Patents Assigned to Universite de Tours
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Publication number: 20240424086Abstract: A fusion protein including fragments of the spike protein and of the nucleoprotein of a coronavirus. Also a vaccine, a composition, a pharmaceutical composition, or a diagnostic kit including the fusion protein, a method for diagnosing an infection by a coronavirus and to a method for preventing or treating a coronavirus infection based on the use of the fusion protein.Type: ApplicationFiled: September 7, 2022Publication date: December 26, 2024Applicants: UNIVERSITE DE TOURS, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (INRAE), UNIVERSITÉ DE LILLE, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, CENTRE HOSPITALIER UNIVERSITAIRE DE LILLEInventors: Nicolas AUBREY, Fanny BOURSIN, Zineb LAKHRIF, Isabelle DIMIER-POISSON, Mathieu EPARDAUD, Rodolphe CARPENTIER, Antoine TOUZE, Marie-Noëlle MEVELEC
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Patent number: 12123058Abstract: A method for predicting the risk of prostate cancer recurrence in a subject affected with prostate cancer, including: (a) providing a sample from the subject, (b) determining the TMPRSS/ERG fusion status of the sample, (c) if the sample is positive for TMPRSS/ERG fusion (Fus+), determining a molecular signature of the sample by measuring the expression level of at least 6 prostate cancer markers selected from the ANPEP, AZGP1, CHRNA2, COMP, KHDRBS3 and SFRP4, (d) comparing the molecular signature to a reference signature, and (e) assigning the subject to a risk group based on the correlation of the molecular signature with the reference signature, thereby predicting the risk of cancer recurrence in the subject.Type: GrantFiled: January 25, 2019Date of Patent: October 22, 2024Assignees: SORBONNE UNIVERSITE, CTRE RECHERCHE PATHOLOGIES PROSTATIQUES, LIGUE NATIONALE CONTRE LE CANCER, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ DE TOURS, CENTRE HOSPITALIER RÉGIONAL UNIVERSITAIRE DE TOURSInventors: Olivier Cussenot, Aurélie Kamoun, Aurélien De Reynies, Géraldine Cancel-Tassin, Gaëlle Fromont-Hankard
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Patent number: 12115393Abstract: The present invention relates the field of ultrasound and neurostimulation. The inventors have shown that using ultrasound neurostimulation with specific parameters provides similar or better effects that fluoxetine administration in depression. Such assessment was made in unpredictable chronic mild stress model in mouse. The proposed use also provides with positive effects in other cases, such as modulating emotion or attenuating anxiety-related behaviours (stress notably).Type: GrantFiled: May 11, 2020Date of Patent: October 15, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ DE TOURSInventors: Ayache Bouakaz, Catherine Belzung
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Patent number: 12085630Abstract: The invention relates to quality control devices and methods for magnetic resonance imaging (MRI) systems, more particularly for medical imaging applications. An example is stereotactic surgery where MRI images are combined with X-ray images to accurately locate a target in a subject. A test device (1), and an associated method using said test object, are used to easily detect a faulty calibration or a malfunction of an MRI device. The test device includes: a hermetically sealable hollow body (20) having a substantially cylindrical shape, a support frame (22) configured to be removably inserted in the hollow body and defining a target region (V22) having a substantially cylindrical shape; and a plurality of target objects (24) made of a material visible on X-ray images and MRI images said target objects being arranged in the target region and being attached to the support frame.Type: GrantFiled: August 6, 2020Date of Patent: September 10, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE TOURS, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURSInventors: Christophe Destrieux, Laurent Barantin
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Patent number: 11932638Abstract: The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R? is an -A1-Cy1 group, or R is an -A1-Cy1 group and R? is an R1 group, R1 particularly being H or (C1-C6)alkyl group; A1 being an —NH— radical or —NH—CH2— radical; Cy1 particularly being a phenyl group, A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.Type: GrantFiled: May 23, 2018Date of Patent: March 19, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE, UNIVERSITE D'ORLEANS, UNIVERSITE DE TOURS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE SCIENTIFIQUE (INSERM), CHU NANTESInventors: Sylvain Routier, Frédéric Buron, Nuno Rodrigues, Gaëlle Fourriere-Grandclaude, Christophe Vandier, Aurélie Chantome, Marie Potier-Cartereau, Maxime Gueguinou, Séverine Marionneau-Lambot
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Publication number: 20230372416Abstract: A combination of agents capable of binding an infectious agent, such as an antibody, an antibody derivative, or an antibody mimetic, and immunomodulatory agents, such as probiotic strains, for the treatment or prevention of respiratory infections, in particular bacterial respiratory infections. The agents capable of binding an infectious agent are administered by inhalation.Type: ApplicationFiled: October 8, 2021Publication date: November 23, 2023Applicants: UNIVERSITÉ DE TOURS, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Nathalie HEUZE-VOURC'H, Thomas SECHER, Muriel THOMAS
