Patents Assigned to Universite Pierre et Marie Curie
  • Patent number: 11717543
    Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: August 8, 2023
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, ECOLE D'INGENIEURS DE PURPAN
    Inventors: Philippe Langella, Sylvie Miquel, Rebeca Martin Rosique, Luis Bermudez Humaran, Muriel Thomas, Harry Sokol, Frédéric Carvalho, Vassilia Theodorou
  • Patent number: 11654212
    Abstract: Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: May 23, 2023
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Nadine Nassif, Francisco Miguel Moreira Martins Fernandes, Cedric Boissiere, Clement Sanchez, Marie-Madeleine Giraud-Guille
  • Patent number: 11508261
    Abstract: The invention relates to a method for obtaining a numerical model, the numerical model associating at least one objective measurement to a subjective sensation, the method comprising the steps of: a) imaging the at least one area of the brain by using unfocused waves produced by a transcranial ultrasound probe (20), to obtain at least one acquired image of the activity of the area, b) evaluating a physical quantity representative of the activity of the at least one area based on the acquired images, to obtain at least one objective measurement, c) obtaining from the subject at least one numerical value representative of a subjective sensation, and d) determining the numerical model by using the obtained objective measurement and the obtained numerical value.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: November 22, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Centre National de la recherche scientifique, Université Pierre et Marie Curie, Université Paris Diderot, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Thomas Deffieux, Mickaël Tanter, Jean-Luc Gennisson, Zsolt Lenkei, Mathieu Pernot
  • Patent number: 11234677
    Abstract: The invention concerns a detecting apparatus (12) comprising:—at least two sensors (24, 26, 28), with at least one sensor (24) being an ultrasound transducer adapted to produce ultrasound waves, and—a positioning device (16) defining several compartments (22), each compartment (22) being adapted to hold a sensor (24, 26, 28) and each compartment (22) being located at predetermined location, the positioning device (16) comprising a holder adapted to be fixed on the skull of a subject, the positioning device (16) being adapted to be maintained on the head of the subject using the holder.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: February 1, 2022
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie (Paris 6), Université Paris Diderot—Pris 7, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: Jean-Luc Gennisson, Mickaël Tanter, Thomas Deffieux, Mathieu Pernot
  • Patent number: 11203788
    Abstract: The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: December 21, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT GUSTAVE-ROUSSY, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE HENRI BECQUEREL, UNIVERSITE PIERRE ET MARIE CURIE, UNIVERSITE PARIS-SUD
    Inventors: Franck Viguie, Olivier Bernard, Michaela Fontenay, Christian Bastard, Francois Delhommeau, William Vainchenker
  • Patent number: 11170945
    Abstract: The invention relates to a supercapacitor comprising: an electrolyte having a first end and a second end opposite the first end, a first electrode in contact with the first end of the electrolyte, and a second electrode in contact with the second end of the electrolyte. In particular, the electrolyte is made of a solid material that is ion-conductive and electronically insulating.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: November 9, 2021
    Assignees: PARIS SCIENCES ET LETTRES—QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELLES DE LA VILLE DE
    Inventors: Brigitte Leridon, Stéphane Hole, Rémi Federicci
  • Patent number: 11110252
    Abstract: Device (100) for holding in position a probe for placing the inside of a patient's body in communication with the outside, characterized in that it comprises, arranged along a longitudinal axis (X-X?) of the device: at its distal end, a means (110) of supporting the device on the patient's body and that extends radially, comprising an axial opening (114) for the passage of said probe and comprising a first radial opening (111) communicating with the said axial opening, at its proximal end, a means (120) of guiding said probe comprising a second radial opening (121), a means (130) of spacing said bearing means and said guide means apart longitudinally.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: September 7, 2021
    Assignees: MMG, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Thomas Similowski, Serge Renaux
  • Patent number: 11103615
    Abstract: The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: August 31, 2021
    Assignees: Centre National De La Recherche Scientifique CNRS, Hemarina, Universite Pierre Et Marie Curie
    Inventors: Franck Zal, Morgane Rousselot
  • Publication number: 20210190726
    Abstract: An electromagnetic sensing device comprising: a reference microfluidic reservoir to receive a reference substance with magnetic nanoparticles; an analyte microfluidic reservoir to receive an analyte and magnetic nanoparticles; a first excitation magnetic coil to subject the reference microfluidic reservoir to an alternating magnetic field at a first frequency; a second excitation magnetic coil to subject the analyte microfluidic reservoir to an alternating magnetic field at the first frequency; a third excitation magnetic coil to subject the reference microfluidic reservoir to an alternating magnetic field at a second frequency distinct from the first frequency; a fourth excitation magnetic coil to subject the analyte microfluidic reservoir to an alternating magnetic field at the second frequency; a first detection magnetic coil to detect a response magnetic field of the magnetic nanoparticles in the reference microfluidic reservoir; a second detection magnetic coil to detect a response magnetic field of the
    Type: Application
    Filed: October 5, 2018
    Publication date: June 24, 2021
    Applicants: Université Pierre et Marie Curie, Centre National de la Recherche Scientifique, Forschungszentrum Jülich GmbH
    Inventors: Hamid Kokabi, Hans-Joachim Krause, Kieu An Ngo, Amine Rabehi
  • Patent number: 10981021
    Abstract: The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 20, 2021
    Assignees: Carthera, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie (Paris 6)
    Inventors: Alexandre Carpentier, Michael Canney, Alexandre Vignot
  • Patent number: 10952701
    Abstract: The invention concerns a detecting apparatus (12) for imaging at least two areas of a brain of a subject (10), the detecting apparatus (12) comprising: —a holder comprising: —a frame (14) devoted to be cemented on the skull of the subject (10), the frame (14) delimitating an inner portion (18) which is transparent to ultrasound waves, —a removable imaging device comprising: —a platform (16) delimitating an inner space (28), the inner space (28) facing the inner portion (18), —a fixing element (30) adapted to temporary fix and lock the platform (16) to the holder, —an ultrasound probe (32), and —a moving stage (34) holding the ultrasound probe (32) and being adapted to move the ultrasound probe (32) within the inner space (28).
