Patents Assigned to Universite Rene Descartes Paris 5
-
Patent number: 10168327Abstract: The present invention relates to the field of medicine, in particular of research and diagnosis. It relates more particularly to a novel tool for detecting antibodies in a biological sample originating from a mammal. This tool, which is in the form of a protein chip, can be used in screening for new targets of interest involved in the occurrence of an autoimmune disease, in particular of a disease affecting the nervous system of a mammal, and also in the diagnosis or the monitoring of the progression of such an autoimmune disease. The invention also relates to a method for producing such a tool and also to kits comprising it and enabling its use.Type: GrantFiled: February 1, 2013Date of Patent: January 1, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE RENE DESCARTES PARIS 5, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Florian Lesage, Franck Chatelain, Michel Mazzuca, Veronique Rogemond, Marie-Madeleine Larroque, Jerome Honnorat
-
Patent number: 10105393Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.Type: GrantFiled: August 10, 2015Date of Patent: October 23, 2018Assignees: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
-
Patent number: 9125883Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.Type: GrantFiled: October 11, 2013Date of Patent: September 8, 2015Assignees: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
-
Publication number: 20140205630Abstract: The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDl capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.Type: ApplicationFiled: February 6, 2014Publication date: July 24, 2014Applicants: UNIVERSITE RENE DESCARTES PARIS 5, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, INSTITUT CURIEInventor: Eric TARTOUR
-
Patent number: 8685408Abstract: The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDI capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.Type: GrantFiled: December 26, 2007Date of Patent: April 1, 2014Assignees: Universite Rene Descartes Paris 5, Institut Curie, Assistance Publique Hopitaux de Paris, Centre National de la Recherche Scientifique-CNRSInventor: Eric Tartour
-
Patent number: 8598142Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.Type: GrantFiled: January 7, 2011Date of Patent: December 3, 2013Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Universite Rene Descartes Paris 5Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
-
Publication number: 20120115171Abstract: The invention relates to a method for diagnosing thrombophilia in a subject suffering from HIV or from a systemic auto-immune disease, said method comprising determining in a blood sample obtained from said subject the level of free Protein S having Activated Protein C (APC) cofactor activity and the level of total Protein S.Type: ApplicationFiled: May 7, 2010Publication date: May 10, 2012Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, UNIVERSITE RENE DESCARTES PARIS 5, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventors: Sebastien Lacroix-des-Mazes, Vincent Mallet, Srinivas Kaveri, Stanislas Pol
-
Publication number: 20110245199Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.Type: ApplicationFiled: January 7, 2011Publication date: October 6, 2011Applicants: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5Inventors: Karim Senni, Farida Gueniche, Myriam Yousfi, Florence Fioretti, Gaston-Jacques Godeau, Sylvia Colliec-Jouault, Jacqueline Ratiskol, Corinne Sinquin, Gérard Raguenes, Anthony Courtois, Jean Guezennec
-
Patent number: 7951391Abstract: The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration.Type: GrantFiled: February 21, 2007Date of Patent: May 31, 2011Assignees: Universite Rene Descartes Paris 5, Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER)Inventors: Sylvie Igondjo-Tchen Changotade, Karim Senni, Alexandrine Foucault-Bertaud, Grégory Korb, Maya Brigitte Baroukh, Jean-Louis Saffar, Gaston-Jacques Godeau, Corinne Sinquin, Sylvia Colliec-Jouault, Patrick Durand
-
Publication number: 20100298437Abstract: The invention relates to the use of L-citrulline (I) or of one of its pharmaceutically acceptable salts in the preparation of a drug for the treatment of states or undernutrition as linked to a lowering of protein synthesis within the framework of pathologies which do not result from an intestinal insufficiency.Type: ApplicationFiled: August 29, 2007Publication date: November 25, 2010Applicants: UNIVERSITE RENE DESCARTES-PARIS 5, BIOCODEXInventors: Christophe Moinard, Marion Jourdan, Stephane Walrand, Luc Cynober
-
Patent number: 7833990Abstract: The invention relates to the use of certain low-molecular weight highly sulphated polysaccharide derivatives obtained from a bacterial polysaccharide for preparing a pharmaceutical composition suitable for modulating angiogenesis, particularly for use in accelerating vascular endothelial repair with a low haemorrhage risk in the event of thrombotic injuries.Type: GrantFiled: June 6, 2005Date of Patent: November 16, 2010Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Universite Rene Descartes Paris 5Inventors: Sabine Matou, Sylvia Colliec-Jouault, Dominique Helley, Jacqueline Ratiskol, Corinne Sinquin, Claire Boisset, Jean Guezennec, Anne-Marie Fischer
-
Publication number: 20100196417Abstract: The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDI capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.Type: ApplicationFiled: December 26, 2007Publication date: August 5, 2010Applicants: UNIVERSITE RENE DESCARTES PARIS 5, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventor: Eric Tartour