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Publication number: 20230287031Abstract: New glycolipids derivatives of Formula (I) and their use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels. Also, pharmaceutical compositions including compounds of Formula (I) for use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels.Type: ApplicationFiled: July 16, 2021Publication date: September 14, 2023Applicants: UNIVERSITÉ DE BRETAGNE OCCIDENTALE, UNIVERSITÉ DE TOURS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALEInventors: Paul Alain JAFFRES, Hélène COUTHON, Charlotte SEVRAIN, Alicia BAUDUIN, Christophe VANDIER, Aurélie CHANTÖME, Delphine FONTAINE
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Publication number: 20230236122Abstract: A method for determining the risk of developing a blood disorder, which includes the steps of: exposing a biological sample from an individual to radiation to obtain a spectrum characteristic of the sample, the spectrum being processed in order to obtain a spectral signature; comparing the spectral signature obtained with one or more reference spectral signatures; and concluding, if the spectral signature of the individual is significantly different from control spectral signatures, that the individual is likely to develop a blood disorder, and, if not, that the individual is not likely to develop a blood disorder.Type: ApplicationFiled: May 24, 2021Publication date: July 27, 2023Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS, UNIVERSITÉ DE TOURSInventors: Olivier HERAULT, Olivier SIRE
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Publication number: 20230203197Abstract: New human therapeutic monoclonal antibodies, which are directed against neutrophil proteinase 3. The monoclonal antibodies are specifically directed against a conformational epitope of the neutrophil proteinase 3 and are capable of inhibiting by at least 30% the production for reactive oxygen derivatives by neutrophils. Also, a pharmaceutical composition including as an active substance at least the monoclonal antibody, and a method for early treatment and/or prevention of relapse of granulomatosis with polyangiitis, which includes the administration of the pharmaceutical composition.Type: ApplicationFiled: October 16, 2020Publication date: June 29, 2023Applicants: UNIVERSITE DE TOUR, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Roxane LEMOINE, Cyrille HOARAU, Eric MORELLO, Brice KORKMAZ, Yann GALLAIS
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Publication number: 20220396612Abstract: A new monoclonal antibody targeting the VP-1 protein of the capsid of the BK polyomavirus, fragments thereof, and uses of same for detecting infection with the BK polyomavirus. The monoclonal antibody is capable of recognizing at least all serotypes Ia, Ib2, II, III and IV of the VP-1 protein of the BK polyomavirus.Type: ApplicationFiled: June 2, 2020Publication date: December 15, 2022Applicants: UNIVERSITÉ DE TOURS, UNIVERSITE DE PICARDIE JULES VERNE, CENTRE HOSPITALIER UNIVERSITAIRE AMIENS-PICARDIEInventors: Antoine TOUZE, Pauline GABORIAUD, Etienne BROCHOT
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Patent number: 11504094Abstract: An apparatus and a method for contrast-enhanced ultrasound (CEUS) including use of a fluid dynamics model for the analysis of dynamic contrast-enhanced ultrasound (DCEUS).Type: GrantFiled: July 27, 2018Date of Patent: November 22, 2022Assignees: (INSERM) INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ DE TOURS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX (IPB)Inventors: Baudouin Denis de Senneville, Franck Perrotin, Jean-Michel Escoffre, Ayache Bouakaz
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Publication number: 20220233607Abstract: A strain of an Apicomplexa of the family Sarcocystidae, wherein the strain is replicative and expresses one or more heterologous protein(s) selected from the group including therapeutic proteins, antigens, recombinant surface receptor or combinations thereof, and wherein the strain is selected from the group including Toxoplasma gondii and Neospora caninium. Also, the use of the strain for preventing or treating cancers or infectious diseases in a subject in need thereof.Type: ApplicationFiled: May 29, 2020Publication date: July 28, 2022Applicants: UNIVERSITÉ DE TOURS, KYMERIS THERAPEUTICS INC., INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L' ALIMENTATION ET L'ENVIRONNEMENTInventors: Isabelle DIMIER-POISSON, Marie-Noëlle MEVELEC, Anne DI TOMMASO, Nicolas AUBREY, Louis LANTIER, Gordon LEE
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Patent number: 11340211Abstract: The invention relates to an in vitro method for evaluating digestive efficiency (DE) of poultry, in particular chickens, by measuring color of a sample of liquid fraction of blood of said poultry.Type: GrantFiled: September 13, 2019Date of Patent: May 24, 2022Assignees: UNIVERSITE DE TOURS, INSTITUT NATIONAL DE RECHERCHE POUR LAGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENTInventors: Sandrine Grasteau, Elisabeth Duval, Stéphane Beauclercq
