Abstract: The invention relates to membrane vesicles from non-pathogenic amoeba, in particular from the amoeba Dictyostelium discoideum, containing a molecule of therapeutic interest, to a method of preparing such vesicles and to the use of the vesicles as a vehicle for transferring the molecule therapeutic interest to an eukaryotic mammalian cell.

Abstract: The present invention relates to an isolated cell capable of fixing tumour cells, expressing the CD10 protein and expressing at least one MDR protein, and to the use of this cell for screening for anti-tumour compounds.

Abstract: The invention relates to membrane vesicles from non-pathogenic amoeba, in particular from the amoeba Dictyostelium discoideum, containing a molecule of therapeutic interest, to a method of preparing such vesicles and to the use of the vesicles as a vehicle for transferring the molecule therapeutic interest to an eukaryotic mammalian cell.

Abstract: Isolated DNAs encoding the enzyme I-SpomI and its recognition and cutting site are provided. The DNA sequences can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.

Abstract: This invention concerns an acousto-optic imaging method comprising a step which consists in engraving in a dynamic holographic material a complex index array resulting from the interference of the acousto-optic component of the signal wave and a pump wave of frequency equal to the frequency of the acousto-optic component.

Abstract: A system, method, device, and computer program product to extract and gather peak information from an automated sequencer of bioinformatics into a peak database, and to manipulate and analyze the peak information within the database.

Abstract: The invention relates to membrane vesicles from non-pathogenic amoeba, in particular from the amoeba Dictyostelium discoideum, containing a molecule of therapeutic interest, to a method of preparing such vesicles and to the use of said vesicles as a vehicle for transferring the molecule therapeutic interest to an eukaryotic mammalian cell.

Abstract: The endoprosthesis is designed to be implanted in an aneurysm (12) of a patient, the aneurysm (12) resulting from deformation of a vessel wall, in particular the wall of an artery (14), the endoprosthesis including: a tubular envelope (22, 24) that extends in a direction (Y-Y'), and a plurality of pressure probes (26) fixed on the envelope (22, 24), each probe (26) including: a sensor (28) for measuring pressure, and elements (34, 36) for transmitting the pressure measurement to a monitoring apparatus located outside the patient. The elements (34, 36) for transmitting the pressure measurement from each probe (26) are designed to generate an electromagnetic pressure measurement transmission signal including at least one distinctive characteristic of the probe (26) of which these elements (34, 36) form part.

Abstract: The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.

Abstract: A device for detecting the improper adjustment of a ventilatory support machine used on a mammal. The device (12) includes measuring elements (40) for taking a measurement, as a function of time, of a neurophysiological signal involved in the respiratory process of the mammal for at least two successive breathing cycles, each breathing cycle comprising a respiratory initiation time; an input for receiving a respiratory initiation signal (to) which is different from the neurophysiological signal; elements (42) for processing the neurophysiological signals, which are configured to process the neurophysiological signals for each respiratory initiation time over a period of time starting from the respiratory initiation time; and elements (44) for detecting an improper adjustment of the ventilator using the processed signals.

Abstract: The present invention relates to the use of a Rho/ROCK/PI3K/Akt pathway modulator for the manufacture of a medicament intended for the prevention or the treatment of pathologies associated with an infection by a protozoan parasite.

Abstract: A vacuum magnetic ion trap includes an assembly forming a permanent magnet including at least two magnetized structures (30, 32) in the form of hollow cylinders, one convergent radial structure, magnetized along a convergent radial direction, and one divergent radial structure, magnetized along a divergent radial direction, the convergent and divergent radial magnetized structures (30, 32) being arranged along a common longitudinal axis (XX?) The trap also includes a sealed chamber (4) containing anion confinement cell (8) fixed between the at least two magnetized structures (30, 32) and including at least two trapping electrodes (10) connectable to a voltage generator (12).

Abstract: Optical scanning device for the production of a 2D computer image of a liquid or humid biological sample observed by transparency, wherein an even thickness of the liquid biological sample is disposed in a tank optically enclosed between an illumination assembly and an optical sensing assembly, the optical sensing assembly having a moving part able to move in a plane parallel to the sample as to scan an area of the sample of sensibly equal thickness, the illumination assembly having a luminous source sensibly homogeneous at least in the scanned area and including towards the sample, an optical grid filter with a surface parallel to the plane and transmitting only light rays sensibly perpendicular to its surface. The sample can be observed by reflection. The tank is open and joint to the optical sensing assembly.

Abstract: A recombinant heteromultimeric protein including at least (a) a polypeptide fusion molecule A consisting of a C4BP ?-chain C-terminal fragment and a polypeptide fragment heterologous to said ? chain, and (b) a polypeptide fusion molecule B consisting of a C4BP ?-chain C-terminal fragment and a polypeptide fragment heterologous to said ?-chain, wherein (a) and (b) are linked in the C-terminal portion to form said multimeric protein.

Abstract: The present invention relates to a tetracycline dependent gene regulatory system or composition controlling the expression of a target gene in a cell and to methods using said system or composition. The present invention more specifically discloses compositions, vectors and methods allowing tetracycline-controlled expression of short-hairpin RNAs (shRNAs), and demonstrates inducible, reversible and stable RNA interference (RNAi) using the same in a cell. The invention can be used to cause reversible control of the expression of any gene and may therefore find applications in the fields of mammalian, in particular human, genetics and molecular therapeutics, in cell and gene therapy, research as well as in genetic studies using transgenic animals.

Abstract: The invention concerns a vacuum magnetic ion trap comprising an assembly forming a permanent magnet including at least two magnetized structures (30, 32) in the form of hollow cylinders, one convergent radial structure, magnetized along a convergent radial direction, and one divergent radial structure, magnetized along a divergent radial direction, said convergent and divergent radial magnetized structures (30, 32) being arranged along a common longitudinal axis (XX?). Said trap also comprises a sealed chamber (4) containing an ion confinement cell (8) fixed between said at least two magnetized structures (30, 32) and including at least two trapping electrodes (10) connectable to a voltage generator (12).

Abstract: The present invention relates to compounds which can go to make up mesostructured porous hybrid organic-inorganic materials (MPHOIMs) and can serve, within these materials, as probe molecules for the detection or quantitative determination of halogenated gaseous compounds. It also relates to MPHOIMs in which these compounds are grafted by covalent or iono-covalent bonding, to a process for manufacturing these MPHOIMs, and also to chemical sensors for the detection or quantitative determination of halogenated gaseous compounds and comprising these MPHOIMs as sensitive materials. The invention applies, in particular, to the detection and quantitative determination of halogenated gaseous compounds used in the microelectronics field and, more especially, halogenated boron complexes.

Abstract: The invention relates to a method for assessing the proliferative state of cells in a human or non human biological sample, comprising using Chromatin Assembly Factor-1 (CAF-1 in short) subunits as proliferation markers. Application for cancer prognosis or diagnosis and monitoring tumor response in therapy.

Abstract: A recombinant heteromultimeric protein including at least (a) a polypeptide fusion molecule A consisting of a C4BP ?-chain C-terminal fragment and a polypeptide fragment heterologous to said a chain, and (b) a polypeptide fusion molecule B consisting of a C4BP ?-chain C-terminal fragment and a polypeptide fragment heterologous to said ?-chain, wherein (a) and (b) are linked in the C-terminal portion to form said multimeric protein.

Abstract: The present invention relates to a peptide labelled with fluorine-18 for the specific recognition of lipid vectors.