Patents Assigned to University College Cork-National University of Ireland
  • Publication number: 20190264168
    Abstract: The current invention provides use of a CLA-producing bacterium for the in vivo conversion in the gut of polyunsaturated fatty acids to CLA. The CLA-producing bacterium is selected from one or more of the group consisting of propionibacteria, lactobacilli, lactococci and streptococci, and bifidobacteria.
    Type: Application
    Filed: December 3, 2018
    Publication date: August 29, 2019
    Applicants: University College Cork, National University of Ireland, Teagasc- The Agriculture and Food Development Authority, Alimentary Health Ltd.
    Inventors: Liam O'Mahony, Fergus Shanahan, Eamonn Quigley, Paul Ross, Catherine Stanton
  • Patent number: 10279083
    Abstract: Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25 pg to 950 pg of IGF-1 directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: May 7, 2019
    Assignee: University College Cork, National University of Ireland, Cork
    Inventor: Noel Caplice
  • Publication number: 20190056380
    Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.
    Type: Application
    Filed: May 16, 2018
    Publication date: February 21, 2019
    Applicant: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Louise Kenny, Philip Newton Baker, David Broadhurst
  • Publication number: 20170354519
    Abstract: Described herein are methods that result in less cell death resulting from myocardial infarction than would otherwise occur in an individual who has suffered myocardial infarction. Also described are compositions useful in reducing cell death post myocardial infarction.
    Type: Application
    Filed: November 13, 2015
    Publication date: December 14, 2017
    Applicant: University College Cork - National University of Ireland, Cork
    Inventor: Noel Caplice
  • Publication number: 20170281830
    Abstract: Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25 pg to 950 pg of IGF-I directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.
    Type: Application
    Filed: April 27, 2017
    Publication date: October 5, 2017
    Applicant: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventor: Noel Caplice
  • Publication number: 20170253638
    Abstract: An antimicrobial peptide having potent antibacterial activity against Listeria monocytogenes and Staphylococcus aureus is described. Also described is an isolated Lactobacillus salivarius DPC6502 strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 41840, and variants thereof, wherein the isolated bacteria and variants thereof express an antimicrobial peptide of the invention.
    Type: Application
    Filed: April 3, 2017
    Publication date: September 7, 2017
    Applicants: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK, AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC)
    Inventors: Paul ROSS, Eileen O'SHEA, Colin HILL
  • Publication number: 20170172523
    Abstract: The present invention discloses a method and system of providing a real time audification of neonatal EEG signals. The method comprises the steps of: receiving preprocessed neonatal EEG signals; changing a characteristic of the preprocessed signals in a phase vocoder; resampling the output signals from the vocoder to a predetermined audio frequency range; converting the resampled signals into stereo signals; and selecting a plurality of channels from the stereo signals as the output audio signals.
    Type: Application
    Filed: July 7, 2015
    Publication date: June 22, 2017
    Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Andriy TEMKO, Gordon LIGHTBODY, Liam MARNANE, Geraldine BOYLAN
  • Patent number: 9669134
    Abstract: Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25 pg to 950 pg of IGF-1 directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.
    Type: Grant
    Filed: November 27, 2009
    Date of Patent: June 6, 2017
    Assignee: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventor: Noel Caplice
  • Patent number: 9597362
    Abstract: The disclosure relates to the live cultures of probiotic bacteria to treat infectious diseases in humans and animals. Food-grade or non-pathogenic cultures are used to treat localised infections.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: March 21, 2017
    Assignees: TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY, UNIVERSITY COLLEGE, CORK-NATIONAL UNIVERSITY OF IRELAND
    Inventors: Paul Ross, Colin Hill, William Meaney
  • Publication number: 20170026633
    Abstract: A method for performing high dynamic range optical image detection of a scene. The method comprises imaging incident light from a scene onto an object plane of an Optical Array Device, the OAD operating in time modulation mode; determining the locations of those pixels in the object plane of a first light level; detecting the optical irradiance values of those pixels of the first light level to produce a first detected image; detecting the optical irradiance values of those pixels of a second light level to produce a second detected image; and generating a high dynamic range optical irradiance map of the scene by combining the first detected image and the second detected image into a single image.
    Type: Application
    Filed: May 24, 2016
    Publication date: January 26, 2017
    Applicant: University College Cork - National University of Ireland, Cork
    Inventor: Nabeel Agha RIZA
  • Publication number: 20160348175
    Abstract: A method for screening a distressed neonate for risk of having or developing HIE comprises the steps of assaying a biological sample obtained from the distressed neonate, the mother of the neonate, or from the umbilical cord or placenta, for an abundance of miR-374a in the sample, and comparing the abundance of miR-374a in the sample with a reference abundance of miR-374a, wherein a reduced abundance of miR-374a in the sample compared with the reference abundance of miR-374a is indicative of the distressed neonate being at risk of having or developing HIE. Risk of severe HIE can be determined by assaying a biological sample from the distressed neonate identified as being at risk of HIE for an abundance of a plurality of metabolites including succinate, glycerol, acetone and 3-hydroxybutyrate, providing the sum of glycerol and succinate abundance and the sum of acetone and 3-hydroxybutyrate; and correlating the sums with risk of severe HIE.
    Type: Application
    Filed: January 16, 2015
    Publication date: December 1, 2016
    Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Deirdre Murray, Ann Marie Looney, Geraldine Boylan, John Cryan
  • Publication number: 20160304885
    Abstract: The present invention concerns a method for genetically transforming a Bifidobacterium strain comprising a step of methylation of a shuttle vector in an E. coli or a Gram-positive bacterium strain by two type II DNA methyltransferases from a Bifidobacterium: a methyltransferase enzyme that methylates the adenine base at position 4 of the nucleotide sequence RTCAGG and a methyltransferase enzyme that methylates the cytosine base at position 4 of the nucleotide sequence GGWCC. The present invention also concerns genetic tools and culture media useful for carrying out said method.
