Abstract: The present invention provides peptide hydrogelators capable of forming hydrogels as carriers of active ingredients and acting as sustained or controlled release drug delivery systems.

Abstract: The invention provides in an electron microscopy grid, comprising: a perforated substrate; a support film on the perforated substrate; a mixture of different linker molecules according to Structure (I), wherein AG is an anchoring group, for anchoring the linker molecule to the solid support; BU is a binding unit, for binding to the analyte; L1 is a first linear linker section; L2 is a second linear linker section; ? is the angle between the linear linker section L1 and the linear linker section L2; AS is an angled linker section, connecting the linear linker section L1 and the linear linker section L2. The invention further provides in method of structural determination of analytes, using such EM-grids.

Abstract: The present invention relates to the use of a known enzyme ‘denominated as a Starmerella bombicola lactone esterase (Sble)’ to perform a transesterification and/or hydrolysis reaction. More specifically the Sble enzyme performs a transesterification and/or hydrolysis reaction on bola amphiphilic glycolipids. The invention indeed discloses that said Sble is capable to convert bola sophorolipids into lactonic and/or acidic sophorolipids and saccharides, and, that yeast strains containing a non-functional or dysfunctional Sble enzyme and/or a disabled sble gene and/or not containing the sble gene produce (acetylated) bola amphiphilic glycolipids.

Abstract: The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to pharmaceutical compositions comprising the CD8 binding agents and their use in the treatment of various diseases, including, for example, cancers.

Abstract: A method to provide a microfluidic flow comprising a central flow and at least one outer flow, such that the central flow includes a first material and the at least one outer flow comprises a second material. One of the first material and the second material has cells and the other of the first material and the second material has solid particles. The method involves injection of a first suspension including the first material through a central inlet with a flow rate Q2 and injection of a second suspension comprising the second material through a pair of side inlets with a flow rate Q2, whereby the ratio of the flow rate Q2 over the flow rate Q1 is at least 4. A device provides such microfluidic flow and a method is provided to alter biological cells.

Abstract: A device for medium access control in a node of a wireless communication network with time-shared medium includes a slot allocation module configured to allocate a timeslot for transmission from the node to a destination node over the time-shared medium; a validation module configured to validate a data packet before transmission to the destination node based on a latency requirement for the data packet, and an expected latency for the data packet based on the position in time of the timeslot, resulting in an approved data packet or a disapproved data packet; a scheduling module configured to schedule an approved data packet in the timeslot for transmission to the destination node.

Abstract: Bifunctional modified biopolymer based polymer comprise at least one polymer chain comprising n first functional groups and m second functional groups. The first functional groups comprise groups able of being radically cross-linked following a free radical chain-growth polymerisation. The second functional groups comprise groups able to thiol-ene crosslinking. Preferred bifunctional modified biopolymer based polymers comprise bifunctional modified gelatin and bifunctional modified collagen. The invention further relates to a method to prepare such a bifunctional modified biopolymer based polymer and to a method to prepare a hydrogel starting from such bifunctional modified biopolymer based polymer. Furthermore the invention relates to hydrogels obtainable starting from such bifunctional modified biopolymer based polymers and to the use of such hydrogels.

Abstract: The present invention relates to the field of sustainable agriculture. Specifically, the invention provides microbial compositions and methods useful for the production of crop plants. In particular, the compositions and methods disclosed herein are useful for enhancing plant growth and/or plant yield as well as for promoting cold and salt tolerance.

Abstract: A light sensing device includes: a light sensitive layer having a phosphor with two different types of lanthanides dopant ions, switching between a first state and a second state; one or more optical filters on top of the light sensitive layer. When the dopant ions are in the second state after exposure of the light sensitive layer to the second light energy, the light sensitive layer measures a first light intensity of light of the first light energy. When the dopant ions are in the first state after exposure of the light sensitive layer to the first light energy, the light sensitive layer measures a second light intensity of light of the second light energy.

Abstract: The disclosure includes a system for photoacoustic inspection of an object. The system includes a broadband emission source configured to generate an emission beam, a direction apparatus including at least one spectrum splitter configured to split the emission beam into at least a first and a second component, the direction apparatus being configured to sequentially direct the respective components to N respective locations on the object at N times to generate N respective acoustic waves within the object. The N respective locations and N times are such that the respective N acoustic waves at least semi-constructively interfere to generate a respective propagating acoustic wave within the object. The system also includes a vibration sensing system configured to detect said respective propagating acoustic waves at a respective detection location on the object.

