Patents Assigned to Universiti Sains Malaysia
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Patent number: 10627394Abstract: The present invention relates to methods of screening biological samples for the presence of Strongyloides spp. More particularly, the present invention relates to a sensitive and specific screening test for the presence of anti-Strongyloides spp antibodies, protein or nucleic acid in subjects using particular Strongyloides spp L3 stage antigens and nucleic acids encoding same which have diagnostic efficacy.Type: GrantFiled: August 30, 2016Date of Patent: April 21, 2020Assignee: Universiti Sains MalaysiaInventors: Rahmah Binti Noordin, Norsyahida Binti Arifin
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Patent number: 10060922Abstract: The present invention relates to methods of screening biological samples for the presence of T. gondii. More particularly, the present invention relates to a sensitive and specific screening test for the presence of Toxoplasmosis in subjects by using or detecting the in vivo-induced T. gondii RAP domain binding protein antigen. The invention further relates to the use of the in vivo-induced antigen in the prevention or therapy of Toxoplasmosis.Type: GrantFiled: October 1, 2015Date of Patent: August 28, 2018Assignee: UNIVERSITI SAINS MALAYSIAInventors: Rahmah Binti Noordin, Atefeh Amerizadeh
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Patent number: 9212128Abstract: (R)-6-(dimethylamino)-4,4-diphenylheptan-3-one and a process to produce thereof.Type: GrantFiled: February 28, 2012Date of Patent: December 15, 2015Assignee: UNIVERSITI SAINS MALAYSIAInventors: Rusli Ismail, Asaraf Ali, Soo Choon Tan
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Patent number: 9112894Abstract: A platform to support real time passive distributed network monitoring and security monitoring applications wherein the platform will use the open architecture concept for other application developers to add functionality or extend existing functionalities; wherein the platform proposes three new concepts in real time passive network monitoring and security monitoring; the 3-tier monitoring architecture; the innovative buffering technique; and the distributed passive data gathering; wherein each element has intelligence built-in to pre-process the gathered data and reduce the bandwidth consumption between the central coordination server and the distributed monitoring elements; allowing other applications to extend the platform cores through it is available APIs and extension points; and can be easily integrated into heterogeneous network environments running different operating systems due to it is cross platform nature; wherein a central coordination and monitoring server that is locally accessible by the diType: GrantFiled: December 31, 2009Date of Patent: August 18, 2015Assignee: Universiti Sains MalaysiaInventors: Sureswaran Ramadass, Ahmed Mansour Manasrah
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Patent number: 8962259Abstract: A vector comprising a polynucleotide sequence encoding a polypeptide having an amino acid sequence of SEQ ID NO: 2 for detecting antibody against Toxocara spp. in a biological sample.Type: GrantFiled: February 27, 2009Date of Patent: February 24, 2015Assignee: Universiti Sains MalaysiaInventors: Rahmah Binti Noordin, Suharni Binti Mohamad
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Patent number: 8895477Abstract: A method for preparing lignin graft copolymer comprising: reacting lignocellulosic materials with an acrylic compound by bulk condensation under nitrogen atmosphere in the presence of a non-oxidizing strong organic acid as catalyst; separating the reaction mixture to obtain a solid phase mainly containing lignocellulosic materials and a liquid phase containing lignin graft copolymer and unreacted acrylic compound; and removing solvent from the liquid phase to obtain the lignin graft copolymer.Type: GrantFiled: October 21, 2009Date of Patent: November 25, 2014Assignee: Universiti Sains MalaysiaInventors: Mohamad Nasir Bin Mohamad Ibrahim, Mohamed Rashid Ahmed Mohamed Haras, Coswald Stephen Sipaut
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Publication number: 20140017738Abstract: The present invention relates to a system for producing L-homophenylalanine and a process for producing L-homophenylalanine using the system. The system and the process include monitoring and controlling of the reaction conditions (e.g., temperature and pH) to desired or predetermined values. The monitoring, adjusting and agitating steps provided by the method thereby result in a more complete conversion of the available substrate and produce a sufficient yield of L-homophenylalanine.Type: ApplicationFiled: August 27, 2013Publication date: January 16, 2014Applicant: Universiti Sains MalaysiaInventors: Abdul Latif AHMAD, Pei Ching OH, Syamsul Rizal ABD. SHUKOR
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Publication number: 20130046082Abstract: The present invention provides a composition including a polar organic extract of Eurycoma longifolia and a fraction derived from the polar organic extract, said composition comprising of quassinoids, coumarins, their glycosides, analogues and derivatives, which exhibits bioactivity of increasing spermatozoa production and spermatozoa quality in terms of morphology and motility, as well as increasing testosterone synthesis and release from cells of males. The extraction method of E. longifolia plant to produce the polar organic extract, and the subsequent purification to produce the fraction of polar organic extract containing the quassinoids, coumarins, their glycosides, analogues and derivatives, and uses for manufacturing a preparation for infertility treatment are also provided. The fraction of polar organic extract containing the quassinoids, coumarins, their glycosides, analogues and derivatives is formulated for medical applications via several routes of administration.Type: ApplicationFiled: June 12, 2012Publication date: February 21, 2013Applicant: Universiti Sains MalaysiaInventors: Kit Lam CHAN, Bin Seng Low, David Sue San Ho
