Abstract: A method for the diagnosis and/or prognosis of inflammatory states, and the use of at least one soluble receptor-binding (RBD), for the identification and quantification of the expression of membrane receptors present on the surface of target granulocytes, said identification and quantification taking place at a given time or during a given time interval, and allowing the diagnosis and/or prognosis of inflammatory states in a mammal.
Type:
Grant
Filed:
September 19, 2011
Date of Patent:
October 13, 2015
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, STANFORD UNIVERSITY
Inventors:
Rabindra Tirouvanziam, Julie Laval, Jean-Luc Battini, Marc Sitbon
Abstract: The present invention relates to a method for preparing a silica grafted with an organosilicon compound, to a grafted silica obtained according to said method and to the use thereof in compositions of silicone crosslinkable into an elastomer.
Type:
Grant
Filed:
August 16, 2012
Date of Patent:
September 8, 2015
Assignees:
BLUESTAR SILICONES FRANCE SAS, UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES, ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE MMONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Abstract: The present invention concerns a funtionalisable polysilylated organosilane precursors with formula (I): in which: Z1 represents a moiety with formula (a) and Z2 represents a moiety with formula (b) Z1 and Z2 simultaneously represent a moiety chosen from the moieties R7R8Si(OH), R9Si(OH)2, Si(OH)3, R7R8SiO1/2, R9SiO or Si03/2; U represents a moiety chosen from the moieties with formulas (U1), (U2), (U3), (U4), (U5), (U6), (U7), (U8).
Type:
Application
Filed:
July 8, 2013
Publication date:
August 20, 2015
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), ECOLE NATIONALE SUPERIEURE DE CHIMIE DE DE MONTPEILLIER, UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES
Inventors:
Michel Wong Chi Man, Xavier Cattoen, Nirmalya Moitra, Kristyna Burglova, Jana Hodacova
Abstract: The invention relates to a method for functionalizing natural fatty substances: According to said method, plant oils including at least two unsaturations and the derivatives thereof, fatty acids including at least one unsaturated compound and the derivatives thereof, and mixtures of same, are reacted with a thiol derivative of formula (I), at a temperature of between 0° C. and the temperature of total degradation of the natural fatty substance and in the presence of a thermal initiator compound or a redox initiator, or by UV radiation, or by UV radiation and in the presence of a photoinitiator. The invention also relates to the resulting functionalized fatty substances and to the use thereof for the preparation of polymers. The invention further relates to a method for preparing polymers from at least one functionalized fatty substance obtained by said functionalization method.
Type:
Grant
Filed:
June 30, 2011
Date of Patent:
August 18, 2015
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES
Inventors:
Sylvain Caillol, Bernard Boutevin, Myriam Desroches
Abstract: The present invention relates to FLT3 receptor antagonists or inhibitors of FLT3 receptor gene expression for the treatment or the prevention of pain disorders.
Type:
Grant
Filed:
January 5, 2011
Date of Patent:
August 18, 2015
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE MONTPELLIER 1, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
Abstract: The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.
Type:
Application
Filed:
June 6, 2013
Publication date:
June 18, 2015
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N. R.S.), UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES, ECOLE NATIONALE SUPERIEURE DE CHIME DE MONTPELLIER
Inventors:
Marc Taillefer, Florian Monnier, Anis Tlili, Grégory Danoun
Abstract: The present invention concerns novel carbonic anhydrase IX inhibitors comprising a nitroimidazole moiety and their use in therapy of hypoxic conditions, in particular cancer treatment, especially chemotherapy and radiotherapy. The compounds of the invention have an increased specificity for the carbonic anhydrase IX enzyme compared to the art.
Abstract: A method is provided for manufacturing near-field optical probes including at least one organo-mineral material with an organic part and a mineral part, the method including steps of irradiating at least partially the organo-mineral material with a radiation beam to polymerize the organic part in the irradiated areas, and polycondensing the mineral part by sol-gel process. Also disclosed are near-field optical probes and AFM and SNOM systems using the probes.
Type:
Grant
Filed:
January 9, 2012
Date of Patent:
May 26, 2015
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
Abstract: A method for preparing a formaldehyde-free phenolic plastic resin, includes a step of preparing a hardener via careful oxidation of a polyol and a step of reacting the hardener with phenolic compounds.
Type:
Grant
Filed:
November 19, 2010
Date of Patent:
May 26, 2015
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
Inventors:
Sylvain Caillol, Bernard Boutevin, Ghislain David, Carine Burguiere
Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.