    Type: Application
    Filed: December 2, 2013
    Publication date: October 20, 2016
    Applicants: Compagnie Gervais Danone, University College Cork - National University of Ireland, Cork
    Inventors: Douwe van Sinderen, Mary O'Connell Motherway, Debbie Watson, Tamara Smokvina, Peggy Garault
  • Publication number: 20160223517
    Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.
    Type: Application
    Filed: January 7, 2016
    Publication date: August 4, 2016
    Applicant: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Louise Kenny, Philip Newton Baker, David Broadhurst
  • Publication number: 20160120963
    Abstract: A non-therapeutic method of reducing weight gain, serum cholesterol levels, or liver triglyceride levels, in a non-obese mammal, comprises the step of administering to the gut of a mammal an effective amount of a bacteria expressing a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof; a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof for use as a medicament; isolated bacterial strains expressing functional variants of BSH1.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 5, 2016
    Applicant: University College Cork, National University of Ireland
    Inventors: Susan Joyce, Cormac Gahan, Colin Hill
  • Publication number: 20160095329
    Abstract: A process for making an edible snack food product having a low water content and a high solids content is described. The process comprises a step of providing an edible porous body, for example a freeze-dried fruit or vegetable slice or an extruded cereal product, and coating the body in a high-solids polymer solution, for example 25% (w/w) whey protein isolate, such that the polymer solution infuses into the pores at or close to the surface of the body but does not rehydrate the porous body. Coating may be achieved by spraying the product with the polymer solution or by briefly immersing the porous body in the solution. The coated porous body is then heated to a high temperature to dehydrate the infused polymer solution. This results in closure of the pores at or close to the surface of the porous body.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 7, 2016
    Applicant: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventor: Yrjo ROOS
  • Patent number: 9262582
    Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: February 16, 2016
    Assignee: University College Cork, National University of Ireland, Cork
    Inventors: Louise Kenny, Philip Newton Baker, David Broadhurst
  • Publication number: 20160043074
    Abstract: The invention provides a three dimensional (3D) semi-conductor device comprising a first junctionless transistor doped with dopants of the same polarity; a second junctionless transistor doped with dopants of the same polarity; and the second junctionless transistor and the first junctionless transistor comprise an opposite dopant polarity are stacked in a vertical arrangement, where the first and second junctionless transistors are separated by an insulating layer. The invention makes use of the fact that the transistors are uniformly doped with the same polarity to provide a junctionless transistor. The junctionless concept provides that the junction is already formed, so there is no high temperature step associated with junction formation or junction regrowth. This is an important advantage in the junctionless concept in relation to 3D monolithic integration that allows for vertical stacking of the transistors to form a three dimensional CMOS inverter.
    Type: Application
    Filed: April 7, 2014
    Publication date: February 11, 2016
    Applicant: University College Cork - National University of Ireland, Cork
    Inventors: Paul HURLEY, Karim CHERKAOUI, Vladimir DJARA
  • Publication number: 20150328449
    Abstract: A thoracoscopic electroporation device for carrying out electroporation on tissue includes a suction head and a plurality of needle electrodes. The needle electrodes include a central needle providing a first electrode and a plurality of second needles which are spaced-apart around the periphery of the suction head. The electrodes are movable from a retracted configuration to a deployed configuration and in the deployed configuration the needles extend from the suction head. The suction head has a retracted delivery configuration and an expanded deployed configuration. The suction head includes a suitable flexible material for biasing the suction head into the expanded deployed configuration. The suction head has channels for the needles and the needles are movable through the channels from the retracted to the deployed configuration. In the deployed configuration, the central first needle extends beyond the peripheral needles.
    Type: Application
    Filed: December 19, 2013
    Publication date: November 19, 2015
    Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Declan SODEN, John HINCHION
  • Patent number: 9187766
    Abstract: A non-therapeutic method of accumulating a polymeric or high molecular weight molecular product within a bacterial microcompartment in bacterial cytoplasm, which method employs a recombinant bacteria which is transformed to express a microcompartment containing an enzyme capable of converting a low molecular weight substrate into a polymeric or high molecular weight product, the method comprising the steps of: incubating the recombinant bacteria with the low-molecular weight substrate, or a precursor of the low molecular weight substrate which is capable of being metabolized to the substrate within the recombinant bacteria, such that the substrate or precursor is taken up by the bacteria, wherein the substrate enters the microcompartment and the enzyme within the microcompartment converts the substrate to a polymeric or high molecular weight molecular product, and wherein the polymeric or high molecular weight molecular product is accumulated within the microcompartment due to its size.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: November 17, 2015
    Assignees: University College Cork, National University of Ireland, University of Kent
    Inventors: Michael Prentice, Martin Warren, Mingzhi Liang
  • Publication number: 20150303345
    Abstract: In one embodiment the invention relates to a photodetector device sensitive for wavelengths comprising a doped Ge absorbing material bonded to a substrate material locally of opposite doping polarity and an interface layer formed between the Ge absorbing material and the substrate material to form a p-n junction. In one embodiment the bonded material comprises a p-doped Ge wafer and n-doped Si or So I wafer and obtained from a low-temperature heat treatment after bonding. The invention also discloses a process for making a photodetector.
    Type: Application
    Filed: November 25, 2013
    Publication date: October 22, 2015
    Applicant: University College Cork-National University of Ireland, Cork
    Inventors: Farzan Gity, Brian Corbett, Alan Morrison, John Hayes