Abstract: The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

Abstract: The present invention provides SOCE inhibitors that are useful as therapeutic agents in a variety of applications. The present invention also relates to pharmaceutical compositions, products and kits comprising such SOCE inhibitors, and methods of using the SOCE inhibitors in the treatment of a variety of diseases.

Abstract: The present invention concerns a solid nanocomposite material consisting of a polymer-matrix in which are dispersed alkali metal, hydronium or ammonium salts of polyanionic components, wherein the polymer-matrix comprises at least a linear or branched polymer or copolymer containing one or several poly(ethylene oxide) (PEO) chains, said polymer or copolymer being optionally crosslinked and each PEO chain having at least 4 ethylene oxide monomer units. The present invention relates also to a photonic, e.g. optoelectronic, device comprising such a nanocomposite material. Such material and device can be used as phosphorescence emitter, for crop growth lighting or for generating singlet oxygen.

Abstract: A shielding element comprises a rigid substrate and at least one electrically conductive two-dimensional structure which is placed on one of the faces of the substrate. The substrate and the electrically conductive two-dimensional structure are such that the shielding element has optical-transmission and shielding-efficiency values at least one of which varies between two zones of the shielding element. Such a shielding element enables easier assembly of a detection system comprising multiple optical sensors.

Abstract: Hydrocarbon copolymer P comprising 2 alkoxysilane end groups F1 and F2 of formulae: —F1 : (R?O)3-tRtSi—R?—NH—C(O)O—(CH2)g1— and F2: —(CH2)d1—OC(O)—NH—R?—SiRtOR?)3-t; or —F1: (R?O)3-tRtSi—R?—NR??—C(O)—NH—(CH2)g1— and F2: —(CH2)d1—NH—C(O)—NR??—R?—SiRt(OR?)3-t; or —F1: (R?O)3-tRtSi—R?—NR??—C(O)—(CH2)g2— and F2: —(CH2)d2C(O)—NR??—R?—SiRt(OR?)3-t; wherein t is 0, 1 or 2; g1 and d1 are 1, 2 or 3; g2 and d2 are 0, 1, 2 or 3; R and R? represent a C1-C4 alkyl; R? is a C1-C4 alkylene radical; R?? is method for producing the copolymer, by heating a statistical bipolymer A: poly(butadiene-isoprene), poly(butadiene-myrcene) or poly(butadiene-farnesene); and heating the formed product, in the presence of a chain transfer agent of formula (C) and adhesive composition of the copolymer and a crosslinking catalyst.

Abstract: The invention relates to a module (6) for producing an MRI and/or MRS reference signal (S0), characterized in that the module comprises: a first receiving input (621) for receiving of an MRI and/or MRS synchronization signal (S3), a second receiving input (612) for receiving of a time signal (S8) of external stimulation, supply means (62) for supplying of a prescribed signal (RV) representing an MRI and/or MRS virtual object (RVV), generating means for generating of the MRI and/or MRS reference signal (S0), for temporally varying the MRI and/or MRS reference signal (S0) in the same way as a time characteristic determined from the time signal (S8) of external stimulation and in synchronization with the MRI and/or MRS synchronization signal (S3), a supply output (632) for supplying of the MRI and/or MRS reference signal (S0).

Abstract: A process for preparing a polyaminoborane comprising reacting at least one monomer with an aminoborane, wherein the at least one monomer is selected from the group consisting of ammonia, a primary amine and a substituted or unsubstituted hydrazine; and wherein the aminoborane comprises a borane substituted by a secondary amino group; polyaminoboranes obtainable by said process; use of said polyaminoboranes for the preparation of a ceramic precursor or a ceramic, the production of boron nitride, or the storage and/or production of dihydrogen; ceramic precursors, ceramics, hydrogen cells or energy materials comprising said polyaminoboranes.

Abstract: The present invention provides nine selective c-FLIP inhibitors that are useful in the treatment of cancer, alone or in combination with other chemotherapeutic agents, in particular with TRAIL-based chemotherapeutic agents. The present invention also relates to pharmaceutical compositions and kits comprising at least one of the nine selective c-FLIP inhibitors and their use in methods for the treatment of cancer, in particular to overcome chemoresistance or to improve sensitivity of tumors to TRAIL-based therapy.

Abstract: The present invention provides cyclic antimicrobial pseudopeptides that are useful in a variety of applications. Also provided are pharmaceutical compositions, products and kits comprising such cyclic antimicrobial peptides and methods of using these antimicrobial peptides for modifying infectivity, killing microorganisms or inhibiting microbial growth or function and for preventing and/or treating an infection or contamination caused by such microorganisms.

Abstract: 1) Hydrocarbon polymer having two azlactone end groups F1 is formula (IIa) and F2 is formula (IIb): g and d are 0, 1, 2 or 3; R14 and R15 are C1-C4 or a cyclohexyl radical; R1 to R12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R13 is oxygen or sulphur or divalent —CH2— n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.

