Abstract: A nasal fluid-spray device having: a reservoir containing at least one dose (D) of fluid; and a dispenser system that, each time the device is actuated, sprays a dose (D) of fluid through a spray orifice, generating a spray that extends axially from the spray orifice. The device further includes a generator system for generating a secondary flow, which generator system is actuated simultaneously with the dispenser system, the secondary flow generator system having a secondary flow channel provided with an outlet orifice, the outlet orifice arranged downstream from the spray orifice, and the secondary flow extending from the outlet orifice along an axis (B) that forms an angle (?) relative to the axis (A) of the spray and that intersects the axis (A), thereby deforming and/or deflecting the spray.

Abstract: The present invention relates to the field of mechanical-ventilation devices, in particular devices that enable drugs to be fed into the airflow, generated by the ventilation device and directed to the respiratory pathways of a patient, using an aerosol dosing device and/or nebulizer. Specifically, the invention relates to an inhalation chamber (1) to be built into a circuit of a mechanical-ventilation respiratory device (100) through which a gas stream is to pass, said inhalation chamber (1) consisting of two portions on either side of the longitudinal axis (A) thereof, and comprising openings that lead into the inner space (Vi) thereof, wherein two openings (10, 11) are to be connected to the circuit of the respirator, i.e.

Abstract: Strains of Sarcocystidae selected from Toxoplasma spp or Neospora spp isolated from their natural environment and having an immunostimulant effect, for the use thereof in the prevention or the treatment, in a mammal, of a pathology associated with an apicomplexan of the family Cryptosporidiidae.

Abstract: Disclosed is a method for the diagnosis, and/or the classification, of a hematological disorder, including the steps of: a). measuring, the expression level of at least the genes of a sub-group of 6 genes, b). comparing the expression level of each genes measured in step a)., with the expression level of the same genes in healthy control sample, and c). determining the status of the biological sample.

Abstract: The present invention relates to the use of a specific family of glycerolipid compounds of formula (I) described in the detailed description or the manufacture of a medicament for the prevention or for the treatment of cancer metastasis.

Abstract: An immunogenic fusion protein includes at least, on the C-terminal side, a first peptide composed of the S protein deleted of the transmembrane domain thereof located at the N-terminal end thereof, of a hepatitis B virus (HBV) isolate, and on the N-terminal side, a second peptide composed of the transmembrane domain and of the ectodomain of at least one envelope protein of a hepatitis C virus (HCV) isolate. A hybrid nucleic acid molecule encoding the fusion protein, and a vector including the hybrid nucleic acid molecule, a subviral particle including the fusion protein, an immunogenic composition including at least the fusion protein, or at least the hybrid nucleic acid molecule, or at least the subviral particle, and a cell line for the production of the fusion protein, or of the hybrid nucleic acid molecule, or of the subviral particle are described.

Abstract: The disclosure relates to an acoustic method and device for localized, contactless, measurement of elastic and dissipative non-linearities and dynamic non-linear viscoelasticity in a medium subjected to a low-frequency acoustic stress and probed by ultrasonic pulses or wave trains.

Abstract: Disclosed is a method for the diagnosis, and/or the classification, of a hematological disorder, including the steps of: a). measuring, the expression level of at least the genes of a sub-group of 6 genes, b). comparing the expression level of each genes measured in step a)., with the expression level of the same genes in healthy control sample, and c). determining the status of the biological sample.

Abstract: The present invention relates to the use of a specific family of glycerolipid compounds of formula (I) described in the detailed description or the manufacture of a medicament for the prevention or for the treatment of cancer metastasis.

Abstract: Methods are provided to determine the cancer prognosis of subjects and/or to adapt the treatment protocol of subjects having or susceptible to cancer. Embodiments include the steps of determining in vitro the genotype of said subject at a polymorphism in the C3-ITGAM axis, making a cancer prognosis of the subject based on said genotype and selecting an anti-cancer treatment for the subject.

Abstract: The disclosure relates to an acoustic method and device for localized, contactless, measurement of elastic and dissipative non-linearities and dynamic non-linear viscoelasticity in a medium subjected to a low-frequency acoustic stress and probed by ultrasonic pulses or wave trains.

Abstract: An immunogenic fusion protein includes at least, on the C-terminal side, a first peptide composed of the S protein deleted of the transmembrane domain thereof located at the N-terminal end thereof, of a hepatitis B virus (HBV) isolate, and on the N-terminal side, a second peptide composed of the transmembrane domain and of the ectodomain of at least one envelope protein of a hepatitis C virus (HCV) isolate. A hybrid nucleic acid molecule encoding the fusion protein, and a vector including the hybrid nucleic acid molecule, a subviral particle including the fusion protein, an immunogenic composition including at least the fusion protein, or at least the hybrid nucleic acid molecule, or at least the subviral particle, and a cell line for the production of the fusion protein, or of the hybrid nucleic acid molecule, or of the subviral particle are described.

Abstract: The invention relates to a system for locating an object in a volume comprising:—a first matrix of scanning antennas positioned in a first plane;—first detection means arranged so as to detect a first signal received by the object in response to a first electromagnetic signal emitted by the first matrix towards the volume;—first means of two-dimensional locating that are arranged so as to determine the position of a projection of the object into the first plane as a function of the first signal received; in which the system comprises:—a second matrix of scanning antennas which is positioned in a second plane, the second plane not being parallel to the first plane, second detection means arranged so as to detect a second signal received by the object in the volume in response to a second electromagnetic signal emitted by the second matrix of antennas towards the volume;—second means of two-dimensional locating which are arranged so as to determine the position of a projection of the object in the second plane

Abstract: The invention relates to hyperactive, non-phosphorylated, mutant transposases of mariner mobile genetic elements. The invention also relates to recombinant nucleotide sequences encoding such transposases. The invention further relates to a method of producing said transposases and to the use thereof for in vitro or in vivo transposition.

Abstract: The invention relates to hyperactive, non-phosphorylated, mutant transposases of mariner mobile genetic elements. The invention also relates to recombinant nucleotide sequences encoding such transposases. The invention further relates to a method of producing said transposases and to the use thereof for in vitro or in vivo transposition.