Patents Assigned to Universiti Sains Malaysia
  • Patent number: 10627394
    Abstract: The present invention relates to methods of screening biological samples for the presence of Strongyloides spp. More particularly, the present invention relates to a sensitive and specific screening test for the presence of anti-Strongyloides spp antibodies, protein or nucleic acid in subjects using particular Strongyloides spp L3 stage antigens and nucleic acids encoding same which have diagnostic efficacy.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: April 21, 2020
    Assignee: Universiti Sains Malaysia
    Inventors: Rahmah Binti Noordin, Norsyahida Binti Arifin
  • Patent number: 10060922
    Abstract: The present invention relates to methods of screening biological samples for the presence of T. gondii. More particularly, the present invention relates to a sensitive and specific screening test for the presence of Toxoplasmosis in subjects by using or detecting the in vivo-induced T. gondii RAP domain binding protein antigen. The invention further relates to the use of the in vivo-induced antigen in the prevention or therapy of Toxoplasmosis.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 28, 2018
    Assignee: UNIVERSITI SAINS MALAYSIA
    Inventors: Rahmah Binti Noordin, Atefeh Amerizadeh
  • Patent number: 9212128
    Abstract: (R)-6-(dimethylamino)-4,4-diphenylheptan-3-one and a process to produce thereof.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: December 15, 2015
    Assignee: UNIVERSITI SAINS MALAYSIA
    Inventors: Rusli Ismail, Asaraf Ali, Soo Choon Tan
  • Patent number: 9112894
    Abstract: A platform to support real time passive distributed network monitoring and security monitoring applications wherein the platform will use the open architecture concept for other application developers to add functionality or extend existing functionalities; wherein the platform proposes three new concepts in real time passive network monitoring and security monitoring; the 3-tier monitoring architecture; the innovative buffering technique; and the distributed passive data gathering; wherein each element has intelligence built-in to pre-process the gathered data and reduce the bandwidth consumption between the central coordination server and the distributed monitoring elements; allowing other applications to extend the platform cores through it is available APIs and extension points; and can be easily integrated into heterogeneous network environments running different operating systems due to it is cross platform nature; wherein a central coordination and monitoring server that is locally accessible by the di
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: August 18, 2015
    Assignee: Universiti Sains Malaysia
    Inventors: Sureswaran Ramadass, Ahmed Mansour Manasrah
  • Patent number: 8962259
    Abstract: A vector comprising a polynucleotide sequence encoding a polypeptide having an amino acid sequence of SEQ ID NO: 2 for detecting antibody against Toxocara spp. in a biological sample.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: February 24, 2015
    Assignee: Universiti Sains Malaysia
    Inventors: Rahmah Binti Noordin, Suharni Binti Mohamad
  • Patent number: 8895477
    Abstract: A method for preparing lignin graft copolymer comprising: reacting lignocellulosic materials with an acrylic compound by bulk condensation under nitrogen atmosphere in the presence of a non-oxidizing strong organic acid as catalyst; separating the reaction mixture to obtain a solid phase mainly containing lignocellulosic materials and a liquid phase containing lignin graft copolymer and unreacted acrylic compound; and removing solvent from the liquid phase to obtain the lignin graft copolymer.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: November 25, 2014
    Assignee: Universiti Sains Malaysia
    Inventors: Mohamad Nasir Bin Mohamad Ibrahim, Mohamed Rashid Ahmed Mohamed Haras, Coswald Stephen Sipaut
  • Publication number: 20140017738
    Abstract: The present invention relates to a system for producing L-homophenylalanine and a process for producing L-homophenylalanine using the system. The system and the process include monitoring and controlling of the reaction conditions (e.g., temperature and pH) to desired or predetermined values. The monitoring, adjusting and agitating steps provided by the method thereby result in a more complete conversion of the available substrate and produce a sufficient yield of L-homophenylalanine.
    Type: Application
    Filed: August 27, 2013
    Publication date: January 16, 2014
    Applicant: Universiti Sains Malaysia
    Inventors: Abdul Latif AHMAD, Pei Ching OH, Syamsul Rizal ABD. SHUKOR
  • Publication number: 20130046082
    Abstract: The present invention provides a composition including a polar organic extract of Eurycoma longifolia and a fraction derived from the polar organic extract, said composition comprising of quassinoids, coumarins, their glycosides, analogues and derivatives, which exhibits bioactivity of increasing spermatozoa production and spermatozoa quality in terms of morphology and motility, as well as increasing testosterone synthesis and release from cells of males. The extraction method of E. longifolia plant to produce the polar organic extract, and the subsequent purification to produce the fraction of polar organic extract containing the quassinoids, coumarins, their glycosides, analogues and derivatives, and uses for manufacturing a preparation for infertility treatment are also provided. The fraction of polar organic extract containing the quassinoids, coumarins, their glycosides, analogues and derivatives is formulated for medical applications via several routes of administration.
