach the predefined capacity, and —an inverse hash function, using an algebraic solving of the hash function, is applied to the concatenation of the hashed word and security key, to retrieve the data.

Abstract: The present invention is situated in the field of multimers used for targeted therapies. More particularly, the invention relates to methods for preparing multifunctional heteromultimeric protein complexes with a defined ratio of functional components and to multifunctional heteromultimeric protein complexes for directing complement-dependent cytolysis, optionally comprising a scaffold, which display three or more different functional components present in a defined relative ratio, of which one is a tracking component.

Abstract: The subject matter of the present invention is a photopolymerizable liquid composition comprising at least one epoxidized polybutadiene prepolymer, at least one cationic photoinitiator, and at least one thioxanthone-derived photosensitizer, which can, for example, be in the form of a liquid dressing. The subject matter of the invention is also a process for obtaining a polymerized film from said photopolymerizable liquid composition, characterized in that said composition is applied to tissues such as the skin, the skin appendages or the mucous membranes so as to form a uniform liquid film, and the film thus obtained is subjected to ultraviolet radiation, preferably ultraviolet-visible radiation having a wavelength of between 380 and 405 nm, preferably between 385 and 395 nm.

Abstract: A method for detecting and quantifying fibrosis, which involves at least; positioning a non-colored fixed tissue sample on a support; carrying out infrared acquisition, by scanning, of points of the sample; converting the infrared spectrum produced by each acquired point into at least one spectral image; carrying out a digital processing operation on the spectral image by distinguishing between at least physiological collagen and pathological collagen from fibrosis, attributing, to each point, a spectral class defined by an algorithm classifying the spectra according to the spectral similarities % thereof, then attributing a status to each class by statistically comparing with a digital model of spectra; quantifying the relative surface area occupied by the points of each status; and recording the result.

Abstract: The invention relates to new ?-vinyl carbonylated compounds corresponding to general formula (I), wherein R1, R2,R3, R4, R5 and Y are as defined in claim 1, their isomers, their diastereoisomers and acid addition salts or a pharmaceutically acceptable base. The invention also relates to a method for producing said compounds (I). It further relates to the use of said compound (I) as selective metalloprotease inhibitors, especially matrix metalloproteases 12 (MMP-12) and/or 9 (MMP-9). The compounds (I) are particularly useful for the prevention and/or treatment of chronic obstructive pulmonary disease (COPD), particularly emphysema induced by cigarette smoke.

Abstract: The method for producing a mixture of neutral oligosaccharides extracted from flaxseed includes oligosaccharides having high molar masses generated by fractionation by ultrafiltration at a cut-off of between 15,000 and 50,000 Da and between 5,000 and 15,000 Da. The mixture of oligosaccharides produced as a result of the implementation of the method, and to the applications of the mixture can be used for skin repair and skin aging control.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

Abstract: Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.

Abstract: A photoacoustic detection device including a nanophotonic circuit including a first chip on which is formed at least one optical waveguide and in which is formed a set of cavities defining a Helmholtz resonator; at least one optical source capable of emitting an optical signal in a given wavelength range, capable of being modulated at an acoustic modulation frequency, this source being attached to the first chip; a second chip forming a cap for said cavities and including acoustic sensors; and electronic circuits for processing the output of the acoustic sensors formed in the first or the second chip.

Abstract: The subject matter of the present invention is a photopolymerizable liquid composition comprising at least one epoxidized polybutadiene prepolymer, at least one cationic photoinitiator, and at least one thioxanthone-derived photosensitizer, which can, for example, be in the form of a liquid dressing. The subject matter of the invention is also a process for obtaining a polymerized film from said photopolymerizable liquid composition, characterized in that said composition is applied to tissues such as the skin, the skin appendages or the mucous membranes so as to form a uniform liquid film, and the film thus obtained is subjected to ultraviolet radiation, preferably ultraviolet-visible radiation having a wavelength of between 380 and 405 nm, preferably between 385 and 395 nm.

Abstract: The present invention discloses compositions of novel DYRK1A protein inhibitors based on a 3,5-diarylazaindole motif and their preparation and use as medications in the treatment of cognitive disorders associated with dysfunction of DYRK1A protein, with Down's syndrome and with Alzheimer's disease.

Abstract: A structural part (10) for a motor vehicle includes first (12A) and second (12B) mats, each mat comprising fibers and a resin bonding the fibers, and a separator (14) inserted between the first (12A) and second (12B) mats, the first (12A) and second (12B) mats being fixed on opposite faces of the separator (14). At least one of the first (12A) and second (12B) mats includes at least one continuous web of fibers (16), said web (16) comprising a plurality of parallel fibers bonded together by a thermosetting resin, at least part of the fibers of each web (16) having a length greater than 20 cm, in particular greater than 50 cm.

Abstract: The invention relates to new ?-vinyl carbonylated compounds corresponding to general formula (I), wherein R1, R2, R3, R4, R5 and Y are as defined in claim 1, their isomers, their diastereoisomers and acid addition salts or a pharmaceutically acceptable base. The invention also relates to a method for producing said compounds (I). It further relates to the use of said compounds (I) as selective metalloprotease inhibitors, especially matrix metalloproteases 12 (MMP-12) and/or 9 (MMP-9). The compounds (I) are particularly useful for the prevention and/or treatment of chronic obstructive pulmonary disease (COPD), particularly emphysema induced by cigarette smoke.

Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.

Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.

Abstract: The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts A, B and C. The first peptide part A corresponds to a hexapeptide repeated at least three times, the part A being capable of bonding to a receptor elastin-binding protein in order to stimulate collagen synthesis. The second peptide part B corresponds to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and of being cleaved by said protease. The third peptide part C corresponds to a tripeptide occupying at least one active site of the matrix metallo-proteinases in order to enable inhibition of the proteinases. The present invention further concerns a cosmetic and/or pharmaceutical composition incorporating the bifunctional peptide.

Abstract: A curable composition, and a material obtained by curing the composition, in which the curable composition includes a vinylester polymerisable compound, jointly with a sulphonated polyaromatic thermoplastic polymer, and an N-vinyl lactam, and which is characterised in that it further includes, a first non-vinylester polymerisable compound which includes at least one isocyanurate group bearing at least two (meth)acrylate groups; and a second non-vinylester polymerisable compound which includes at least one carbopolycyclic or heteropolycyclic group bearing at least two (meth)acrylate groups.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.