Abstract: The present invention relates to a vaccine containing at least one particulate immunogen and an adjuvanting amount of B subunits of heat-labile enterotoxin characteristic of E. Coli. More in particular, this invention relates to vaccines wherein the adjuvanting LTB is free from contaminating A subunits or holotoxin. To this end, preferably, use is made of LTB prepared by recombinant DNA techniques. The particulate immunogens can relate to or can be derived from e.g. viruses, bacteria or fungi. This vaccine is particularly suitable for the induction of a protective response against said particulate immunogen upon mucosal (e.g. intra-nasal) administration. It was found that such administration results in both systemic and mucosal protection against the pathogen to which the particulate immunogen relates.
Type:
Grant
Filed:
December 13, 2000
Date of Patent:
September 21, 2004
Assignees:
Duphar International Research BV, Universiteit Van Groningen
Inventors:
Gustaaf J. M. van Scharrenburg, Rudi Brands, Lolke de Haan, Willem Ronald Verweij, Jan C. Wilschut, Etienne Agsteribbe