Patents Assigned to Universite Paris Diderot-Paris 7
  • Publication number: 20210178384
    Abstract: The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.
    Type: Application
    Filed: February 26, 2021
    Publication date: June 17, 2021
    Applicants: Paris Sciences Et Lettres - Quartier Latin, Centre National de la Recherche Scientifique (CNRS), Universite Paris Diderot Paris 7, Sorbonne Universite
    Inventors: Vincent Croquette, David Bensimon, Jimmy Ouellet, Jean-François Allemand, Charles Andre, Gordon Hamilton
  • Patent number: 10961219
    Abstract: The present invention relates to a compound of formula (I) wherein P1, P3, P4 and P5 are amino acid residues. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: March 30, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DIDEROT-PARIS 7
    Inventor: Etienne Jacotot
  • Patent number: 10960388
    Abstract: The present invention relates to photochemical compositions comprising: a solution comprising an organic solvent, preferably selected from dimethylformamide, acetonitrile, and mixtures thereof with water, a sacrificial electron donor; a proton donor having a pKa in acetonitrile greater than or equal to 28; a photosensitizer whose reduced state has a standard redox potential more negative than ?1.45 V vs SCE; and a metal porphyrin complex of formula (I) as defined in claim 1, useful in the production of CH4 from CO2 or CO by photochemical catalysis, to a photochemical cell comprising same and to a method for producing CH4 from CO2 or CO by photochemical catalysis using same.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: March 30, 2021
    Assignees: UNIVERSITE PARIS DIDEROT PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Marc Robert, Julien Bonin
  • Publication number: 20200385665
    Abstract: A fluidic system for producing extracellular vesicles from producer cells, including at least one container, a liquid medium contained by the container and producer cells, characterised in that it also includes microcarriers suspended in the liquid medium, the majority of producer cells being adherent to the surface of the microcarriers, and a liquid medium agitator, the agitator and the dimensions of the container being adapted to control a turbulent flow of the liquid medium in the container.
    Type: Application
    Filed: June 29, 2018
    Publication date: December 10, 2020
    Applicants: UNIVERSITE PARIS DIDEROT PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), GENETHON
    Inventors: Florence GAZEAU, Amanda Karine Andriola SILVA, Otto-Wilhelm MERTEN, Claire WILHELM, Max PIFFOUX
  • Patent number: 10844109
    Abstract: The invention relates to a novel method for the synthesis of an erythrocyte protein, in which said protein is synthesized in an acellular system for the production of proteins, in the presence of at least one detergent which is non-ionic, of liposomes or of nanodiscs. The invention also relates to compositions comprising the proteins produced in this way.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: November 24, 2020
    Assignees: Institut National Transfusion Sanguine, Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris Diderot Paris 7
    Inventors: Isabelle Mouro-Chanteloup, Sandrine Genetet
  • Patent number: 10827568
    Abstract: A microwave oven comprising a cavity in which a material can be placed for heating and a magnetron for generating a microwave. The microwave oven further comprises an electromagnetic element adapted to interact with microwaves into the cavity and a control unit that provides a control signal to the electromagnetic element for modifying an impedance of the electromagnetic element during time of heating.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: November 3, 2020
    Assignees: Centre National de la Recherche Scientifique—CNRS, Universite Paris Diderot-Paris 7
    Inventors: Geoffroy Lerosey, Mathias Fink, Nadege Kaina, Mathieu Dupre
  • Patent number: 10816560
    Abstract: The present invention relates to a method to analyse the ability of a substance (3) to cross a bilayer membrane comprising the following steps: (i) providing in a hydrophobic medium (1) a first droplet D1 of an aqueous solution AS1, wherein the droplet D1 is surrounded by a monolayer of amphiphilic molecules (2), (ii) providing in the said hydrophobic medium (1) a second droplet D2 of an aqueous solution AS2 containing the substance (3) to be analysed, wherein the droplet D2 is surrounded by a monolayer of amphiphilic molecules (2), (iii) putting the first droplet D1 and the second droplet D2 into contact so as to form a bilayer of amphiphilic molecules (2) in the contact area and to have a contact angle 2? between the two droplets D1 and D2 comprised between 10° and 180°, (iv) adding to the hydrophobic medium (1) a solvent capable of separating the droplets D1 and D2 put into contact, (v) collecting the droplet D1, and (vi) analysing the content of the droplet D1 in order to determine the presence or not of
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: October 27, 2020
    Assignees: Paris Sciences Et Lettres—Quartier Latia, Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventor: Abdou Rachid Thiam
  • Publication number: 20200308269
    Abstract: Embodiments of the disclosure relate to the use of an IL-17 pathway inhibitor for treating chronic infections caused by one or more HPVs.
