Abstract: The present invention relates to a product selected from a protein, a fragment of the protein, a derived sequence and a homologous sequence of the protein, the protein including or being constituted by the 28 kDa glutathione S-transferase protein from a schistosome selected from Schistosoma haematobium, Schistosoma mansoni, Schistosoma bovis represented respectively by the sequences SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 for the use thereof in the treatment of an inflammatory autoimmune disease generating a response of type Th1 and/or Th17.
Type:
Grant
Filed:
February 6, 2013
Date of Patent:
March 14, 2017
Assignees:
UNIVERSITE DU DROIT ET DE LA SANTE DE LILLE 2, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
Inventors:
Monique Capron, Mohamed El Nady, Jean-Frederic Colombel, Gilles Riveau
Abstract: The present invention relates to a product selected from a protein, a fragment of the protein, a derived sequence and a homologous sequence of the protein, the protein including or being constituted by the 28 kDa glutathione S-transferase protein from a schistosome selected from Schistosoma haematobium, Schistosoma mansoni, Schistosoma bovis represented respectively by the sequences SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 for the use thereof in the treatment of an inflammatory autoimmune disease generating a response of type Th1 and/or Th17.
Type:
Application
Filed:
February 6, 2013
Publication date:
April 30, 2015
Applicants:
UNIVERSITE DU DROIT ET DE LA SANTE DE LILLE 2, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
Inventors:
Monique Capron, Mohamed El Nady, Jean-Frederic Colombel, Gilles Riveau
Abstract: Process for preserving insulin secreting cells intended to be transplanted, including the following steps: introducing an initial volume of culture medium and insulin-secreting cells into a culture container, providing a culture medium source, and replacing, at time intervals below 8 hours, the culture medium in the culture container with culture medium from the source so as to renew the culture medium contained in the container.
Type:
Grant
Filed:
May 15, 2009
Date of Patent:
February 4, 2014
Assignees:
Maco Pharma, Centre Hospitalier Regional Universitaire de Lille, Universite du Droit et de la Sante de Lille 2
Inventors:
Francois Pattou, Julie Kerr-Conte, Cecile Coissac Blondel, Bruno Lukowiak, Brigitte Vandewalle, Antoine Heron
Abstract: A method for preserving a preparation of insulin-secreting cells includes the step of placing the preparation of insulin-secreting cells in contact with a biological medium, the biological medium including a nutritive product including albumin, and further includes a peptone or a mixture of peptones in sufficient quantity to preserve the insulin-secreting cells.
Type:
Application
Filed:
May 5, 2011
Publication date:
January 5, 2012
Applicants:
MACO PHARMA, UNIVERSITE DU DROIT ET DE LA SANTE DE LILLE 2, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
Abstract: The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.
Type:
Grant
Filed:
December 28, 2006
Date of Patent:
November 16, 2010
Assignees:
Institute Pasteur de Lille, Inserm (Institut National de la Sante Et de la Recherche Medicale), Universite Libre de Bruxelles, Universite du Droit Et de la Sante de Lille II
Abstract: Process for preserving insulin secreting cells intended to be transplanted, including the following steps: introducing an initial volume of culture medium and insulin-secreting cells into a culture container, providing a culture medium source, and replacing, at time intervals below 8 hours, the culture medium in the culture container with culture medium from the source so as to renew the culture medium contained in the container.
Type:
Application
Filed:
May 15, 2009
Publication date:
November 19, 2009
Applicants:
MACO PHARMA, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE, UNIVERSITE DU DROIT ET DE LA SANTE DE LILLE 2
Inventors:
Francois Pattou, Julie Kerr-Conte, Cecile Coissac Blondel, Bruno Lukowiak, Brigitte Vandewalle, Antoine Heron
Abstract: The eye is positioned relative to a detection device in such a manner as to co-operate with the device to form a Fabry-Perot cavity having a main optical axis and comprising two opposite reflecting faces on the main optical axis, one of these two faces being constituted by a stationary reflecting element and the other being formed by the cornea of the eye. An incident laser beam is injected into said cavity so as to be centered on the main optical axis of the Fabry-Perot cavity, the cornea is aligned laterally and longitudinally relative to the main optical axis in such a manner as to obtain longitudinal interference between the go and the return laser beams reflected between the two reflecting faces of the cavity, and an optoelectronic detector is used to detect the intensity I of said interference as a function of time. The invention is applicable to measuring intraocular pressure.
Type:
Grant
Filed:
October 9, 2001
Date of Patent:
October 28, 2008
Assignees:
Centre Hospitalier Regional Universitaire de Lille, Universite des Sciences et Technologies de Lille, Universite du Droit et de la Sante de Lille
Abstract: The present invention relates to a method for the preparation of a macromolecule produced by bacteria of the Bifidobacterium breve I-2219 strain and the use of the said macromolecule for the preparation of medicines designed for the prevention and treatment of inflammatory rheumatic disease.
Type:
Application
Filed:
October 14, 2005
Publication date:
February 14, 2008
Applicant:
UNIVERSITE DU DROIT ET DE LA SANTE DE LILLE
Inventors:
Marie-Benedicte ROMOND, Marie-Francoise ODOU-PARIS, Elisabeth SINGER
Abstract: The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.
Type:
Application
Filed:
December 28, 2006
Publication date:
September 13, 2007
Applicants:
Institut Pasteur de Lille, Inserm (institut National de la Sante et de la Recherche Medicale), Universite Libre de Bruxelles, Universite du Droit et de la Sante de Lille II