Abstract: The nucleoside analog 2′-fluoro-5-methyl-1-&bgr;-D-arabinofuranosyluracil (FMAU) has been found to have an especially desirable combination of properties for use as an imaging agent, including in particular limited in vivo catabolism. Methods for the preparation of the [11C]-and [18F]-labeled FMAU and for the use of the labeled material are also provided.
Type:
Grant
Filed:
March 6, 1998
Date of Patent:
December 18, 2001
Assignee:
University Advanced Bio-imaging Associates
Inventors:
Peter S. Conti, Mian M. Alauddin, John D. Fissekis
Abstract: The nucleoside analog 2'-fluoro-5-methyl-1-.beta.-D-arabinofuranosyluracil (FMAU) has been found to have an especially desirable combination of properties for use as an imaging agent, including in particular limited in vivo catabolism. Methods for the preparation of the ?.sup.11 C!-labelled FMAU and for the use of the labelled material are also provided.
Type:
Grant
Filed:
August 23, 1995
Date of Patent:
March 9, 1999
Assignee:
University Advanced Bio-Imaging Associates
Inventors:
Peter S. Conti, Mian M. Alauddin, John D. Fissekis