    Type: Application
    Filed: May 24, 2017
    Publication date: October 1, 2020
    Applicants: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, UNIVERSITE PARIS DIDEROT - PARIS 7
    Inventors: Vincent Descamps, Florence Brunet-Possenti
  • Patent number: 10695416
    Abstract: The invention relates to vaccine compositions for treating and/or preventing infections by a bacterium of the Chlalmydiaceae family, said compositions comprising bacteria of the Chlamydiaceae family, which have been previously treated by at least one peptidoglycan inhibitor, or extracts of said treated bacteria.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: June 30, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS DIDEROT PARIS 7, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Philippe Verbeke, Colette Kanellopoulos
  • Patent number: 10690680
    Abstract: A method to analyze the activity of an ion channel comprising: providing in a hydrophobic medium a first droplet of an aqueous solution AS1 comprising a concentration q of an ion I with c1?0, wherein the droplet is surrounded by a monolayer of amphiphilic molecules; providing in the hydrophobic medium a second droplet of an aqueous solution AS2 comprising a concentration c2 of the ion I with c2?0, and c2?c1, wherein the second droplet is surrounded by a monolayer of amphiphilic molecules further comprising the ion channels to an analyzed; bringing the first droplet and the second droplet into contact so as to form a bilayer of amphiphilic molecules, wherein the bilayer further comprises ion channels to be analyzed, and measuring the radius of the two droplets when they are brought into contact referred to as initial state; and maintaining the first droplet and the second droplet in contact until equilibrium is reached and measuring the radius of the two contacted droplets or determining the number of resultin
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 23, 2020
    Assignees: Paris Sciences Et Lettres - Quartier Latin, Universite Paris Diderot Paris 7, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Abdou Rachid Thiam, Béatrice Schaack
  • Publication number: 20200155725
    Abstract: A regenerative material in the connective tissues (such as bone, dentin or pulp) regeneration field. More precisely, a connective tissue regenerative material, preferably a bone, dentin or pulp regenerative material, including: a porous polymer matrix having interconnected pores; and non-hydrated calcium silicate particles; wherein: the polymer matrix is anhydrous; the non-hydrated calcium silicate particles have a d50 granulometry, preferably ranging from 0.05 ?m to less than the average diameter size of the pores of the matrix; and the non-hydrated calcium silicate particles being coated on the inside walls of the pores of the matrix. Also, a method for preparing the connective tissue regenerative material and uses of the regenerative materials, such as in the dental field; especially, for providing regenerative materials with improved biomechanical and osteoinductive properties (i.e.
    Type: Application
    Filed: April 13, 2018
    Publication date: May 21, 2020
    Applicants: SEPTODONT OU SEPTODONT SAS OU SPECIALITES SEPTODONT, UNIVERSITÉ PARIS DESCARTES - PARIS V, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), SORBONNE UNIVERSITE, UNIVERSITE PARIS DIDEROT (PARIS 7)
    Inventors: Fleur BERES, Gilles RICHARD, Arnaud DESSOMBZ, Stéphane SIMON, Juliane ISAAC
  • Publication number: 20200049127
    Abstract: The invention relates to a method for designing a flexible blade or an articulated rigid blade with one or more torsion springs, for a wind turbine or a water turbine, the flexible blade being designed to passively control the pitch angle of the wind turbine or of the water turbine during operation, the method comprising the following steps: a) receiving the known geometric profile; b) determining a change in the optimal pitch angle, 0o opt rigid, as a function of the specific speed ?; c) determining the local behaviour of the flexible blade or of the articulated blade and local ratios relating to the aerodynamic loading and to the centrifugal force being exerted on the blade; d) determining local values of the bending modulus B of the flexible blade/the stiffness of the torsion spring and of the mass density p of the blade; and e) providing information relating to the selection of the material.
    Type: Application
    Filed: February 14, 2018
    Publication date: February 13, 2020
    Applicants: Universite Paris Diderot Paris 7, Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris, Centre National de la Recherche Scientifique (CNRS), Universite Pierre Et Marie Curie (Paris 6)
    Inventors: Vincent Cognet, Sylvain Courrech Du Pont, Benjamin Thiria
  • Publication number: 20190379817
    Abstract: High dynamic range (HDR) images are generated on the basis of a plurality of images obtained by non-destructive reading of an image sensor, called NDRO images. An HDR image generation method includes: the determination of a criterion of desired quality for the HDR image; at least two non-destructive readings of the sensor delivering at least two successive NDRO images; the selection, as a function of the criterion of desired quality, of the first and of the last NDRO image to be used to generate the HDR image; the generation of the HDR image on the basis of information extracted from a series of successive NDRO images starting with the first and terminating with the last NDRO image to be used; the storage of a single image at one and the same time throughout the entire HDR generation phase.
    Type: Application
    Filed: December 22, 2017
    Publication date: December 12, 2019
    Applicants: Centre National de la Recherche Scientifique, Sorbonne Université, Université Paris Diderot - Paris 7 Diderot Valorisation, Ecole Normale Superieure de Paris, Université de Bourgogne
    Inventors: David DARSON, Julien DUBOIS, Barthélémy HEYRMAN, Dominique GINHAC, Mustapha BOUDERBANE
  • Publication number: 20190367608
    Abstract: The present invention relates to an isolated humanized protein binding to human Glycoprotein VI (hGPVI) for treating a GPVI-related condition in a subject in need thereof, wherein said isolated humanized protein is to be administered during at least 2 hours to the subject, preferably during at least 4 to 6 hours.
