Patents Assigned to Universite Louis Pasteur Strasbourg
  • Compounds and kits for the detection and the quantification of cell apoptosis
    Patent number: 7880021
    Abstract: 3-hydroxyflavone derivatives are useful in the detection and the quantification of cell apoptosis. Such derivatives are also useful as fluorescent probes in studying lipid asymmetry of cell plasma membrane and in detecting apopoptic cells. The derivatives can be used to monitor the evolution of diseases involving cell apoptosis.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: February 1, 2011
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Louis Pasteur (Strasbourg I)
    Inventors: Yves Mely, Andrey Klymchenko, Oleksandr Demchenko, Vasyl Shynkar
  • Transgenic arthritic mice expressing a T-cell receptor transgene
    Patent number: 5675060
    Abstract: A transgenic animal model for arthritis is disclosed. The arthritic condition results from genetic (or immunologic) manipulations that result in the T cell receptor (TCR) repertoire of the animal being substantially limited relative to the TCR repertoire of a wildtype control animal. The TCR repertoire of the arthritic animal, albeit limited, is functionally viable. In a preferred embodiment, the invention relates to transgenic arthritic mice wherein arthritis results from (1) a transgenic allele which encodes and expresses TCR .alpha. and .beta. subunits that combine in T lymphocytes of the transgenic animal to form a TCR that recognizes an antigen comprising one or more epitopes of an oligopeptide derived from amino acids 41-61 of bovine pancreatic ribonuclease and/or (2) polypeptide arthritogenic self antigens derived from endogenous proteins.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: October 7, 1997
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, Strasbourg 1, E.R. Squibb & Sons, Inc.
    Inventors: Christophe O. Benoist, Diane J. Mathis, Valerie Kouskoff
  • Antibodies specific for retinoic acid receptor-.gamma.
    Patent number: 5663303
    Abstract: The present invention discloses methods for preparing antibodies which bind to specific isoforms of the human retinoic acid receptor-.gamma. (RAR-.gamma.). In addition, several monoclonal antibodies are described which bind to human RAR-.gamma., but not to mouse or which bind to RAR-.gamma.1, but not to RAR-.gamma.2. Methods and kits are described which allow one to detect the isotype of RAR-.gamma. which is expressed in a test sample. Such methods are useful in determining the tissue specific pattern of expression of various RAR-.gamma. isoforms.
    Type: Grant
    Filed: November 4, 1991
    Date of Patent: September 2, 1997
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, Strasbourg I, E.R. Squibb & Sons, Inc.
    Inventors: Cecille Rochette-Egly, Yves Lutz, Michael Saunders, Isabelle Scheuer, Marie-Pierre Gaub, Pierre Chambon
  • Analytical markers for malignant breast cancer
    Patent number: 5236844
    Abstract: The present invention relates to a gene encoding a new member of the metalloproteinase family which has been found to be specifically associated with invasive breast cancer, and to methods of diagnosis for such cancer comprising detection of the marker or its nucleotide sequence, and to treatment or prophylaxis by inhibiting, altering the activity of or binding the marker, or by interfering with its synthesis.
    Type: Grant
    Filed: November 21, 1991
    Date of Patent: August 17, 1993
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de Recherche Scientifique, Universite Louis Pasteur Strasbourg
    Inventors: Paul Basset, Jean-Pierre Bellocq, Pierre Chambon