Abstract: A method for determining a rate of sedimentation or of creaming of a mixture in suspension, including an application of a sample of the mixture in suspension to a photonic microresonator, an application of a first optical signal at the input of the photonic microresonator carrying the sample of the mixture in suspension, an acquisition and a recording of a second optical signal, delivered at the output of the microresonator carrying the sample of the mixture in suspension, and a determination of information representing a rate of sedimentation or of creaming of the mixture from the recorded second signal, by successive iterations of spectral analysis of the second optical signal.

Abstract: The present invention relates the field of reducing CD95-mediated cell motility in a subject, in particular for their use in the reduction of CD-95 mediated cancer cell motility, the reduction of CD95-mediated lymphocyte motility and/or B cell maturation, or the treatment of B-cell tumors, in a subject. The inventors identified a novel family of compounds having the ability to disrupt CD95/PLC?1 interaction and to neutralize the CD95-mediated calcium signaling pathway and cell migration in human peripheral blood lymphocytes (PBLs) and Th17 cells.

Abstract: The invention concerns a system for controlling the temperature of a microfluidic chip comprising a Peltier module (10) having a cold face (10a) and a hot face (10b) and connected to a power generator (11), a thermal regulation device (12) having a thermal regulated face (12a) applied against one of the faces of the Peltier module, at least one temperature sensor (17) being applied on the other face of the Peltier module and being intended to be applied against one of the main faces of a microfluidic chip and control means (18) configured to control the power generator (11) of the Peltier module depending on a temperature of the face of the Peltier module provided with said at least one temperature sensor and at least one temperature setting information selected from a target temperature and a target temporal temperature profile to regulate a temperature of the face of the Peltier module to said temperature setting information.

Abstract: The invention relates to the use of a ternary alloy having the formula SixTiyNiz, wherein x, y and z are natural numbers, for use in electrolysis and photoelectrolysis, in particular photo-oxidation of water. One aspect of the invention relates to a method for the manufacture of an electrode, the method comprising a step of heating a carrier comprising a surface having a layer of silicon on which a layer of TiO2 is disposed, the layer of TiO2 being covered with a layer of NiO; the heating step being carried out at a temperature above 1,000° C., and preferably between 1,150° C. and 1,250° C. The invention also relates to an electrode comprising a carrier, said electrode having either: an outer surface on which particles of a ternary alloy having the formula SixTiyNiz are positioned, wherein x, y and z are natural numbers, and wherein the particles form protrusions; or an outer surface consisting of a layer of said alloy, the layer comprising protrusions.

Abstract: The biotelemetry device (100) comprises a microcontroller (101) for generating an electrical setpoint signal (CS); a radio antenna (103) for transmitting an electromagnetic wave (EMS) by converting an incident electrical signal (IS); a radiofrequency circuit (102), interconnected between the microcontroller (101) and the radio antenna (103). The radio antenna (103) is configured such that, when the biotelemetry device (100) is placed in the biological medium (110), it can be impedance-mismatched relative to the radiofrequency circuit (102) so as to generate a reflected electrical signal (RS) by reflecting a fraction of the incident electrical signal at the same time that the radio antenna is transmitting the electromagnetic wave (EMS).

Abstract: The present invention relates to a reporter system for trans-translation based on the reassembly of GFP and on the capacity of tmRNA to add a peptide tag to a protein blocked on a ribosome. The invention also relates to the in vivo or in vitro use of this reporter system for studying trans-translational activity and for identifying compounds capable of inhibiting trans-translation and therefore capable of being of interest as antibiotics.

Abstract: An active light-emitting layer composition including a thermally activated delayed fluorescence (TADF) molecule with TADF properties as a host material and a luminescent molecule with circularly polarized (CP) properties as a dopant. Also, a light-emitting device, such as an organic light-emitting diodes (OLED), including the active light-emitting layer made of this composition.

Abstract: The invention relates to a monoethylenically unsaturated monomer of formula (I), and to the use thereof for producing a polymer. The invention also relates to the polymer obtained by polymerising said monomer, and to the use thereof in a composition for producing coatings.

Abstract: An optically transparent electromagnetic shielding assembly exhibiting a shielding efficiency that is increased when a conducting or polarizable fluid produces a low electrical impedance value between a periphery and a central region of a window. Such shielding assembly is useful in detection systems that are exposed to varying intensities of electromagnetic radiation, such as microwave radiation.

Abstract: A method for simulating a deep-brain stimulation in a computer-assisted platform that includes providing to a neurosurgeon, through a man-machine interface, visual information of a pre-operative situation, including a representation of a brain. The method also includes monitoring inputs of said neurosurgeon on the man-machine interface, until a trajectory is determined between an entry point and a target for the placement of an electrode. The method further includes comparing said trajectory to a set of previously-established trajectories for the pre-operative situation, so as to determine an overall measurement representative of a quality of the trajectory compared to the previously-established trajectories.

Abstract: The present invention relates to compounds simultaneously having thermally activated delayed fluorescence (TADF), circularly polarised luminescence (CPL) and aggregation-induced emission enhancement (AIEE) properties. The invention also relates to the use of such compounds as a photocatalyst or as a dopant, in particular in the emitting layers of light-emitting diodes (OLEDs), as well as light-emitting devices or light-emitting diodes (OLEDs) comprising such compounds.

