Abstract: A vibrotactile stimulation device intended to be applied against a body medium (MC) to be stimulated, produced in the form of a functional unit, comprising a vibrating effector suitable for applying, to said medium, pulses of mechanical vibrational energy, and a controller for controlling the effector according to stimulation rules. The functional unit further houses a first electrode suitable for cooperating with at least one second electrode separated from the first electrode in order to supply signals representative of a cardiac activity and a muscular activity on the medium to be stimulated, said controller being sensitive to cardiac activity and muscular activity signals in order to influence the stimulation. The stimulation device may be used for body stimulation in combating sleep apnea, with improved detection.

Abstract: The present invention relates to method of therapy selection for patient suffering from glioblastoma. Using in vitro and in vivo approaches, the inventors demonstrated the critical role of CD90 in GBM migration/invasion. They showed that CD90 signaling though SRC, FAK and RhoA promotes cell migration and importantly, that high CD90 expression impacts on the cell response to the SRC inhibitor dasatinib. In particular, the present invention relates to a method for predicting whether a subject will be eligible to a treatment with a drug selected from the group consisting of SRC inhibitor, FAK inhibitor or RhoA inhibitor by determining the expression level of CD90 in a sample obtained from the subject.

Abstract: A vibrotactile stimulation device intended to be applied against a body environment (MC) to be stimulated and having a vibrating effector suitable for applying, to the environment, pulses of mechanical vibrational energy, and a controller controlling the effector according to stimulation rules. The device further includes vibration detector suitable for being exposed to the body environment in order to receive a part of the vibrational energy transmitted to the environment during the application of the pulses of vibrational energy, and determine a transmission characteristic of the vibrational energy between the effector and the environment to be stimulated, the vibration detector being linked to the controller. An application to improving the efficacy of body stimulation in combating sleep apnea is also disclosed.

Abstract: Disclosed is a process and device allowing for fast measurements of the physicochemical properties of amphiphiles (lipids, surfactants, soaps, . . . ). A Marangoni flow is created and characterized using amphiphiles to be characterized. The observed flow is characterized, and using the disclosed process, one can deduce from this measurement many important physicochemical parameters of the amphiphiles such as their critical micellar concentration. Compared to existing techniques, the disclosed process offers the advantage that it requires a single experiment to deduce the parameters, when other techniques (pendant drop method, conductometry, etc . . . ) require the measurement of a quantity (interfacial tension, conductometry) against a systematically varied parameter (amphiphile concentration, . . . ). The disclosed process and devices are ideal to characterize and/or screen rapidly amphiphiles molecules based on their interaction with a solvent.

Abstract: The present invention provides a curable adhesive composition comprising at least one curable silylated polymer and at least one curing catalyst obtained by reaction of a metal alkoxide and an oxime. The present invention also provides the use of a metal compound obtained by reaction of a metal alkoxide and an oxime as curing catalyst for silylated polymers.

Abstract: 1) Hydrocarbon-based polymer of formula (I): in which F1 and F2 have the respective formulae (IIa) and (IIb) or (II?a) and (II?b): a process for its preparation, and use as an adhesive.

Abstract: 1) Hydrocarbon polymer having two azlactone end groups F1 is formula (IIa) and F2 is formula (IIb): g and d are 0, 1, 2 or 3; R14 and R15 are C1-C4 or a cyclohexyl radical; R1 to R12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R13 is oxygen or sulphur or divalent —CH2— n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.

Abstract: 1) Hydrocarbon-based polymer of formula (I): in which F1 and F2 have the respective formulae (IIa) and (IIb) or (II?a) and (II?b): a process for its preparation, and use as an adhesive.

Abstract: F1 is formula (IIa) and F2 is formula (IIb): g and d are 0, 1, 2 or 3; R14 and R15 are C1-C4 or a cyclohexyl radical; R1 to R12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R13 is oxygen or sulphur or divalent —CH2— n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.

Abstract: The present invention relates to methods and pharmaceutical compositions for preventing or reducing metastatic dissemination (i.e. reducing motility of cancer cells). In particular, the present invention relates to a method for preventing or reducing metastatic dissemination (i.e. reducing motility of cancer cells) in a subject suffering from a cancer comprising the steps consisting of i) determining the expression level of at least one biomarker selected from the group consisting of soluble CD95L and EMT promoting factors in a sample obtained from the subject, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) administering the subject with a therapeutically effective amount of C16-ceramide or derivatives such as C16-sphingomyelin and C16-glycosphingolipids when the expression level determined at step i) is higher than the predetermined reference value.

