Abstract: Mutated viral ENV proteins having mutations in the immunosuppressive domain (ISU) of the transmembrane subunit (TM) have decreased immunosuppressive activity with respect to the wild-type ENV protein. Pharmaceutical compositions that include the protein and nucleic acids coding for the protein are also disclosed.
Type:
Application
Filed:
February 17, 2012
Publication date:
July 26, 2012
Applicants:
Institut Gustave Roussy, Universite Paris Sud X1, Centre National De La Recherche Scientifique