    Type: Application
    Filed: February 2, 2018
    Publication date: December 5, 2019
    Applicants: Acticor Biotech, Université Paris Diderot - Paris 7, Université Paris-XIII, Nserm (Institut National de la Santé et de la Recherche Médicale), Université Paris-Sud 11
    Inventors: Philippe BILLIALD, Martine JANDROT-PERRUS, Gilles AVENARD
  • Patent number: 10495531
    Abstract: Disclosed is a force sensor, including: at least one measurement cell, each measurement cell being filled with a filling material in which at least one inclusion of a substance is embedded; for each cell, at least one light source arranged in order to illuminate the inclusion embedded in this cell; for each cell, a measurement system including at least one optical measurement point arranged in order to capture light originating from the inclusion embedded in this cell; for each cell, a unit arranged in order to convert optical signals originating from the measurement system of this cell to a signal representative of a force exerted on this cell, this signal being dependent on a movement of the inclusion embedded within the filling material of this cell.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: December 3, 2019
    Assignees: MUSEUM NATIONAL D'HISTOIRE NATURELLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, UNIVERSITE PARIS DIDEROT-PARIS 7
    Inventors: Séverine Toussaint, Artémis Llamosi
  • Publication number: 20190337885
    Abstract: The present invention relates to a compound of the following formula (I). The invention also relates to uses thereof as a chromophore as such or for building pigments displaying special optical effects, including metal-like reflection.
    Type: Application
    Filed: December 28, 2017
    Publication date: November 7, 2019
    Applicants: Centre National de la Recherche Scientifique (CNRS), Universite Paris Diderot Paris 7
    Inventors: Philippe Laine, Laurélie Poulard, Grégory Dupeyre
  • Patent number: 10463713
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of viral infection.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: November 5, 2019
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DIDEROT-PARIS 7, INSTITUT PASTEUR
    Inventors: Jean-Luc Poyet, Asier Saez-Cirion, Heriberto Bruzzoni-Giovanelli, Leonard Jagot-Lacoussiere, Annie David, Anastassia Mikhailova
  • Publication number: 20190331793
    Abstract: A method for detecting movements of a plurality of points (P) of a surface (21), comprising a measuring step during which an incident ultrasonic wave is emitted into the air towards the surface and an ultrasonic wave reflected into the air by the surface (21) is detected. During the measuring step, each measuring point is illuminated by the incident ultrasonic wave at a multiplicity of angles of incidence, and the reflected ultrasonic wave is detected by a network of receiving transducers (3) comprising a plurality of ultrasonic receiving transducers (3a). The movements of the surface are determined at a measuring point by determining a delay and/or a phase shift between two beam-forming signals for said measuring point.
    Type: Application
    Filed: July 10, 2017
    Publication date: October 31, 2019
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PARIS DIDEROT - PARIS 7
    Inventors: Ros Kiri Ing, Nathan Jeger-Madiot, Mathias Fink, Thomas Similowski
  • Publication number: 20190242914
    Abstract: The present invention relates to a method to analyse the ability of a substance (3) to cross a bilayer membrane comprising the following steps: (i) providing in a hydrophobic medium (1) a first droplet D1 of an aqueous solution AS1, wherein the droplet D1 is surrounded by a monolayer of amphiphilic molecules (2), (ii) providing in the said hydrophobic medium (1) a second droplet D2 of an aqueous solution AS2 containing the substance (3) to be analysed, wherein the droplet D2 is surrounded by a monolayer of amphiphilic molecules (2), (iii) putting the first droplet D1 and the second droplet D2 into contact so as to form a bilayer of amphiphilic molecules (2) in the contact area and to have a contact angle 2? between the two droplets D1 and D2 comprised between 10° and 180°, (iv) adding to the hydrophobic medium (1) a solvent capable of separating the droplets D1 and D2 put into contact, (v) collecting the droplet D1, and (vi) analysing the content of the droplet D1 in order to determine the presence or not of
    Type: Application
    Filed: July 4, 2017
    Publication date: August 8, 2019
    Applicants: Paris Sciences Et Lettres - Quartier Latin, Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventor: Abdou Rachid Thiam
  • Publication number: 20190224659
    Abstract: The present invention relates to photochemical compositions comprising: a solution comprising an organic solvent, preferably selected from dimethylformamide, acetonitrile, and mixtures thereof with water, a sacrificial electron donor; a proton donor having a pKa in acetonitrile greater than or equal to 28; a photosensitizer whose reduced state has a standard redox potential more negative than ?1.45V vs SCE; and a metal porphyrin complex of formula (I) as defined in claim 1, useful in the production of CH4 from CO2 or CO by photochemical catalysis, to a photochemical cell comprising same and to a method for producing CH4 from CO2 or CO by photochemical catalysis using same.
    Type: Application
    Filed: January 25, 2018
    Publication date: July 25, 2019
    Applicants: UNIVERSITE PARIS DIDEROT PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Marc ROBERT, Julien BONIN