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Patent number: 10961588Abstract: This invention relates to an in vitro method for prognosis of the response to a chemotherapy of an individual suffering from chronic myeloid leukemia, comprising a. a step of measuring the expression level of at least one subgroup of genes chosen from a group of genes, b. a comparing step, and c. a step of determining a score S such that—if S is less than 1, said individual will have more than a 40% chance of responding to the chemotherapy, and—if S is greater than or equal to 1, said individual will have less than a 40% chance of responding to the chemotherapy.Type: GrantFiled: November 26, 2015Date of Patent: March 30, 2021Assignee: UNIVERSITÉ DE TOURSInventor: Olivier Herault
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Publication number: 20210040563Abstract: A method for predicting the risk of prostate cancer recurrence in a subject affected with prostate cancer, including: (a) providing a sample from the subject, (b) determining the TMPRSS/ERG fusion status of the sample, (c) if the sample is positive for TMPRSS/ERG fusion (Fus+), determining a molecular signature of the sample by measuring the expression level of at least 6 prostate cancer markers selected from the ANPEP, AZGP1, CHRNA2, COMP, KHDRBS3 and SFRP4, (d) comparing the molecular signature to a reference signature, and (e) assigning the subject to a risk group based on the correlation of the molecular signature with the reference signature, thereby predicting the risk of cancer recurrence in the subject.Type: ApplicationFiled: January 25, 2019Publication date: February 11, 2021Applicants: SORBONNE UNIVERSITE, CTRE RECHERCHE PATHOLOGIES PROSTATIQUES, LIGUE NATIONALE CONTRE LE CANCER, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ DE TOURS, CENTRE HOSPITALIER RÉGIONAL UNIVERSITAIRE DE TOURSInventors: Olivier CUSSENOT, Aurélie KAMOUN, Aurélien DE REYNIES, Géraldine CANCEL-TASSIN, Gaëlle FROMONT-HANKARD
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Patent number: 10906900Abstract: The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases.Type: GrantFiled: September 26, 2017Date of Patent: February 2, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'ORLEANS, UNIVERSITE DE TOURS, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Sylvain Routier, Franck Suzenet, Sylvie Chalon, Frederic Buron, Johnny Vercouillie, Ronald Melki, Liliana Boiaryna, Denis Guilloteau, Laura Pieri
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Patent number: 10814079Abstract: A nasal fluid-spray device having: a reservoir containing at least one dose (D) of fluid; and a dispenser system that, each time the device is actuated, sprays a dose (D) of fluid through a spray orifice, generating a spray that extends axially from the spray orifice. The device further includes a generator system for generating a secondary flow, which generator system is actuated simultaneously with the dispenser system, the secondary flow generator system having a secondary flow channel provided with an outlet orifice, the outlet orifice arranged downstream from the spray orifice, and the secondary flow extending from the outlet orifice along an axis (B) that forms an angle (?) relative to the axis (A) of the spray and that intersects the axis (A), thereby deforming and/or deflecting the spray.Type: GrantFiled: September 1, 2015Date of Patent: October 27, 2020Assignee: UNIVERSITE DE TOURSInventors: Mirvatte Francis, Laurent Vecellio-None
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Publication number: 20200330568Abstract: The present invention relates to a strain of Neospora caninum for use in treating cancer or infectious diseases.Type: ApplicationFiled: July 1, 2020Publication date: October 22, 2020Applicants: UNIVERSITÉ DE TOURS, KYMERIS THERAPEUTICS INC., Institut national de recherche pour l'agriculture, l'alimentation et l'environnementInventors: Isabelle DIMIER-POISSON, Marie-Noëlle MEVELEC, Céline DUCOURNAU, Nathalie MOIRE, Richard MCCRAE
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Patent number: 10766930Abstract: An immunogenic fusion protein includes at least the following two peptides a) —on the C-terminal side, a first peptide constituted of: —the amino acid sequence of the protein S or the protein M of a human hepatitis B virus (HBV) isolate, which protein S or protein M is optionally deleted at the N-terminal end thereof, and b) —on the N-terminal side, a second peptide constituted of: —the sequence of amino acids of at least one transmembrane domain and the ectodomain of at least one protein of a Zika virus isolate selected from the envelope protein E or a fusion peptide including the envelope protein E and the protein prM.Type: GrantFiled: June 16, 2017Date of Patent: September 8, 2020Assignees: UNIVERSITE DE TOURS, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE—INSERMInventors: Christophe Hourioux, Romuald Patient, Elodie Beaumont, Philippe Roingeard
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Patent number: 10736947Abstract: The present invention relates to a strain of Neospora caninum for use in treating cancer or infectious diseases.Type: GrantFiled: June 8, 2018Date of Patent: August 11, 2020Assignees: UNIVERSITÉ DE TOURS, KYMERIS THERAPUETICS INC., Institut national de recherche pour l' agriculture, l' alimentation et l'environneementInventors: Isabelle Dimier-Poisson, Marie-Noëlle Mevelec, Céline Ducournau, Nathalie Moire, Richard McCrae