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Publication number: 20120124200Abstract: A platform to support real time passive distributed network monitoring and security monitoring applications wherein the platform will use the open architecture concept for other application developers to add functionality or extend existing functionalities; wherein the platform proposes three new concepts in real time passive network monitoring and security monitoring; the 3-tier monitoring architecture; the innovative buffering technique; and the distributed passive data gathering; wherein each element has intelligence built-in to pre-process the gathered data and reduce the bandwidth consumption between the central coordination server and the distributed monitoring elements; allowing other applications to extend the platform cores through it is available APIs and extension points; and can be easily integrated into heterogeneous network environments running different operating systems due to it is cross platform nature; wherein a central coordination and monitoring server that is locally accessible by the diType: ApplicationFiled: December 31, 2009Publication date: May 17, 2012Applicants: INETMON SDN BHD, UNIVERSITI SAINS MALAYSIAInventors: Sureswaran Ramadass, Ahmed Mansour Manasrah
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Patent number: 7994288Abstract: This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitising agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.Type: GrantFiled: July 15, 2009Date of Patent: August 9, 2011Assignees: The Board of the Rubber Research Institute of Malaysia, Universiti Sains MalaysiaInventors: Mary Jane Cardosa, Hamid Sharifah, Shirley Samuel-Verghese, Elumalai Sunderasan, Hoong Yeet Yeang, Hamzah Samsidar
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Patent number: 7838016Abstract: Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproculture having all the identifying characteristics of Vibrio cholerae 0139 synonym Bengal is described. In this strain the hem A gene is mutated by inserting a kanamycin resistant gene cassette. Another metabolic auxotroph of Vibrio cholerae 01 E1 Tor where the hem A gene is mutated by a frame shift mutation is disclosed. Methods of producing the strains are disclosed.Type: GrantFiled: May 24, 2007Date of Patent: November 23, 2010Assignee: Universiti Sains MalaysiaInventors: Manickam Ravichandran, Syed Atif Ali, Nur Haslindawaty Abdul Rashid, Lalitha Pattabiraman, Zainul Fadziruddin Zainuddin
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Publication number: 20100221370Abstract: The present invention provides a composition including a polar organic extract of Eurycoma longifolia and a fraction derived from the polar organic extract, said composition comprising of quassinoids, coumarins, their glycosides, analogues and derivatives, which exhibits bioactivity of increasing spermatozoa production and spermatozoa quality in terms of morphology and motility, as well as increasing testosterone synthesis and release from cells of males. The extraction method of E. longifolia plant to produce the polar organic extract, and the subsequent purification to produce the fraction of polar organic extract containing the quassinoids, coumarins, their glycosides, analogues and derivatives, and uses for manufacturing a preparation for infertility treatment are also provided. The fraction of polar organic extract containing the quassinoids, coumarins, their glycosides, analogues and derivatives is formulated for medical applications via several routes of administration.Type: ApplicationFiled: August 6, 2007Publication date: September 2, 2010Applicant: UNIVERSITI SAINS MALAYSIAInventors: Kit Lam Chan, Bin Seng Low, David Sue San Ho
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Publication number: 20100159582Abstract: A polymerase chain reaction (PCR) device including a chip assembly, a plurality of chambers being provided in said chip assembly adapted to hold samples, heating means wherein said chip assembly being located on said heating means whereby said chip assembly is allowed to operatively rotate on said heating means, a rotary wheel aiding said chip rotation and wherein said heating means comprises of plural temperature zones in a manner that on rotation of said chip means said sample chamber is shifted from one temperature zone to another by means of a rotary-linear motion system.Type: ApplicationFiled: July 27, 2009Publication date: June 24, 2010Applicant: UNIVERSITI SAINS MALAYSIAInventors: Asma ISMAIL, Sugumar DHARMALINGAM, Lingxue KONG
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Publication number: 20100021926Abstract: There is provided by this invention a specific and sensitive diagnostic method for rapid detection of lymphatic filariasis. The method employs a combination of SXP/SXP-recombinant antigen, mouse monoclonal anti-human IgG4 antibody conjugated to a detection reagent and the technique of immunochromatography.Type: ApplicationFiled: April 10, 2007Publication date: January 28, 2010Applicant: UNIVERSITI SAINS MALAYSIAInventor: Rahmah Noordin
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Patent number: 7576184Abstract: This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitising agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.Type: GrantFiled: April 8, 2004Date of Patent: August 18, 2009Assignees: The Board of the Rubber Research Institute of Malaysia, Universiti Sains MalaysiaInventors: Mary Jane Cardosa, Hamid Sharifah, Shirley Samuel-Verghese, Elumalai Sunderasan, Hoong Yeet Yeang, Hamzah Samsidar
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Patent number: 6759517Abstract: This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitizing agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.Type: GrantFiled: September 15, 1995Date of Patent: July 6, 2004Assignees: Universiti Sains Malaysia, The Board of the Rubber Research Institute of MalaysiaInventors: Mary Jane Cardosa, Hamid Sharifah, Shirley Samuel-Verghese, Elumalai Sunderasan, Hoong Yeet Yeang, Hamzah Samsidar
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Patent number: 6743866Abstract: A rubber derivative comprises a coordination compound of a natural or syntheticrubber containing double bonds and/or epoxy or other groups containing an electronegative atom or atoms and preferably having a weight average molecular weight of from 20,000 to 90,000, more preferably, 20,000 to 85,000, especially about 80,000, with an alkali or alkaline earth metal.Type: GrantFiled: December 7, 2001Date of Patent: June 1, 2004Assignee: Universiti Sains MalaysiaInventor: Mas Rosemal Hakim b Mas Haris
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Publication number: 20020012668Abstract: The genetic material encoding for a specific outer membrane protein (OMP) of Salmonella typhi has been isolated and characterized. This genetic material (ST50) allows for the production of specific proteins/peptides/DNA/RNA for its use in diagnostics, detection of the bacteria S.typhi or in the production of vaccines for typhoid fever.Type: ApplicationFiled: February 28, 2001Publication date: January 31, 2002Applicant: Universiti Sains MalaysiaInventors: Asma Binti Ismail, Ong Kok Hai, Manickam Ravichandran, Zainoodin S. A. Kader