Patents Assigned to Universite Rene Descartes
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Patent number: 10436686Abstract: The invention relates to a method of separating biological particles from the liquid containing same for purification, analysis and optionally diagnostic purposes. The inventive method comprises at least one step involving vertical filtration through a filter having a porosity that is adapted to the type of biological particles to be separated, such that said particles are retained by the filter. The invention is characterised in that: (i) the method involves the use of a filter comprising at least one basic filtration zone, whereby each basic filtration zone has a limited surface area; and (ii) the surface area of each basic filtration zone and the number of basic filtration zones are selected as a function of the type of liquid to be filtered, the type of biological particles to be separated and the volume of liquid to be filtered.Type: GrantFiled: September 18, 2017Date of Patent: October 8, 2019Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, UNIVERSITE RENE DESCARTES-PARIS VInventor: Patrizia Paterlini-Brechot
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Patent number: 10168327Abstract: The present invention relates to the field of medicine, in particular of research and diagnosis. It relates more particularly to a novel tool for detecting antibodies in a biological sample originating from a mammal. This tool, which is in the form of a protein chip, can be used in screening for new targets of interest involved in the occurrence of an autoimmune disease, in particular of a disease affecting the nervous system of a mammal, and also in the diagnosis or the monitoring of the progression of such an autoimmune disease. The invention also relates to a method for producing such a tool and also to kits comprising it and enabling its use.Type: GrantFiled: February 1, 2013Date of Patent: January 1, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE RENE DESCARTES PARIS 5, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Florian Lesage, Franck Chatelain, Michel Mazzuca, Veronique Rogemond, Marie-Madeleine Larroque, Jerome Honnorat
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Patent number: 10105393Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.Type: GrantFiled: August 10, 2015Date of Patent: October 23, 2018Assignees: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
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Publication number: 20180003602Abstract: The invention relates to a method of separating biological particles from the liquid containing same for purification, analysis and optionally diagnostic purposes. The inventive method comprises at least one step involving vertical filtration through a filter having a porosity that is adapted to the type of biological particles to be separated, such that said particles are retained by the filter. The invention is characterised in that: (i) the method involves the use of a filter comprising at least one basic filtration zone, whereby each basic filtration zone has a limited surface area; and (ii) the surface area of each basic filtration zone and the number of basic filtration zones are selected as a function of the type of liquid to be filtered, the type of biological particles to be separated and the volume of liquid to be filtered.Type: ApplicationFiled: September 18, 2017Publication date: January 4, 2018Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, UNIVERSITE RENE DESCARTES - PARIS VInventor: Patrizia PATERLINI-BRECHOT
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Patent number: 9766167Abstract: The invention relates to a method of separating biological particles from the liquid containing same for purification, analysis and optionally diagnostic purposes. The inventive method comprises at least one step involving vertical filtration through a filter having a porosity that is adapted to the type of biological particles to be separated, such that said particles are retained by the filter. The invention is characterized in that: (i) the method involves the use of a filter comprising at least one basic filtration zone, whereby each basic filtration zone has a limited surface area; and (ii) the surface area of each basic filtration zone and the number of basic filtration zones are selected as a function of the type of liquid to be filtered, the type of biological particles to be separated and the volume of liquid to be filtered.Type: GrantFiled: October 17, 2014Date of Patent: September 19, 2017Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, UNIVERSITE RENE DESCARTES-PARIS VInventor: Patrizia Paterlini-Brechot
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Patent number: 9125883Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.Type: GrantFiled: October 11, 2013Date of Patent: September 8, 2015Assignees: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
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Publication number: 20140205630Abstract: The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDl capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.Type: ApplicationFiled: February 6, 2014Publication date: July 24, 2014Applicants: UNIVERSITE RENE DESCARTES PARIS 5, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, INSTITUT CURIEInventor: Eric TARTOUR
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Patent number: 8685408Abstract: The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDI capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.Type: GrantFiled: December 26, 2007Date of Patent: April 1, 2014Assignees: Universite Rene Descartes Paris 5, Institut Curie, Assistance Publique Hopitaux de Paris, Centre National de la Recherche Scientifique-CNRSInventor: Eric Tartour
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Patent number: 8598142Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.Type: GrantFiled: January 7, 2011Date of Patent: December 3, 2013Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Universite Rene Descartes Paris 5Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