-
Patent number: 7651838Abstract: The invention concerns a novel non-invasive prenatal diagnostic method implemented with a sample of maternal blood. Said method enables prenatal diagnosis on isolated non-apoptotic epithelial foetal cells of maternal blood after they have been enriched by filtration, morphologically or immunologically and genetically analysed. Said method is advantageous in that it is perfectly harmless for the mother and the foetus and provides a highly sensitive and specific diagnosis. It enables early detection of a genetic or chromosomal abnormality of the foetus, of a genetic or infectious (viral, bacterial or parasitic) pathology of the foetus, of accurate genotype, and in particular of the genetic sex of the foetus.Type: GrantFiled: October 30, 2003Date of Patent: January 26, 2010Assignees: Institut National de la Sante et de la Recherche Medicale, Assistance Publique-Hopitaux de Paris, Universite Rene Descartes Paris 5Inventor: Patrizia Paterlini-Brechot
-
Publication number: 20090028924Abstract: The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the re-generation and protection of the non-mineralised connective tissue of the periodontium.Type: ApplicationFiled: December 6, 2007Publication date: January 29, 2009Applicant: UNIVERSITE RENE DESCARTES PARIS 5Inventors: Karim Senni, Corinne Sinquin, Sylvia Colliec-Jouault, Gaston-Jacques Godeau, Jean Guezennec
-
Publication number: 20080317860Abstract: The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the engineering of non-mineralised connective tissues, in particular for skin and cartilage engineering.Type: ApplicationFiled: December 6, 2006Publication date: December 25, 2008Applicants: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), UNIVERSITE RENE DESCARTES PARIS 5Inventors: Karim Senni, Corinne Sinquin, Sylvia Colliec-Jouault, Gaston-Jacques Godeau, Jean Guezennec
-
Publication number: 20080312263Abstract: The present invention relates to the use, of at least one statin, or of a pharmaceutically acceptable salt thereof, in combination with at least one compound of the following formula (I): in which R represents, —H, or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended for the prevention or treatment of atherosclerosis, in particular of primary or secondary atherosclerosis, hypertension, diabetes, or neurodegenerative diseases, in particular Alzheimer's disease.Type: ApplicationFiled: July 14, 2008Publication date: December 18, 2008Applicant: UNIVERSITE RENE DESCARTES-PARIS 5Inventors: REMY COUDERC, Carole Rasmusen, Chantal Martin, Viviane Tricottei, Luc Cynober, Christophe Moinard
-
Publication number: 20080064978Abstract: A skin potential measurement system including a plurality of measurement electrodes (3) and a data processing unit (4, 2). The electrodes and the processing unit are in wireless communication. Each electrode receives a digital identification code and transmits an analog signal indicative of a patient's measured skin potential. The processing unit shapes the analog signal prior to digitization then processing thereof.Type: ApplicationFiled: April 28, 2005Publication date: March 13, 2008Applicant: Universite Rene Descartes- Paris 5Inventor: Michel Bouchoucha
-
Patent number: 7316897Abstract: A cell separation process for the isolation of pathogenic cells in a small concentration in a biological fluid specimen, including treating the biological specimen to modify in a differential manner selected rare cells and other cells and causing differential migration of cells that reacted during treatment versus cells that did not react during treatment.Type: GrantFiled: February 22, 2001Date of Patent: January 8, 2008Assignees: L'Institut National de la Sante et de la Recherche Medicale (INSERM), L'Assistance Publique, Hopitaux de Paris (AP-HP), L'Universite Rene Descartes Paris 5Inventors: Jean-Claude Bisconte de Saint Julien, Patricia Paterlini
-
Publication number: 20070259833Abstract: The invention relates to the use of certain low-molecular weight highly sulphated polysaccharide derivatives obtained from a bacterial polysaccharide for preparing a pharmaceutical composition suitable for modulating angiogenesis, particularly for use in accelerating vascular endothelial repair with a low haemorrhage risk in the event of thrombotic injuries.Type: ApplicationFiled: June 6, 2005Publication date: November 8, 2007Applicants: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (FREMER), UNIVERSITE RENE DESCARTES PARIS 5Inventors: Sabine Matou, Sylvia Colliec-Jouault, Dominique Helley, Jacqueline Ratiskol, Corinne Sinquin, Claire Boisset, Jean Guezennec, Anne-Marie Fischer
-
Publication number: 20070219225Abstract: The present invention relates to the use, of at least one statin, or of a pharmaceutically acceptable salt thereof, in combination with at least one compound of the following formula (I): in which R represents, —H, or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended for the prevention or treatment of atherosclerosis, in particular of primary or secondary atherosclerosis, hypertension, diabetes, or neurodegenerative diseases, in particular Alzheimer's disease.Type: ApplicationFiled: April 29, 2005Publication date: September 20, 2007Applicant: UNIVERSITE RENE DESCARTES-PARIS 5Inventors: Remy Couderc, Carole Rasmusen, Chantal Martin, Viviane Tricottet, Luc Cynober, Christophe Moinard