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 23, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE RECHERCHE MEDICAL (INSERM), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT—PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Thomas Deffieux, Jean-Luc Gennisson, Mickaël Tanter, Ivan Cohen, Mathieu Pernot
  • Patent number: 10947152
    Abstract: The invention relates to a process for permanently electrostatically doping a layer of a conductive or non-conductive material that is deposited on a solid substrate, to the doped material obtained according to this process, and to the use of such a material.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: March 16, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIC, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Abhay Shukla, Johan Biscaras, Andrea Paradisi
  • Patent number: 10939838
    Abstract: The invention relates to a method for detecting a physiological state of a patient deviating from a reference physiological state, in which, after having determined, in each of Q frequency bands, R reference matrices PRq,r with qe[1 . . . Q] and r?[1 . . . R] which correspond to the reference physiological state, the following steps are repeated in a loop: carrying out measurements, in M time segments, of an electroencephalographic signal; filtering and centering the measurements in Q frequency bands to obtain and determine M×Q scaled matrices of spatial covariance; for each time segment m, calculating a deviation from the reference physiological state, and comparing each of the deviations from the reference physiological state to a predefined threshold. The invention also relates to a monitoring device applying said method.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: March 9, 2021
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FONDATION ICM—INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Thomas Similowski, Mathieu Raux, Mario Chavez, Jacques Martinerie, Pierre Pouget
  • Patent number: 10881380
    Abstract: The present invention concerns a method for obtaining a functional parameter of a muscle having a part, the method comprising the steps of: a) applying ultrasound waves to the muscle, b) collecting the ultrasound waves retrodiffused by the muscle at a plurality of times, to obtain collected ultrasound waves, c) determining a first plurality of values representative of stiffness values of one part at a first plurality of times by using the collected ultrasound waves, d) determining a second plurality of values representative of deformation values of said part at a second plurality of times by using the collected ultrasound waves, and e) deducing at least one functional parameter based on the first plurality of values and the second plurality of values. The invention also concerns a corresponding device.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: January 5, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT—PARIS 7, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Mickael Tanter, Mathieu Pernot
  • Patent number: 10869705
    Abstract: An implant and guide are described, together with methods for configuring the same. The implant and guide are for maxillofacial osteosynthesis and may be provided as a kit. Three-dimensional models of the pre- and post-operative anatomy are used to define attachment points. These attachment points are used to define a structure for the implant and the guide.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: December 22, 2020
    Assignees: OBL S.A., Université Pierre et Marie Curie (Paris 6), Assistance Publique—Hôpitaux de Paris (Paris)
    Inventors: Guillaume Dubois, Patrick Goudot, Thomas Schouman
  • Patent number: 10857239
    Abstract: The invention relates to the use of HNRNPC-expressing vectors for preventing and/or treating a tauopathy, such as Alzheimer's disease. The invention relates to methods for detecting a risk of developing a tauopathy such Alzheimer's disease in a patient, comprising the step of detecting the level of HNRNPC in a biological sample obtained from said patient.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: December 8, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Thierry Leveillard, Jose-Alain Sahel, Hawa Camara
  • Patent number: 10844367
    Abstract: The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniques.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: November 24, 2020
    Assignees: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE NICE SOPHIA ANTIPOLIS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Alain Nicolas, Gianni Liti
  • Patent number: 10780435
    Abstract: Disclosed is a minifluidic device including a matrix, an elongated guiding duct embedded at least in part in the matrix, with at least one port to the outside of the matrix, a movable fiber at least partly contained in the guiding duct, and able to undergo within the guiding duct, and at least along some part of the fiber, at least one action selected among a sliding, or a deformation, or a rotation and at least one of the movable fiber or the guiding duct is elastic or is non linear along at least part of its length, or at least part of the matrix is elastic.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: September 22, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE PIERRE ET MARIE CURIE
    Inventors: Bastien Venzac, Ayako Yamada, Jean-Louis Viovy, Stephanie Descroix, Laurent Malaquin
  • Patent number: 10765412
    Abstract: The invention relates to an endoscopic instrument (1) having an elongate body with a distal end (4) designed to be introduced into the body of the patient so as to come into proximity with an internal organ, the distal end carrying a tool (7) for intervention on the internal organ. The endoscopic instrument has a fool (10) rigidly connected to the distal end and designed to bear on the internal organ, and also controllable means (13) for conferring movements on the tool, at least in directions transverse to a longitudinal axis (X) of the distal end of the endoscopic instrument, when the foot is bearing against the internal organ.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: September 8, 2020
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MAUNA KEA TECHNOLOGIES, ENDOCONTROL
    Inventors: Benoît Rosa, Benoît Herman, Jérôme Szewczyk, Guillaume Morel, Clément Vidal, Patrick Henri, François Lacombe, Jérôme Lopez
  • Patent number: 10736927
    Abstract: The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: August 11, 2020
    Assignees: INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Harry Sokol, Mathias Lavie-Richard, Marie-Laure Michel, Bruno Michel Lamas, Philippe Langella