Abstract: An isolated monoclonal antibody against the interleukin 1-alpha or beta receptor antagonist, known as IL-1RA. The antibody inhibits the interaction of IL-1RA with the membrane-binding chain thereof, the interleukin-1 receptor. Also, nucleic acid molecule encoding for a light chain of the monoclonal antibody, and a nucleic acid molecule encoding for a heavy chain of the monoclonal antibody. Also, a method for treating an inflammatory, infectious or autoimmune disease, which includes administering the isolated monoclonal antibody or a nucleic acid coding for the isolated monoclonal antibody, and a method of or the diagnosis of an inflammatory, infectious or autoimmune diseases, which includes contacting a biological sample with the isolated monoclonal antibody.

Abstract: The invention relates to an antenna comprising a radiative antenna element able to emit a signal in at least two disjoint frequency bands and a waveguide covered by the radiative antenna element, comprising two nested resonant cavities, each single-mode or mostly single-mode in a separate frequency band.

Abstract: The present invention concerns a solid nanocomposite material consisting of a polymer-matrix in which are dispersed alkali metal, hydronium or ammonium salts of polyanionic components, wherein the polymer-matrix comprises at least a linear or branched polymer or copolymer containing one or several poly(ethylene oxide) (PEO) chains, said polymer or copolymer being optionally crosslinked and each PEO chain having at least 4 ethylene oxide monomer units. The present invention relates also to a photonic, e.g. optoelectronic, device comprising such a nanocomposite material. Such material and device can be used as phosphorescence emitter, for crop growth lighting or for generating singlet oxygen.

Abstract: Disclosed is a radio antenna comprising a substrate of dielectric material; a ground plane of electrically conductive material on a first face of the substrate; a resonator for converting an incident electrical signal into an electromagnetic wave and for resonating at at least two different resonant frequencies. The resonator comprises at least three elements, each in the form of strips of conductive material and arranged on a second face of the substrate opposite the first face. A second element is electrically connected to the ground plane by means of a via passing through the substrate at a first end of the corresponding strip, forms an extension of the first element, and is electrically connected directly to the first element at a second end of said strip which is opposite the first end.

Abstract: The invention relates to an optical device (FILT) for filtering light received, by polarisation or mechanically, from a medium presenting a graphic and/or textual content, characterized in that cycles of opening and closing a vision space, in a visible light spectrum, are realized periodically using the optical device (FILT) at a preset frequency Fd and in that the successive open periods each have a duration (T1) comprised in an interval of values ranging from 15 to 35% of the duration (T) of the realized cycles.

Abstract: A shielding element comprises a rigid substrate and at least one electrically conductive two-dimensional structure which is placed on one of the faces of the substrate. The substrate and the electrically conductive two-dimensional structure are such that the shielding element has optical-transmission and shielding-efficiency values at least one of which varies between two zones of the shielding element. Such a shielding element enables easier assembly of a detection system comprising multiple optical sensors.

Abstract: A vibrotactile stimulation device intended to be applied against a body medium (MC) to be stimulated, produced in the form of a functional unit, comprising a vibrating effector suitable for applying, to said medium, pulses of mechanical vibrational energy, and a controller for controlling the effector according to stimulation rules. The functional unit further houses a first electrode suitable for cooperating with at least one second electrode separated from the first electrode in order to supply signals representative of a cardiac activity and a muscular activity on the medium to be stimulated, said controller being sensitive to cardiac activity and muscular activity signals in order to influence the stimulation. The stimulation device may be used for body stimulation in combating sleep apnea, with improved detection.

Abstract: A method of obtaining 3D cell structures including differentiated human hepatic cells. The method includes: a first step of culturing stem cell-derived or immortalized human hepatic progenitors in a non-adherent culture vessel, preferably a low or ultra-low attachment culture vessel; a second step of transferring the stem cell-derived or immortalized human hepatic progenitors to a culture medium including methacrylated gelatin (GelMa), thereby embedding the stem cell-derived or immortalized human hepatic progenitors in a GelMa matrix; and a third step of covering the GelMa matrix with culture medium and culturing the stem cell-derived or immortalized human hepatic progenitors embedded in the GelMa matrix, thereby obtaining 3D cell structures including differentiated human hepatic cells. Also, methods for engineering an artificial liver model or an artificial liver organ, and for assessing in vitro the metabolism, toxicity and/or therapeutic effects of a compound.

Abstract: The present invention relates to a method of treatment and method of therapy selection for patient suffering from cancer. The inventors provide the first demonstration of a dual role of IRE1 downstream signaling in cancer. Indeed, the inventors demonstrate that the modulation of IRE1 signaling characteristics in GBM cells controls tumor aggressiveness. Furthermore, the inventors provide evidence supporting a novel concept where IRE-downstream signals play combined/integrated roles in cancer development, where XBP1s provides pro-tumoral signals, whereas RIDD of mRNA and miR17 rather elicits anti-tumoral features. Their data, obtained using established cell lines, patient tumor samples and primary GBM lines, depict a complex scenario where IRE1 signaling orchestrates distinct aspects of GBM biology. In particular, the invention relates to a method for predicting whether a subject will be eligible to a treatment with an IRE1 RNase inhibitor.