Abstract: Polyoxazoline polymers, polymer combinations, and compositions comprising those polymers or combinations of polymers are disclosed. The invention further relates to the use of said polyoxazoline polymers, said combinations and compositions comprising such polymers and combinations for the sustained release of one or more active ingredients, in particular one or more active pharmaceutical ingredients. It further relates to the use of polyoxazoline polymers or polymer combinations as drug carrier.

Abstract: A filter includes cascaded building blocks, for filtering an incoming signal. Each building block has first and second delay elements. A first scaling device is between an input node of the first delay element and an output node of the second delay element, and a second scaling device is between an output node of the first delay element and an input node of the second delay element. The building block has a cross scaling device between the output nodes of the first delay element and of the second delay element, and/or between the input nodes of the first delay element and of the second delay element. The building block is configured such that, in operation, incoming signals at the input node and output node of the second delay element are summed together.

Abstract: The present invention provides means and methods for the production in eukaryotic cells of homogeneous forms of small glycan structures which carry terminal galactose residues. In addition, the invention provides glycan-conjugates based on specific coupling with galactose residues present on the recombinant glycoproteins.

Abstract: The invention relates to a method to deink and/or to delaminate plastic material, preferably to a method to deink and delaminate plastic material in a single step. The method comprises the step of contacting the plastic material with an amine or a composition comprising said amine, wherein the amine comprises a nitrogen atom having at least one hydrocarbon substituent comprising an acyclic or cyclic alkyl group. The total number of carbon atoms of all hydrocarbon substituents of the nitrogen atom is at least (5).

Abstract: The present invention relates to a modified cytokine of the TNF superfamily, with reduced activity to its receptor, wherein said modified cytokine is specifically delivered to target cells. Preferably, said modified cytokine is a single chain variant of the TNF superfamily, even more preferably, one or more of the chains can-y one or more mutations, resulting in a low affinity to the receptor, wherein said mutant cytokine is specifically delivered to target cells. The targeting is realized by fusion of the modified cytokine of the TNF superfamily to a targeting moiety, preferably an antibody or antibody-like molecule. The invention relates further to the use of such targeted modified cytokine of the TNF superfamily to treat diseases.

Abstract: The invention relates to an admixture for a cementitious material suitable to influence the rheological properties of the cementitious material. The admixture includes a compound having a backbone chain provided with at least one first functionality and at least one second functionality. The at least one first functionality is adapted to adsorb to the cement particles of the cementitious material. The at least one second functionality is adapted to respond to an external trigger signal of an electric field, a magnetic field or an electromagnetic field, thereby influencing the rheological properties of the cementitious material. The rheological properties are influenced by influencing the interaction of the at least one first functionality with the cement particles and/or by influencing the interparticle interaction between the cement particles. The invention further relates to a cementitious material including such admixture.

Abstract: The disclosure relates to the field of reducing malodor, which is due to bacterial conversion of molecules that are present in sweat. Indeed, the disclosure describes acids, which steer the microbiome by inhibiting the growth of specific malodor-producing bacteria and/or promoting the growth of bacteria known to be beneficial in relation to malodor. The acids of the disclosure can thus be used in deodorants, washing powders, clothing finishing agents or any method to reduce malodor. The disclosure thus relates to a topical composition or textile finisher for use as a prebiotic.

Abstract: The present invention relates to solution electrospun fibers comprising a ingredient in an amorphous form, compositions and their manufacturing process thereof. More specifically, the present invention relates to solution electrospun fibers and a compositions comprising at least one of said fibers, said fiber obtained by solution electrospinning a ingredient with a polymer.

Abstract: The present invention provides a lipid nanoparticle comprising a fentanyl hapten, and a T helper peptide and/or an adjuvant, wherein the fentanyl hapten is conjugated to the outer surface of the lipid nanoparticle, and wherein the T helper peptide and/or the adjuvant is/are encapsulated within the lipid nanoparticle. The invention further provides a pharmaceutical composition comprising the lipid nanoparticle and uses thereof for inducing an immune response against fentanyl and the prevention or treatment of a fentanyl abuse disorder or a fentanyl addiction or a fentanyl overdose in a subject. Further provided herein is a method for preparing the lipid nanoparticle of the invention.

Abstract: The present invention is in the field of auditory devices. In particular, the present invention provides a method for converting an auditory stimulus to a processed auditory output. The present invention also relates to uses of the method, auditory devices configured to perform the method, and computer programs configured to perform the method for converting an auditory stimulus to a processed auditory output.