Abstract: The invention relates to a method for coating an organic or metallic material by covalent grafting of at least one organic compound A having at least one aromatic group substituted with a diazonium function, on a surface of said material, characterized in that the material is porous or fibrillar having a geometric surface area of at least 10 cm2 of material, and in that said method includes a step of continuous imposition of a non-zero pulsed current in an intensiostatic mode on the surface of the material in order to electrochemically reduce the diazonium ion or ions. The invention further relates to the resulting composite materials and to the use of such materials for manufacturing electrodes.

Abstract: A vibrotactile stimulation device intended to be applied against a body environment (MC) to be stimulated and comprising a vibrating effector suitable for applying, to said environment, pulses of mechanical vibrational energy, and a controller controlling the effector according to stimulation rules. The device is remarkable in that it further comprises vibration detector suitable for being exposed to the body environment in order to receive a part of the vibrational energy transmitted to said means by said environment during the application of the pulses of vibrational energy, and determine a transmission characteristic of the vibrational energy between the effector and the environment to be stimulated, said vibration detector being linked to the controller. An application to improving the efficacy of body stimulation in combating sleep apnoea is also disclosed.

Abstract: A vibrotactile stimulation device intended to be applied against a body medium (MC) to be stimulated, produced in the form of a functional unit, comprising a vibrating effector suitable for applying, to said medium, pulses of mechanical vibrational energy, and a controller for controlling the effector according to stimulation rules. The functional unit further houses a first electrode suitable for cooperating with at least one second electrode separated from the first electrode in order to supply signals representative of a cardiac activity and a muscular activity on the medium to be stimulated, said controller being sensitive to cardiac activity and muscular activity signals in order to influence the stimulation. The stimulation device may be used for body stimulation in combating sleep apnea, with improved detection.

Abstract: The invention relates to a therapeutic composition including a complex having the following formula (1), including a rare-earth radioisotope in ionic form, said complex being solubilized in an organic lipophilic phase: [M(L)3] in which: M denotes the rare-earth radioisotope in ionic form, and L denotes a tropolone ligand or a ligand derived from tropolone.

Abstract: A method for preparing a powder of an alloy based on uranium and molybdenum in a metastable ? phase is provided, which comprises: a) putting at least one first reagent selected from uranium oxides and mixtures thereof, uranium fluorides and mixtures thereof, into contact with a second reagent consisting in molybdenum and a third reagent consisting in a reducing metal, the first, second and third reagents being in a divided form; b) reacting the reagents at a temperature?the melting temperature of the third reagent and under an inert atmosphere, whereby this reaction leads to the formation of the alloy comprising uranium and molybdenum in the form of a powder, for which the particles are covered with a reducing metal oxide or fluoride layer; c) cooling the so formed powder at a rate at least equal to 450° C./hour; and d) removing the reducing metal oxide or fluoride layer which covers the particles of the powder of the alloy comprising uranium and molybdenum.

Abstract: Cyclic peptides having a random alternation of L-?-aminoacyl residues and aza-?3-aminoacyl residues and their uses.

Abstract: The invention relates to new 3?-, 7-substituted-indirubins of formula (I) wherein R represents N—OH, N—O-alkyl or N—O—CO-alkyl, NO—(Ra)n1-Het, N—O—(Y)n1—NRaRb, N—O—CO—N(RbRc), radical with Het representing an aliphatic nitrogeneous heterocycle, Y being an optionally substituted —CH2— radical, n1 being 1 to 3, and X is an halogen atom selected in the group comprising F, Cl, Br, I, and Z is H or CH3 and the salts thereof.

Abstract: Cyclic peptides having a random alternation of L-?-aminoacyl residues and aza-?3-aminoacyl residues and their uses.

Abstract: An apparatus for testing passive two terminal devices in the VHF range comprises an electrical signal generator whose frequency is variable over the VHF range, a distributed constant line having a first end connected to the generator and a second end connected to the device to be tested. A resistive .pi. network is connected to the first end of the line to measure directly the values of the incident wave and of the reflected wave or the maxima and the minima of the total wave at the first end of the line are detected, so as to determine the coefficient of reflection of the line connected to the device to be tested.

Abstract: Nitrides and oxynitrides which can be used as selective detectors of reducing gases in the atmosphere, and a detection device containing them. Selective detectors of nitrogen-containing reducing gases in the atmosphere, in particular ammonia and gases containing NH and/or NH.sub.2 groups, of the semiconductor resistance type, the nitrides and oxynitrides according to the invention are of tetrahedral structure and contain:a metal chosen from the group comprising Li, Na, K, Be, Mg, Ca, Sr, Ba, Zn and Mn;a second element chosen from the group comprising Si, Ge, P, Al and Ga;nitrogen and, if appropriate,oxygen.