Patents Assigned to Universiteit Utrecht
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Publication number: 20230382961Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: ApplicationFiled: February 8, 2023Publication date: November 30, 2023Applicant: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Publication number: 20230355399Abstract: A prosthesis for a mammal comprises a prosthesis body (302) with a dorsal surface (311) and a ventral surface (312) shaped to fit in a joint between a tibia and a femur so that the dorsal surface faces a distal end of the femur and the ventral surface faces a proximal end of the tibia. At least one fixation element (303) is provided for fixing the prosthesis body (302) to the tibia (150), wherein the dorsal surface (311) is inclined in a dorsal direction towards a caudal edge of the prosthesis body, to stabilize the femur.Type: ApplicationFiled: September 9, 2021Publication date: November 9, 2023Applicants: ATRO Medical B.V., Universiteit Utrecht Holding B.V.Inventors: Antonius Christiaan van der Zanden, Albert van der Veen, Meropi Adriana Tryfonidou, Björn Petrus Meij, Tony George van Tienen
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Publication number: 20230221333Abstract: This disclosure relates to new methods for antibody characterization sequencing, such as middle down antibody characterization and sequencing, for example, for de novo antibody sequencing, identifying known antibodies in a sample, or verifying the sequence of antibodies in a sample. In some embodiments, the methods involve exposing antibodies to cathepsin D, cathepsin L, and/or cathepsin D and L, followed by mass spectrometry and sequence identification and deconvolution.Type: ApplicationFiled: January 17, 2023Publication date: July 13, 2023Applicants: Genentech, Inc., Universiteit Utrecht Holding B.V.Inventors: Wendy Noel Sandoval, Tomislav Caval, Albert J.R. Heck, Elizabeth Sara Hecht
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Publication number: 20230201799Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: ApplicationFiled: February 10, 2023Publication date: June 29, 2023Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Patent number: 11622862Abstract: An implant, a fitting plate suitable for placing of an implant, and a method for manufacturing an implant suitable for application on one or more bones.Type: GrantFiled: May 30, 2017Date of Patent: April 11, 2023Assignees: UMC UTRECHT HOLDING B.V., UNIVERSITEIT UTRECHT HOLDING B.V.Inventors: Bart Cornelis Hendrikus Van Der Wal, Ralph Johan Bernard Sakkers, Björn Petrus Meij, Lucas Alphonsus Maria Evers, Hermanus Hendricus Weinans
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Patent number: 11624082Abstract: The present invention relates to a method for monitoring kinase activity or activation in a sample, the method comprises the steps of a) providing a sample comprising a kinase, b) incubating the sample with a protease to cleave the kinase provided in step a) into protease specific proteolytic peptides, c) applying phosphopeptide enrichment to the sample, d) analysing the sample obtained in step c) via liquid chromatography-mass spectrometry, and e) detecting phosphorylations of the kinase provided in step a), wherein the detection of step e) is performed only in case a proteolytic peptide associated with the activation region of the kinase is identified.Type: GrantFiled: June 21, 2019Date of Patent: April 11, 2023Assignee: UNIVERSITEIT UTRECHT HOLDING B.V.Inventors: Adrianus Fredrik Maarten Altelaar, Thierry Thomas Schmidlin
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Patent number: 11612877Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: GrantFiled: December 4, 2018Date of Patent: March 28, 2023Assignees: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Patent number: 11603391Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: GrantFiled: October 13, 2020Date of Patent: March 14, 2023Assignee: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Publication number: 20230046628Abstract: The present invention relates to a method for preparing a macromolecular composition comprising phenylglyoxaldehyde-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules, for instance to remove such small molecules from a solution.Type: ApplicationFiled: November 20, 2020Publication date: February 16, 2023Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Publication number: 20220401889Abstract: The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.Type: ApplicationFiled: November 20, 2020Publication date: December 22, 2022Applicants: Stichting voor de Technische Wetenschappen, UMC Utrecht Holding B.V., Universiteit Utrecht Holding B.V., Universiteit TwenteInventors: Dimitrios Stamatialis, Ilaria Geremia, Cornelus Franciscus van Nostrum, Karin Gerarda Frederika Gerritsen, Robert Smakman, Wilhelmus Everhardus Hennink, Jacobus Adrianus Wilhelmus Jong, Yong Guo
