Patents Assigned to UNIVERSITE PIERRE ET MARIE CURRIE (PARIS 6)
  • Nucleic acid molecules and methods for exchanging exon(s) by transsplicing
    Patent number: 9303078
    Abstract: The present invention provided methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and to mediate a simple or double trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (Chimeric RNA).
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: April 5, 2016
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PIERRE ET MARIE CURRIE (PARIS 6)
    Inventors: Luis Garcia, Stéphanie Lorain