    Type: Application
    Filed: June 12, 2012
    Publication date: February 21, 2013
    Applicant: Universiti Sains Malaysia
    Inventors: Kit Lam CHAN, Bin Seng Low, David Sue San Ho
  • Publication number: 20120124200
    Abstract: A platform to support real time passive distributed network monitoring and security monitoring applications wherein the platform will use the open architecture concept for other application developers to add functionality or extend existing functionalities; wherein the platform proposes three new concepts in real time passive network monitoring and security monitoring; the 3-tier monitoring architecture; the innovative buffering technique; and the distributed passive data gathering; wherein each element has intelligence built-in to pre-process the gathered data and reduce the bandwidth consumption between the central coordination server and the distributed monitoring elements; allowing other applications to extend the platform cores through it is available APIs and extension points; and can be easily integrated into heterogeneous network environments running different operating systems due to it is cross platform nature; wherein a central coordination and monitoring server that is locally accessible by the di
    Type: Application
    Filed: December 31, 2009
    Publication date: May 17, 2012
    Applicants: INETMON SDN BHD, UNIVERSITI SAINS MALAYSIA
    Inventors: Sureswaran Ramadass, Ahmed Mansour Manasrah
  • Patent number: 7994288
    Abstract: This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitising agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: August 9, 2011
    Assignees: The Board of the Rubber Research Institute of Malaysia, Universiti Sains Malaysia
    Inventors: Mary Jane Cardosa, Hamid Sharifah, Shirley Samuel-Verghese, Elumalai Sunderasan, Hoong Yeet Yeang, Hamzah Samsidar
  • Patent number: 7838016
    Abstract: Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproculture having all the identifying characteristics of Vibrio cholerae 0139 synonym Bengal is described. In this strain the hem A gene is mutated by inserting a kanamycin resistant gene cassette. Another metabolic auxotroph of Vibrio cholerae 01 E1 Tor where the hem A gene is mutated by a frame shift mutation is disclosed. Methods of producing the strains are disclosed.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: November 23, 2010
    Assignee: Universiti Sains Malaysia
    Inventors: Manickam Ravichandran, Syed Atif Ali, Nur Haslindawaty Abdul Rashid, Lalitha Pattabiraman, Zainul Fadziruddin Zainuddin
  • Publication number: 20100221370
    Abstract: The present invention provides a composition including a polar organic extract of Eurycoma longifolia and a fraction derived from the polar organic extract, said composition comprising of quassinoids, coumarins, their glycosides, analogues and derivatives, which exhibits bioactivity of increasing spermatozoa production and spermatozoa quality in terms of morphology and motility, as well as increasing testosterone synthesis and release from cells of males. The extraction method of E. longifolia plant to produce the polar organic extract, and the subsequent purification to produce the fraction of polar organic extract containing the quassinoids, coumarins, their glycosides, analogues and derivatives, and uses for manufacturing a preparation for infertility treatment are also provided. The fraction of polar organic extract containing the quassinoids, coumarins, their glycosides, analogues and derivatives is formulated for medical applications via several routes of administration.
    Type: Application
    Filed: August 6, 2007
    Publication date: September 2, 2010
    Applicant: UNIVERSITI SAINS MALAYSIA
    Inventors: Kit Lam Chan, Bin Seng Low, David Sue San Ho
  • Publication number: 20100159582
    Abstract: A polymerase chain reaction (PCR) device including a chip assembly, a plurality of chambers being provided in said chip assembly adapted to hold samples, heating means wherein said chip assembly being located on said heating means whereby said chip assembly is allowed to operatively rotate on said heating means, a rotary wheel aiding said chip rotation and wherein said heating means comprises of plural temperature zones in a manner that on rotation of said chip means said sample chamber is shifted from one temperature zone to another by means of a rotary-linear motion system.
    Type: Application
    Filed: July 27, 2009
    Publication date: June 24, 2010
    Applicant: UNIVERSITI SAINS MALAYSIA
    Inventors: Asma ISMAIL, Sugumar DHARMALINGAM, Lingxue KONG
  • Publication number: 20100021926
    Abstract: There is provided by this invention a specific and sensitive diagnostic method for rapid detection of lymphatic filariasis. The method employs a combination of SXP/SXP-recombinant antigen, mouse monoclonal anti-human IgG4 antibody conjugated to a detection reagent and the technique of immunochromatography.
    Type: Application
    Filed: April 10, 2007
    Publication date: January 28, 2010
    Applicant: UNIVERSITI SAINS MALAYSIA
    Inventor: Rahmah Noordin
  • Patent number: 7576184
    Abstract: This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitising agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: August 18, 2009
    Assignees: The Board of the Rubber Research Institute of Malaysia, Universiti Sains Malaysia
    Inventors: Mary Jane Cardosa, Hamid Sharifah, Shirley Samuel-Verghese, Elumalai Sunderasan, Hoong Yeet Yeang, Hamzah Samsidar
  • Patent number: 6759517
    Abstract: This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitizing agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: July 6, 2004
    Assignees: Universiti Sains Malaysia, The Board of the Rubber Research Institute of Malaysia
    Inventors: Mary Jane Cardosa, Hamid Sharifah, Shirley Samuel-Verghese, Elumalai Sunderasan, Hoong Yeet Yeang, Hamzah Samsidar
  • Patent number: 6743866
    Abstract: A rubber derivative comprises a coordination compound of a natural or syntheticrubber containing double bonds and/or epoxy or other groups containing an electronegative atom or atoms and preferably having a weight average molecular weight of from 20,000 to 90,000, more preferably, 20,000 to 85,000, especially about 80,000, with an alkali or alkaline earth metal.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: June 1, 2004
    Assignee: Universiti Sains Malaysia
    Inventor: Mas Rosemal Hakim b Mas Haris
  • Publication number: 20020012668
    Abstract: The genetic material encoding for a specific outer membrane protein (OMP) of Salmonella typhi has been isolated and characterized. This genetic material (ST50) allows for the production of specific proteins/peptides/DNA/RNA for its use in diagnostics, detection of the bacteria S.typhi or in the production of vaccines for typhoid fever.
    Type: Application
    Filed: February 28, 2001
    Publication date: January 31, 2002
    Applicant: Universiti Sains Malaysia
    Inventors: Asma Binti Ismail, Ong Kok Hai, Manickam Ravichandran, Zainoodin S. A. Kader