Patents Assigned to Universite Paris-VI
  • Method of treatment for increasing the number of NMDA receptors in a mammalian brain
    Publication number: 20030225049
    Abstract: The invention concerns the use of DHEAS for making a pharmaceutical composition designed to increase the number of NMDA receptors in a mammal's brain. A method is also provided for increasing the number of NMDA receptors in the brain of a mammal by administering to the mammal a pharmaceutical composition containing dehydroepiandrosterone sulfate, wherein the mammal is a human being of from 40 to 60 years of age and wherein the dehydroepiandrosterone sulfate is administered for a period of at least 20 days.
    Type: Application
    Filed: May 20, 2003
    Publication date: December 4, 2003
    Applicant: UNIVERSITE PARIS VI
    Inventor: Monique Vincens
  • Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
    Publication number: 20030113887
    Abstract: An-isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.
    Type: Application
    Filed: April 18, 2001
    Publication date: June 19, 2003
    Applicant: Institut Pasteur and Universite Paris VI
    Inventors: Bernard Dujon, Andre Choulika, Laurence Colleaux, Cecile Fairhead, Arnaud Perrin, Anne Plessis, Agnes Thierry
  • Nucleotide sequence encoding the enzyme I SceI and the use thereof
    Patent number: 6395959
    Abstract: An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.
    Type: Grant
    Filed: May 6, 1996
    Date of Patent: May 28, 2002
    Assignees: Institut Pasteur, Universite Paris VI/Universite Pierre et Marie Curie
    Inventors: Bernard Dujon, Andre Choulika, Arnaud Perrin, Jean-Francois Nicolas
  • Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
    Patent number: 5962327
    Abstract: An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: October 5, 1999
    Assignee: Institut Pasteur Universite Paris-VI
    Inventors: Bernard Dujon, Andre Choulika, Laurence Colleaux, Cecile Fairhead, Arnaud Perrin, Anne Plessis, Agnes Thierry
  • Rapid detection of isoniazid resistance in mycobacterium tuberculosis probes for selecting nucleic acid encoding isoniazid resistance, and methods and kits
    Patent number: 5633131
    Abstract: Multi-drug resistant strains of Mycobacterium tuberculosis represent a considerable threat to public health worldwide. Resistance to isoniazid (INH), a key component of anti-tuberculosis regimens, is often associated with loss of catalase activity and virulence. The katG gene, encoding HPI catalase-peroxidase, mediates INH-sensitivity and that the high level resistance encountered clinically may be due to deletions, insertions or point mutations which reduce or eliminate the expression of the catalase gene in the chromosomal region encompassing katG. INH-resistant strains of Mycobacterium tuberculosis are detected by nucleic acid hybridization with a unique nucleic acid sequence or by amplification techniques.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: May 27, 1997
    Assignees: Institut Pasteur, Medical Research Council, Assistance Publique, Universite Paris VI
    Inventors: Beate Heym, Stewart T. Cole, Douglas B. Young, Ying Zhang
  • Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
    Patent number: 5474896
    Abstract: An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: December 12, 1995
    Assignees: Institut Pasteur, Universite Paris-VI
    Inventors: Bernard Dujon, Andre Choulika, Laurence Colleaux, Cecile Fairhead, Arnaud Perrin, Anne Plessis, Agnes Thierry