Abstract: A regenerative material in the connective tissues (such as bone, dentin or pulp) regeneration field. More precisely, a connective tissue regenerative material, preferably a bone, dentin or pulp regenerative material, including: a porous polymer matrix having interconnected pores; and non-hydrated calcium silicate particles; wherein: the polymer matrix is anhydrous; the non-hydrated calcium silicate particles have a d50 granulometry, preferably ranging from 0.05 ?m to less than the average diameter size of the pores of the matrix; and the non-hydrated calcium silicate particles being coated on the inside walls of the pores of the matrix. Also, a method for preparing the connective tissue regenerative material and uses of the regenerative materials, such as in the dental field; especially, for providing regenerative materials with improved biomechanical and osteoinductive properties (i.e.
Type:
Application
Filed:
April 13, 2018
Publication date:
May 21, 2020
Applicants:
SEPTODONT OU SEPTODONT SAS OU SPECIALITES SEPTODONT, UNIVERSITÉ PARIS DESCARTES - PARIS V, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), SORBONNE UNIVERSITE, UNIVERSITE PARIS DIDEROT (PARIS 7)
Abstract: Treatment of a disease associated with retinal degenerative disorder. The present invention relates to human Transferrin or an active fragment thereof for use in the treatment of a disease associated with retinal degenerative disorder.
Type:
Application
Filed:
October 16, 2017
Publication date:
February 8, 2018
Applicants:
INSERM (Institut National de Sante et de la Recherche Medicale), Assistance Publique Hopitaux de Paris, Universite Paris Descartes - Paris V
Abstract: The present invention relates to methods for diagnosing and treating Myhre Syndrome. The invention provides a method for diagnosing or predicting Myhre Syndrome, or a risk of Myhre Syndrome, in a subject, which method comprises detecting a mutation in SMAD4 gene, as compared to a control population, wherein the presence of said mutation is indicative of Myhre Syndrome or of a risk of Myhre Syndrome. The present invention also relates to an inhibitor of the SMAD4-mediated TG?/BMP signalling pathway for use in the treatment of Myhre Syndrome.
Type:
Application
Filed:
September 6, 2016
Publication date:
December 22, 2016
Applicants:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Universite Paris Descartes - Paris V
Inventors:
Valerie Cormier-Daire, Carine Le Goff, Arnold Munnich
Abstract: The present invention provides a method for cryoprotecting a biological specimen comprising the step of freezing said biological specimen in the presence of a hydrogel and in the absence of cryoprotectant.
Type:
Grant
Filed:
January 17, 2013
Date of Patent:
December 20, 2016
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DESCARTES (PARIS V), UNIVERSITE DE VERSAILLES—SAINT QUENTIN EN YVELINES
Inventors:
Anne Pelle Meddahi, Aicha Abed, Didier Letourneur, Anne Baudot
Abstract: The present invention provides methods and kits for the prognosis of survival time of a patient suffering from a cancerous tumor. The method involves quantitating the density of Th17 cells at the center of the tumor and at the invasive margin of the tumor, where low density values at each location indicate a favourable prognosis, high values at each location indicate an unfavourable prognosis, and heterogeneous values at the two locations (one high, one low) indicate an intermediate prognosis.
Type:
Application
Filed:
August 27, 2015
Publication date:
December 24, 2015
Applicants:
Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris Descartes - Paris V, Assistance Publique - Hopitaux de Paris
Inventors:
Jerome GALON, Franck PAGES, Herve FRIDMAN, Bernhard MLECNIK
Abstract: The present invention relates to methods for diagnosing and treating Myhre Syndrome. The invention provides a method for diagnosing or predicting Myhre Syndrome, or a risk of Myhre Syndrome, in a subject, which method comprises detecting a mutation in SMAD4 gene, as compared to a control population, wherein the presence of said mutation is indicative of Myhre Syndrome or of a risk of Myhre Syndrome. The present invention also relates to an inhibitor of the SMAD4-mediated TGF?/BMP signalling pathway for use in the treatment of Myhre Syndrome.
Type:
Application
Filed:
July 27, 2012
Publication date:
October 16, 2014
Applicants:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS DESCARTES - PARIS V
Inventors:
Valérie Cormier-Daire, Carine Le Goff, Arnold Munnich