Abstract: A pharmaceutical composition in which the active substance includes or is: (i) a protein including the sequence SEQ ID NO: 1, representing the APRIL protein, (ii) any derived protein, which is derived from protein of sequence SEQ ID NO: 1 by substitution, removal or addition of one or more amino-acids, provided it allows the binding of the derived protein to an astrocyte and/or CSPG, (iii) any homologous protein, the sequence of which has a percentage of identity of at least approximately 70%, and in particular 85% with the sequence SEQ ID NO: 1, provided it allows the binding of the homologous protein to an astrocyte and/or CSPG, or (iv) any fragment of the protein of sequence SEQ ID NO: 1, provided it allows the binding of the fragment to an astrocyte and/or CSPG. The active substance is in association with an acceptable pharmaceutical vehicle.

Abstract: A capsule configured for collecting samples in the intestine, comprising a body delimiting at least one compartment for receiving samples and comprising at least one opening for samples intake, and a mobile mechanism for opening and/or closing the opening controlled by the dissolution of a material which is dissolvable in the intestine.

Abstract: A minimally invasive system for dynamic correction of a spinal deformity in patients includes: a flat ligament made of synthetic material, a plurality of staples intended to be anchored on a respective vertebral body of the patient to hold the ligament against each vertebral body, and a device for mechanically tensioning the ligament.

Abstract: A method is described to regenerate an oxygen trap, comprising at least the following steps: circulating a current in the trap material (2) to reduce this material; measuring the value Im of the current and estimating its derivative dIm/dt in relation to time; estimating the length (?) of material reduced by the current as a function of the value of the current and its derivative; stopping circulation of the current when the length of reduced material is at least equal to a threshold value (?s).

Abstract: The invention relates to an electro-optical device for detecting an electric field emitted locally by a sample (100), comprising an upper (20) and a lower (21) polarizer, an active layer of liquid crystals (30) of variable polarization included between an upper (50) and a lower (51) alignment layer, having two perpendicular directions of alignment, and an upper (60) and lower (61) electrode liable to be connected to an AC voltage source (70) such that when a voltage difference (Vext) is applied, the layer of liquid crystals is immersed in the electric field formed between the two electrodes. It is essentially characterized in that it comprises a layer of anisotropic electrical conductors (40) in contact with the upper alignment layer or separated therefrom by the upper polarizer, the conductors being configured to transmit said electric field in only one direction secant to the alignment layers.

Abstract: Embodiments of the disclosure relate to the domain of virology of Paramyxoviruses. The disclosure concerns a method for producing self-assembling paramyxoviral particles and a method for identifying a compound able to inhibit the replication or the transcription of a Paramyxovirus. The disclosure also pertains to the nucleocapsid-like particles obtainable by the method of the invention and their use for biotechnological and pharmaceutical applications.

Abstract: The invention relates to an exfoliation method according to which a fluid loaded with particles flows at a first flow rate into a first (2), and then into a second, section of a pipe (1), the first flow rate being suitable for generating shear stresses and cavitation bubbles in the fluid as it passes through the first section (2) of the pipe (1), the second section (3) having a hydraulic diameter suitable for bringing about an implosion of cavitation bubbles as soon as the fluid exits the first section (2) and flows into the second section (3), so that an exfoliation of the particles is brought about under the combined action of the shear stresses and a shock wave generated by the implosion of the cavitation bubbles, the first section (2) having a hydraulic diameter less than 300 ?m.

Abstract: The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.

Abstract: The invention concerns a bioreactor obtained by compressing a mixture of an enzyme, a conductor and chitosan. The conductor can consist of carbon nanotubes. This bioreactor can be produced according to the following steps: preparing a mixture of powders in which the proportion of enzyme powder relative to a carbon nanotube powder is of the order of 50/50 by weight; preparing a viscous solution of chitosan in a ratio of 5 to 15 (in mg) of chitosan to 0.75 to 1.25 (in ml) of acetic acid diluted to 0.4 to 0.6% by volume in water; adding the viscous chitosan to the mixture of powders in a proportion be weight of 3 to 5 of powder to 5 to 10 of chitosan; carrying out a first compression followed by light grinding; carrying out a second compression to produce a pellet; and drying at ambient temperature.