Abstract: A method is provided for transmitting a sequence of data symbols including at least two data symbols of distinct values, delivering an electromagnetic wave carrying an orbital angular momentum. The method includes, for at least one data symbol to be transmitted: a bijective selection of an order of orbital angular momentum associating, with each distinct value of a data symbol, a distinct order of orbital angular momentum, and delivering a selected order of orbital angular momentum that is representative, by bijection, of the value of the at least one data symbol to be transmitted; and transmitting the electromagnetic wave carrying an orbital angular momentum, the order of orbital angular momentum of which corresponds to the selected order of orbital angular momentum.

Abstract: The invention relates to a module (6) for producing an MRI and/or MRS reference signal (S0), characterized in that the module comprises: a first receiving input (621) for receiving of an MRI and/or MRS synchronization signal (S3), a second receiving input (612) for receiving of a time signal (S8) of external stimulation, supply means (62) for supplying of a prescribed signal (RV) representing an MRI and/or MRS virtual object (RVV), generating means for generating of the MRI and/or MRS reference signal (S0), for temporally varying the MRI and/or MRS reference signal (S0) in the same way as a time characteristic determined from the time signal (S8) of external stimulation and in synchronization with the MRI and/or MRS synchronization signal (S3), a supply output (632) for supplying of the MRI and/or MRS reference signal (S0).

Abstract: This deals with a luminescent salt comprising a metal cluster anion and an organic cation, wherein the metal cluster anion comprises a metal cluster with at least two metal atoms, and ligands, the metal atoms being chosen from the group consisting of molybdenum, rhenium, tungsten, thallium, niobium, and mixtures thereof, wherein the organic cation comprises a cationic head substituted by at least one substituent including a polymerizable functional group. It also deals with a polymeric material comprising a polymer matrix which has polymerized with this luminescent salt.

Abstract: 1) Hydrocarbon-based polymer of formula (I): in which F1 and F2 have the respective formulae (IIa) and (IIb) or (II?a) and (II?b): a process for its preparation, and use as an adhesive.

Abstract: F1 is formula (IIa) and F2 is formula (IIb): g and d are 0, 1, 2 or 3; R14 and R15 are C1-C4 or a cyclohexyl radical; R1 to R12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R13 is oxygen or sulphur or divalent —CH2— n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.

Abstract: The present invention relates to methods and pharmaceutical compositions for preventing or reducing metastatic dissemination (i.e. reducing motility of cancer cells). In particular, the present invention relates to a method for preventing or reducing metastatic dissemination (i.e. reducing motility of cancer cells) in a subject suffering from a cancer comprising the steps consisting of i) determining the expression level of at least one biomarker selected from the group consisting of soluble CD95L and EMT promoting factors in a sample obtained from the subject, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) administering the subject with a therapeutically effective amount of C16-ceramide or derivatives such as C16-sphingomyelin and C16-glycosphingolipids when the expression level determined at step i) is higher than the predetermined reference value.

Abstract: Chalcogenide glass-ceramic having, for example, the following composition GeSe2—Sb2Se3—CuI, this glass-ceramic comprising at least one crystalline phase, characterised in that the crystallisation rate and the dimensions of the crystals in the crystalline phase are such that the crystals are substantially in contact with each other in such a way that this crystalline phase has an electrical conductivity greater than or equal to 10?4 s·cm?1 which increases under lighting due to the creation of charge carriers within the crystalline phase.

Abstract: A method for the isotopic separation of at least two different isotopes of a body in gaseous form by: (a) converting into the form of a gas (SF6, UF6 or MoF6) the body of interest containing the sought isotope; (b) creating a flow of said gas at supersonic speed, of the laminar or slightly turbulent type; (c) exciting the molecules by laser; (d) inhibiting, by means of a laser, the nucleation of one of the isotopologs, thus forming less massive aggregates of said isotopolog than the aggregates formed by the molecules of the other isotopolog; (e) ionizing the molecules and aggregates of said gas; (f) submitting the ionized molecules and aggregates of molecules to an electromagnetic field to make the ionized molecules and aggregates of one of the isotopologs migrate towards the outside of the flow; and (g) retrieving the part of the gas flow with the highest concentration in the sought isotope.

Abstract: Computer tool characterised in that it comprises: a working memory (206) to receive input data, an auxiliary memory (204) to store several approximation dictionaries, a reducer (202) arranged for the iterative calculation of the approximation data of the input data, where the successive iterations are of the “matching pursuit” type, a selector (200) arranged to choose an approximation dictionary in the auxiliary memory based on a selection rule based on at least some of the preceding iterations, in which the reducer (202) calls the selector (200) in each iteration, and uses the dictionary thus selected in the adaptive matching.

Abstract: The invention relates to the cosmetic use of a compound chosen from the compounds of formula (A) and the salts of same as an agent for depigmenting the skin and/or keratinous appendages.