Type:
Application
Filed:
March 26, 2013
Publication date:
March 26, 2015
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ECOLE NATIONAL SUPERIEURE DE CHIMIE DE MONTPELLIER
Inventors:
Frederique Cunin, Jean-Olivier Durand, Michael J. Sailor, Marcel Garcia, Emilie Secret, Magali Gary-Bobo, Marie Maynadier, Alain Morere
Abstract: Fusion proteins that contain the fusion of (i) a peptide of less than 100 amino acids comprising a first amino acid sequence comprising AASSG (SEQ ID NO: 1) and a second amino acid sequence comprising XAGXDXXTEXPXS (SEQ ID NO: 2), wherein X designates any amino acid, and (ii) a protein transduction domain (PTD) are provided, along with pharmaceutical compositions containing the fusion protein. The proteins can be used to treat Huntington's disease.
Type:
Grant
Filed:
April 12, 2012
Date of Patent:
March 24, 2015
Assignees:
Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Montpellier 2 Sciences et Techniques
Abstract: A method for measuring a dose related to the non-ionizing effects of a radiation of particles comprises the irradiation of a capacitive element provided with an electrode made from a semiconductor material, the measurement of the capacitance of the capacitive element in an accumulation regime and the determination of the dose related to the non-ionizing effects from the measurement of capacitance of the capacitive element in the accumulation regime.
Type:
Grant
Filed:
January 31, 2012
Date of Patent:
March 17, 2015
Assignee:
Universite Montpellier 2 Sciences et Techniques
Inventors:
Richard Arinero, Julien Mekki, Antoine Touboul, Frederic Saigne, Jean-Roch Vaille
Abstract: The present invention concerns novel carbonic anhydrase IX inhibitors comprising a nitroimidazole moiety and their use in therapy of hypoxic conditions, in particular cancer treatment, especially chemotherapy and radiotherapy. The compounds of the invention have an increased specificity for the carbonic anhydrase IX enzyme compared to the art. The present invention relates to novel nitroimidazole derivates represented by formula (1).
Abstract: The present invention relates to microarrays, sets of primers and methods for determining the co-receptor usage of a virus, in particular whether HIV uses CXCR4 or CCR5 as co-receptor. The methods and compositions of the invention are based on microRNA analysis. The invention can be used to determine virus tropism in any species or organism that expresses microRNAs, particularly in human beings.
Type:
Application
Filed:
March 15, 2013
Publication date:
February 26, 2015
Applicants:
Prestizia, Centre NAtional de la Rechercxhe Scientifique, Universite Montpellier 2 Sciences et Techniques
Abstract: The present invention concerns a method for treating and/or preventing a disease in a subject comprising the step of administrating an effective amount of a compound of formula I to a subject in need thereof.
Type:
Grant
Filed:
November 5, 2012
Date of Patent:
January 27, 2015
Assignees:
Centre National de la Recherche Scientifique (CNRS), Universite Montpellier 2 Sciences et Techniques
Abstract: Metal-accumulating plants for preparing compositions including a metal catalyst derived from the plants. The composition is substantially devoid of organic matter. Also, carrying out chemical reactions with the compositions prepared from metal-accumulating plants.
Type:
Application
Filed:
March 5, 2013
Publication date:
January 8, 2015
Applicants:
UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: A method for determining a trajectory of an aqueous flow, implementing a mobile autonomous measurement device inserted into the aqueous flow, includes a step of measuring and a step of saving acceleration data in a reference base of the mobile device, and a step of processing data collected during the step of measuring to determine the trajectory by double integration of the processed data.
Type:
Application
Filed:
December 13, 2012
Publication date:
November 6, 2014
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
Inventors:
Severin Pistre, Pascal Falgayrettes, Vivien Hakoun
Abstract: The present invention relates to a method for preparing a silica grafted with an organosilicon compound, to a grafted silica obtained according to said method and to the use thereof in compositions of silicone crosslinkable into an elastomer.
Type:
Application
Filed:
August 16, 2012
Publication date:
October 9, 2014
Applicants:
BLUESTAR SILICONES FRANCE SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), ECOLE NATIONAL SUPÉRIEURE DE CHIMIE DE MONTPELLIER, UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES
Abstract: A method for automatic detection of defects in TSV vias formed in a layer of semiconductor material, this detection taking place before stacking this layer with a plurality of other layers of semiconductor material for the design of a multilayer chip integrated circuit, comprising: measurement on each of said TSV vias of at least one parameter derived from an electrical characteristic of the TSV vias; detection of defects in said TSV vias according to a comparison of the parameters measured with at least one reference parameter, and calculation of said at least one reference parameter using the measured parameters. The parameter measured on each of the TSV vias comprises an oscillation frequency value derived from a capacitive characteristic of the TSV vias.
Type:
Application
Filed:
March 14, 2014
Publication date:
September 18, 2014
Applicants:
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENE ALT, Universite Montpellier 2 Sciences et Techniques, Centre National de la Recherche Scientifique
Inventors:
Yassine FKIH, Pascal VIVET, Bruno ROUZEYRE, Marie-Lise FLOTTES, Giorgio DI NATALE