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Publication number: 20220260763Abstract: A method of producing a diffractive optical element (1) comprises the steps of providing at least one substrate (3) having a surface (4) and generating a relief structure (2) in the surface (4) of the substrate (3) using a processing device (5). The relief structure (2) is generated such that a distance (D) between a surface (8) of the relief structure (2) and the surface (4) of the substrate (3) along the third direction (z) varies essentially continuously. A diffractive optical element (1) comprises a relief structure (2), wherein at least in a portion of the relief structure (2) a distance (D) between the surface (8) of the relief structure (2) and the surface (4) of the substrate (3) varies essentially continuously. A virtual image display device comprises at least a first and a second of such diffractive optical elements (1).Type: ApplicationFiled: July 7, 2020Publication date: August 18, 2022Applicants: ETH Zurich, Universiteit Utrecht Holding B.V.Inventors: David J. NORRIS, Nolan LASSALINE, Raphael BRECHBÜHLER, Freddy RABOUW
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Patent number: 11186619Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: GrantFiled: April 10, 2019Date of Patent: November 30, 2021Assignee: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Patent number: 11130781Abstract: The invention relates to the field of antibiotics, more specifically to peptide antibiotics, such as antimicrobial peptides and their use in the treatment of diseases associated with microbial infections. In particular, the invention provides a peptide with antimicrobial activity comprising an amino acid sequence RRWVQRWIRRWR (SEQ ID NO: 24) or an analogue thereof.Type: GrantFiled: April 24, 2018Date of Patent: September 28, 2021Assignees: Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Marinus Van Eijk, Albert Van Dijk, Hendrik Peter Haagsman, Cornelis Korstiaan Van Der Ent
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Publication number: 20210246177Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: ApplicationFiled: October 13, 2020Publication date: August 12, 2021Applicant: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Publication number: 20200368721Abstract: The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.Type: ApplicationFiled: December 4, 2018Publication date: November 26, 2020Applicants: Stichting voor de Technische Wetenschappen, Universiteit Utrecht Holding B.V., UMC Utrecht Holding B.V.Inventors: Robert Smakman, Wilhelmus Everhardus Hennink, Karin Gerarda Frederika Gerritsen, Jacobus Adrianus Wilhelmus Jong, Cornelus Franciscus van Nostrum
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Patent number: 10829524Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: GrantFiled: May 8, 2015Date of Patent: November 10, 2020Assignee: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Publication number: 20190233483Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: ApplicationFiled: April 10, 2019Publication date: August 1, 2019Applicant: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Patent number: 10301363Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: GrantFiled: March 26, 2015Date of Patent: May 28, 2019Assignee: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Publication number: 20190151098Abstract: An implant, a fitting plate suitable for placing of an implant, and a method for manufacturing an implant suitable for application on one or more bones.Type: ApplicationFiled: May 30, 2017Publication date: May 23, 2019Applicants: UMC UTRECHT HOLDING B.V., UNIVERSITEIT UTRECHT HOLDING B.V.Inventors: Bart Cornelis Hendrikus VAN DER WAL, Ralph Johan Bernard SAKKERS, Bjorn Petrus MEIJ, Lucas Alphonsus Maria EVERS, Hermanus Hendricus WEINANS, I
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Patent number: 10143738Abstract: The invention pertains to a vaccine for use in protecting a pig against an infection with porcine epidemic diarrhea virus (PEDV), the vaccine comprising non-live PEDV antigen and a non-metabolizable oil containing adjuvant, wherein the total amount of oil in the vaccine is less than 50% v/v, by administration of a dose of the antigen corresponding to at least 3.0E6 TCID50 killed whole PEDV. The invention also pertains to a method of protecting a pig against an infection with porcine epidemic diarrhea virus.Type: GrantFiled: September 11, 2015Date of Patent: December 4, 2018Assignees: Intervet Inc., Universiteit Utrecht Holding B.V.Inventors: Erwin Born, van den, Berend Jan Bosch, Peter Rottier