Abstract: A spectral imager, including: a photodetector including a plurality of photosensitive sites exposed on a photosensitive surface; a collimating lens including an intermediate focal plane; an array of interferometers including two main waves, each including a cavity defined by two faces; an array of microlenses arranged in a plane parallel to the photosensitive surface, each microlens paired with an interferometer to form an optical pair, including an image focal plane coinciding with the photosensitive surface and facing a section of the photosensitive surface.

Abstract: The present invention concerns heterocyclic naphthoquinones derivatives for use in the treatment of Cushing disease and other cancers, in particular via the inhibition of Ubiquitin Specific Proteases (USP) 8 and/or 2.

Abstract: The present invention relates to a method for in vivo production of glycosaminoglycans (GAG), by metabolic engineering in a genetically modified cell. In a method according to the invention, said cell is genetically modified in order to express the genes coding for the enzymes that are suitable for synthesizing GAG from an exogenous precursor, preferably internalized by the cell. According to one specific feature, the present invention relates to a method for producing chondroitin or heparosan in a genetically modified bacterial cell, from an exogenous beta-galactoside precursor, preferably internalized by the cell. According to another specific feature, the present invention relates to the use of an Escherichia coli cell comprising at least the genes glcA-T, kfoC, kfiD and wbpP for the production of chondroitin.

Abstract: The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N0) which has the property to inhibit the replication of viruses from the subfamily Paramyxovirinae (like Henipavirus, Rubulavirus or Morbillivirus). These isolated peptides may be used for the prevention or the treatment of Paramyxovirinae infection.

Abstract: Photonic devices for generating linearly frequency modulated arbitrary microwave signals comprise a laser, and assembly for forming the emitted signal and a photoreceiver the passband of which is in the domain of the microwave frequencies. The forming assembly comprises: a first beam splitter; a first optical channel including a frequency-shifting loop comprising a beam splitter, a first optical amplifier, an optical isolator, a first spectral optical filter and an acousto-optical frequency shifter; a second optical channel including an electro-optical frequency shifter; a second beam splitter; a second optical amplifier; and a second optical filter; the acousto-optical frequency shift, the electro-optical frequency shift and the amplification gain of the first optical amplifier being adjustable.

Abstract: Process for in vitro diagnosis and/or monitoring and/or prognosis and/or theranosis of hepatic disorders from a biological sample originating from a subject, in which process the presence and/or the concentration of the marker ADH1B (SEQ ID NO.2) and/or the presence and/or the concentration of the combination of the markers ADH1B (SEQ ID NO.2) and ADH1A(SEQ ID NO.1) is determined.

Abstract: Novel grafted dinuclear metal complexes having formula (I) or of formula (II) wherein M represents a metal ion, and also the use thereof as sensors in a method for detecting and/or characterising cellular microparticles.

Abstract: The invention relates to an X-ray imaging system wherein images are obtained using an X-ray blocking element, the system comprising means for determining a position of the detector (40) on the basis of coordinates of projected patterns of the blocker (20, 220) in an image in order to especially be able to perform a calibration and/or correct the contribution of the scatter radiation in a radiographic image obtained by the system.

Abstract: The detection device comprises a cold finger which performs thermal connection between a detector fitted on a cooling plate and a cooling system. The cold finger comprises at least one side wall at least partially formed by an area made from the hafnium-based amorphous metal alloy. Advantageously, the whole of the cold finger is made from the hafnium-based amorphous metal alloy.

Abstract: The invention is a method for estimating a product of convolution of a measurement function, representing measurements, defined according to first coordinates, with a convolution kernel. The convolution product is estimated at second coordinates, different from said first coordinates. The measurement function represents measurements performed on the basis of a detector, in particular a detector of physical quantities. An exemplary application of the method relates to Magnetic Resonance Imaging, the method allowing a redistributing of measured data, not uniformly distributed, according to a uniform mesh, prior to the application of a fast Fourier transform algorithm.

Abstract: The invention relates to a device for measuring the speed of blood in a blood vessel of the eye. Said device includes: a light source (5), two detectors provided with input diaphragms (36, 46) for receiving two light beams backscattered by a blood vessel, an optical system including a Dove prism (70) through which the source beam and backscattered beams pass and which is rotatably adjustable about an axis parallel to the source beam passing therethrough, and a focusing system (62) capable of forming the image of a blood vessel on the input diaphragms, a processor capable of processing the signals from the detectors, and an opitcal element (52) that can be inserted during the device adjustment phase so as to convert the light spot, provided by the light source, into a line coplanar with the source beam and the backscattered beams.