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Patent number: 8329661Abstract: This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytcs, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No 1, in combination with at least one physiologically acceptable excipient.Type: GrantFiled: February 22, 2011Date of Patent: December 11, 2012Assignees: Instiut National de la Santéet de la Recherche Médicale (INSERM), Universite Rene DescartesInventors: Laurence Christa, Christian Brechot, Marie-Thérèse Simon-Gage-Soufflot, Alain Pauloin, J. Guilherme Tralhao
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Publication number: 20120177613Abstract: The invention relates to the use of gingival fibroblasts for obtaining a cellular composition for treating arterial-remodelling pathology, for example an aneurysm, post-cryoplasty stenosis and restenosis, an aortic dissection or atherosclerosis.Type: ApplicationFiled: January 6, 2012Publication date: July 12, 2012Applicants: L'assistance Publique - Hopitaux De Paris, Universite Rene Descartes (Paris V)Inventors: Antoine Lafont, Bruno Gogly
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Publication number: 20120115171Abstract: The invention relates to a method for diagnosing thrombophilia in a subject suffering from HIV or from a systemic auto-immune disease, said method comprising determining in a blood sample obtained from said subject the level of free Protein S having Activated Protein C (APC) cofactor activity and the level of total Protein S.Type: ApplicationFiled: May 7, 2010Publication date: May 10, 2012Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, UNIVERSITE RENE DESCARTES PARIS 5, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventors: Sebastien Lacroix-des-Mazes, Vincent Mallet, Srinivas Kaveri, Stanislas Pol
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Publication number: 20120070051Abstract: The invention relates to a method for processing image data, comprising the steps of: receiving a first set of ultrasound image data representing a given volume, said set being organized into first planes sharing a common segment; and, on the basis of the first data set, reconstructing a second set of image data representing at least partially the given volume, said second set being organized into second planes parallel to each other.Type: ApplicationFiled: February 9, 2010Publication date: March 22, 2012Applicant: UNIVERSITE RENE DESCARTESInventors: Nicole Vincent, Arnaud Boucher, Philippe Arbeille, Florence Cloppet
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Publication number: 20110245199Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.Type: ApplicationFiled: January 7, 2011Publication date: October 6, 2011Applicants: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
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Publication number: 20110144036Abstract: This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytcs, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No 1, in combination with at least one physiologically acceptable excipient.Type: ApplicationFiled: February 22, 2011Publication date: June 16, 2011Applicants: Institut National de la Santé et de la Recherche Médicale (INSERM), Universite Rene DescartesInventors: Laurence Christa, Christian Brechot, Marie-Thérèse Simon-Gage-Soufflot, Alain Pauloin, J. Guilherme Tralhao
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Patent number: 7951593Abstract: The present invention relates to a gingival fibroblast culture medium free of animal serum, comprising an animal cell culture medium, free of animal serum, to which is added: from 0.1 ng/ml to 100 ng/ml bFGF, and/or from 1 ?g/ml to 50 ?g/ml insulin.Type: GrantFiled: March 19, 2008Date of Patent: May 31, 2011Assignee: Universite Rene Descartes-Paris VInventors: Bruno Gogly, Bernard Coulomb, Antoine Lafont
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Patent number: 7951391Abstract: The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration.Type: GrantFiled: February 21, 2007Date of Patent: May 31, 2011Assignees: Universite Rene Descartes Paris 5, Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER)Inventors: Sylvie Igondjo-Tchen Changotade, Karim Senni, Alexandrine Foucault-Bertaud, Grégory Korb, Maya Brigitte Baroukh, Jean-Louis Saffar, Gaston-Jacques Godeau, Corinne Sinquin, Sylvia Colliec-Jouault, Patrick Durand
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Publication number: 20100298437Abstract: The invention relates to the use of L-citrulline (I) or of one of its pharmaceutically acceptable salts in the preparation of a drug for the treatment of states or undernutrition as linked to a lowering of protein synthesis within the framework of pathologies which do not result from an intestinal insufficiency.Type: ApplicationFiled: August 29, 2007Publication date: November 25, 2010Applicants: UNIVERSITE RENE DESCARTES-PARIS 5, BIOCODEXInventors: Christophe Moinard, Marion Jourdan, Stephane Walrand, Luc Cynober
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Patent number: 7833990Abstract: The invention relates to the use of certain low-molecular weight highly sulphated polysaccharide derivatives obtained from a bacterial polysaccharide for preparing a pharmaceutical composition suitable for modulating angiogenesis, particularly for use in accelerating vascular endothelial repair with a low haemorrhage risk in the event of thrombotic injuries.Type: GrantFiled: June 6, 2005Date of Patent: November 16, 2010Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Universite Rene Descartes Paris 5Inventors: Sabine Matou, Sylvia Colliec-Jouault, Dominique Helley, Jacqueline Ratiskol, Corinne Sinquin, Claire Boisset, Jean Guezennec, Anne-Marie Fischer
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Publication number: 20100196417Abstract: The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDI capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.Type: ApplicationFiled: December 26, 2007Publication date: August 5, 2010Applicants: UNIVERSITE RENE DESCARTES PARIS 5, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventor: Eric Tartour