Abstract: A motorized, modular instrumentation device and an endoscopy system including such device. The motorized, modular instrumentation device includes at least one operational unit mounted on at least one support structure and integrating a motorized medical instrument module including, first, an elongated medical instrument with a tool arranged on one distal end, it being possible to bend the corresponding end portion of the instrument, and second, at least one electrical actuating element controlling the operation of the tool and/or the bending of the distal end portion, via transmission elements extending within the elongated body of the instrument. The actuating element(s) is/are installed in a hollow body connected to the proximal end of the instrument and the hollow body is itself arranged, with rotational guiding, within a reception housing adapted to move, at least translationally, on the support structure, the movements of the hollow body and the reception housing being motorized.